MX336427B - Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas. - Google Patents
Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas.Info
- Publication number
- MX336427B MX336427B MX2013012241A MX2013012241A MX336427B MX 336427 B MX336427 B MX 336427B MX 2013012241 A MX2013012241 A MX 2013012241A MX 2013012241 A MX2013012241 A MX 2013012241A MX 336427 B MX336427 B MX 336427B
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- positive bacteria
- detection
- gram positive
- streptococcus
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a métodos, composiciones y artículos de fabricación útiles para la mejora y tratamiento profiláctico y terapéutico de bacterias gram-positivas, incluyendo Streptococcus y Staphylococcus, y condiciones relacionadas; la invención provee composiciones y métodos que incorporan y utilizan usinas bacteriófagas derivadas de Streptococcus suis, particularmente enzimas líticas PlySs2 y/o PlySs1 y variantes de las mismas, incluyendo sus truncamientos; se proveen métodos para el tratamiento de humanos. Una composición farmacéutica para destruir bacterias gram positivas, la composición caracterizada porque comprende el polipéptido de lisina aislado que comprende la secuencia de aminoácidos de SEQ ID NO:3, o variantes del mismo que tienen por lo menos 80% de identidad con el polipéptido de SEQ ID NO: 3, y es eficaz para destruir bacterias gram positivas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161477836P | 2011-04-21 | 2011-04-21 | |
PCT/US2012/034456 WO2012145630A2 (en) | 2011-04-21 | 2012-04-20 | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013012241A MX2013012241A (es) | 2014-05-07 |
MX336427B true MX336427B (es) | 2016-01-18 |
Family
ID=47042182
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016000588A MX370442B (es) | 2011-04-21 | 2012-04-20 | Proteínas quiméricas de una lisina de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas. |
MX2013012241A MX336427B (es) | 2011-04-21 | 2012-04-20 | Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas. |
MX2021007008A MX2021007008A (es) | 2011-04-21 | 2013-10-18 | Lisinas de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016000588A MX370442B (es) | 2011-04-21 | 2012-04-20 | Proteínas quiméricas de una lisina de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007008A MX2021007008A (es) | 2011-04-21 | 2013-10-18 | Lisinas de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas. |
Country Status (12)
Country | Link |
---|---|
US (7) | US9034322B2 (es) |
EP (2) | EP2699253B1 (es) |
JP (4) | JP6139509B2 (es) |
CN (4) | CN107189997A (es) |
AU (3) | AU2012245357B2 (es) |
CA (1) | CA2833409A1 (es) |
DK (1) | DK2699253T3 (es) |
ES (1) | ES2682670T3 (es) |
HK (2) | HK1244503A1 (es) |
IL (4) | IL228869B (es) |
MX (3) | MX370442B (es) |
WO (1) | WO2012145630A2 (es) |
Families Citing this family (33)
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EP3252076B1 (en) | 2011-01-14 | 2019-09-04 | The Regents Of The University Of California | Diagnostic use of antibodies against ror-1 protein |
WO2012145573A2 (en) * | 2011-04-21 | 2012-10-26 | Universiteit Utrecht Holding Bv | Streptococcus bacteriophage lysins for treatment of gram positive bacteria in companion animals and livestock |
NL2007038C2 (en) * | 2011-07-04 | 2013-01-07 | Vereniging Voor Christelijk Hoger Onderwijs | System and method for predicting the viability of a body tissue in a patient, and measuring device used therein. |
CN111803620A (zh) * | 2012-05-09 | 2020-10-23 | 康特拉费克特公司 | 使用噬菌体溶素的生物膜预防、破坏和处理 |
KR20210121313A (ko) * | 2012-05-09 | 2021-10-07 | 콘트라펙트 코포레이션 | 그람 양성 박테리아에 대한 박테리오파지 리신과 항생제의 병용물 |
CN104073478A (zh) * | 2014-06-13 | 2014-10-01 | 上海交通大学 | 杀灭革兰氏阳性菌的酶抗生素及其制备、用途 |
CN106659748B (zh) | 2014-06-26 | 2021-08-31 | 洛克菲勒大学 | 不动杆菌属溶素 |
CN104726439B (zh) * | 2015-04-13 | 2017-11-14 | 武汉菲吉乐科生物科技有限公司 | 一种广谱的链球菌裂解酶及其应用 |
CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
WO2017023680A1 (en) * | 2015-07-31 | 2017-02-09 | The Regents Of The University Of California | Mycobacterium lysterase: a novel treatment for acne |
WO2017044989A1 (en) * | 2015-09-13 | 2017-03-16 | The Rockefeller University | Clostridium difficile BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF Clostridium difficile BACTERIA INFECTION |
CN108348574B (zh) | 2015-09-17 | 2022-11-01 | 抗非特公司 | 具有对抗革兰氏阴性菌的活性的溶素多肽 |
MX2018013372A (es) | 2016-05-12 | 2019-05-09 | Contrafect Corp | Metodo de microdilucion en caldo para evaluar y determinar la concentracion inhibitoria minima de polipeptidos antibacterianos. |
CA3069679A1 (en) * | 2017-07-10 | 2019-01-17 | Contrafect Corporation | Blood component potentiation of lytic protein anti-bacterial activity and methods and uses thereof |
JP2021509582A (ja) * | 2018-01-05 | 2021-04-01 | アジトラ インコーポレーテッド | ブドウ球菌(Staphylococcus)属細菌の栄養要求株 |
EP3758738A4 (en) * | 2018-02-26 | 2021-12-08 | Contrafect Corporation | MODIFIED PLYSS2-LYSINE AND USES THEREOF |
KR102073086B1 (ko) * | 2018-06-04 | 2020-02-04 | (주)인트론바이오테크놀로지 | 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-1 및 이의 스트렙토코커스 수이스 균 증식 억제 용도 |
KR102073088B1 (ko) * | 2018-06-04 | 2020-02-04 | (주)인트론바이오테크놀로지 | 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-2 및 이의 스트렙토코커스 수이스 균 증식 억제 용도 |
KR102073094B1 (ko) * | 2018-06-04 | 2020-02-04 | (주)인트론바이오테크놀로지 | 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-3 및 이의 스트렙토코커스 수이스 균 증식 억제 용도 |
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CN114025782A (zh) * | 2019-03-22 | 2022-02-08 | 康特拉费克特公司 | 治疗感染性心内膜炎的方法 |
JP2022526978A (ja) * | 2019-04-05 | 2022-05-27 | コントラフェクト コーポレイション | ヒト血清の存在下でシュードモナス・エルギノーサに対する殺菌活性を有する溶解素及びその誘導体 |
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CA3178761A1 (en) * | 2020-05-19 | 2021-11-25 | Raymond Schuch | Modified plyss2 lysins and antibiotic combinations for use against gram-positive bacteria |
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CN114480299B (zh) * | 2020-10-27 | 2023-08-29 | 暨南大学 | 一种蜡样芽胞杆菌噬菌体及其应用 |
CN112760312B (zh) * | 2021-01-20 | 2022-06-17 | 华中农业大学 | 一种裂解革兰氏阳性菌的裂解酶plyssX609及其应用 |
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CN116640754B (zh) * | 2023-07-21 | 2023-10-10 | 临沂大学 | 一种链球菌前噬菌体裂解酶lys224及应用 |
CN117051043B (zh) * | 2023-10-11 | 2024-01-30 | 圆因(北京)生物科技有限公司 | 一种基于环状rna编码耐甲氧西林金黄色葡萄球菌内溶素及其应用 |
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2012
- 2012-04-20 JP JP2014506576A patent/JP6139509B2/ja active Active
- 2012-04-20 AU AU2012245357A patent/AU2012245357B2/en active Active
- 2012-04-20 MX MX2016000588A patent/MX370442B/es unknown
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