RU2342373C2 - Ацетоновый сольват диметоксидоцетаксела и способ его получения - Google Patents

Ацетоновый сольват диметоксидоцетаксела и способ его получения Download PDF

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Publication number
RU2342373C2
RU2342373C2 RU2006113122/04A RU2006113122A RU2342373C2 RU 2342373 C2 RU2342373 C2 RU 2342373C2 RU 2006113122/04 A RU2006113122/04 A RU 2006113122/04A RU 2006113122 A RU2006113122 A RU 2006113122A RU 2342373 C2 RU2342373 C2 RU 2342373C2
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Russia
Prior art keywords
acetone
hydroxy
water
dimethoxy
benzoyloxy
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RU2006113122/04A
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English (en)
Russian (ru)
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RU2006113122A (ru
Inventor
Эрик ДИДЬЕ (FR)
Эрик Дидье
Марк-Антуан ПЕРРЭН (FR)
Марк-Антуан ПЕРРЭН
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Авентис Фарма С.А.
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Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2006113122/04A 2003-09-19 2004-09-16 Ацетоновый сольват диметоксидоцетаксела и способ его получения RU2342373C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0311016A FR2859996B1 (fr) 2003-09-19 2003-09-19 Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR0311016 2003-09-19

Publications (2)

Publication Number Publication Date
RU2006113122A RU2006113122A (ru) 2006-08-27
RU2342373C2 true RU2342373C2 (ru) 2008-12-27

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ID=34224354

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Application Number Title Priority Date Filing Date
RU2006113122/04A RU2342373C2 (ru) 2003-09-19 2004-09-16 Ацетоновый сольват диметоксидоцетаксела и способ его получения

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2672110C2 (ru) * 2013-10-23 2018-11-12 Индена С.П.А. Безводная кристаллическая форма кабазитаксела, способ ее получения и фармацевтические композиции

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TWI526437B (zh) * 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
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ES2716799T3 (es) * 2011-11-28 2019-06-17 Fresenius Kabi Oncology Ltd Forma cristalina de cabazitaxel y proceso para la preparación de la misma
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CN102675257B (zh) * 2012-05-10 2014-07-02 上海金和生物技术有限公司 一种卡巴他赛晶体及其制备方法
CN102746258B (zh) 2012-07-25 2015-02-04 重庆泰濠制药有限公司 卡巴他赛的结晶形式及其制备方法
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EP2884963B1 (en) 2012-08-15 2017-12-27 Yung Shin Pharm. Ind. Co. Ltd. Stable pharmaceutical formulation of cabazitaxel
CN103664836B (zh) * 2012-09-20 2016-04-20 齐鲁制药有限公司 7β,10β-二甲氧基多西紫杉醇氘代丙酮合物的晶型A及其制备方法
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CN103804323A (zh) * 2012-11-14 2014-05-21 上海希迈医药科技有限公司 一种卡巴他赛溶剂化物及其制备方法和应用
CN103058960B (zh) * 2012-12-12 2014-12-10 江苏奥赛康药业股份有限公司 卡巴他赛多晶型形式及其制备方法
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CN103910696B (zh) * 2012-12-30 2016-01-20 上海医药工业研究院 卡巴他赛异丙醚合物及其结晶
CN103910698B (zh) * 2012-12-30 2016-01-20 上海医药工业研究院 卡巴他赛丙酮合物及其结晶
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WO2015000165A1 (zh) * 2013-07-04 2015-01-08 北京新天宇科技开发有限公司 二甲氧基多西紫杉醇一丙酮化物的稳定转化物及其结晶形式、以及它们的制备方法
CN104277014A (zh) * 2013-07-04 2015-01-14 北京新天宇科技开发有限公司 二甲氧基多西紫杉醇一丙酮化物的稳定转化物及其结晶形式、以及它们的制备方法
EP2865674A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
CN103601704B (zh) * 2013-11-22 2015-05-06 石家庄智恒医药科技有限公司 无定形卡巴他赛的制备
WO2016113752A2 (en) 2015-01-12 2016-07-21 Emcure Pharmaceuticals Limited Liquid formulation of cabazitaxel
JP6841772B2 (ja) * 2015-02-17 2021-03-10 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム 前立腺癌の処置におけるカバジタキセルの使用
EP3093014A1 (en) 2015-05-13 2016-11-16 Aventis Pharma S.A. Cabazitaxel and its use for treating cancer
US10188626B2 (en) 2015-11-03 2019-01-29 Cipla Limited Stabilized cabazitaxel formulations
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CN110312721A (zh) 2016-11-29 2019-10-08 显莎制药公司 墨蝶呤的多晶型物
EP3675863A4 (en) 2017-09-01 2021-01-27 PTC Therapeutics MP, Inc. PHARMACEUTICAL COMPOSITIONS WITH SEPIAPTERIN AND USES THEREOF
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WO1997032869A1 (fr) * 1996-03-06 1997-09-12 Rhone-Poulenc Rorer S.A. Taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
RU97101875A (ru) * 1994-07-08 1999-02-27 Рон-Пуленк Роре С.А. СПОСОБ ПОЛУЧЕНИЯ ТРИГИДРАТА (2R,3S)-3-ТРЕТ-БУТОКСИКАРБОНИЛАМИНО-2-ГИДРОКСИ-3- ФЕНИЛПРОПИОНАТА 4-АЦЕТОКСИ-2α-БЕНЗОИЛОКСИ-5β,,20-ЭПОКСИ- 1,7β,,10β-ТРИГИДРОКСИ-9-ОКСО-ТАКС-11-ЕН-13α-ИЛА

