RU2598072C2 - Новые кристаллические формы ингибиторов дипептидилпептидазы-iv - Google Patents
Новые кристаллические формы ингибиторов дипептидилпептидазы-iv Download PDFInfo
- Publication number
- RU2598072C2 RU2598072C2 RU2014102773/04A RU2014102773A RU2598072C2 RU 2598072 C2 RU2598072 C2 RU 2598072C2 RU 2014102773/04 A RU2014102773/04 A RU 2014102773/04A RU 2014102773 A RU2014102773 A RU 2014102773A RU 2598072 C2 RU2598072 C2 RU 2598072C2
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- Russia
- Prior art keywords
- crystalline form
- crystalline
- difluorophenyl
- pyran
- methylsulfonyl
- Prior art date
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- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title description 4
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 58
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims abstract description 15
- 238000002441 X-ray diffraction Methods 0.000 claims abstract description 13
- 239000003112 inhibitor Substances 0.000 claims abstract description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
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- 239000000126 substance Substances 0.000 claims abstract description 9
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 45
- MKMPWKUAHLTIBJ-ISTRZQFTSA-N omarigliptin Chemical compound C1([C@H]2OC[C@@H](C[C@@H]2N)N2CC3=CN(N=C3C2)S(=O)(=O)C)=CC(F)=CC=C1F MKMPWKUAHLTIBJ-ISTRZQFTSA-N 0.000 claims description 33
- 229940088679 drug related substance Drugs 0.000 claims description 28
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 22
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 20
- 238000002411 thermogravimetry Methods 0.000 claims description 15
- 238000002844 melting Methods 0.000 claims description 10
- 230000008018 melting Effects 0.000 claims description 10
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- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 2
- -1 tetrahydro-2H-pyran-3-amine compound Chemical class 0.000 abstract description 19
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
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- 238000002329 infrared spectrum Methods 0.000 description 9
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- IUYHWZFSGMZEOG-UHFFFAOYSA-M magnesium;propane;chloride Chemical compound [Mg+2].[Cl-].C[CH-]C IUYHWZFSGMZEOG-UHFFFAOYSA-M 0.000 description 4
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- 238000000371 solid-state nuclear magnetic resonance spectroscopy Methods 0.000 description 4
- SNEHALFDVXIDSZ-UHFFFAOYSA-N tert-butyl 2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carboxylate Chemical compound CS(=O)(=O)N1N=C2CN(C(=O)OC(C)(C)C)CC2=C1 SNEHALFDVXIDSZ-UHFFFAOYSA-N 0.000 description 4
- OTCULXVRRSCLLI-UONOGXRCSA-N tert-butyl n-[(2r,3s)-2-(2,5-difluorophenyl)-5-oxooxan-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H]1CC(=O)CO[C@@H]1C1=CC(F)=CC=C1F OTCULXVRRSCLLI-UONOGXRCSA-N 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
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- RHQNBUOAURLQOG-UHFFFAOYSA-N tert-butyl 6a-hydroxy-1,3a,4,6-tetrahydropyrrolo[3,4-c]pyrazole-5-carboxylate Chemical compound C1=NNC2(O)CN(C(=O)OC(C)(C)C)CC21 RHQNBUOAURLQOG-UHFFFAOYSA-N 0.000 description 3
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| PCT/US2012/043922 WO2013003249A1 (en) | 2011-06-29 | 2012-06-25 | Novel crystalline forms of a dipeptidyl peptidase-iv inhibitor |
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| CN105037367A (zh) * | 2014-04-18 | 2015-11-11 | 四川海思科制药有限公司 | 氨基六元环类衍生物及其在医药上的应用 |
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| JP6574474B2 (ja) * | 2014-07-21 | 2019-09-11 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | キラルジペプチジルペプチダーゼ−ｉｖ阻害剤の製造方法 |
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| CN105130995B (zh) * | 2015-09-09 | 2017-08-11 | 杭州成邦医药科技有限公司 | 吡咯酮类化合物及其制备方法和应用 |
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| CN105399744B (zh) * | 2015-12-17 | 2017-07-18 | 黄燕鸽 | 一种奥格列汀的合成方法 |
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| PT3395819T (pt) * | 2015-12-25 | 2023-07-05 | Sichuan Haisco Pharmaceutical Co Ltd | Forma cristalina de derivado de aminopirano substituído |
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| JP6997760B2 (ja) * | 2016-08-12 | 2022-01-18 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Ｄｐｐ－ｉｖ長時間作用型阻害剤の結晶及びその塩 |
| CN107793389B (zh) * | 2016-09-05 | 2021-06-29 | 中国科学院上海药物研究所 | 手性四氢吡喃衍生物及其制备与用途 |
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