MX2015004290A - Formulacion que contiene virus y uso de la misma. - Google Patents
Formulacion que contiene virus y uso de la misma.Info
- Publication number
- MX2015004290A MX2015004290A MX2015004290A MX2015004290A MX2015004290A MX 2015004290 A MX2015004290 A MX 2015004290A MX 2015004290 A MX2015004290 A MX 2015004290A MX 2015004290 A MX2015004290 A MX 2015004290A MX 2015004290 A MX2015004290 A MX 2015004290A
- Authority
- MX
- Mexico
- Prior art keywords
- formulation
- relates
- present
- virus
- dry product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invención se refiere a una formulación que comprende (i) por lo menos un material basado en virus, (ii) por lo menos un polímero seleccionado del grupo de polivinilpirrolidona y derivados de la misma, (iii) por lo menos un azúcar, (iv )por lo menos dos diferentes aminoácidos, (v) por menos dos sales farmacéuticamente aceptables, en donde al menos una de dichas sales es una sal de fosfato y, opcionalmente (vi) un regulador de pH farmacéuticamente aceptable; una formulación así es especialmente adecuada para liofilizarse; la presente invención también se refiere al producto seco correspondiente, así como a su procedimiento de preparación; la presente invención también se refiere a un material reconstituido que comprende dicho producto seco, que puede ser administrado a un paciente que lo necesita; dichas formulación y material reconstituido son útiles como vacunas, de preferencia para el tratamiento y/o la prevención de cánceres, enfermedades infecciosas y/o desórdenes autoinmunes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12306198 | 2012-10-02 | ||
PCT/EP2013/070590 WO2014053571A1 (en) | 2012-10-02 | 2013-10-02 | Virus-containing formulation and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015004290A true MX2015004290A (es) | 2016-01-20 |
Family
ID=47018930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015004290A MX2015004290A (es) | 2012-10-02 | 2013-10-02 | Formulacion que contiene virus y uso de la misma. |
Country Status (18)
Country | Link |
---|---|
US (1) | US10111947B2 (es) |
EP (1) | EP2903600B1 (es) |
JP (1) | JP6466332B2 (es) |
KR (1) | KR102181658B1 (es) |
CN (1) | CN104797242B (es) |
AU (1) | AU2013326548B2 (es) |
BR (1) | BR112015007314B1 (es) |
CA (1) | CA2887156C (es) |
DK (1) | DK2903600T3 (es) |
ES (1) | ES2928670T3 (es) |
HK (1) | HK1211206A1 (es) |
IL (1) | IL238064B (es) |
MX (1) | MX2015004290A (es) |
NZ (1) | NZ707328A (es) |
RU (1) | RU2686108C2 (es) |
SG (1) | SG11201502621XA (es) |
TW (1) | TWI690322B (es) |
WO (1) | WO2014053571A1 (es) |
Families Citing this family (33)
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US11273127B2 (en) | 2014-05-06 | 2022-03-15 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for thermally stable multi-targeted antigens |
PL3169341T3 (pl) | 2014-07-16 | 2019-12-31 | Transgene Sa | Wirus onkolityczny do ekspresji modulatorów punktu kontroli immunologicznej |
DK3226894T3 (da) | 2014-12-01 | 2019-10-21 | Transgene Sa | Stabile flydende vacciniavirus-formuleringer |
EP3256156A1 (en) * | 2015-02-13 | 2017-12-20 | Transgene SA | Immunotherapeutic vaccine and antibody combination therapy |
WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
CA2977660A1 (en) | 2015-02-25 | 2016-09-15 | Memorial Sloan-Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva) as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
CA2982896A1 (en) | 2015-04-17 | 2016-10-20 | Memorial Sloan Kettering Cancer Center | Use of modified vaccinia ankara virus (mva) or mva with a deletion of virulence factor e8 as immunotherapeutic agent against solid tumors |
MX2018010204A (es) | 2016-02-25 | 2019-05-06 | Memorial Sloan Kettering Cancer Center | Virus de la vaccinia atenuada competentes para replicacion con la supresion de timidina quinasa con y sin la expresion del flt3l o gm-csf humanos para inmunoterapia del cancer. |
MX2018010231A (es) | 2016-02-25 | 2019-06-06 | Memorial Sloan Kettering Cancer Center | Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapéuticos contra tumores sólidos. |
MX2018011226A (es) * | 2016-03-14 | 2019-05-16 | Baylor College Medicine | Tc24-c4, antígeno de vacuna de la enfermedad de chagas con estabilidad mejorada y agregación disminuida. |
MX2018011837A (es) * | 2016-03-31 | 2019-02-13 | Takeda Vaccines Inc | Composiciones y metodos para estabilizar alfavirus con formulaciones mejoradas. |
CA3023022A1 (en) | 2016-05-04 | 2017-11-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
