RU2686108C2 - Вирусосодержащий препарат и его применение - Google Patents

Вирусосодержащий препарат и его применение Download PDF

Info

Publication number
RU2686108C2
RU2686108C2 RU2015116539A RU2015116539A RU2686108C2 RU 2686108 C2 RU2686108 C2 RU 2686108C2 RU 2015116539 A RU2015116539 A RU 2015116539A RU 2015116539 A RU2015116539 A RU 2015116539A RU 2686108 C2 RU2686108 C2 RU 2686108C2
Authority
RU
Russia
Prior art keywords
virus
immunogenic
composition according
composition
lyophilized composition
Prior art date
Application number
RU2015116539A
Other languages
English (en)
Russian (ru)
Other versions
RU2015116539A (ru
Inventor
Клод СЕН
Мелина ШАСЛЬ
Original Assignee
Трансген Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Трансген Са filed Critical Трансген Са
Publication of RU2015116539A publication Critical patent/RU2015116539A/ru
Application granted granted Critical
Publication of RU2686108C2 publication Critical patent/RU2686108C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A61K39/285—Vaccinia virus or variola virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2015116539A 2012-10-02 2013-10-02 Вирусосодержащий препарат и его применение RU2686108C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12306198 2012-10-02
EP12306198.8 2012-10-02
PCT/EP2013/070590 WO2014053571A1 (en) 2012-10-02 2013-10-02 Virus-containing formulation and use thereof

Publications (2)

Publication Number Publication Date
RU2015116539A RU2015116539A (ru) 2016-11-27
RU2686108C2 true RU2686108C2 (ru) 2019-04-24

Family

ID=47018930

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015116539A RU2686108C2 (ru) 2012-10-02 2013-10-02 Вирусосодержащий препарат и его применение

Country Status (17)

Country Link
US (1) US10111947B2 (enExample)
EP (1) EP2903600B1 (enExample)
JP (1) JP6466332B2 (enExample)
KR (1) KR102181658B1 (enExample)
CN (1) CN104797242B (enExample)
AU (1) AU2013326548B2 (enExample)
BR (1) BR112015007314B1 (enExample)
CA (1) CA2887156C (enExample)
DK (1) DK2903600T3 (enExample)
ES (1) ES2928670T3 (enExample)
IL (1) IL238064B (enExample)
MX (1) MX374287B (enExample)
NZ (1) NZ707328A (enExample)
RU (1) RU2686108C2 (enExample)
SG (1) SG11201502621XA (enExample)
TW (1) TWI690322B (enExample)
WO (1) WO2014053571A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11273127B2 (en) 2014-05-06 2022-03-15 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for thermally stable multi-targeted antigens
CN120555373A (zh) 2014-07-16 2025-08-29 特兰斯吉恩股份有限公司 用于表达免疫检查点调节因子的溶瘤病毒
KR102507483B1 (ko) 2014-12-01 2023-03-07 트랜스진 안정한 액체 백시니아 바이러스 제제
CN107949397A (zh) * 2015-02-13 2018-04-20 特兰斯吉恩股份有限公司 免疫治疗疫苗和抗体组合治疗
WO2016131945A1 (en) 2015-02-20 2016-08-25 Transgene Sa Combination product with autophagy modulator
EP3261669B1 (en) 2015-02-25 2022-08-03 Memorial Sloan Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
