RU2413728C2 - Способ получения r-(-)-сертаконазола мононитрата и полуацетонат r-(-)-сертаконазола мононитрата - Google Patents
Способ получения r-(-)-сертаконазола мононитрата и полуацетонат r-(-)-сертаконазола мононитрата Download PDFInfo
- Publication number
- RU2413728C2 RU2413728C2 RU2007113921/04A RU2007113921A RU2413728C2 RU 2413728 C2 RU2413728 C2 RU 2413728C2 RU 2007113921/04 A RU2007113921/04 A RU 2007113921/04A RU 2007113921 A RU2007113921 A RU 2007113921A RU 2413728 C2 RU2413728 C2 RU 2413728C2
- Authority
- RU
- Russia
- Prior art keywords
- group
- sertaconazole mononitrate
- sertaconazole
- water
- mononitrate
- Prior art date
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 16
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- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims abstract description 6
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- 229910017604 nitric acid Inorganic materials 0.000 claims abstract description 6
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- VBQDSLGFSUGBBE-UHFFFAOYSA-N benzyl(triethyl)azanium Chemical compound CC[N+](CC)(CC)CC1=CC=CC=C1 VBQDSLGFSUGBBE-UHFFFAOYSA-N 0.000 claims description 2
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
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- QIIPQYDSKRYMFG-UHFFFAOYSA-N phenyl hydrogen carbonate Chemical group OC(=O)OC1=CC=CC=C1 QIIPQYDSKRYMFG-UHFFFAOYSA-N 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 239000011574 phosphorus Chemical group 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
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- 229910052717 sulfur Inorganic materials 0.000 claims description 2
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- ADBMSVFHVFJBFR-UHFFFAOYSA-N triethyl(hexadecyl)azanium Chemical compound CCCCCCCCCCCCCCCC[N+](CC)(CC)CC ADBMSVFHVFJBFR-UHFFFAOYSA-N 0.000 claims description 2
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- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
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- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200402184 | 2004-09-13 | ||
| ES200402184A ES2249992B1 (es) | 2004-09-13 | 2004-09-13 | Un procedimiento para fabricar compuestos enantiomericos del imidazol. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007113921A RU2007113921A (ru) | 2008-10-20 |
| RU2413728C2 true RU2413728C2 (ru) | 2011-03-10 |
Family
ID=35614444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007113921/04A RU2413728C2 (ru) | 2004-09-13 | 2005-09-13 | Способ получения r-(-)-сертаконазола мононитрата и полуацетонат r-(-)-сертаконазола мононитрата |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7626038B2 (enExample) |
| EP (1) | EP1794152B1 (enExample) |
| JP (1) | JP5048500B2 (enExample) |
| KR (1) | KR100903922B1 (enExample) |
| CN (1) | CN101023077B (enExample) |
| AR (1) | AR050931A1 (enExample) |
| AT (1) | ATE402171T1 (enExample) |
| AU (1) | AU2005284330B2 (enExample) |
| BR (1) | BRPI0515259A (enExample) |
| CA (1) | CA2577247C (enExample) |
| DE (1) | DE602005008454D1 (enExample) |
| DK (1) | DK1794152T3 (enExample) |
| ES (1) | ES2249992B1 (enExample) |
| MX (1) | MX2007002939A (enExample) |
| NO (1) | NO20071817L (enExample) |
| PA (1) | PA8645501A1 (enExample) |
| PE (1) | PE20060720A1 (enExample) |
| PL (1) | PL1794152T3 (enExample) |
| PT (1) | PT1794152E (enExample) |
| RU (1) | RU2413728C2 (enExample) |
| TW (1) | TWI405760B (enExample) |
| UY (1) | UY29115A1 (enExample) |
| WO (1) | WO2006029811A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8635593B2 (en) * | 2008-05-13 | 2014-01-21 | Hewlett-Packard Development Company, L.P. | Dynamic autocompletion tool |
| CN112595803A (zh) * | 2020-12-31 | 2021-04-02 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑乳膏的鉴别方法 |
| CN113480517B (zh) * | 2021-07-30 | 2022-09-09 | 海南海神同洲制药有限公司 | 3-溴甲基-7-氯苯并[b]噻吩的合成方法 |
| CN113501814A (zh) * | 2021-07-30 | 2021-10-15 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑的纯化方法 |
| CN113501815A (zh) * | 2021-07-30 | 2021-10-15 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑晶型的制备方法 |
| CN113816947A (zh) * | 2021-08-25 | 2021-12-21 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑的重结晶方法 |
