NZ611620A - Cyclosporine analogue molecules modified at amino acid 1 and 3 - Google Patents

Cyclosporine analogue molecules modified at amino acid 1 and 3

Info

Publication number
NZ611620A
NZ611620A NZ611620A NZ61162011A NZ611620A NZ 611620 A NZ611620 A NZ 611620A NZ 611620 A NZ611620 A NZ 611620A NZ 61162011 A NZ61162011 A NZ 61162011A NZ 611620 A NZ611620 A NZ 611620A
Authority
NZ
New Zealand
Prior art keywords
amino acid
disclosed
molecules modified
analogue molecules
cyclosporine analogue
Prior art date
Application number
NZ611620A
Other languages
English (en)
Inventor
Alexander Hegmans
Bruce W Fenske
Dan J Trepanier
Mark D Abel
Shin Sugiyama
Daren R Ure
Original Assignee
Ciclofilin Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciclofilin Pharmaceuticals Corp filed Critical Ciclofilin Pharmaceuticals Corp
Publication of NZ611620A publication Critical patent/NZ611620A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
NZ611620A 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3 NZ611620A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42357610P 2010-12-15 2010-12-15
PCT/CA2011/050773 WO2012079172A1 (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3

Publications (1)

Publication Number Publication Date
NZ611620A true NZ611620A (en) 2016-02-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
NZ611620A NZ611620A (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3

Country Status (25)

Country Link
US (2) US9200038B2 (OSRAM)
EP (2) EP3461835A1 (OSRAM)
JP (3) JP6144627B2 (OSRAM)
KR (3) KR102011339B1 (OSRAM)
CN (2) CN107496902B (OSRAM)
AU (1) AU2011342284C1 (OSRAM)
BR (1) BR112013014890B1 (OSRAM)
CA (1) CA2821009C (OSRAM)
DK (1) DK2651965T3 (OSRAM)
ES (1) ES2705750T3 (OSRAM)
HR (1) HRP20190096T1 (OSRAM)
HU (1) HUE042490T2 (OSRAM)
IL (1) IL226792A (OSRAM)
LT (1) LT2651965T (OSRAM)
MX (1) MX353720B (OSRAM)
MY (2) MY192981A (OSRAM)
NZ (1) NZ611620A (OSRAM)
PH (1) PH12013501213A1 (OSRAM)
PL (1) PL2651965T3 (OSRAM)
PT (1) PT2651965T (OSRAM)
RU (1) RU2630690C9 (OSRAM)
SG (2) SG191069A1 (OSRAM)
SI (1) SI2651965T1 (OSRAM)
TR (1) TR201900128T4 (OSRAM)
WO (1) WO2012079172A1 (OSRAM)

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TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
CN118324867A (zh) * 2016-05-17 2024-07-12 美国科技环球有限公司 新型环孢菌素衍生物及其用途
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AR111464A1 (es) 2017-04-14 2019-07-17 Contravir Pharmaceuticals Inc Terapia combinada para el tratamiento de infecciones virales
EP3612540A1 (en) 2017-04-20 2020-02-26 Rising Tide Foundation Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
ES2990218T3 (es) * 2018-08-22 2024-11-29 Bacainn Biotherapeutics Ltd Composiciones de ciclosporina y métodos de uso
US12409206B2 (en) 2020-02-19 2025-09-09 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues for treating fibrosis
AR121404A1 (es) * 2020-02-25 2022-06-01 Hepion Pharmaceuticals Inc Uso de análogos de ciclosporina para tratar cáncer
WO2021190603A1 (en) * 2020-03-26 2021-09-30 Farsight Medical Technology (Shanghai) Co., Ltd. Cyclophilin inhibitors and uses thereof
TW202144379A (zh) 2020-03-26 2021-12-01 大陸商睿諾醫療科技（上海）有限公司 親環蛋白抑制劑及其用途
CN116829168A (zh) * 2020-11-29 2023-09-29 海必恩制药公司 环孢菌素类似物作为抗血栓形成剂的用途
CN113173974B (zh) 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
CN115677533B (zh) * 2021-07-30 2023-12-05 沈阳化工研究院有限公司 一种4-庚基苯甲腈的制备方法
IT202300001116A1 (it) * 2023-01-25 2024-07-25 Indena Spa Processo per la preparazione di un intermedio utile per la sintesi di voclosporina
CN121219307A (zh) * 2023-06-02 2025-12-26 睿诺医疗科技（上海）有限公司 亲环蛋白抑制剂及其用途
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