US10548930B2 (en) 2015-04-17 2020-02-04 Memorial Sloan Kettering Cancer Center Use of MVA or MVAΔE3L as immunotherapeutic agents against solid tumors
WO2017147553A2 (en) 2016-02-25 2017-08-31 Memorial Sloan-Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy
IL261321B2 (en) 2016-02-25 2023-12-01 Memorial Sloan Kettering Cancer Center Recombinant MVA or MVADELE3L expressing human FLT3L and their use as immunotherapeutic agents against solid tumors
MX2018011226A (es) * 2016-03-14 2019-05-16 Baylor College Medicine Tc24-c4, antígeno de vacuna de la enfermedad de chagas con estabilidad mejorada y agregación disminuida.
PE20190149A1 (es) * 2016-03-31 2019-01-22 Takeda Vaccines Inc Composiciones y metodos para estabilizar alfavirus con formulaciones mejoradas
WO2017191147A1 (en) 2016-05-04 2017-11-09 Transgene Sa Combination therapy with cpg tlr9 ligand
TW201825674A (zh) 2016-09-09 2018-07-16 美商艾斯合顧問有限公司 表現雙特異性接合分子的溶瘤病毒
WO2018069316A2 (en) 2016-10-10 2018-04-19 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
CN111107872A (zh) 2017-05-12 2020-05-05 纪念斯隆-凯特林癌症中心 有用于癌症免疫疗法的牛痘病毒突变体
KR102658198B1 (ko) 2017-05-15 2024-04-16 얀센 백신스 앤드 프리벤션 비.브이. 안정한 바이러스 함유 조성물
AU2018269319A1 (en) 2017-05-15 2019-11-07 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
WO2018234506A2 (en) 2017-06-21 2018-12-27 Transgene Sa PERSONALIZED VACCINE
JP2021505610A (ja) * 2017-12-05 2021-02-18 アプライド ジェネティック テクノロジーズ コーポレイション ウイルス粒子のための製剤最適化
AU2019229653B2 (en) 2018-03-07 2025-09-11 Transgene Parapoxvirus vectors
KR20240014102A (ko) 2018-06-29 2024-01-31 우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 레버 유전성 시신경병증의 치료를 위한 조성물 및 방법
JP7403852B2 (ja) 2018-08-20 2023-12-25 ウーハン ニューロフス バイオテクノロジー リミテッド カンパニー レーベル遺伝性視神経症を治療するための組成物及び方法
CA3111273C (en) * 2018-09-06 2024-03-26 Bavarian Nordic A/S Storage improved poxvirus compositions
AU2019339535B2 (en) 2018-09-15 2025-11-20 Memorial Sloan Kettering Cancer Center Recombinant poxviruses for cancer immunotherapy
JP7557738B2 (ja) 2018-10-30 2024-09-30 国立大学法人 東京大学 がん治療のための腫瘍溶解性ウイルス
IL284421B2 (en) 2018-12-28 2025-05-01 Transgene M2-defective poxvirus
WO2020136232A1 (en) 2018-12-28 2020-07-02 Transgene Sa Immunosuppressive m2 protein
CN113025633B (zh) 2019-12-09 2024-08-27 武汉纽福斯生物科技有限公司 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用
EP3842065A1 (en) 2019-12-23 2021-06-30 Transgene Process for designing a recombinant poxvirus for a therapeutic vaccine
IL296250A (en) 2020-03-12 2022-11-01 Bavarian Nordic As Compositions improving poxvirus stability
WO2022148736A1 (en) 2021-01-05 2022-07-14 Transgene Vectorization of muc1 t cell engager
CN119654339A (zh) 2022-07-01 2025-03-18 特兰斯吉恩股份有限公司 包含表面活性蛋白-d和tnfsf成员的融合蛋白
CN115040656B (zh) * 2022-07-05 2024-04-26 吉林惠康生物药业有限公司 狂犬疫苗冻干保护剂、应用和疫苗及其制备方法
TW202413636A (zh) 2022-08-18 2024-04-01 法商傳斯堅公司 嵌合痘病毒

