CN101578102B - 在生理性pH缓冲液中显示增强的溶解性的胰高血糖素类似物 - Google Patents

在生理性pH缓冲液中显示增强的溶解性的胰高血糖素类似物 Download PDF

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CN101578102B
CN101578102B CN2008800016731A CN200880001673A CN101578102B CN 101578102 B CN101578102 B CN 101578102B CN 2008800016731 A CN2008800016731 A CN 2008800016731A CN 200880001673 A CN200880001673 A CN 200880001673A CN 101578102 B CN101578102 B CN 101578102B
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glucagon
seq
peptide
amino acid
asp
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CN101578102A (zh
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R·D·迪马基
M·迪马基
J·沙贝内
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Indiana University Research and Technology Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

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CN2008800016731A 2007-01-05 2008-01-03 在生理性pH缓冲液中显示增强的溶解性的胰高血糖素类似物 Expired - Fee Related CN101578102B (zh)

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US87891907P 2007-01-05 2007-01-05
US60/878,919 2007-01-05
PCT/US2008/050099 WO2008086086A2 (en) 2007-01-05 2008-01-03 Glucagon analogs exhibiting enhanced solubility in physiological ph buffers

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CN101578102A CN101578102A (zh) 2009-11-11
CN101578102B true CN101578102B (zh) 2013-07-17

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US (1) US8669228B2 (enExample)
EP (1) EP2124974B1 (enExample)
JP (1) JP5890085B2 (enExample)
CN (1) CN101578102B (enExample)
AU (1) AU2008205229B2 (enExample)
CA (1) CA2674354A1 (enExample)
ES (1) ES2628063T3 (enExample)
IL (1) IL199263A (enExample)
MX (1) MX2009006564A (enExample)
RU (1) RU2477286C2 (enExample)
SG (1) SG177953A1 (enExample)
WO (1) WO2008086086A2 (enExample)

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US20100190699A1 (en) 2010-07-29
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