RU2434871C2 - Пирролопиримидины, применимые в качестве ингибиторов протеинкиназы - Google Patents

Пирролопиримидины, применимые в качестве ингибиторов протеинкиназы Download PDF

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RU2434871C2
RU2434871C2 RU2007132908/04A RU2007132908A RU2434871C2 RU 2434871 C2 RU2434871 C2 RU 2434871C2 RU 2007132908/04 A RU2007132908/04 A RU 2007132908/04A RU 2007132908 A RU2007132908 A RU 2007132908A RU 2434871 C2 RU2434871 C2 RU 2434871C2
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RU2007132908/04A
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RU2007132908A (ru
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Марк В. ЛЕДЕБУР (US)
Марк В. Ледебур
Альберт К. ПИРС (US)
Альберт К. ПИРС
Гай У. БЕМИС (US)
Гай У. БЕМИС
Люк Дж. ФАРМЕР (US)
Люк Дж. Фармер
Тяньшэн ВАН (US)
Тяньшэн Ван
Дэвид МЕССЕРСМИТ (US)
Дэвид МЕССЕРСМИТ
Джон П. ДАФФИ (US)
Джон П. Даффи
Цзянь ВАН (US)
Цзянь ВАН
Франческо Г. САЛИТУРО (US)
Франческо Г. САЛИТУРО
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Вертекс Фармасьютикалз Инкорпорейтед
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
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  • Endocrinology (AREA)
  • Reproductive Health (AREA)
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RU2007132908/04A 2005-02-03 2006-02-02 Пирролопиримидины, применимые в качестве ингибиторов протеинкиназы RU2434871C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64978105P 2005-02-03 2005-02-03
US60/649,781 2005-02-03

Publications (2)

Publication Number Publication Date
RU2007132908A RU2007132908A (ru) 2009-03-10
RU2434871C2 true RU2434871C2 (ru) 2011-11-27

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Country Status (16)

Country Link
US (2) US8633205B2 (enExample)
EP (1) EP1844050B1 (enExample)
JP (2) JP5227032B2 (enExample)
KR (1) KR20070104641A (enExample)
CN (1) CN101142218B (enExample)
AT (1) ATE420883T1 (enExample)
AU (1) AU2006221065A1 (enExample)
CA (1) CA2596830A1 (enExample)
DE (1) DE602006004844D1 (enExample)
ES (1) ES2320487T3 (enExample)
IL (1) IL184898A0 (enExample)
MX (1) MX2007009429A (enExample)
NO (1) NO20074431L (enExample)
RU (1) RU2434871C2 (enExample)
WO (1) WO2006096270A1 (enExample)
ZA (1) ZA200707342B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2618673C2 (ru) * 2011-12-21 2017-05-10 Цзянсу Хэнжуй Медсин Ко., Лтд. Производные пирролопиримидина, полезные в качестве ингибиторов jak-киназы
RU2665680C2 (ru) * 2013-06-07 2018-09-04 Цзянсу Хэнжуй Медсин Ко., Лтд. Бисульфат ингибитора янус-киназы (jak) и способ его получения
RU2712269C2 (ru) * 2015-07-31 2020-01-28 Тайхо Фармасьютикал Ко., Лтд. Пирроло[2,3-d]пиримидиновое соединение или его соль
RU2716260C2 (ru) * 2014-11-05 2020-03-11 Цзянсу Хэнжуй Медсин Ко., Лтд. Кристаллическая форма бисульфатного ингибитора jak-киназы и способ ее получения
RU2810252C1 (ru) * 2023-05-25 2023-12-25 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" 5-Амино-1-(2-оксо-2-фенилэтилиден)-3-(пирролидин-1-карбонил)-6,7,8,9-тетрагидробензо[4,5]тиено[3,2-e]пирроло[1,2-a]пиримидин-2(1Н)-он, обладающий анальгетической активностью

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7884109B2 (en) 2005-04-05 2011-02-08 Wyeth Llc Purine and imidazopyridine derivatives for immunosuppression
JP2008545660A (ja) * 2005-05-20 2008-12-18 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼ阻害剤として有用なピロロピリジン化合物
WO2007038215A1 (en) * 2005-09-22 2007-04-05 Incyte Corporation Tetracyclic inhibitors of janus kinases
AU2015201850B2 (en) * 2005-12-13 2017-03-02 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
HUE028588T2 (hu) * 2005-12-13 2016-12-28 Incyte Holdings Corp Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
NZ592968A (en) 2006-01-17 2012-08-31 Vertex Pharma Azaindoles substituted with either triazine or pyrimidine useful as inhibitors of janus kinases consisting of JAK1, JAK2, JAK3, and TYK2
US7989459B2 (en) 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
JP2009532475A (ja) * 2006-04-05 2009-09-10 バーテックス ファーマシューティカルズ インコーポレイテッド ヤヌスキナーゼの阻害剤として有用なデアザプリン
TW200837064A (en) 2006-10-04 2008-09-16 Pharmacopeia Inc 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression
US7902187B2 (en) 2006-10-04 2011-03-08 Wyeth Llc 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
TW200831104A (en) 2006-10-04 2008-08-01 Pharmacopeia Inc 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
KR20090082453A (ko) 2006-11-01 2009-07-30 버텍스 파마슈티칼스 인코포레이티드 야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물
KR20100014271A (ko) * 2006-11-16 2010-02-10 파마코페이아, 엘엘씨. 면역 억제를 위한 7-치환된 퓨린 유도체
WO2008079346A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
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