RU2630690C9 - МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ - Google Patents

МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ Download PDF

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RU2630690C9
RU2630690C9 RU2013127162A RU2013127162A RU2630690C9 RU 2630690 C9 RU2630690 C9 RU 2630690C9 RU 2013127162 A RU2013127162 A RU 2013127162A RU 2013127162 A RU2013127162 A RU 2013127162A RU 2630690 C9 RU2630690 C9 RU 2630690C9
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compound
formula
substituted
group
cyp
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RU2013127162A
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RU2630690C2 (ru
RU2013127162A (ru
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Александр ХЕГМАНС
Брюс У. ФЕНСКЕ
Дэн Дж. ТРЕПАНЬЕ
Марк Д. АБЕЛЬ
Син СУГИЯМА
Дарен Р. УРЕ
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КонтраВир Фармасьютикалз, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
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RU2013127162A 2010-12-15 2011-12-14 МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ RU2630690C9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42357610P 2010-12-15 2010-12-15
US61/423,576 2010-12-15
PCT/CA2011/050773 WO2012079172A1 (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3

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RU2013127162A RU2013127162A (ru) 2015-06-10
RU2630690C2 RU2630690C2 (ru) 2017-09-12
RU2630690C9 true RU2630690C9 (ru) 2017-12-28

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US (2) US9200038B2 (OSRAM)
EP (2) EP2651965B1 (OSRAM)
JP (3) JP6144627B2 (OSRAM)
KR (3) KR20190002731A (OSRAM)
CN (2) CN107496902B (OSRAM)
AU (1) AU2011342284C1 (OSRAM)
BR (1) BR112013014890B1 (OSRAM)
CA (1) CA2821009C (OSRAM)
DK (1) DK2651965T3 (OSRAM)
ES (1) ES2705750T3 (OSRAM)
HR (1) HRP20190096T1 (OSRAM)
HU (1) HUE042490T2 (OSRAM)
IL (1) IL226792A (OSRAM)
LT (1) LT2651965T (OSRAM)
MX (1) MX353720B (OSRAM)
MY (2) MY192981A (OSRAM)
NZ (1) NZ611620A (OSRAM)
PH (1) PH12013501213A1 (OSRAM)
PL (1) PL2651965T3 (OSRAM)
PT (1) PT2651965T (OSRAM)
RU (1) RU2630690C9 (OSRAM)
SG (2) SG191069A1 (OSRAM)
SI (1) SI2651965T1 (OSRAM)
TR (1) TR201900128T4 (OSRAM)
WO (1) WO2012079172A1 (OSRAM)

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US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
CN107496902B (zh) * 2010-12-15 2022-01-18 康卓维尔制药公司 在氨基酸1和3位修改的环孢菌素类似分子
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US20160002299A1 (en) * 2013-03-01 2016-01-07 Ucl Business Plc Non-immunosuppressive cyclosporin derivatives as antiviral agents
MX2016002458A (es) * 2013-08-26 2016-08-08 Enanta Pharm Inc Análogos novedosos de ciclosporina para prevenir o tratar la infección por hepatitis c.
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
EP3458470A4 (en) * 2016-05-17 2020-04-22 S&T Global Inc. NEW CYCLOSPOR DERIVATIVES AND USES THEREOF
WO2018106931A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
WO2018106928A1 (en) 2016-12-08 2018-06-14 Contravir Pharmaceuticals, Inc. Treatment and prevention of hbv diseases by cyclosporine analogue molecules modified at amino acides 1 and 3
WO2018112255A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
WO2018191579A1 (en) 2017-04-14 2018-10-18 Contravir Pharmaceuticals, Inc. Combination therapy for treating viral infections
EP3612540A1 (en) 2017-04-20 2020-02-26 Rising Tide Foundation Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
US12252556B2 (en) 2018-08-22 2025-03-18 Bacainn Biotherapeutics, Ltd. Cyclosporine compositions and methods of use
CA3171882A1 (en) 2020-02-19 2021-08-26 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues for treating fibrosis
MX2022010454A (es) * 2020-02-25 2022-09-19 Hepion Pharmaceuticals Inc Uso de analogos de ciclosporina para el tratamiento contra el cancer.
BR112022018929A2 (pt) 2020-03-26 2022-12-06 Farsight Medical Tech Shanghai Co Ltd Inibidores da ciclofilina e seus usos
CN115315432A (zh) * 2020-03-26 2022-11-08 睿诺医疗科技（上海）有限公司 亲环蛋白抑制剂及其用途
JP2023551503A (ja) * 2020-11-29 2023-12-08 ヘピオン ファーマシューティカルズ インコーポレイテッド 抗血栓剤としてのシクロスポリン類似体の使用
CN113173974B (zh) 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
CN115677533B (zh) * 2021-07-30 2023-12-05 沈阳化工研究院有限公司 一种4-庚基苯甲腈的制备方法
IT202300001116A1 (it) * 2023-01-25 2024-07-25 Indena Spa Processo per la preparazione di un intermedio utile per la sintesi di voclosporina
WO2024245384A1 (en) * 2023-06-02 2024-12-05 Farsight Medical Technology (Shanghai) Co., Ltd. Cyclophilin inhibitors and uses thereof
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