RU2384331C2 - Способ лечения аномального роста клеток - Google Patents

Способ лечения аномального роста клеток Download PDF

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Publication number
RU2384331C2
RU2384331C2 RU2008122471/14A RU2008122471A RU2384331C2 RU 2384331 C2 RU2384331 C2 RU 2384331C2 RU 2008122471/14 A RU2008122471/14 A RU 2008122471/14A RU 2008122471 A RU2008122471 A RU 2008122471A RU 2384331 C2 RU2384331 C2 RU 2384331C2
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cancer
hgfr
met
carcinoma
cells
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RU2008122471/14A
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English (en)
Russian (ru)
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RU2008122471A (ru
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Джеймс Гейл КРИСТЕНСЕН (US)
Джеймс Гейл КРИСТЕНСЕН
Яхун ЦЗОУ (US)
Яхун ЦЗОУ
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Пфайзер Продактс Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2008122471/14A 2005-12-05 2006-11-23 Способ лечения аномального роста клеток RU2384331C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74276605P 2005-12-05 2005-12-05
US60/742,766 2005-12-05
US86463706P 2006-11-07 2006-11-07
US60/864,637 2006-11-07

Publications (2)

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RU2008122471A RU2008122471A (ru) 2009-12-10
RU2384331C2 true RU2384331C2 (ru) 2010-03-20

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US (1) US7825137B2 (enExample)
EP (1) EP1959955B1 (enExample)
JP (1) JP4619346B2 (enExample)
KR (1) KR101026676B1 (enExample)
AR (1) AR056832A1 (enExample)
AT (1) ATE488237T1 (enExample)
AU (1) AU2006323027B2 (enExample)
BR (1) BRPI0619424B1 (enExample)
CA (1) CA2632286C (enExample)
CY (1) CY1110931T1 (enExample)
DE (1) DE602006018354D1 (enExample)
DK (1) DK1959955T3 (enExample)
IL (1) IL191471A (enExample)
NZ (1) NZ568654A (enExample)
PL (1) PL1959955T3 (enExample)
PT (1) PT1959955E (enExample)
RU (1) RU2384331C2 (enExample)
SI (1) SI1959955T1 (enExample)
TW (1) TWI321050B (enExample)
WO (1) WO2007066187A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014104924A1 (ru) * 2012-12-28 2014-07-03 Lobko Vladimir Pavlovich Противоопухолевое средство (варианты)
RU2675850C2 (ru) * 2012-11-06 2018-12-25 Шанхай Фокон Фармасьютикал Ко Лтд Ингибиторы alk-киназы
RU2788606C2 (ru) * 2018-03-22 2023-01-23 Вертикаль Био АГ Комбинация антитела против hgfr и hegfr для лечения опухоли и/или метастаза
US11814433B2 (en) 2018-03-22 2023-11-14 Vertical Bio Ag Combination of anti-HGFR antibody and HEGFR for the treatment of a tumor and/or metastasis

