BR112018073205A2 - método de microdiluição em caldo para avaliação e determinação da concentração inibitória mínima de polipeptídeos antibacterianos - Google Patents
método de microdiluição em caldo para avaliação e determinação da concentração inibitória mínima de polipeptídeos antibacterianosInfo
- Publication number
- BR112018073205A2 BR112018073205A2 BR112018073205-2A BR112018073205A BR112018073205A2 BR 112018073205 A2 BR112018073205 A2 BR 112018073205A2 BR 112018073205 A BR112018073205 A BR 112018073205A BR 112018073205 A2 BR112018073205 A2 BR 112018073205A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitory concentration
- minimum inhibitory
- determination
- broth microdilution
- evaluation
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 238000002815 broth microdilution Methods 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 238000011156 evaluation Methods 0.000 title 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
a presente invenção fornece componentes, ensaios e métodos para avaliar a eficácia antibacteriana e determinar a concentração inibitória mínima (cim) de polipeptídeos, incluindo polipeptídeos de lisina, que exterminam bactérias. são fornecidos componentes e métodos de microdiluição em caldo modificado, incluindo suplementos para permitir uma determinação precisa da cim, imitando a atividade do polipeptídeo de lisina em matrizes humanas, incluindo soro e sangue.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662335129P | 2016-05-12 | 2016-05-12 | |
| US62/335,129 | 2016-05-12 | ||
| PCT/US2017/032344 WO2017197227A1 (en) | 2016-05-12 | 2017-05-12 | Broth microdilution method for evaluating and determining minimal inhibitory concentration of antibacterial polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018073205A2 true BR112018073205A2 (pt) | 2019-02-19 |
Family
ID=60266856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018073205-2A BR112018073205A2 (pt) | 2016-05-12 | 2017-05-12 | método de microdiluição em caldo para avaliação e determinação da concentração inibitória mínima de polipeptídeos antibacterianos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10851401B2 (pt) |
| EP (1) | EP3454888B1 (pt) |
| JP (1) | JP6875756B2 (pt) |
| KR (1) | KR20190004799A (pt) |
| CN (1) | CN109152822B (pt) |
| AU (1) | AU2017263563A1 (pt) |
| BR (1) | BR112018073205A2 (pt) |
| CA (1) | CA3023730A1 (pt) |
| DK (1) | DK3454888T3 (pt) |
| IL (1) | IL262844B2 (pt) |
| MX (1) | MX2018013372A (pt) |
| RU (1) | RU2754667C2 (pt) |
| WO (1) | WO2017197227A1 (pt) |
| ZA (1) | ZA201806685B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016030580B1 (pt) * | 2014-06-26 | 2023-12-19 | The Rockefeller University | Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas |
| BR112020017219A2 (pt) * | 2018-02-26 | 2020-12-22 | Contrafect Corporation | Lisinas plyss2 modificadas e usos das mesmas |
| CN113164909A (zh) * | 2018-07-11 | 2021-07-23 | 赛录科试诊断公司 | 用于抗微生物剂敏感性测试的测定和试剂 |
| AU2020244764A1 (en) * | 2019-03-22 | 2021-10-14 | Contrafect Corporation | Method of treating infective endocarditis |
| CA3136461A1 (en) * | 2019-04-11 | 2020-10-15 | Contrafect Corporation | Method of treating and preventing bone and joint infections |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8108587A (en) | 1986-10-08 | 1988-05-06 | David Bernstein | Method for exposing group a streptococcal antigens and an improved diagnostic test for the identification of group a streptococci |
| US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
| US6248324B1 (en) | 1997-10-31 | 2001-06-19 | Vincent Fischetti | Bacterial phage associated lysing enzymes for treating dermatological infections |
| US6264945B1 (en) | 1997-10-31 | 2001-07-24 | Vincent A Fischetti | Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections |
| US6254866B1 (en) | 1997-10-31 | 2001-07-03 | New Horizons Diagnostics Corporation | Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract |
