CA2887156C - Virus-containing formulation and use thereof - Google Patents
Virus-containing formulation and use thereof Download PDFInfo
- Publication number
- CA2887156C CA2887156C CA2887156A CA2887156A CA2887156C CA 2887156 C CA2887156 C CA 2887156C CA 2887156 A CA2887156 A CA 2887156A CA 2887156 A CA2887156 A CA 2887156A CA 2887156 C CA2887156 C CA 2887156C
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- CA
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- Prior art keywords
- formulation
- phosphate
- virus
- arginine
- poxvirus
- Prior art date
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| US3915794A (en) * | 1973-02-09 | 1975-10-28 | Rit Rech Ind Therapeut | Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them |
| US4338335A (en) * | 1980-02-05 | 1982-07-06 | Merck & Co., Inc. | Vaccine stabilizer containing L-glutamic acid and L-arginine |
| FR2505657A1 (fr) * | 1981-05-13 | 1982-11-19 | Pasteur Institut | Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation |
| AU568666B2 (en) * | 1983-08-25 | 1988-01-07 | Thomas, G. | Production of phosphates from alkali-proecessed phosphate rock |
| FR2643817B1 (fr) | 1989-03-06 | 1993-12-17 | Transgene Sa | Composition pharmaceutique, utile a titre preventif ou curatif contre les tumeurs induites par les papillomavirus |
| GB8801338D0 (en) | 1988-01-21 | 1988-02-17 | Quadrant Bioresources Ltd | Preservation of viruses |
| JP3064413B2 (ja) * | 1989-08-15 | 2000-07-12 | マサチユセツツ・インスチチユート・オブ・テクノロジー | 安定化ワクチン組成物 |
| FR2668064B1 (fr) | 1990-10-23 | 1994-12-16 | Transgene Sa | Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne. |
| US5756102A (en) | 1990-11-20 | 1998-05-26 | Virogenetics Corporation | Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants |
| DE69233158T2 (de) | 1991-03-07 | 2004-05-13 | Connaught Technology Corp., Greenville | Gentechnologisch hergestellter stamm für impfstoffe |
| FR2710536B1 (fr) | 1993-09-29 | 1995-12-22 | Transgene Sa | Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire. |
| CA2158935A1 (en) | 1993-10-12 | 1995-04-20 | Chiron Viagene, Inc. | Methods for preserving recombinant viruses |
| WO1995031105A1 (en) | 1994-05-13 | 1995-11-23 | Thomas Jefferson University | A method of inducing an immune response using vaccinia virus recombinants |
| WO1996029096A1 (en) | 1995-03-17 | 1996-09-26 | Hisamitsu Pharmaceutical Co., Inc. | Gene transfer preparation |
| FR2742756B1 (fr) * | 1995-12-22 | 1998-04-03 | Pasteur Merieux Serums Vacc | Stabilisants pour vaccins vivants, vaccins les contenant et procedes pour leur preparation |
| FR2751879B1 (fr) | 1996-07-30 | 1998-10-30 | Transgene Sa | Composition pharmaceutique contre les tumeurs et infections a papillomavirus |
| FR2766091A1 (fr) | 1997-07-18 | 1999-01-22 | Transgene Sa | Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee |
| US6210683B1 (en) * | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| KR20040074067A (ko) | 2001-12-10 | 2004-08-21 | 버베리안 노딕 에이/에스 | 폭스바이러스를 포함하는 제형 및 폭스바이러스를포함하는 안정한 조성물을 제조하기 위한 방법 |
| FR2855758B1 (fr) | 2003-06-05 | 2005-07-22 | Biomerieux Sa | Composition comprenant la polyproteine ns3/ns4 et le polypeptide ns5b du vhc, vecteurs d'expression incluant les sequences nucleiques correspondantes et leur utilisation en therapeutique |
| WO2005011739A1 (en) * | 2003-08-05 | 2005-02-10 | Fuji Photo Film B.V. | Use of recombinant or synthetic gelatin as a stabiliser in vaccines |
| WO2005058356A2 (en) * | 2003-12-17 | 2005-06-30 | Wyeth | Methods for porducing storage stable viruses and immunogenic compositions thereof |