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101023064B (zh) 2004-08-26 2011-02-16 辉瑞大药厂 作为蛋白激酶抑制剂的对映异构体纯的氨基杂芳基化合物
DK1889836T3 (da) * 2005-08-24 2013-08-19 Eisai R&D Man Co Ltd Hidtil ukendt pyridinderivat og pyrimidinderivat
EP1963302B1 (en) * 2005-12-05 2013-02-27 Pfizer Products Inc. Polymorphs of a c-met/hgfr inhibitor
US20120208824A1 (en) 2006-01-20 2012-08-16 Cell Signaling Technology, Inc. ROS Kinase in Lung Cancer
US8168383B2 (en) 2006-04-14 2012-05-01 Cell Signaling Technology, Inc. Gene defects and mutant ALK kinase in human solid tumors
PL2450437T3 (pl) 2006-04-14 2017-12-29 Cell Signaling Technology Inc Defekty genu i zmutowana kinaza ALK w ludzkich guzach litych
CA2661333C (en) * 2006-08-23 2014-08-05 Eisai R&D Management Co., Ltd. Salt of phenoxypyridine derivative or crystal thereof and process for producing the same
US7790885B2 (en) 2006-08-31 2010-09-07 Eisai R&D Management Co., Ltd. Process for preparing phenoxypyridine derivatives
JP2009132660A (ja) * 2007-11-30 2009-06-18 Eisai R & D Management Co Ltd 食道癌治療用組成物
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
US20090227556A1 (en) * 2008-01-31 2009-09-10 Eisai R&D Management Co., Ltd. Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives
US20110206691A1 (en) * 2008-02-15 2011-08-25 Mosse Yael P Methods and Compositions for Treating Neuroblastoma
WO2009103061A2 (en) * 2008-02-15 2009-08-20 The Children's Hospital Of Philadelphia Methods and compositions for identifying, diagnosing, and treating neuroblastoma
JPWO2009104520A1 (ja) * 2008-02-18 2011-06-23 エーザイ・アール・アンド・ディー・マネジメント株式会社 フェノキシピリジン誘導体の製造方法(2)
EP2143441A1 (en) * 2008-07-08 2010-01-13 Pierre Fabre Medicament Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer
CN101653607B (zh) * 2008-08-19 2013-02-13 鼎泓国际投资(香港)有限公司 含有肝细胞生长因子受体抑制剂和丝裂原细胞外激酶抑制剂的药物组合物及其用途
WO2010064300A1 (ja) * 2008-12-02 2010-06-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 食道癌治療用組成物
DE102009003954A1 (de) 2009-01-07 2010-07-08 Merck Patent Gmbh Pyridazinonderivate
DE102009004061A1 (de) 2009-01-08 2010-07-15 Merck Patent Gmbh Pyridazinonderivate
JP5675850B2 (ja) 2010-02-05 2015-02-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung ヘタリール−[1,8]ナフチリジン誘導体
US8378104B2 (en) * 2010-02-11 2013-02-19 OSI Pharmaceuticals, LLC 7-aminofuropyridine derivatives
WO2011138751A2 (en) 2010-05-04 2011-11-10 Pfizer Inc. Heterocyclic derivatives as alk inhibitors
EP2586443B1 (en) 2010-06-25 2016-03-16 Eisai R&D Management Co., Ltd. Antitumor agent using compounds having kinase inhibitory effect in combination
KR20130131293A (ko) 2010-07-05 2013-12-03 메르크 파텐트 게엠베하 키나아제 - 유도된 질환의 치료에 유용한 바이피리딜 유도체
US20120101108A1 (en) 2010-08-06 2012-04-26 Cell Signaling Technology, Inc. Anaplastic Lymphoma Kinase In Kidney Cancer
US9145390B2 (en) 2011-03-03 2015-09-29 Concert Pharmaceuticals, Inc. Derivatives of pyrazole-substituted amino-heteroaryl compounds
WO2012119006A2 (en) * 2011-03-03 2012-09-07 Concert Pharmaceuticals, Inc. Derivatives of pyrazole-substituted amino-heteroaryl compounds
US9051318B2 (en) 2011-03-09 2015-06-09 Merck Patent Gmbh Pyrido [2, 3-B] pyrazine compounds and their therapeutical uses such as for inhibiting ATP consuming proteins and treating diseases associated therewith
WO2013041038A1 (en) * 2011-09-21 2013-03-28 Teligene Ltd. Pyridine compounds as inhibitors of kinase
CA2863515C (en) 2012-01-31 2018-02-27 Daiichi Sankyo Company, Limited Pyridone derivatives
KR101692600B1 (ko) 2012-03-06 2017-01-03 화이자 인코포레이티드 증식성 질환 치료용 거대환형 유도체
WO2013148537A1 (en) * 2012-03-29 2013-10-03 Ning Xi Substituted spirobicyclic compounds and methods of use
US20150056193A1 (en) 2012-04-18 2015-02-26 Cell Signaling Technology, Inc. Egfr and ros1 kinase in cancer
CN103509008A (zh) * 2012-06-22 2014-01-15 康瑟特制药公司 吡唑取代的氨基-杂芳基化合物的衍生物
WO2014020467A2 (en) 2012-07-30 2014-02-06 Fresenius Kabi Oncology Ltd Process for the preparation of pyrazole substituted aminoheteroaryl compounds
WO2014046730A1 (en) 2012-09-24 2014-03-27 Ventana Medical Systems, Inc. Method of identifying treatment responsive non-small cell lung cancer using anaplastic lymphoma kinase (alk) as a marker
AU2013364953A1 (en) 2012-12-21 2015-04-30 Eisai R&D Management Co., Ltd. Amorphous form of quinoline derivative, and method for producing same
WO2014115169A2 (en) * 2013-01-24 2014-07-31 Hetero Research Foundation Crizotinib solid dispersion
KR20150118159A (ko) 2013-02-22 2015-10-21 에프. 호프만-라 로슈 아게 암의 치료 방법 및 약물 내성의 예방 방법
WO2014140159A1 (en) * 2013-03-13 2014-09-18 Ratiopharm Gmbh Dosage form comprising crizotinib
CA2912219C (en) 2013-05-14 2021-11-16 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
JP6291179B2 (ja) * 2013-07-26 2018-03-14 関東化學株式会社 光学活性2級アルコールの製造方法
US20160214961A1 (en) * 2013-09-10 2016-07-28 Shilpa Medicare Limited Novel salts of crizotinib and their preparation
RU2550346C2 (ru) 2013-09-26 2015-05-10 Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
EP3066118B1 (en) 2013-11-06 2020-01-08 The U.S.A. as represented by the Secretary, Department of Health and Human Services Alk antibodies, conjugates, and chimeric antigen receptors, and their use
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JP2017530950A (ja) 2014-08-25 2017-10-19 ファイザー・インコーポレイテッド 癌を処置するためのpd−1アンタゴニストおよびalk阻害剤の併用
EP4089076A1 (en) 2014-08-28 2022-11-16 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
KR102763349B1 (ko) 2015-02-25 2025-02-07 에자이 알앤드디 매니지먼트 가부시키가이샤 퀴놀린 유도체의 고미 억제 방법
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
RU2729936C2 (ru) 2015-06-16 2020-08-13 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противораковое средство
SG11201801083UA (en) 2015-08-20 2018-03-28 Eisai R&D Man Co Ltd Tumor therapeutic agent
JP2018529719A (ja) 2015-09-30 2018-10-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Alk陰性がんを処置するためのpd−1系結合アンタゴニストおよびalk阻害剤の組合せ
US12066428B2 (en) * 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
CN109890387B (zh) 2016-05-20 2022-06-14 拜尔哈文制药股份有限公司 谷氨酸调节剂与免疫疗法用以治疗癌症的用途
GB201616116D0 (en) * 2016-09-22 2016-11-09 Astrazeneca Ab Use of c-Met inhibitors to treat cancers harbouring MET mutations
KR102539920B1 (ko) 2017-02-08 2023-06-05 에자이 알앤드디 매니지먼트 가부시키가이샤 종양-치료용 약제학적 조성물
SG11201910100PA (en) 2017-05-16 2019-11-28 Eisai R&D Man Co Ltd Treatment of hepatocellular carcinoma
CN108047231B (zh) * 2018-01-02 2020-02-11 江苏医药职业学院 [1,2,4]三嗪并[6,1-a]异吲哚化合物的盐酸盐及其应用
EP4007585A4 (en) 2019-08-02 2023-11-08 OneHealthCompany, Inc. TREATMENT OF CANINE CANCERS

