BR112018002130A2 - anticorpo de domínio único e proteínas derivadas respectivas contra um ligante de morte programada (pdl1) - Google Patents

anticorpo de domínio único e proteínas derivadas respectivas contra um ligante de morte programada (pdl1)

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Publication number
BR112018002130A2
BR112018002130A2 BR112018002130-0A BR112018002130A BR112018002130A2 BR 112018002130 A2 BR112018002130 A2 BR 112018002130A2 BR 112018002130 A BR112018002130 A BR 112018002130A BR 112018002130 A2 BR112018002130 A2 BR 112018002130A2
Authority
BR
Brazil
Prior art keywords
pdl1
programmed death
death ligand
single domain
domain antibody
Prior art date
Application number
BR112018002130-0A
Other languages
English (en)
Chinese (zh)
Inventor
Xu Ting
Dang Yanrong
Wang Pilin
Chen Ting
Original Assignee
Suzhou Alphamab Co., Ltd.
3D Medicines (Beijing) Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Alphamab Co., Ltd., 3D Medicines (Beijing) Co., Ltd. filed Critical Suzhou Alphamab Co., Ltd.
Publication of BR112018002130A2 publication Critical patent/BR112018002130A2/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

presente invenção refere-se ao campo da biologia médica e divulga um anticorpo de domínio único e proteínas derivadas respectivas contra um ligante de morte programada (pdl1). em particular, a presente invenção divulga uma molécula de ligação do ligante de morte programada 1 (pdl1) e uso respectivo, especialmente o uso para tratamento e/ou prevenção ou diagnóstico de doenças relevantes do pdl1, como um tumor.
BR112018002130-0A 2015-07-31 2016-08-01 anticorpo de domínio único e proteínas derivadas respectivas contra um ligante de morte programada (pdl1) BR112018002130A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510465481.8A CN106397592A (zh) 2015-07-31 2015-07-31 针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白
CN201510465481.8 2015-07-31
PCT/CN2016/092680 WO2017020802A1 (zh) 2015-07-31 2016-08-01 针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白

Publications (1)

Publication Number Publication Date
BR112018002130A2 true BR112018002130A2 (pt) 2018-09-11

Family

ID=57942455

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018002130-0A BR112018002130A2 (pt) 2015-07-31 2016-08-01 anticorpo de domínio único e proteínas derivadas respectivas contra um ligante de morte programada (pdl1)

Country Status (15)

Country Link
US (2) US20180291103A1 (pt)
EP (2) EP3330290A4 (pt)
JP (2) JP6946289B2 (pt)
KR (1) KR102138447B1 (pt)
CN (4) CN106397592A (pt)
AU (1) AU2016302951B2 (pt)
BR (1) BR112018002130A2 (pt)
CA (1) CA2994339C (pt)
HK (2) HK1251591A1 (pt)
MX (1) MX2018001387A (pt)
MY (1) MY195474A (pt)
NZ (1) NZ739499A (pt)
PH (1) PH12018500233A1 (pt)
RU (1) RU2715595C2 (pt)
WO (2) WO2017020802A1 (pt)

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