RU2705301C2 - Композиция вирусоподобных частиц - Google Patents

Композиция вирусоподобных частиц Download PDF

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RU2705301C2
RU2705301C2 RU2014133527A RU2014133527A RU2705301C2 RU 2705301 C2 RU2705301 C2 RU 2705301C2 RU 2014133527 A RU2014133527 A RU 2014133527A RU 2014133527 A RU2014133527 A RU 2014133527A RU 2705301 C2 RU2705301 C2 RU 2705301C2
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virus
polypeptide
antigen
seq
present
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RU2014133527A
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RU2014133527A (ru
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Рюдзи УЭНО
Ватару АКАХАТА
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Влп Терапьютикс, Ллк
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48984367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2705301(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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    • C07K14/08RNA viruses
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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RU2014133527A 2012-02-16 2013-02-15 Композиция вирусоподобных частиц RU2705301C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261599746P 2012-02-16 2012-02-16
US61/599,746 2012-02-16
PCT/JP2013/054422 WO2013122262A1 (en) 2012-02-16 2013-02-15 Virus like particle composition

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RU2014133527A RU2014133527A (ru) 2016-03-10
RU2705301C2 true RU2705301C2 (ru) 2019-11-06

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US (2) US9249191B2 (cg-RX-API-DMAC7.html)
EP (1) EP2814847B1 (cg-RX-API-DMAC7.html)
JP (2) JP6306518B2 (cg-RX-API-DMAC7.html)
KR (1) KR102181258B1 (cg-RX-API-DMAC7.html)
CN (2) CN104220462A (cg-RX-API-DMAC7.html)
AP (1) AP2014007864A0 (cg-RX-API-DMAC7.html)
AR (1) AR092796A1 (cg-RX-API-DMAC7.html)
AU (1) AU2013221187B9 (cg-RX-API-DMAC7.html)
BR (1) BR112014020052B8 (cg-RX-API-DMAC7.html)
CA (1) CA2863695C (cg-RX-API-DMAC7.html)
MX (1) MX357202B (cg-RX-API-DMAC7.html)
NZ (2) NZ628206A (cg-RX-API-DMAC7.html)
RU (1) RU2705301C2 (cg-RX-API-DMAC7.html)
SG (2) SG10201606635SA (cg-RX-API-DMAC7.html)
TW (1) TWI695844B (cg-RX-API-DMAC7.html)
WO (1) WO2013122262A1 (cg-RX-API-DMAC7.html)
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9249191B2 (en) 2012-02-16 2016-02-02 Vlp Therapeutics, Llc Virus like particle composition
EP2712871A1 (en) * 2012-09-27 2014-04-02 Institut Pasteur Recombinant Measles virus expressing Chikungunya virus polypeptides and their applications
EP2971010B1 (en) 2013-03-14 2020-06-10 ModernaTX, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
JP6734651B2 (ja) 2013-06-03 2020-08-05 ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーVLP Therapeutics, LLC マラリアワクチン
TWI676636B (zh) * 2013-07-12 2019-11-11 Vlp醫療股份有限公司 包含pd-1抗原或pd-1配體抗原的類病毒粒子
EP3041934A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
US10385101B2 (en) 2014-08-08 2019-08-20 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
US9969986B2 (en) 2014-08-08 2018-05-15 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
MX383330B (es) 2014-09-11 2025-03-13 Vlp Therapeutics Inc Particula tipo virus de flavivirus.
GB2535753A (en) * 2015-02-26 2016-08-31 The Native Antigen Company Particles comprising fusion proteins
US10166281B2 (en) * 2015-09-04 2019-01-01 Vlp Therapeutics, Llc Method and composition for modulating immune response
CN105176936B (zh) * 2015-10-23 2019-01-11 中国科学院武汉物理与数学研究所 复制耐受型的西门利克森林病毒的亚克隆及制备方法和应用
CA3009799A1 (en) * 2016-01-04 2017-07-13 Cour Pharmaceuticals Development Company Inc. Particles encapsulating fusion proteins containing linked epitopes
CA3030451C (en) * 2016-07-15 2023-09-05 Etubics Corporation Compositions and methods for alphavirus vaccination
KR101875055B1 (ko) * 2016-10-19 2018-07-06 연세대학교 원주산학협력단 융합 단백질 및 그의 용도
EP3589312A1 (en) * 2017-03-03 2020-01-08 New York University Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins
TW201907937A (zh) 2017-05-08 2019-03-01 美商葛利史東腫瘤科技公司 阿爾法病毒新抗原載體
EP3625246A1 (en) 2017-05-18 2020-03-25 ModernaTX, Inc. Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof
MX2020006567A (es) 2017-12-20 2020-09-25 Vlp Therapeutics Llc Particula de replicon de alfavirus.
AU2019205330B2 (en) 2018-01-04 2025-09-11 Iconic Therapeutics Llc Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
JP2021512966A (ja) * 2018-02-07 2021-05-20 イミュジーン、リミテッドImugene Limited ワクチン組成物およびその使用
US11560421B2 (en) 2018-02-09 2023-01-24 Osaka University Broad-spectrum monoclonal antibodies against chikungunya virus E1 structural protein
JP6906207B2 (ja) * 2018-02-09 2021-07-21 国立大学法人大阪大学 チクングニアウイルス検出用免疫クロマト分析装置
IL288283B2 (en) 2019-05-30 2025-05-01 Gritstone Bio Inc Modified adenovirus
CN112852852B (zh) * 2019-11-27 2023-07-25 中国医学科学院医学生物学研究所 一种ox40抗原表位重组病毒样颗粒及其制备方法和应用
TWI891771B (zh) 2020-04-17 2025-08-01 美商Vlp醫療股份有限公司 冠狀病毒疫苗
WO2021215952A1 (ru) 2020-04-24 2021-10-28 Общество С Ограниченной Ответственностью "Индженик" Способ получения частиц бактериофагов семейства levivirus
IL297564A (en) 2020-04-30 2022-12-01 Vlp Therapeutics Inc Cytokine immunotherapy
IL300026A (en) 2020-08-06 2023-03-01 Gritstone Bio Inc Multiepitope vaccine cassettes
US20220193225A1 (en) * 2020-08-31 2022-06-23 Bruce Lyday Compositions and methods for sars-2 vaccine with virus replicative particles and recombinant glycoproteins
WO2024015890A1 (en) 2022-07-13 2024-01-18 Modernatx, Inc. Norovirus mrna vaccines
WO2025029700A1 (en) 2023-07-28 2025-02-06 Modernatx, Inc. Vlp enteroviral vaccines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062396A2 (en) * 2008-11-26 2010-06-03 Government Of The United States Of America , As Represented By The Secretary, Department Of Health And Human Services Virus like particle compositions and methods of use
RU2409667C2 (ru) * 2004-09-21 2011-01-20 Цитос Биотехнологи Аг Вирусоподобные частицы, включающие гибридный белок белка оболочки бактериофага ар205 и антигенного полипептида

