RU2477286C2 - АНАЛОГИ ГЛЮКАГОНА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ РАСТВОРИМОСТЬЮ В БУФЕРАХ С ФИЗИОЛОГИЧЕСКИМ ЗНАЧЕНИЕМ pH - Google Patents
АНАЛОГИ ГЛЮКАГОНА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ РАСТВОРИМОСТЬЮ В БУФЕРАХ С ФИЗИОЛОГИЧЕСКИМ ЗНАЧЕНИЕМ pH Download PDFInfo
- Publication number
- RU2477286C2 RU2477286C2 RU2009129961/10A RU2009129961A RU2477286C2 RU 2477286 C2 RU2477286 C2 RU 2477286C2 RU 2009129961/10 A RU2009129961/10 A RU 2009129961/10A RU 2009129961 A RU2009129961 A RU 2009129961A RU 2477286 C2 RU2477286 C2 RU 2477286C2
- Authority
- RU
- Russia
- Prior art keywords
- glucagon
- seq
- amino acid
- peptide
- glucagon peptide
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87891907P | 2007-01-05 | 2007-01-05 | |
| US60/878,919 | 2007-01-05 | ||
| PCT/US2008/050099 WO2008086086A2 (en) | 2007-01-05 | 2008-01-03 | Glucagon analogs exhibiting enhanced solubility in physiological ph buffers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009129961A RU2009129961A (ru) | 2011-02-10 |
| RU2477286C2 true RU2477286C2 (ru) | 2013-03-10 |
Family
ID=39609306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009129961/10A RU2477286C2 (ru) | 2007-01-05 | 2008-01-03 | АНАЛОГИ ГЛЮКАГОНА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ РАСТВОРИМОСТЬЮ В БУФЕРАХ С ФИЗИОЛОГИЧЕСКИМ ЗНАЧЕНИЕМ pH |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8669228B2 (enExample) |
| EP (1) | EP2124974B1 (enExample) |
| JP (1) | JP5890085B2 (enExample) |
| CN (1) | CN101578102B (enExample) |
| AU (1) | AU2008205229B2 (enExample) |
| CA (1) | CA2674354A1 (enExample) |
| ES (1) | ES2628063T3 (enExample) |
| IL (1) | IL199263A (enExample) |
| MX (1) | MX2009006564A (enExample) |
| RU (1) | RU2477286C2 (enExample) |
| SG (1) | SG177953A1 (enExample) |
| WO (1) | WO2008086086A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2850091C1 (ru) * | 2020-07-15 | 2025-11-05 | Ханми Фарм. Ко., Лтд. | Терапевтическое применение производного глюкагона или его конъюгата при заболевании печени |
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| CA2628241C (en) | 2005-11-07 | 2016-02-02 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting physiological solubility and stability |
| EP2124974B1 (en) | 2007-01-05 | 2017-03-15 | Indiana University Research and Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological ph buffers |
| EP2487184A1 (en) * | 2007-02-15 | 2012-08-15 | Indiana University Research and Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| WO2009058662A2 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Glucagon antagonists |
| WO2009058734A1 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Compounds exhibiting glucagon antagonist and glp-1 agonist activity |
| JP2011511778A (ja) * | 2008-01-30 | 2011-04-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | エステルに基づいたペプチドプロドラッグ |
| WO2009102467A2 (en) | 2008-02-13 | 2009-08-20 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| KR20110039230A (ko) * | 2008-06-17 | 2011-04-15 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 생리학적 pH 완충액에서 강화된 용해도 및 안정성을 나타내는 글루카곤 유사체 |
| BRPI0915282A2 (pt) | 2008-06-17 | 2017-02-07 | Univ Indiana Res & Tech Corp | agonistas mistos baseados no gip para o tratamento de distúrbios metabólicos e obesidade |
| AU2009260302B2 (en) | 2008-06-17 | 2014-10-23 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
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| CN103179979A (zh) | 2010-06-24 | 2013-06-26 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰高血糖素超家族肽前药 |
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| EA201390941A1 (ru) | 2010-12-22 | 2013-12-30 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Аналоги глюкагона, проявляющие активность на рецепторе gip |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2850091C1 (ru) * | 2020-07-15 | 2025-11-05 | Ханми Фарм. Ко., Лтд. | Терапевтическое применение производного глюкагона или его конъюгата при заболевании печени |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5890085B2 (ja) | 2016-03-22 |
| RU2009129961A (ru) | 2011-02-10 |
| JP2010515686A (ja) | 2010-05-13 |
| US8669228B2 (en) | 2014-03-11 |
| IL199263A (en) | 2013-09-30 |
| WO2008086086A3 (en) | 2008-11-20 |
| CN101578102A (zh) | 2009-11-11 |
| EP2124974B1 (en) | 2017-03-15 |
| AU2008205229B2 (en) | 2014-03-27 |
| MX2009006564A (es) | 2009-06-26 |
| EP2124974A4 (en) | 2010-03-31 |
| EP2124974A2 (en) | 2009-12-02 |
| ES2628063T3 (es) | 2017-08-01 |
| CA2674354A1 (en) | 2008-07-17 |
| WO2008086086A2 (en) | 2008-07-17 |
| CN101578102B (zh) | 2013-07-17 |
| SG177953A1 (en) | 2012-02-28 |
| US20100190699A1 (en) | 2010-07-29 |
| AU2008205229A1 (en) | 2008-07-17 |
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