ZA200707342B - Pyrrolopyrimidines useful as inhibitors of protein kinase - Google Patents

Pyrrolopyrimidines useful as inhibitors of protein kinase

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Publication number
ZA200707342B
ZA200707342B ZA200707342A ZA200707342A ZA200707342B ZA 200707342 B ZA200707342 B ZA 200707342B ZA 200707342 A ZA200707342 A ZA 200707342A ZA 200707342 A ZA200707342 A ZA 200707342A ZA 200707342 B ZA200707342 B ZA 200707342B
Authority
ZA
South Africa
Prior art keywords
inhibitors
protein kinase
useful
pyrrolopyrimidines
pyrrolopyrimidines useful
Prior art date
Application number
ZA200707342A
Other languages
English (en)
Inventor
Mark W Ledeboer
Albert C Pierce
Guy W Bemis
Luc J Farmer
Wang Tiansheng
Messersmith David
John P Duffy
Wang Jian
Francesco G Salituro
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of ZA200707342B publication Critical patent/ZA200707342B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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ZA200707342A 2005-02-03 2006-02-02 Pyrrolopyrimidines useful as inhibitors of protein kinase ZA200707342B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64978105P 2005-02-03 2005-02-03

Publications (1)

Publication Number Publication Date
ZA200707342B true ZA200707342B (en) 2009-03-25

Family

ID=36498734

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200707342A ZA200707342B (en) 2005-02-03 2006-02-02 Pyrrolopyrimidines useful as inhibitors of protein kinase

Country Status (17)

Country Link
US (2) US8633205B2 (xx)
EP (1) EP1844050B1 (xx)
JP (2) JP5227032B2 (xx)
KR (1) KR20070104641A (xx)
CN (1) CN101142218B (xx)
AT (1) ATE420883T1 (xx)
AU (1) AU2006221065A1 (xx)
CA (1) CA2596830A1 (xx)
DE (1) DE602006004844D1 (xx)
ES (1) ES2320487T3 (xx)
HK (1) HK1116349A1 (xx)
IL (1) IL184898A0 (xx)
MX (1) MX2007009429A (xx)
NO (1) NO20074431L (xx)
RU (1) RU2434871C2 (xx)
WO (1) WO2006096270A1 (xx)
ZA (1) ZA200707342B (xx)

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US7915268B2 (en) 2006-10-04 2011-03-29 Wyeth Llc 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression
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US8247421B2 (en) 2006-12-21 2012-08-21 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
US8513270B2 (en) 2006-12-22 2013-08-20 Incyte Corporation Substituted heterocycles as Janus kinase inhibitors
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CL2008001709A1 (es) * 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
EA017952B1 (ru) 2008-02-06 2013-04-30 Новартис Аг ПИРРОЛО[2,3-d]ПИРИДИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ТИРОЗИНКИНАЗЫ
PT2288610T (pt) 2008-03-11 2016-10-17 Incyte Holdings Corp Derivados de azetidina e de ciclobutano como inibidores de jak
AU2009259867A1 (en) 2008-06-20 2009-12-23 Genentech, Inc. Triazolopyridine JAK inhibitor compounds and methods
CN102131389A (zh) * 2008-06-20 2011-07-20 健泰科生物技术公司 三唑并吡啶jak抑制剂化合物和方法
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WO2010148197A1 (en) 2009-06-17 2010-12-23 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
US9346809B2 (en) 2009-07-08 2016-05-24 Leo Pharma A/S Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors
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