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8923123D0 (en) 1989-10-13 1989-11-29 Connaught Lab A vaccine for human immunodeficiency virus
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
JP3954643B2 (ja) 1991-11-16 2007-08-08 グラクソスミスクライン・バイオロジカルス・ソシエテ・アノニム マラリア原虫由来のCSおよびHBsAG間のハイブリッド蛋白質
US5580773A (en) * 1992-06-17 1996-12-03 Korea Green Cross Corporation Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV)
CA2143491C (en) 1994-03-01 2011-02-22 Yasumasa Ishida A novel peptide related to human programmed cell death and dna encoding it
CA2232669A1 (en) * 1995-09-27 1997-04-03 Frances Joanne Morling Recombinant viruses incorporating a protease cleavable protein
AU3289199A (en) 1998-02-11 1999-08-30 Maxygen, Inc. Antigen library immunization
EP1210428B1 (en) 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
US20110262389A1 (en) * 2001-02-13 2011-10-27 Mosca Joseph D Tumor-derived Biological Antigen Presenting Particles
WO2002096939A2 (en) 2001-05-30 2002-12-05 Transgene S.A. Adenovirus protein ix, its domains involved in capsid assembly, transcriptional activity and nuclear reorganization
ES2350687T3 (es) 2002-07-03 2011-01-26 Ono Pharmaceutical Co., Ltd. Composiciones de inmunopotenciación.
WO2004043399A2 (en) 2002-11-13 2004-05-27 The United States Of America As Represented By The Secretary Of The Navy Methods and compositions for inducing immune responses and protective immunity by priming with alphavirus replicon vaccines
US7790181B2 (en) 2003-05-29 2010-09-07 The United States Of America As Represented By The Secretary Of The Army Live attenuated viral vaccines for Eastern Equine Encephalitis virus
US7541038B2 (en) * 2003-06-05 2009-06-02 Wyeth Holdings Corporation Fusogenic, self-propagating blebs as immunogenic compositions
CA2547511A1 (en) 2003-12-01 2005-07-28 Dow Global Technolgies Inc. Recombinant icosahedral virus like particle production in pseudomonads
CN101023103A (zh) * 2004-09-21 2007-08-22 赛托斯生物技术公司 包含ap205外壳蛋白和抗原性多肽的融合蛋白的病毒样颗粒
MX2007004031A (es) 2004-10-14 2007-11-08 Crucell Holland Bv Vacunas de cebado/refuerzo contra el paludismo.
JP4819792B2 (ja) 2005-02-16 2011-11-24 国立大学法人東京工業大学 改変されたウイルスカプシドタンパク質及びその使用
MX349137B (es) 2005-06-08 2017-07-13 Dana-Farber Cancer Inst Metodos y composiciones para el tratamiento de infecciones persistentes y cancer por inhibicion de la ruta de muerte celular programada (pd-1).
GB0513421D0 (en) 2005-06-30 2005-08-03 Glaxosmithkline Biolog Sa Vaccines
CU23586A1 (es) 2005-11-22 2010-10-30 Ct Ingenieria Genetica Biotech Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus
EP1997887B1 (en) 2006-03-03 2013-09-04 Ono Pharmaceutical Co., Ltd. Multimer of extracellular domain of cell surface functional molecule
US20100120092A1 (en) 2006-08-30 2010-05-13 Hepgenics Pty Ltd. Recombinant proteins and virus like particles comprising l and s polypeptides of avian hepadnaviridae and methods, nucleic acid constructs, vectors and host cells for producing same
WO2009079185A2 (en) 2007-11-26 2009-06-25 Novartis Vaccines And Diagnostics, Inc. Methods of generating alphavirus particles
CA2774640C (en) 2009-09-18 2019-11-26 Fraunhofer Usa Inc. Virus like particles comprising target proteins fused to plant viral coat proteins
WO2012006180A1 (en) 2010-06-29 2012-01-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv immunogens
