RU2659208C2 - Комбинации лизина бактериофага и антибиотика против грам-положительных бактерий - Google Patents
Комбинации лизина бактериофага и антибиотика против грам-положительных бактерий Download PDFInfo
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- RU2659208C2 RU2659208C2 RU2014149351A RU2014149351A RU2659208C2 RU 2659208 C2 RU2659208 C2 RU 2659208C2 RU 2014149351 A RU2014149351 A RU 2014149351A RU 2014149351 A RU2014149351 A RU 2014149351A RU 2659208 C2 RU2659208 C2 RU 2659208C2
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| JP6348901B2 (ja) | 2012-05-09 | 2018-06-27 | コントラフェクト コーポレイション | バクテリオファージ溶解素によるバイオフィルムの防止、破壊および処置 |
| KR102441211B1 (ko) | 2014-06-26 | 2022-09-07 | 더 락커펠러 유니버시티 | 아시네토박터 라이신 |
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| RU2724545C2 (ru) * | 2015-09-17 | 2020-06-23 | Контрафект Корпорейшн | Полипептиды лизина, активные против грамотрицательных бактерий |
| DK3454888T3 (da) * | 2016-05-12 | 2021-04-26 | Contrafect Corp | Bouillon-mikrofortyndingsfremgangsmåde til evaluering og bestemmelse af minimal inhibitorisk koncentration for antibakterielle polypeptider |
| EP3641753B1 (en) | 2017-06-19 | 2022-09-21 | Syddansk Universitet | Bacitracin and/or daptomycin combined with cannabidiol for treatment of bacterial infections |
| JP2020527551A (ja) * | 2017-07-10 | 2020-09-10 | コントラフェクト コーポレイション | 血液成分による溶菌タンパク質の抗菌活性の強化、並びにその方法及び使用 |
| EP3758738A4 (en) * | 2018-02-26 | 2021-12-08 | Contrafect Corporation | MODIFIED PLYSS2-LYSINE AND USES THEREOF |
| CN112867398A (zh) * | 2018-06-22 | 2021-05-28 | 康特拉费克特公司 | 溶素及其衍生物使金黄色葡萄球菌和革兰氏阳性菌对抗生素重新敏感 |
| CN109668873B (zh) * | 2018-12-05 | 2021-03-16 | 山东恒业生物技术有限公司 | 一种活载体疫苗活性检测装置及其使用方法 |
| CA3127898A1 (en) * | 2019-02-05 | 2020-08-13 | Elanco Us Inc. | A genetically modified lactobacillus and uses thereof |
| BR112021018219A2 (pt) * | 2019-03-22 | 2022-01-18 | Contrafect Corp | Método de tratamento de endocardite infecciosa |
| KR20210151188A (ko) * | 2019-04-11 | 2021-12-13 | 콘트라펙트 코포레이션 | 뼈 및 관절 감염증의 치료 및 예방 방법 |
| EP4603484A2 (en) * | 2019-12-19 | 2025-08-20 | Georgia State University Research Foundation, Inc. | Compounds for the treatment of bacterial infections and potentiation of antibiotics |
| AU2021275048A1 (en) * | 2020-05-19 | 2023-02-02 | Contrafect Corporation | Modified PlySs2 lysins and antibiotic combinations for use against Gram-positive bacteria |
| RU2755817C1 (ru) * | 2020-07-22 | 2021-09-21 | Федеральное Государственное бюджетное научное учреждение "Федеральный научный центр биологических систем и агротехнологий российской академии наук" | Способ снижения грамположительной микрофлоры в кишечнике птицы |
| KR102528412B1 (ko) * | 2020-09-08 | 2023-05-04 | 클립스비엔씨 주식회사 | 신규한 포도상구균 감염 질환의 예방 또는 치료용 조성물 |
| WO2022261360A1 (en) * | 2021-06-09 | 2022-12-15 | Contrafect Corporation | Plyss2 lysins and variants thereof for use against multidrug resistant gram-positive bacteria |
| CN115105491B (zh) * | 2022-07-08 | 2023-12-22 | 东北农业大学 | 丝氨酸在制备抑制猪链球菌药物中的用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070254321A1 (en) * | 2004-03-24 | 2007-11-01 | Fischetti Vincent A | Lytic Enzymes and Spore Surface Antigen for Detection and Treatment of Bacillus Anthracis Bacteria and Spores |
| WO2010002959A2 (en) * | 2008-07-03 | 2010-01-07 | The Rockefeller University | A chimeric bacteriophage lysin with activity against staphylococci bacteria |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0285649A4 (en) | 1986-10-08 | 1990-06-27 | David Bernstein | METHOD FOR EXPOSING ANTIGENS OF GROUP A STREPTOCOCCUS AND IMPROVED DIAGNOSTIC TEST FOR THE IDENTIFICATION OF GROUP A STREPTOCOCCUS |
| ZA883887B (en) | 1987-06-10 | 1990-02-28 | Lilly Co Eli | Chromatographic purification process |
| WO1997039111A1 (en) * | 1996-04-15 | 1997-10-23 | Nymox Corporation | Compositions containing bacteriophages and methods of using bacteriophages to treat infections |
| US20060292135A1 (en) | 1997-10-31 | 2006-12-28 | Lawrence Loomis | Use of bacterial phage-associated lysing proteins for preventing and treating bacterial infections in humans, animals and fowl |
| US6264945B1 (en) | 1997-10-31 | 2001-07-24 | Vincent A Fischetti | Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections |
| US6254866B1 (en) | 1997-10-31 | 2001-07-03 | New Horizons Diagnostics Corporation | Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract |
| US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
| US6248324B1 (en) | 1997-10-31 | 2001-06-19 | Vincent Fischetti | Bacterial phage associated lysing enzymes for treating dermatological infections |
| JP2002537350A (ja) | 1999-02-25 | 2002-11-05 | ニュー ホライズンズ ダイアグノスティックス インコーポレーティッド | 連鎖球菌感染の予防的及び治療的な処置のための手段 |
| US6056955A (en) | 1999-09-14 | 2000-05-02 | Fischetti; Vincent | Topical treatment of streptococcal infections |
| US6444813B2 (en) | 2000-02-02 | 2002-09-03 | Pharmacia & Upjohn Company | Linezolid-crystal form II |
| EP1501925A4 (en) | 2002-05-17 | 2006-10-25 | New Horizons Diagnostics Corp | IDENTIFICATION OF A LYTIC ENZYME ASSOCIATED WITH A PHAGE TO DETECT AND ELIMINATE RAPIDLY AND SPECIFICALLY BACILLUS ANTHRACIS |
| US7569223B2 (en) | 2004-03-22 | 2009-08-04 | The Rockefeller University | Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions |
| US8389469B2 (en) | 2005-06-06 | 2013-03-05 | The Rockefeller University | Bacteriophage lysins for Bacillus anthracis |
| US7582291B2 (en) | 2005-06-30 | 2009-09-01 | The Rockefeller University | Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria |
| ATE491026T1 (de) | 2005-08-24 | 2010-12-15 | Univ Rockefeller | Ply-gbs-lysinmutanten |
| US20090053149A1 (en) | 2007-08-24 | 2009-02-26 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Surfactant-based antimicrobial solution for inhalation |
| KR101016918B1 (ko) | 2009-01-08 | 2011-02-25 | 주식회사 인트론바이오테크놀로지 | 박테리아 특이적 넓은 항균 활성을 갖는 신규한 리신 단백질 |
| CN103080307A (zh) | 2010-01-25 | 2013-05-01 | 美艾利尔斯卡保罗有限公司 | A25噬菌体溶解酶 |
| WO2012145530A2 (en) * | 2011-04-20 | 2012-10-26 | Visa International Service Association | Managing electronic tokens in a transaction processing system |
| US20140179594A1 (en) | 2011-04-21 | 2014-06-26 | The Rockefeller University | Streptococcus bacteriophage lysins for treatment of gram positive bacteria in companion animals and livestock |
| MX383544B (es) | 2011-04-21 | 2025-03-14 | Univ Rockefeller | Lisinas de bacteriofago de streptococcus para la deteccion y tratamiento de bacterias gram positivas |
| US9016640B2 (en) | 2011-04-22 | 2015-04-28 | Rks Design, Inc. | Instrument retention assembly |
| US20140120074A1 (en) | 2011-04-27 | 2014-05-01 | Lysando Ag | Antimicrobial agents |
| JP6348901B2 (ja) * | 2012-05-09 | 2018-06-27 | コントラフェクト コーポレイション | バクテリオファージ溶解素によるバイオフィルムの防止、破壊および処置 |
| KR20210121313A (ko) | 2012-05-09 | 2021-10-07 | 콘트라펙트 코포레이션 | 그람 양성 박테리아에 대한 박테리오파지 리신과 항생제의 병용물 |
-
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-
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- 2014-11-07 MX MX2021011843A patent/MX2021011843A/es unknown
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- 2017-12-20 US US15/848,886 patent/US20180221456A1/en not_active Abandoned
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- 2018-04-27 JP JP2018086685A patent/JP2018138045A/ja not_active Withdrawn
-
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- 2019-12-06 JP JP2019221319A patent/JP2020054370A/ja active Pending
-
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- 2020-05-21 IL IL274832A patent/IL274832A/en unknown
- 2020-09-16 AU AU2020233683A patent/AU2020233683A1/en not_active Abandoned
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-
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- 2021-01-05 US US17/141,692 patent/US20210128696A1/en not_active Abandoned
-
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- 2022-01-20 JP JP2022007043A patent/JP2022058682A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070254321A1 (en) * | 2004-03-24 | 2007-11-01 | Fischetti Vincent A | Lytic Enzymes and Spore Surface Antigen for Detection and Treatment of Bacillus Anthracis Bacteria and Spores |
| WO2010002959A2 (en) * | 2008-07-03 | 2010-01-07 | The Rockefeller University | A chimeric bacteriophage lysin with activity against staphylococci bacteria |
Non-Patent Citations (1)
| Title |
|---|
| DANIEL A et al. Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus, Antimicrobial agents and chemotherapy, Apr. 2010, N 54 (4), c. 1603-1612. ДЕХНИЧ А.В. и др. Даптомицин: обзор фармакологических, клинических и микробиологических параметров. Клиническая микробиология и антимикробная химиотерапия, 2010, том 12, N 4, с. 295-312. * |
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