| WO2005066333A1 (en) * | 2003-12-30 | 2005-07-21 | Aventis Pasteur, Inc. | Stabilizing compositions for recombinant viruses |
| CN100475268C (zh) | 2004-01-17 | 2009-04-08 | 上海三维生物技术有限公司 | 重组腺病毒冻干制剂及制备方法 |
| NZ555501A (en) * | 2004-11-24 | 2010-01-29 | Medpointe Healthcare Inc | Compositions comprising azelastine and methods of use thereof |
| TWI398272B (zh) | 2005-03-08 | 2013-06-11 | Intervet Int Bv | 化學定義的安定劑 |
| WO2007028047A2 (en) * | 2005-09-01 | 2007-03-08 | Celgene Corporation | Immunological uses of immunodulatory compounds for vaccine and anti-infections disease therapy |
| KR20090004839A (ko) | 2005-09-07 | 2009-01-12 | 제네렉스, 인코포레이티드 | Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법 |
| KR101357685B1 (ko) * | 2005-11-21 | 2014-02-06 | 사노피 파스퇴르 리미티드 / 사노피 파스퇴르 리미떼 | 재조합 바이러스용 안정화 제형 |
| BRPI0710242A2 (pt) | 2006-04-21 | 2011-08-09 | Transgene Sa | uso de uma composição |
| HUE037866T2 (hu) | 2006-06-20 | 2018-09-28 | Transgene Sa | Eljárás poxvírusok és poxvírus-készítmények elõállítására |
| BRPI0714265A2 (pt) * | 2006-08-10 | 2013-04-16 | Cipla Ltd | composiÇço oral sàlida, processo para preparar uma composiÇço oral sàlida, uso de uma composiÇço e mÉtodo para tratar hiv |
| KR20080084528A (ko) | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
| GB0705245D0 (en) | 2007-03-19 | 2007-04-25 | Stabilitech Ltd | Stable biological products |
| PL2212345T3 (pl) | 2007-11-19 | 2016-07-29 | Transgene Sa | Onkolityczne wektory pokswirusowe |
| NZ584201A (en) | 2007-11-19 | 2012-06-29 | Transgene Sa | Poxviral oncolytic vectors comprising a defective f2l gene |
| US8609392B2 (en) | 2009-05-12 | 2013-12-17 | Transgene S.A. | Method for orthopoxvirus production and purification |
| US9393299B2 (en) | 2009-08-07 | 2016-07-19 | Transgene S.A. | Composition for treating HBV infection |
| US20110243988A1 (en) * | 2009-10-01 | 2011-10-06 | Aridis Pharmaceuticals | Methods and Compositions for Stabilization of a Virus Vaccine |
| US8557253B2 (en) * | 2009-10-07 | 2013-10-15 | Sanofi Pasteur Sa | Stabilizing excipient for inactivated whole virus vaccine |
| CN102892424B (zh) | 2010-03-31 | 2015-04-01 | 稳定性科技有限公司 | 病毒颗粒的稳定 |
| CA2993242C (en) * | 2010-04-15 | 2020-12-15 | Shin Nippon Biomedical Laboratories, Ltd. | Methods and compositions for intranasal delivery |
| TWI575070B (zh) | 2011-07-12 | 2017-03-21 | 傳斯堅公司 | Ｈｂｖ聚合酶突變體 |
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| EP2903600A1 (en) | 2015-08-12 |
| IL238064B (en) | 2019-07-31 |
| KR102181658B1 (ko) | 2020-11-23 |
| TW201417820A (zh) | 2014-05-16 |
| BR112015007314B1 (pt) | 2023-05-09 |
| JP2015531387A (ja) | 2015-11-02 |
| TWI690322B (zh) | 2020-04-11 |
| MX2015004290A (es) | 2016-01-20 |
| BR112015007314A2 (enExample) | 2017-08-15 |
| CN104797242B (zh) | 2019-10-01 |
| ES2928670T3 (es) | 2022-11-22 |
| KR20150087206A (ko) | 2015-07-29 |
| NZ707328A (en) | 2018-07-27 |
| CN104797242A (zh) | 2015-07-22 |
| RU2686108C2 (ru) | 2019-04-24 |
| US20150250869A1 (en) | 2015-09-10 |
| SG11201502621XA (en) | 2015-05-28 |
| DK2903600T3 (da) | 2022-09-26 |
| IL238064A0 (en) | 2015-05-31 |
| US10111947B2 (en) | 2018-10-30 |
| AU2013326548A1 (en) | 2015-05-14 |
| WO2014053571A1 (en) | 2014-04-10 |
| RU2015116539A (ru) | 2016-11-27 |
| CA2887156A1 (en) | 2014-04-10 |
| AU2013326548B2 (en) | 2018-07-19 |
| MX374287B (es) | 2025-03-06 |
| EP2903600B1 (en) | 2022-08-31 |
| JP6466332B2 (ja) | 2019-02-06 |
| HK1211206A1 (en) | 2016-05-20 |
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