JP5890085B2 - 生理学的ｐＨの緩衝液中で向上した溶解度を示すグルカゴン類縁体 - Google Patents

生理学的ｐＨの緩衝液中で向上した溶解度を示すグルカゴン類縁体 Download PDF

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JP5890085B2
JP5890085B2 JP2009544968A JP2009544968A JP5890085B2 JP 5890085 B2 JP5890085 B2 JP 5890085B2 JP 2009544968 A JP2009544968 A JP 2009544968A JP 2009544968 A JP2009544968 A JP 2009544968A JP 5890085 B2 JP5890085 B2 JP 5890085B2
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seq
glucagon
amino acid
peptide
acid
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JP2010515686A5 (enExample
JP2010515686A (ja
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ディマルキ，リチャード，ディー．
ディマルキ，マリア
シャベンヌ，ジョセフ
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Indiana University Research and Technology Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2009544968A 2007-01-05 2008-01-03 生理学的ｐＨの緩衝液中で向上した溶解度を示すグルカゴン類縁体 Expired - Fee Related JP5890085B2 (ja)

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US87891907P 2007-01-05 2007-01-05
US60/878,919 2007-01-05
PCT/US2008/050099 WO2008086086A2 (en) 2007-01-05 2008-01-03 Glucagon analogs exhibiting enhanced solubility in physiological ph buffers

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JP2010515686A JP2010515686A (ja) 2010-05-13
JP2010515686A5 JP2010515686A5 (enExample) 2011-07-07
JP5890085B2 true JP5890085B2 (ja) 2016-03-22

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US (1) US8669228B2 (enExample)
EP (1) EP2124974B1 (enExample)
JP (1) JP5890085B2 (enExample)
CN (1) CN101578102B (enExample)
AU (1) AU2008205229B2 (enExample)
CA (1) CA2674354A1 (enExample)
ES (1) ES2628063T3 (enExample)
IL (1) IL199263A (enExample)
MX (1) MX2009006564A (enExample)
RU (1) RU2477286C2 (enExample)
SG (1) SG177953A1 (enExample)
WO (1) WO2008086086A2 (enExample)

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CA2674354A1 (en) 2008-07-17
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