BR112021019884A2 - Método de tratamento e prevenção de infecções ósseas e articulares - Google Patents
Método de tratamento e prevenção de infecções ósseas e articularesInfo
- Publication number
- BR112021019884A2 BR112021019884A2 BR112021019884A BR112021019884A BR112021019884A2 BR 112021019884 A2 BR112021019884 A2 BR 112021019884A2 BR 112021019884 A BR112021019884 A BR 112021019884A BR 112021019884 A BR112021019884 A BR 112021019884A BR 112021019884 A2 BR112021019884 A2 BR 112021019884A2
- Authority
- BR
- Brazil
- Prior art keywords
- bone
- positive bacteria
- gram
- prevention
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Surgery (AREA)
- Dispersion Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
método de tratamento e prevenção de infecções ósseas e articulares. a presente invenção refere-se a um método de tratamento ou prevenção de uma infecção óssea ou articular, cujo método compreende: administrar uma quantidade terapeuticamente eficaz de uma lisina plyss2 compreendendo a sequência de aminoácidos da seq id no: 1 ou uma variante da mesma tendo pelo menos 80% de identidade com a seq id no: 1, em que a variante compreende atividade bactericida e/ou bacteriostática contra as bactérias gram-positivas, a um indivíduo em necessidade da mesma, opcionalmente coadministrada com um ou mais antibióticos, em que a infecção óssea ou articular compreende bactérias gram-positivas, como staphylococcus epidermidis ou staphylococcus aureus. também são divulgados métodos para prevenir ou interromper um biofilme de bactérias gram-positivas formado em um fluido sinovial, como um biofilme formado por staphylococcus epidermidis.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962832754P | 2019-04-11 | 2019-04-11 | |
| US201962849672P | 2019-05-17 | 2019-05-17 | |
| US201962938812P | 2019-11-21 | 2019-11-21 | |
| US202062964755P | 2020-01-23 | 2020-01-23 | |
| PCT/US2020/027752 WO2020210691A1 (en) | 2019-04-11 | 2020-04-10 | Method of treating and preventing bone and joint infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021019884A2 true BR112021019884A2 (pt) | 2022-01-18 |
Family
ID=72752118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021019884A BR112021019884A2 (pt) | 2019-04-11 | 2020-04-10 | Método de tratamento e prevenção de infecções ósseas e articulares |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220193186A1 (pt) |
| EP (1) | EP3980049A4 (pt) |
| JP (1) | JP2022526624A (pt) |
| KR (1) | KR20210151188A (pt) |
| CN (1) | CN114025783A (pt) |
| AU (1) | AU2020271116A1 (pt) |
| BR (1) | BR112021019884A2 (pt) |
| CA (1) | CA3136461A1 (pt) |
| IL (1) | IL286994A (pt) |
| MX (1) | MX2021012375A (pt) |
| WO (1) | WO2020210691A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023081691A1 (en) * | 2021-11-04 | 2023-05-11 | Contrafect Corporation | Method of treating and preventing bone and joint infections |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9034322B2 (en) * | 2011-04-21 | 2015-05-19 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
| CN104736172A (zh) * | 2012-05-09 | 2015-06-24 | 康特拉费克特公司 | 针对革兰氏阳性细菌的噬菌体溶素和抗生素组合 |
| US9499594B2 (en) * | 2012-05-09 | 2016-11-22 | Contrafect Corporation | Biofilm prevention, disruption and treatment with bacteriophage lysin |
| WO2017197227A1 (en) * | 2016-05-12 | 2017-11-16 | Contrafect Corporation | Broth microdilution method for evaluating and determining minimal inhibitory concentration of antibacterial polypeptides |
| MX2020008860A (es) * | 2018-02-26 | 2020-12-10 | Contrafect Corp | Lisinas plyss2 modificadas y sus usos. |
| JP2021527699A (ja) * | 2018-06-22 | 2021-10-14 | コントラフェクト コーポレイション | 溶解素及びその誘導体がスタフィロコッカス・アウレウス及びグラム陽性細菌を抗生物質に再感作する |
-
2020
- 2020-04-10 CN CN202080042979.2A patent/CN114025783A/zh active Pending
- 2020-04-10 EP EP20788204.4A patent/EP3980049A4/en not_active Withdrawn
- 2020-04-10 AU AU2020271116A patent/AU2020271116A1/en not_active Abandoned
- 2020-04-10 US US17/602,064 patent/US20220193186A1/en active Pending
- 2020-04-10 JP JP2021559424A patent/JP2022526624A/ja active Pending
- 2020-04-10 CA CA3136461A patent/CA3136461A1/en active Pending
- 2020-04-10 WO PCT/US2020/027752 patent/WO2020210691A1/en unknown
- 2020-04-10 KR KR1020217036829A patent/KR20210151188A/ko unknown
- 2020-04-10 BR BR112021019884A patent/BR112021019884A2/pt unknown
- 2020-04-10 MX MX2021012375A patent/MX2021012375A/es unknown
-
2021
- 2021-10-05 IL IL286994A patent/IL286994A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022526624A (ja) | 2022-05-25 |
| MX2021012375A (es) | 2021-11-17 |
| CA3136461A1 (en) | 2020-10-15 |
| US20220193186A1 (en) | 2022-06-23 |
| IL286994A (en) | 2021-12-01 |
| KR20210151188A (ko) | 2021-12-13 |
| CN114025783A (zh) | 2022-02-08 |
| EP3980049A4 (en) | 2023-07-19 |
| EP3980049A1 (en) | 2022-04-13 |
| AU2020271116A1 (en) | 2021-11-11 |
| WO2020210691A1 (en) | 2020-10-15 |
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