| KR20020000217A (ko) | 1999-02-25 | 2002-01-05 | 뉴 호라이즌스 다이아그노스틱스, 인코포레이티드 | 스트렙토코커스 감염의 예방 및 치료 방법 |
| US6056955A (en) | 1999-09-14 | 2000-05-02 | Fischetti; Vincent | Topical treatment of streptococcal infections |
| JP4381531B2 (ja) * | 1999-12-08 | 2009-12-09 | 塩野義製薬株式会社 | グリコペプチド誘導体 |
| WO2004027020A2 (en) | 2002-05-17 | 2004-04-01 | New Horizons Diagnostics Corporation | Identification of a phage associated lytic enzyme to rapidly and specifically detect and kill bacillus anthracis |
| US7569223B2 (en) | 2004-03-22 | 2009-08-04 | The Rockefeller University | Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions |
| WO2005089527A2 (en) | 2004-03-24 | 2005-09-29 | The Rockefeller University | Lytic enzymes and spore surface antigen for detection and treatment of bacillus anthracis bacteria and spores |
| US8389469B2 (en) | 2005-06-06 | 2013-03-05 | The Rockefeller University | Bacteriophage lysins for Bacillus anthracis |
| US7582291B2 (en) | 2005-06-30 | 2009-09-01 | The Rockefeller University | Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria |
| EP2360248A1 (en) | 2005-08-24 | 2011-08-24 | The Rockefeller University | Ply-GBS mutant lysins |
| US8840900B2 (en) | 2008-07-03 | 2014-09-23 | The Rockefeller University | Chimeric bacteriophage lysin with activity against Staphylococci bacteria |
| AU2011259309B2 (en) * | 2010-05-25 | 2016-11-17 | Genome Pharmaceuticals Institute Co., Ltd. | Novel cyclic peptide compound, method for producing same, anti-infective agent, antibiotic-containing fraction, antibiotic, method for producing antibiotic, antibiotic-producing microorganism, and antibiotic produced by same |
| JP5823733B2 (ja) * | 2010-05-25 | 2015-11-25 | 株式会社ゲノム創薬研究所 | 抗生物質産生微生物及びそれが産生した抗生物質 |
| AU2012245357B2 (en) | 2011-04-21 | 2017-06-08 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
| US10813983B2 (en) * | 2012-05-09 | 2020-10-27 | Contrafect Corporation | Bacteriophage lysin and antibiotic combinations against gram positive bacteria |
-
2017
- 2017-05-12 KR KR1020187035806A patent/KR20190004799A/ko active IP Right Grant
- 2017-05-12 WO PCT/US2017/032344 patent/WO2017197227A1/en unknown
- 2017-05-12 US US16/096,746 patent/US10851401B2/en active Active
- 2017-05-12 BR BR112018073205-2A patent/BR112018073205A2/pt not_active Application Discontinuation
- 2017-05-12 RU RU2018135238A patent/RU2754667C2/ru active
- 2017-05-12 MX MX2018013372A patent/MX2018013372A/es unknown
- 2017-05-12 DK DK17796910.2T patent/DK3454888T3/da active
- 2017-05-12 CN CN201780029049.1A patent/CN109152822B/zh active Active
- 2017-05-12 EP EP17796910.2A patent/EP3454888B1/en active Active
- 2017-05-12 AU AU2017263563A patent/AU2017263563A1/en active Pending
- 2017-05-12 JP JP2019511834A patent/JP6875756B2/ja active Active
- 2017-05-12 CA CA3023730A patent/CA3023730A1/en active Pending
-
2018
- 2018-10-08 ZA ZA2018/06685A patent/ZA201806685B/en unknown
- 2018-11-07 IL IL262844A patent/IL262844B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190004799A (ko) | 2019-01-14 |
| IL262844B1 (en) | 2023-03-01 |
| EP3454888B1 (en) | 2021-02-24 |
| IL262844A (en) | 2018-12-31 |
| WO2017197227A1 (en) | 2017-11-16 |
| US10851401B2 (en) | 2020-12-01 |
| CN109152822B (zh) | 2023-12-05 |
| US20190106724A1 (en) | 2019-04-11 |
| IL262844B2 (en) | 2023-07-01 |
| JP6875756B2 (ja) | 2021-05-26 |
| CN109152822A (zh) | 2019-01-04 |
| RU2018135238A3 (pt) | 2020-09-11 |
| RU2018135238A (ru) | 2020-06-15 |
| MX2018013372A (es) | 2019-05-09 |
| EP3454888A4 (en) | 2019-12-11 |
| DK3454888T3 (da) | 2021-04-26 |
| JP2019514439A (ja) | 2019-06-06 |
| RU2754667C2 (ru) | 2021-09-06 |
| ZA201806685B (en) | 2021-02-24 |
| CA3023730A1 (en) | 2017-11-16 |
| EP3454888A1 (en) | 2019-03-20 |
| AU2017263563A1 (en) | 2018-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |