MX370442B - Proteínas quiméricas de una lisina de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas. - Google Patents
Proteínas quiméricas de una lisina de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas.Info
- Publication number
- MX370442B MX370442B MX2016000588A MX2016000588A MX370442B MX 370442 B MX370442 B MX 370442B MX 2016000588 A MX2016000588 A MX 2016000588A MX 2016000588 A MX2016000588 A MX 2016000588A MX 370442 B MX370442 B MX 370442B
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- positive bacteria
- detection
- gram positive
- streptococcus
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a proteínas quimérica y métodos y composiciones de las mismas útiles para el mejoramiento terapéutico y tratamiento de bacterias gram positivas, que incluyen Streptococcus y Staphylococcus, y afecciones relacionadas. La presente provee composiciones y métodos que incorporan y utilizan proteínas quiméricas de lisinas de bacteriófago derivadas de Streptococcus suis, particularmente la enzima lítica PlySs2, y variantes de la misma que incluyen porciones biológicamente activas de las mismas. Se provee el uso de composiciones que comprenden proteínas quiméricas en la preparación de un medicamento para la destrucción de bacterias, que incluyen Streptococcus y Staphylococcus, y el tratamiento de una infección bacteriana gram positiva en humanos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161477836P | 2011-04-21 | 2011-04-21 | |
PCT/US2012/034456 WO2012145630A2 (en) | 2011-04-21 | 2012-04-20 | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
Publications (1)
Publication Number | Publication Date |
---|---|
MX370442B true MX370442B (es) | 2019-12-13 |
Family
ID=47042182
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013012241A MX336427B (es) | 2011-04-21 | 2012-04-20 | Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas. |
MX2016000588A MX370442B (es) | 2011-04-21 | 2012-04-20 | Proteínas quiméricas de una lisina de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas. |
MX2021007008A MX2021007008A (es) | 2011-04-21 | 2013-10-18 | Lisinas de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013012241A MX336427B (es) | 2011-04-21 | 2012-04-20 | Lisinas de bacteriofago de estreptococcus para la deteccion y tratamiento de bacterias gram positivas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007008A MX2021007008A (es) | 2011-04-21 | 2013-10-18 | Lisinas de bacteriófago de streptococcus para la detección y tratamiento de bacterias gram positivas. |
Country Status (12)
Country | Link |
---|---|
US (7) | US9034322B2 (es) |
EP (2) | EP2699253B1 (es) |
JP (4) | JP6139509B2 (es) |
CN (4) | CN108578685A (es) |
AU (3) | AU2012245357B2 (es) |
CA (1) | CA2833409A1 (es) |
DK (1) | DK2699253T3 (es) |
ES (1) | ES2682670T3 (es) |
HK (2) | HK1244503A1 (es) |
IL (4) | IL228869B (es) |
MX (3) | MX336427B (es) |
WO (1) | WO2012145630A2 (es) |
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PL3604339T3 (pl) | 2011-01-14 | 2021-12-27 | The Regents Of The University Of California | Terapeutyczne przeciwciała przeciwko białku ror-1 i sposoby ich zastosowania |
US20140179594A1 (en) * | 2011-04-21 | 2014-06-26 | The Rockefeller University | Streptococcus bacteriophage lysins for treatment of gram positive bacteria in companion animals and livestock |
NL2007038C2 (en) * | 2011-07-04 | 2013-01-07 | Vereniging Voor Christelijk Hoger Onderwijs | System and method for predicting the viability of a body tissue in a patient, and measuring device used therein. |
US10813983B2 (en) * | 2012-05-09 | 2020-10-27 | Contrafect Corporation | Bacteriophage lysin and antibiotic combinations against gram positive bacteria |
US9499594B2 (en) * | 2012-05-09 | 2016-11-22 | Contrafect Corporation | Biofilm prevention, disruption and treatment with bacteriophage lysin |
CN104073478A (zh) * | 2014-06-13 | 2014-10-01 | 上海交通大学 | 杀灭革兰氏阳性菌的酶抗生素及其制备、用途 |
KR102441211B1 (ko) * | 2014-06-26 | 2022-09-07 | 더 락커펠러 유니버시티 | 아시네토박터 라이신 |
CN104726439B (zh) * | 2015-04-13 | 2017-11-14 | 武汉菲吉乐科生物科技有限公司 | 一种广谱的链球菌裂解酶及其应用 |
CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
WO2017023680A1 (en) * | 2015-07-31 | 2017-02-09 | The Regents Of The University Of California | Mycobacterium lysterase: a novel treatment for acne |
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AU2016324298B2 (en) | 2015-09-17 | 2022-09-01 | Contrafect Corporation | Lysin polypeptides active against Gram-negative bacteria |
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MX2020000018A (es) * | 2017-07-10 | 2020-10-01 | Contrafect Corp | Potencializacion de componentes sanguineos de actividad anti-bacteriana de proteina litica y metodos y usos de estos. |
EP3735268A4 (en) * | 2018-01-05 | 2021-12-22 | Azitra, Inc. | AUXOTROPHIC STRAINS OF STAPHYLOCOCCUS BACTERIA |
EP3758738A4 (en) * | 2018-02-26 | 2021-12-08 | Contrafect Corporation | MODIFIED PLYSS2-LYSINE AND USES THEREOF |
KR102073088B1 (ko) * | 2018-06-04 | 2020-02-04 | (주)인트론바이오테크놀로지 | 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-2 및 이의 스트렙토코커스 수이스 균 증식 억제 용도 |
KR102073094B1 (ko) * | 2018-06-04 | 2020-02-04 | (주)인트론바이오테크놀로지 | 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-3 및 이의 스트렙토코커스 수이스 균 증식 억제 용도 |
KR102073086B1 (ko) * | 2018-06-04 | 2020-02-04 | (주)인트론바이오테크놀로지 | 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-1 및 이의 스트렙토코커스 수이스 균 증식 억제 용도 |
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2012
- 2012-04-20 ES ES12773653.6T patent/ES2682670T3/es active Active
- 2012-04-20 CN CN201810396150.7A patent/CN108578685A/zh active Pending
- 2012-04-20 MX MX2013012241A patent/MX336427B/es unknown
- 2012-04-20 AU AU2012245357A patent/AU2012245357B2/en active Active
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