MX336427B - Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas. - Google Patents

Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas.

Info

Publication number
MX336427B
MX336427B MX2013012241A MX2013012241A MX336427B MX 336427 B MX336427 B MX 336427B MX 2013012241 A MX2013012241 A MX 2013012241A MX 2013012241 A MX2013012241 A MX 2013012241A MX 336427 B MX336427 B MX 336427B
Authority
MX
Mexico
Prior art keywords
treatment
positive bacteria
detection
gram positive
streptococcus
Prior art date
Application number
MX2013012241A
Other languages
English (en)
Other versions
MX2013012241A (es
Inventor
Vincent A Fischetti
Jonathan Schmitz
Daniel Gilmer
Chad Euler
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of MX2013012241A publication Critical patent/MX2013012241A/es
Publication of MX336427B publication Critical patent/MX336427B/es

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462Lysozyme (3.2.1.17)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/50Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017Lysozyme (3.2.1.17)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a métodos, composiciones y artículos de fabricación útiles para la mejora y tratamiento profiláctico y terapéutico de bacterias gram-positivas, incluyendo Streptococcus y Staphylococcus, y condiciones relacionadas; la invención provee composiciones y métodos que incorporan y utilizan usinas bacteriófagas derivadas de Streptococcus suis, particularmente enzimas líticas PlySs2 y/o PlySs1 y variantes de las mismas, incluyendo sus truncamientos; se proveen métodos para el tratamiento de humanos. Una composición farmacéutica para destruir bacterias gram positivas, la composición caracterizada porque comprende el polipéptido de lisina aislado que comprende la secuencia de aminoácidos de SEQ ID NO:3, o variantes del mismo que tienen por lo menos 80% de identidad con el polipéptido de SEQ ID NO: 3, y es eficaz para destruir bacterias gram positivas.
MX2013012241A 2011-04-21 2012-04-20 Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas. MX336427B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161477836P 2011-04-21 2011-04-21
PCT/US2012/034456 WO2012145630A2 (en) 2011-04-21 2012-04-20 Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria

Publications (2)

Publication Number Publication Date
MX2013012241A MX2013012241A (es) 2014-05-07
MX336427B true MX336427B (es) 2016-01-18

Family

ID=47042182

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016000588A MX370442B (es) 2011-04-21 2012-04-20 Proteínas quiméricas de una lisina de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas.
MX2013012241A MX336427B (es) 2011-04-21 2012-04-20 Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas.
MX2021007008A MX2021007008A (es) 2011-04-21 2013-10-18 Lisinas de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016000588A MX370442B (es) 2011-04-21 2012-04-20 Proteínas quiméricas de una lisina de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021007008A MX2021007008A (es) 2011-04-21 2013-10-18 Lisinas de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas.

Country Status (12)

Country Link
US (7) US9034322B2 (es)
EP (2) EP2699253B1 (es)
JP (4) JP6139509B2 (es)
CN (4) CN107189997A (es)
AU (3) AU2012245357B2 (es)
CA (1) CA2833409A1 (es)
DK (1) DK2699253T3 (es)
ES (1) ES2682670T3 (es)
HK (2) HK1244503A1 (es)
IL (4) IL228869B (es)
MX (3) MX370442B (es)
WO (1) WO2012145630A2 (es)

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US20200002694A1 (en) 2020-01-02
IL271300A (en) 2020-01-30
US20230167427A9 (en) 2023-06-01
EP3252155A1 (en) 2017-12-06
JP6735796B2 (ja) 2020-08-05
JP6139509B2 (ja) 2017-05-31
EP2699253A2 (en) 2014-02-26
ES2682670T3 (es) 2018-09-21
AU2019204660A1 (en) 2019-07-18
NZ731111A (en) 2019-06-28
JP6284976B2 (ja) 2018-02-28
JP2014518849A (ja) 2014-08-07
US20200149025A1 (en) 2020-05-14
US20220064615A1 (en) 2022-03-03
JP6587655B2 (ja) 2019-10-09
IL271300B (en) 2021-12-01
JP2019022504A (ja) 2019-02-14
IL228869B (en) 2019-05-30
US20140072549A1 (en) 2014-03-13
AU2017202728B2 (en) 2019-04-04
WO2012145630A3 (en) 2014-05-01
AU2012245357A1 (en) 2013-11-14
US11111484B2 (en) 2021-09-07
MX370442B (es) 2019-12-13
US9034322B2 (en) 2015-05-19
HK1244503A1 (zh) 2018-08-10
US9914915B2 (en) 2018-03-13
US10544407B2 (en) 2020-01-28
DK2699253T3 (en) 2018-07-16
CN108578685A (zh) 2018-09-28
US20220127590A1 (en) 2022-04-28
CA2833409A1 (en) 2012-10-26
US20170298334A1 (en) 2017-10-19
IL266476B (en) 2020-01-30
US20150267185A1 (en) 2015-09-24
IL287530A (en) 2021-12-01
JP2016147903A (ja) 2016-08-18
AU2017202728A1 (en) 2017-05-18
US11155799B2 (en) 2021-10-26
HK1247956A1 (zh) 2018-10-05
CN107189997A (zh) 2017-09-22
AU2012245357B2 (en) 2017-06-08
JP2017171686A (ja) 2017-09-28
CN115887627A (zh) 2023-04-04
MX2013012241A (es) 2014-05-07
NZ616945A (en) 2015-11-27
WO2012145630A2 (en) 2012-10-26
EP2699253B1 (en) 2018-03-28
EP2699253A4 (en) 2015-07-01
CN103857410A (zh) 2014-06-11
AU2019204660B2 (en) 2021-01-28
IL266476A (en) 2019-06-30
IL228869A0 (en) 2013-12-31
NZ713076A (en) 2017-05-26
MX2021007008A (es) 2022-06-02

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