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2174977C2 (ru) * 1995-03-30 2001-10-20 Пфайзер Инк. Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция
US20050009840A1 (en) * 2003-02-26 2005-01-13 Sugen, Inc. Aminoheteroaryl compounds as protein kinase inhibitors
WO2005026129A1 (en) * 2003-09-15 2005-03-24 Gpc Biotech Ag Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
RU2260592C2 (ru) * 1999-04-15 2005-09-20 Бристол-Маерс Сквибб Ко. Циклические ингибиторы протеинтирозинкиназ
WO2005112918A1 (en) * 2004-05-05 2005-12-01 Celgene Corporation Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725601A (en) 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
GB9201693D0 (en) 1992-01-27 1992-03-11 Smithkline Beecham Intercredit Compounds
JPH07109260A (ja) 1993-10-12 1995-04-25 Fuji Photo Film Co Ltd 5−アミノ−2−ニトロピリジン誘導体及び2,5−ジアミノ−3−ヒドロキシピリジン誘導体の製造方法
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9801526D0 (sv) 1998-04-29 1998-04-29 Astra Ab New compounds
GB9908410D0 (en) 1999-04-13 1999-06-09 Pfizer Ltd Pyridines
JP2003523942A (ja) 1999-06-30 2003-08-12 メルク エンド カムパニー インコーポレーテッド Srcキナーゼ阻害剤化合物
BR0108363A (pt) 2000-02-16 2004-02-10 Neurogen Corp Composto, métodos para modular função de receptor de crf e acoplado a proteìna g, para tratar um distúrbio ou doença do snc, para localizar receptores de crf em amostras de seção de tecidos, para inibir a ligação de crf a um receptor de crf¹ e para alterar a atividade de transdução de sinal de um receptor de crf¹ e composição farmacêutica
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
US6825198B2 (en) 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
US6992087B2 (en) 2001-11-21 2006-01-31 Pfizer Inc Substituted aryl 1,4-pyrazine derivatives
CN101023064B (zh) 2004-08-26 2011-02-16 辉瑞大药厂 作为蛋白激酶抑制剂的对映异构体纯的氨基杂芳基化合物
ES2355923T3 (es) * 2004-08-26 2011-04-01 Pfizer, Inc. Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa.
WO2006021886A1 (en) 2004-08-26 2006-03-02 Pfizer Inc. Aminoheteroaryl compounds as protein tyrosine kinase inhibitors
EP1963302B1 (en) * 2005-12-05 2013-02-27 Pfizer Products Inc. Polymorphs of a c-met/hgfr inhibitor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2174977C2 (ru) * 1995-03-30 2001-10-20 Пфайзер Инк. Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция
RU2260592C2 (ru) * 1999-04-15 2005-09-20 Бристол-Маерс Сквибб Ко. Циклические ингибиторы протеинтирозинкиназ
US20050009840A1 (en) * 2003-02-26 2005-01-13 Sugen, Inc. Aminoheteroaryl compounds as protein kinase inhibitors
WO2005026129A1 (en) * 2003-09-15 2005-03-24 Gpc Biotech Ag Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
WO2005112918A1 (en) * 2004-05-05 2005-12-01 Celgene Corporation Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BACKLUND M et al. Regulation of aryl hydrocarbon receptor signal transduction by protein tyrosine kinases // Cell Signal. 2005 Jan; 17(1): 39-48 - реферат, он-лайн [Найдено в Интернет на www.pubmed.com 08.05.2009], PMID: 15451023 [PubMed - indexed for MEDLINE. MA PC et al. A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin // Clin Cancer Res. 2005 Mar 15;11(6):2312-9. реферат, он-лайн [Найдено в Интернет на www.pubmed.com 08.05.2009], PMID: 15788682 [PubMed - indexed for MEDLINE. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2675850C2 (ru) * 2012-11-06 2018-12-25 Шанхай Фокон Фармасьютикал Ко Лтд Ингибиторы alk-киназы
WO2014104924A1 (ru) * 2012-12-28 2014-07-03 Lobko Vladimir Pavlovich Противоопухолевое средство (варианты)
RU2788606C2 (ru) * 2018-03-22 2023-01-23 Вертикаль Био АГ Комбинация антитела против hgfr и hegfr для лечения опухоли и/или метастаза
US11814433B2 (en) 2018-03-22 2023-11-14 Vertical Bio Ag Combination of anti-HGFR antibody and HEGFR for the treatment of a tumor and/or metastasis