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WO1996003355A1 (de) * 1994-07-22 1996-02-08 Forschungszentrum Karlsruhe Gmbh Verfahren zur herstellung keramischer mikrostrukturen
WO1997032869A1 (fr) * 1996-03-06 1997-09-12 Rhone-Poulenc Rorer S.A. Taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2672110C2 (ru) * 2013-10-23 2018-11-12 Индена С.П.А. Безводная кристаллическая форма кабазитаксела, способ ее получения и фармацевтические композиции

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KR20060072147A (ko) 2006-06-27
PT1667986E (pt) 2013-04-24
IL174240A0 (en) 2006-08-01
CY1114575T1 (el) 2016-10-05
MA28045A1 (fr) 2006-07-03
CA2539309A1 (fr) 2005-03-31
AU2004274212A1 (en) 2005-03-31
CR8292A (es) 2008-10-15
MXPA06002639A (es) 2006-06-05
RS20060189A (sr) 2008-06-05
NO2015013I1 (no) 2015-05-04
RU2006113122A (ru) 2006-08-27
ES2403149T3 (es) 2013-05-14
PA8612401A1 (es) 2005-08-04
HK1093340A1 (zh) 2007-03-02
LU92172I2 (fr) 2013-05-21
NZ545835A (en) 2009-10-30
ME00054B (me) 2011-02-10
MY136668A (en) 2008-11-28
US20050065138A1 (en) 2005-03-24
CN1849311A (zh) 2006-10-18
AR045667A1 (es) 2005-11-02
DK1667986T3 (da) 2013-05-06
JP5010279B2 (ja) 2012-08-29
NO20061714L (no) 2006-04-19
CY2013016I1 (el) 2018-01-10
AU2004274212B2 (en) 2010-03-04
BRPI0414492A8 (pt) 2019-01-15
BE2013C036I2 (enExample) 2023-12-14
PE20050870A1 (es) 2005-11-21
RS54614B1 (sr) 2016-08-31
TNSN06086A1 (en) 2007-10-03
MEP11708A (en) 2010-06-10
JP2007505866A (ja) 2007-03-15
EP1667986B1 (fr) 2013-01-16
PL1667986T3 (pl) 2013-06-28
FR2859996B1 (fr) 2006-02-03
BRPI0414492A (pt) 2006-11-14
CY2013016I2 (el) 2018-01-10
HUS1300025I1 (hu) 2016-08-29
HRP20130322T1 (en) 2013-07-31
SI1667986T1 (sl) 2013-05-31
NO2015013I2 (no) 2015-04-22
FR13C0037I2 (fr) 2015-11-20
TWI382022B (zh) 2013-01-11
TW200524891A (en) 2005-08-01
ES2403149T4 (es) 2013-06-24
FR13C0037I1 (fr) 2013-09-08
EP1667986A1 (fr) 2006-06-14
ZA200602255B (en) 2007-07-25
KR101123588B1 (ko) 2012-03-22
UA87115C2 (ru) 2009-06-25
WO2005028462A1 (fr) 2005-03-31
US7241907B2 (en) 2007-07-10
NO335997B1 (no) 2015-04-20
LU92172I9 (enExample) 2019-01-03
CN100429207C (zh) 2008-10-29
IL174240A (en) 2010-12-30
FR2859996A1 (fr) 2005-03-25

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