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2076787A5 (en) * 1970-01-28 1971-10-15 Merieux Inst Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin
US3915794A (en) * 1973-02-09 1975-10-28 Rit Rech Ind Therapeut Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them
EP0065905A1 (fr) * 1981-05-13 1982-12-01 Institut Pasteur Perfectionnements apportés aux agents de stabilisation de virus vivants pour la préparation de vaccins, et vaccins stabilisés contenant lesdits agents de stabilisation
WO2007056847A1 (en) * 2005-11-21 2007-05-24 Sanofi Pasteur Limited Stabilizing formulations for recombinant viruses
US20100173921A1 (en) * 2006-08-10 2010-07-08 Cipla Limited Antiretroviral Solid Oral Composition

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
AU568666B2 (en) * 1983-08-25 1988-01-07 Thomas, G. Production of phosphates from alkali-proecessed phosphate rock
FR2643817B1 (fr) 1989-03-06 1993-12-17 Transgene Sa Composition pharmaceutique, utile a titre preventif ou curatif contre les tumeurs induites par les papillomavirus
GB8801338D0 (en) 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
EP0487632B1 (en) * 1989-08-15 1998-03-04 Massachusetts Institute Of Technology Stabilized vaccine compositions
FR2668064B1 (fr) 1990-10-23 1994-12-16 Transgene Sa Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne.
US5756102A (en) 1990-11-20 1998-05-26 Virogenetics Corporation Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants
WO1992015672A1 (en) 1991-03-07 1992-09-17 Virogenetics Corporation Genetically engineered vaccine strain
FR2710536B1 (fr) 1993-09-29 1995-12-22 Transgene Sa Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire.
EP0728195A1 (en) 1993-10-12 1996-08-28 Chiron Corporation Methods for preserving recombinant viruses
CA2190290C (en) 1994-05-13 2011-07-05 Michael J. Mastrangelo A method of inducing an immune response using vaccinia virus recombinants
EP0872249A4 (en) 1995-03-17 2001-10-24 Hisamitsu Pharmaceutical Co GENE TRANSFER PREPARATION
FR2742756B1 (fr) * 1995-12-22 1998-04-03 Pasteur Merieux Serums Vacc Stabilisants pour vaccins vivants, vaccins les contenant et procedes pour leur preparation
FR2751879B1 (fr) 1996-07-30 1998-10-30 Transgene Sa Composition pharmaceutique contre les tumeurs et infections a papillomavirus
FR2766091A1 (fr) 1997-07-18 1999-01-22 Transgene Sa Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee
US6210683B1 (en) * 1997-09-05 2001-04-03 Merck & Co., Inc. Stabilizers containing recombinant human serum albumin for live virus vaccines
BR0214822A (pt) 2001-12-10 2004-12-14 Bavarian Nordic As Formulações contendo poxvìrus e processo para preparar composições contendo poxvìrus estáveis
FR2855758B1 (fr) 2003-06-05 2005-07-22 Biomerieux Sa Composition comprenant la polyproteine ns3/ns4 et le polypeptide ns5b du vhc, vecteurs d'expression incluant les sequences nucleiques correspondantes et leur utilisation en therapeutique
EP1651272A1 (en) * 2003-08-05 2006-05-03 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin as a stabiliser in vaccines
MXPA06006947A (es) * 2003-12-17 2007-01-26 Wyeth Corp Metodos para producir virus de almacenamiento estable y composiciones inmunogenicas de estos.
WO2005066333A1 (en) * 2003-12-30 2005-07-21 Aventis Pasteur, Inc. Stabilizing compositions for recombinant viruses
CN100475268C (zh) * 2004-01-17 2009-04-08 上海三维生物技术有限公司 重组腺病毒冻干制剂及制备方法
DK2377557T3 (en) * 2004-11-24 2017-02-06 Meda Pharmaceuticals Inc Compositions comprising azelastine and methods for its use
TWI398272B (zh) * 2005-03-08 2013-06-11 Intervet Int Bv 化學定義的安定劑
ATE499112T1 (de) * 2005-09-01 2011-03-15 Celgene Corp Immunologische verwendungen von immunmodulatorischen verbindungen für einen impfstoff und therapie gegen infektionskrankheiten
AU2006287441B2 (en) 2005-09-07 2012-09-06 Sillajen Biotherapeutics, Inc. Systemic treatment of metastatic and/or systemically-disseminated cancers using GM-CSF-expressing poxviruses
JP2009534331A (ja) 2006-04-21 2009-09-24 トランジェーヌ、ソシエテ、アノニム Ｈｐｖ‐１８を主体とするパピローマウイルスワクチン
EP2029756B1 (en) 2006-06-20 2016-11-09 Transgene S.A. Process for producing poxviruses and poxvirus compositions
KR20080084528A (ko) 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. 종양살상형 백시니아 바이러스 암 치료
GB0705245D0 (en) 2007-03-19 2007-04-25 Stabilitech Ltd Stable biological products
NZ584201A (en) 2007-11-19 2012-06-29 Transgene Sa Poxviral oncolytic vectors comprising a defective f2l gene
ES2567564T3 (es) 2007-11-19 2016-04-25 Transgene Sa Vectores oncolíticos de poxvirus
JP2012526532A (ja) 2009-05-12 2012-11-01 トランジェーヌ、ソシエテ、アノニム 不死化鳥類細胞系およびその用途
SG178254A1 (en) 2009-08-07 2012-03-29 Transgene Sa Composition for treating hbv infection
US20110243988A1 (en) * 2009-10-01 2011-10-06 Aridis Pharmaceuticals Methods and Compositions for Stabilization of a Virus Vaccine
US8557253B2 (en) * 2009-10-07 2013-10-15 Sanofi Pasteur Sa Stabilizing excipient for inactivated whole virus vaccine
ES2543795T3 (es) 2010-03-31 2015-08-21 Stabilitech Ltd. Estabilización de partículas virales
CN102933230B (zh) * 2010-04-15 2016-03-02 株式会社新日本科学 用于鼻内递送的方法和组合物
TWI575070B (zh) 2011-07-12 2017-03-21 傳斯堅公司 Ｈｂｖ聚合酶突變體