WO2018049261A1 (en) | 2016-09-09 | 2018-03-15 | Icellhealth Consulting Llc | Oncolytic virus expressing immune checkpoint modulators |
US20190328869A1 (en) | 2016-10-10 | 2019-10-31 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
CN111107872A (zh) | 2017-05-12 | 2020-05-05 | 纪念斯隆-凯特林癌症中心 | 有用于癌症免疫疗法的牛痘病毒突变体 |
US11306292B2 (en) | 2017-05-15 | 2022-04-19 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
WO2018211419A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
EP3641803A2 (en) | 2017-06-21 | 2020-04-29 | Transgene | Personalized vaccine |
EP3720500A4 (en) * | 2017-12-05 | 2021-08-25 | Applied Genetic Technologies Corporation | FORMULATION OPTIMIZATION FOR VIRAL PARTICLES |
MX2020009262A (es) | 2018-03-07 | 2021-01-08 | Transgene | Vectores de parapoxvirus. |
KR20240014102A (ko) | 2018-06-29 | 2024-01-31 | 우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 | 레버 유전성 시신경병증의 치료를 위한 조성물 및 방법 |
CN112584874A (zh) | 2018-08-20 | 2021-03-30 | 武汉纽福斯生物科技有限公司 | 用于治疗莱伯氏遗传性视神经病变的组合物和方法 |
AU2019336940A1 (en) | 2018-09-06 | 2021-03-11 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
WO2020090871A1 (ja) | 2018-10-30 | 2020-05-07 | 国立大学法人東京大学 | がん治療のための腫瘍溶解性ウイルス |
AU2019412516A1 (en) | 2018-12-28 | 2021-07-15 | Transgene | M2-defective poxvirus |
WO2020136232A1 (en) | 2018-12-28 | 2020-07-02 | Transgene Sa | Immunosuppressive m2 protein |
CN113025633A (zh) | 2019-12-09 | 2021-06-25 | 武汉纽福斯生物科技有限公司 | 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用 |
EP3842065A1 (en) | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
WO2021180943A1 (en) | 2020-03-12 | 2021-09-16 | Bavarian Nordic A/S | Compositions improving poxvirus stability |
WO2022148736A1 (en) | 2021-01-05 | 2022-07-14 | Transgene | Vectorization of muc1 t cell engager |
WO2024003353A1 (en) | 2022-07-01 | 2024-01-04 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
CN115040656B (zh) * | 2022-07-05 | 2024-04-26 | 吉林惠康生物药业有限公司 | 狂犬疫苗冻干保护剂、应用和疫苗及其制备方法 |
WO2024038175A1 (en) | 2022-08-18 | 2024-02-22 | Transgene | Chimeric poxviruses |
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2013
- 2013-10-01 TW TW102135548A patent/TWI690322B/zh active
- 2013-10-02 WO PCT/EP2013/070590 patent/WO2014053571A1/en active Application Filing
- 2013-10-02 EP EP13776991.5A patent/EP2903600B1/en active Active
- 2013-10-02 JP JP2015535011A patent/JP6466332B2/ja active Active
- 2013-10-02 SG SG11201502621XA patent/SG11201502621XA/en unknown
- 2013-10-02 BR BR112015007314-0A patent/BR112015007314B1/pt active IP Right Grant
- 2013-10-02 RU RU2015116539A patent/RU2686108C2/ru active
- 2013-10-02 DK DK13776991.5T patent/DK2903600T3/da active
- 2013-10-02 CN CN201380060245.7A patent/CN104797242B/zh active Active
- 2013-10-02 CA CA2887156A patent/CA2887156C/en active Active
- 2013-10-02 KR KR1020157011647A patent/KR102181658B1/ko active IP Right Grant
- 2013-10-02 US US14/433,142 patent/US10111947B2/en active Active
- 2013-10-02 MX MX2015004290A patent/MX2015004290A/es active IP Right Grant
- 2013-10-02 NZ NZ707328A patent/NZ707328A/en unknown
- 2013-10-02 AU AU2013326548A patent/AU2013326548B2/en active Active
- 2013-10-02 ES ES13776991T patent/ES2928670T3/es active Active
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2015
- 2015-03-31 IL IL238064A patent/IL238064B/en active IP Right Grant
- 2015-12-03 HK HK15111928.7A patent/HK1211206A1/xx unknown
Also Published As
Publication number | Publication date |
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TWI690322B (zh) | 2020-04-11 |
BR112015007314B1 (pt) | 2023-05-09 |
WO2014053571A1 (en) | 2014-04-10 |
EP2903600B1 (en) | 2022-08-31 |
US10111947B2 (en) | 2018-10-30 |
AU2013326548A1 (en) | 2015-05-14 |
SG11201502621XA (en) | 2015-05-28 |
CN104797242A (zh) | 2015-07-22 |
TW201417820A (zh) | 2014-05-16 |
JP2015531387A (ja) | 2015-11-02 |
KR102181658B1 (ko) | 2020-11-23 |
KR20150087206A (ko) | 2015-07-29 |
RU2686108C2 (ru) | 2019-04-24 |
BR112015007314A2 (es) | 2017-08-15 |
AU2013326548B2 (en) | 2018-07-19 |
ES2928670T3 (es) | 2022-11-22 |
IL238064B (en) | 2019-07-31 |
HK1211206A1 (en) | 2016-05-20 |
IL238064A0 (en) | 2015-05-31 |
CA2887156C (en) | 2021-01-19 |
RU2015116539A (ru) | 2016-11-27 |
US20150250869A1 (en) | 2015-09-10 |
NZ707328A (en) | 2018-07-27 |
DK2903600T3 (da) | 2022-09-26 |
EP2903600A1 (en) | 2015-08-12 |
JP6466332B2 (ja) | 2019-02-06 |
CN104797242B (zh) | 2019-10-01 |
CA2887156A1 (en) | 2014-04-10 |
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