MX2021012375A - Metodo para tratar y prevenir infecciones oseas y de articulaciones. - Google Patents

Metodo para tratar y prevenir infecciones oseas y de articulaciones.

Info

Publication number
MX2021012375A
MX2021012375A MX2021012375A MX2021012375A MX2021012375A MX 2021012375 A MX2021012375 A MX 2021012375A MX 2021012375 A MX2021012375 A MX 2021012375A MX 2021012375 A MX2021012375 A MX 2021012375A MX 2021012375 A MX2021012375 A MX 2021012375A
Authority
MX
Mexico
Prior art keywords
gram
treating
bone
preventing
seq
Prior art date
Application number
MX2021012375A
Other languages
English (en)
Inventor
Raymond Schuch
Original Assignee
Contrafect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contrafect Corp filed Critical Contrafect Corp
Publication of MX2021012375A publication Critical patent/MX2021012375A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención está dirigida a un método para tratar o prevenir una infección ósea o articular, método el cual comprende: administrar una cantidad terapéuticamente efectiva de una lisina PlySs2 que comprende la secuencia de aminoácidos de la SEQ ID NO: 1 o una variante de la misma que tiene al menos 80 % de identidad con SEQ ID NO: 1, donde la variante comprende actividad bactericida y/o bacteriostática contra bacterias Grampositivas, a un sujeto que lo necesite, opcionalmente coadministrado con uno o más antibióticos, en donde la infección ósea o articular comprende una bacteria Gram-positiva, tal como Staphylococcus epidermidis o Staphylococcus aureus. También se describen métodos para prevenir o interrumpir una biopelícula de bacterias Gram-positivas formada en líquido sinovial, tal como una biopelícula formada por Staphylococcus epidermidis.
MX2021012375A 2019-04-11 2020-04-10 Metodo para tratar y prevenir infecciones oseas y de articulaciones. MX2021012375A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962832754P 2019-04-11 2019-04-11
US201962849672P 2019-05-17 2019-05-17
US201962938812P 2019-11-21 2019-11-21
US202062964755P 2020-01-23 2020-01-23
PCT/US2020/027752 WO2020210691A1 (en) 2019-04-11 2020-04-10 Method of treating and preventing bone and joint infections

Publications (1)

Publication Number Publication Date
MX2021012375A true MX2021012375A (es) 2021-11-17

Family

ID=72752118

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021012375A MX2021012375A (es) 2019-04-11 2020-04-10 Metodo para tratar y prevenir infecciones oseas y de articulaciones.

Country Status (11)

Country Link
US (1) US20220193186A1 (es)
EP (1) EP3980049A4 (es)
JP (1) JP2022526624A (es)
KR (1) KR20210151188A (es)
CN (1) CN114025783A (es)
AU (1) AU2020271116A1 (es)
BR (1) BR112021019884A2 (es)
CA (1) CA3136461A1 (es)
IL (1) IL286994A (es)
MX (1) MX2021012375A (es)
WO (1) WO2020210691A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023081691A1 (en) * 2021-11-04 2023-05-11 Contrafect Corporation Method of treating and preventing bone and joint infections

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012245357B2 (en) * 2011-04-21 2017-06-08 The Rockefeller University Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
US10813983B2 (en) * 2012-05-09 2020-10-27 Contrafect Corporation Bacteriophage lysin and antibiotic combinations against gram positive bacteria
KR20230135161A (ko) * 2012-05-09 2023-09-22 콘트라펙트 코포레이션 박테리오파지 리신을 이용한 생물막의 예방, 붕괴 및 치료
KR20190004799A (ko) * 2016-05-12 2019-01-14 콘트라펙트 코포레이션 항균 폴리펩티드의 최소 억제 농도를 평가 및 탐지하기 위한 배지미량희석법
BR112020017219A2 (pt) * 2018-02-26 2020-12-22 Contrafect Corporation Lisinas plyss2 modificadas e usos das mesmas
BR112020026267A2 (pt) * 2018-06-22 2021-04-06 Contrafect Corporation Lisinas e seus derivados resensibilizam novamente staphylococcus aureus e bactérias gram-positivas aos antibióticos

Also Published As

Publication number Publication date
US20220193186A1 (en) 2022-06-23
CA3136461A1 (en) 2020-10-15
AU2020271116A1 (en) 2021-11-11
JP2022526624A (ja) 2022-05-25
IL286994A (en) 2021-12-01
BR112021019884A2 (pt) 2022-01-18
WO2020210691A1 (en) 2020-10-15
KR20210151188A (ko) 2021-12-13
CN114025783A (zh) 2022-02-08
EP3980049A1 (en) 2022-04-13
EP3980049A4 (en) 2023-07-19

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