WO2009140215A3 - Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds - Google Patents

Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds Download PDF

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Publication number
WO2009140215A3
WO2009140215A3 PCT/US2009/043505 US2009043505W WO2009140215A3 WO 2009140215 A3 WO2009140215 A3 WO 2009140215A3 US 2009043505 W US2009043505 W US 2009043505W WO 2009140215 A3 WO2009140215 A3 WO 2009140215A3
Authority
WO
WIPO (PCT)
Prior art keywords
resistant
compounds
bacteria
strains
phanquinone
Prior art date
Application number
PCT/US2009/043505
Other languages
French (fr)
Other versions
WO2009140215A2 (en
Inventor
Michel E. Xilinas
Original Assignee
Geraghty, Erin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geraghty, Erin filed Critical Geraghty, Erin
Publication of WO2009140215A2 publication Critical patent/WO2009140215A2/en
Publication of WO2009140215A3 publication Critical patent/WO2009140215A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to new uses of known chelating compounds for the treatment of bacterial in fungal infections, particularly by methicilllin-resistant and other drug-resistant strains of bacteria and fungi. One of more chelating compound is administered with or without additional antibiotic or antifungal drugs to achieve improved therapy. Preferred chelating compounds include clioquinol, 5,7-dichloro-8-hydroxy-quinaldine, phanquinone, 5,7-dichloro-8-hydroxyquinoline, 5,7- di-iodo-8-hydroxyquinoline. By chelation of specific metal ions, these compounds treat any infection by bacteria or fungi whose pathogenicity depends upon metalloenzymes that require these cations. The compounds are also effective against infections caused by extended β lactamase and metallo β lactamase producing bacterial strains. Bacteria targeted by these methods include methicillin-resistant Staphylococcus aureus, penicillin resistant or intermediate resistant Streptococcus pneumoniae and other gram positive and multiresistant gram negative species and strains.
PCT/US2009/043505 2008-05-11 2009-05-11 Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds WO2009140215A2 (en)

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US5221208P 2008-05-11 2008-05-11
US61/052,212 2008-05-11
US5304008P 2008-05-14 2008-05-14
US61/053,040 2008-05-14
US5603208P 2008-05-26 2008-05-26
US61/056,032 2008-05-26
US5607708P 2008-05-27 2008-05-27
US61/056,077 2008-05-27
US5711708P 2008-05-29 2008-05-29
US61/057,117 2008-05-29
US7877108P 2008-07-08 2008-07-08
US61/078,771 2008-07-08
US15691109P 2009-03-03 2009-03-03
US61/156,911 2009-03-03
US15946309P 2009-03-12 2009-03-12
US61/159,463 2009-03-12
US16894409P 2009-04-14 2009-04-14
US61/168,944 2009-04-14

Publications (2)

Publication Number Publication Date
WO2009140215A2 WO2009140215A2 (en) 2009-11-19
WO2009140215A3 true WO2009140215A3 (en) 2010-03-11

Family

ID=41319274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/043505 WO2009140215A2 (en) 2008-05-11 2009-05-11 Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds

Country Status (1)

Country Link
WO (1) WO2009140215A2 (en)

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CN107847507A (en) * 2015-05-29 2018-03-27 德克抗生素股份公司 For treating the halo salicylanilide of fusobacterium infection

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US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
EP2637679A4 (en) * 2010-11-09 2015-09-23 Univ Chicago Role of adam10 and its relevance to disease and therapeutics
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US20150141415A1 (en) * 2013-11-20 2015-05-21 Omonike Arike Olaleye Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases
US20170304288A1 (en) * 2013-11-20 2017-10-26 Texas Southern University Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107847507A (en) * 2015-05-29 2018-03-27 德克抗生素股份公司 For treating the halo salicylanilide of fusobacterium infection

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