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Publication number Publication date
SI1959955T1 (sl) 2011-02-28
CA2632286C (en) 2011-11-15
NZ568654A (en) 2012-02-24
CY1110931T1 (el) 2015-06-10
US7825137B2 (en) 2010-11-02
CA2632286A1 (en) 2007-06-14
AR056832A1 (es) 2007-10-24
IL191471A (en) 2013-03-24
PL1959955T3 (pl) 2011-04-29
AU2006323027A1 (en) 2007-06-14
US20080300273A1 (en) 2008-12-04
AU2006323027B2 (en) 2012-08-02
TW200727899A (en) 2007-08-01
HK1126121A1 (en) 2009-08-28
ATE488237T1 (de) 2010-12-15
DE602006018354D1 (de) 2010-12-30
BRPI0619424B1 (pt) 2022-02-08
WO2007066187A2 (en) 2007-06-14
RU2008122471A (ru) 2009-12-10
KR20080072965A (ko) 2008-08-07
EP1959955A2 (en) 2008-08-27
WO2007066187A3 (en) 2008-01-17
DK1959955T3 (da) 2011-02-07
JP2007153894A (ja) 2007-06-21
IL191471A0 (en) 2009-08-03
KR101026676B1 (ko) 2011-04-04
BRPI0619424A2 (pt) 2011-10-04
JP4619346B2 (ja) 2011-01-26
PT1959955E (pt) 2011-01-04
EP1959955B1 (en) 2010-11-17
TWI321050B (en) 2010-03-01

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