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2076787A5 (en) * 1970-01-28 1971-10-15 Merieux Inst Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin
US3915794A (en) * 1973-02-09 1975-10-28 Rit Rech Ind Therapeut Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them
EP0065905A1 (fr) * 1981-05-13 1982-12-01 Institut Pasteur Perfectionnements apportés aux agents de stabilisation de virus vivants pour la préparation de vaccins, et vaccins stabilisés contenant lesdits agents de stabilisation
US4500512A (en) * 1981-05-13 1985-02-19 Institut Pasteur Stabilizing agents for live viruses for preparing vaccines, and stabilized vaccines containing said stabilizing agents
WO2007056847A1 (en) * 2005-11-21 2007-05-24 Sanofi Pasteur Limited Stabilizing formulations for recombinant viruses
US20100173921A1 (en) * 2006-08-10 2010-07-08 Cipla Limited Antiretroviral Solid Oral Composition

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Burke CJ et.al. Formulation, stability, and delivery of live attenuated vaccines for human use. Crit Rev Ther Drug Carrier Syst. 1999 16(1):1-83. *
Croyle MA et.al. Factors that influence stability of recombinant adenoviral preparations for human gene therapy. Pharm Dev Technol. 1998 Aug;3(3):373-83. *
Croyle MA et.al. Factors that influence stability of recombinant adenoviral preparations for human gene therapy. Pharm Dev Technol. 1998 Aug;3(3):373-83. Burke CJ et.al. Formulation, stability, and delivery of live attenuated vaccines for human use. Crit Rev Ther Drug Carrier Syst. 1999 16(1):1-83. Rexroad J et.al. Lyophilization and the Thermostability of Vaccines. Cell Preservation Technology, Mary Ann Liebert, V.1, N2, 2002. Cryopreservation and freeze-drying protocol. Second edition. Edited by John G. Day, Glyn N. Stacey. Humana Press, New Jersey. 2007. ПОКРОВСКИЙ В.И. Энциклопедический словарь медицинских терминов. 2005, 1591c. *
Cryopreservation and freeze-drying protocol. Second edition. Edited by John G. Day, Glyn N. Stacey. Humana Press, New Jersey. 2007. *
Rexroad J et.al. Lyophilization and the Thermostability of Vaccines. Cell Preservation Technology, Mary Ann Liebert, V.1, N2, 2002. *
ПОКРОВСКИЙ В.И. Энциклопедический словарь медицинских терминов. 2005, 1591c. *

Also Published As

Publication number Publication date
IL238064B (en) 2019-07-31
CA2887156C (en) 2021-01-19
KR20150087206A (ko) 2015-07-29
JP6466332B2 (ja) 2019-02-06
TW201417820A (zh) 2014-05-16
ES2928670T3 (es) 2022-11-22
BR112015007314A2 (enExample) 2017-08-15
AU2013326548A1 (en) 2015-05-14
US10111947B2 (en) 2018-10-30
EP2903600B1 (en) 2022-08-31
RU2015116539A (ru) 2016-11-27
CN104797242A (zh) 2015-07-22
MX374287B (es) 2025-03-06
MX2015004290A (es) 2016-01-20
TWI690322B (zh) 2020-04-11
JP2015531387A (ja) 2015-11-02
EP2903600A1 (en) 2015-08-12
DK2903600T3 (da) 2022-09-26
WO2014053571A1 (en) 2014-04-10
CN104797242B (zh) 2019-10-01
SG11201502621XA (en) 2015-05-28
US20150250869A1 (en) 2015-09-10
CA2887156A1 (en) 2014-04-10
IL238064A0 (en) 2015-05-31
AU2013326548B2 (en) 2018-07-19
NZ707328A (en) 2018-07-27
BR112015007314B1 (pt) 2023-05-09
KR102181658B1 (ko) 2020-11-23
HK1211206A1 (en) 2016-05-20

Similar Documents

Publication Publication Date Title
RU2686108C2 (ru) Вирусосодержащий препарат и его применение
ES2813413T3 (es) Métodos y composiciones para la producción de virus vaccina
CN107206063B (zh) 稳定的液体痘苗病毒制剂
JP4439263B2 (ja) ポックスウイルス含有調合物およびその調製方法
JP2005513109A6 (ja) ポックスウイルス含有調合物およびその調製方法
KR20080070866A (ko) 재조합 바이러스용 안정화 제형
EP3512939A1 (en) A novel method for obtaining efficient viral vector-based compositions for vaccination or gene therapy
JP7712284B2 (ja) ポックスウイルスの安定性を改善する組成物
AU2019336940B2 (en) Storage improved poxvirus compositions
KR102658198B1 (ko) 안정한 바이러스 함유 조성물
HK1211206B (en) Virus-containing formulation and use thereof
WO2021020446A1 (ja) 単純ヘルペスウイルスを含む組成物