WO2012023995A1 (en) 2010-08-18 2012-02-23 Takayuki Shiratsuchi Modification of recombinant adenovirus capsid protein with immunogenic plasmodium circumsporozoite protein epitopes
US9487563B2 (en) * 2011-01-31 2016-11-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Virus-like particles and methods of use
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗
AU2012269907B2 (en) * 2011-06-17 2017-05-18 Bharat Biotech International Limited Vaccine composition comprising an inactivated chikungunya virus strain
CN102321639B (zh) * 2011-09-08 2013-06-26 中国疾病预防控制中心病毒病预防控制所 基孔肯雅病毒病毒样颗粒的制备方法和应用
HK1206366A1 (en) 2011-10-25 2016-01-08 佛罗里达海湾海岸大学理事会 Vaccines and methods for creating a vaccine for inducing immunity to all dengue virus serotypes
US9249191B2 (en) 2012-02-16 2016-02-02 Vlp Therapeutics, Llc Virus like particle composition
CN108912215A (zh) 2012-04-02 2018-11-30 北卡罗来纳-查佩尔山大学 用于登革病毒表位的方法和组合物
CN107540730B (zh) 2012-05-16 2021-07-16 免疫设计公司 用于hsv-2的疫苗
JP6734651B2 (ja) 2013-06-03 2020-08-05 ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーVLP Therapeutics, LLC マラリアワクチン
TWI676636B (zh) 2013-07-12 2019-11-11 Vlp醫療股份有限公司 包含pd-1抗原或pd-1配體抗原的類病毒粒子
WO2015139784A1 (en) 2014-03-18 2015-09-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Distinguishing flavivirus infection using a recombinant mutant envelope protein
US9969986B2 (en) 2014-08-08 2018-05-15 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
US10385101B2 (en) 2014-08-08 2019-08-20 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
US9363353B1 (en) 2014-12-04 2016-06-07 Hon Man Ashley Chik Mobile phone docks with multiple circulating phone connectors
AU2015373928B2 (en) 2014-12-31 2019-10-17 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Novel multivalent nanoparticle-based vaccines
EP3309251A4 (en) 2015-06-12 2019-03-13 Mie University HUMAN PARAIN FLUENZA TYPE 2 VIRUS VIRUS VECTOR AND VACCINE
US10799575B2 (en) 2015-06-25 2020-10-13 Technovax, Inc. Flavivirus and alphavirus virus-like particles (VLPS)
CA2992531C (en) 2015-07-16 2023-09-26 Bharat Biotech International Limited Vaccine compositions
MA42502A (fr) 2015-07-21 2018-05-30 Modernatx Inc Vaccins contre une maladie infectieuse
CN106085974B (zh) 2016-06-07 2019-08-09 博奥生物集团有限公司 一种寨卡病毒假病毒颗粒及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2409667C2 (ru) * 2004-09-21 2011-01-20 Цитос Биотехнологи Аг Вирусоподобные частицы, включающие гибридный белок белка оболочки бактериофага ар205 и антигенного полипептида
WO2010062396A2 (en) * 2008-11-26 2010-06-03 Government Of The United States Of America , As Represented By The Secretary, Department Of Health And Human Services Virus like particle compositions and methods of use
US20120003266A1 (en) * 2008-11-26 2012-01-05 The United States of America,as represented by The Secretary, National Institues of Health Virus like particle compositions and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GUNTHER SPOHN et al., A Virus-Like Particle-Based Vaccine Selectively Targeting Soluble TNF- a Protects from Arthritis without Inducing Reactivation of Latent Tuberculosis, The Journal of Immunology, 2007, Vol.178, pp.7450-7457. *
WATARU AKAHATA et al., A VLP vaccine for epidemic Chikungunya virus protects nonhuman primates against infection, Nat Med., 2010 March, Vol.16, No.3, pp.334-338. *

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