| CN113735843B (zh) * | 2021-09-07 | 2023-05-26 | 海南海神同洲制药有限公司 | 一种低熔点硝酸舍他康唑的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1096361B (it) | 1978-05-18 | 1985-08-26 | Recordati Chem Pharm | Dibenzileteri sostituiti terapeuticamente attivi |
| JPS57169466A (en) * | 1981-04-14 | 1982-10-19 | Ota Seiyaku Kk | Preparation of imidazole derivative |
| US5135943A (en) * | 1984-02-02 | 1992-08-04 | Ferrer Internacional S.A. | 1H-imidazole derivative compounds and pharmaceutical compositions containing the same |
| ES8504779A1 (es) * | 1984-02-02 | 1985-05-01 | Ferrer Int | Procedimiento de obtencion de nuevos derivados de 1h-imidazol |
| CA1250586A (en) | 1984-02-02 | 1989-02-28 | Manuel Raga | 1h-imidazole derivatives and process for their production |
| KR100336642B1 (ko) * | 1995-01-04 | 2002-11-23 | 페레르 인터내쇼날 에스.에이. | 1-[2,4-디클로로-β-[7-클로로벤조[B]티엔-3-일)메톡시]페네틸]이미다졸모노나이트레이트의폴리모르프B및C의제조방법 |
| ATE375332T1 (de) * | 1998-12-24 | 2007-10-15 | Astellas Pharma Inc | Imidazol verbindungen und ihre medizinische verwendung |
| CN1191250C (zh) * | 2001-09-26 | 2005-03-02 | 河北省药物研究所 | 一种硝酸舍他康唑的合成方法 |
| ES2203316B1 (es) * | 2002-02-11 | 2005-03-01 | Ferrer Internacional, S.A. | R-(-)-1-(2-(7-cloro-benzo(b)tiofen-3-il-metoxi)-2-(2,4-dicloro-fenil)-etil)1h-imidazol. |
-
2004
- 2004-09-13 ES ES200402184A patent/ES2249992B1/es not_active Expired - Fee Related
-
2005
- 2005-09-09 PE PE2005001047A patent/PE20060720A1/es not_active Application Discontinuation
- 2005-09-12 PA PA20058645501A patent/PA8645501A1/es unknown
- 2005-09-12 AR ARP050103794A patent/AR050931A1/es not_active Application Discontinuation
- 2005-09-13 CN CN2005800306783A patent/CN101023077B/zh not_active Expired - Fee Related
- 2005-09-13 MX MX2007002939A patent/MX2007002939A/es active IP Right Grant
- 2005-09-13 DE DE602005008454T patent/DE602005008454D1/de not_active Expired - Lifetime
- 2005-09-13 PT PT05799300T patent/PT1794152E/pt unknown
- 2005-09-13 KR KR1020077005699A patent/KR100903922B1/ko not_active Expired - Fee Related
- 2005-09-13 RU RU2007113921/04A patent/RU2413728C2/ru not_active IP Right Cessation
- 2005-09-13 EP EP05799300A patent/EP1794152B1/en not_active Expired - Lifetime
- 2005-09-13 PL PL05799300T patent/PL1794152T3/pl unknown
- 2005-09-13 TW TW094131395A patent/TWI405760B/zh not_active IP Right Cessation
- 2005-09-13 AT AT05799300T patent/ATE402171T1/de active
- 2005-09-13 WO PCT/EP2005/009824 patent/WO2006029811A1/en not_active Ceased
- 2005-09-13 CA CA2577247A patent/CA2577247C/en not_active Expired - Fee Related
- 2005-09-13 BR BRPI0515259-3A patent/BRPI0515259A/pt active Search and Examination
- 2005-09-13 DK DK05799300T patent/DK1794152T3/da active
- 2005-09-13 UY UY29115A patent/UY29115A1/es unknown
- 2005-09-13 US US11/662,255 patent/US7626038B2/en not_active Expired - Fee Related
- 2005-09-13 AU AU2005284330A patent/AU2005284330B2/en not_active Ceased
- 2005-09-13 JP JP2007530669A patent/JP5048500B2/ja not_active Expired - Fee Related
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2007
- 2007-04-04 NO NO20071817A patent/NO20071817L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007002939A (es) | 2007-04-27 |
| US20080108682A1 (en) | 2008-05-08 |
| AR050931A1 (es) | 2006-12-06 |
| PA8645501A1 (es) | 2006-05-16 |
| EP1794152A1 (en) | 2007-06-13 |
| KR100903922B1 (ko) | 2009-06-19 |
| UY29115A1 (es) | 2005-11-30 |
| RU2007113921A (ru) | 2008-10-20 |
| CN101023077B (zh) | 2012-05-23 |
| JP2008512421A (ja) | 2008-04-24 |
| TW200621756A (en) | 2006-07-01 |
| ATE402171T1 (de) | 2008-08-15 |
| ES2249992B1 (es) | 2007-03-01 |
| JP5048500B2 (ja) | 2012-10-17 |
| US7626038B2 (en) | 2009-12-01 |
| PL1794152T3 (pl) | 2008-12-31 |
| CN101023077A (zh) | 2007-08-22 |
| DE602005008454D1 (de) | 2008-09-04 |
| CA2577247A1 (en) | 2006-03-23 |
| EP1794152B1 (en) | 2008-07-23 |
| HK1105416A1 (en) | 2008-02-15 |
| NO20071817L (no) | 2007-05-16 |
| KR20070042206A (ko) | 2007-04-20 |
| PT1794152E (pt) | 2008-10-24 |
| WO2006029811A1 (en) | 2006-03-23 |
| PE20060720A1 (es) | 2006-07-11 |
| AU2005284330A1 (en) | 2006-03-23 |
| TWI405760B (zh) | 2013-08-21 |
| CA2577247C (en) | 2011-07-05 |
| ES2249992A1 (es) | 2006-04-01 |
| BRPI0515259A (pt) | 2008-07-15 |
| AU2005284330B2 (en) | 2011-01-06 |
| DK1794152T3 (da) | 2008-11-17 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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