RU2322444C2 - Соединения оксазолидинона, обладающие антибактериальной активностью, способ получения (варианты) и фармацевтическая композиция на их основе - Google Patents

Соединения оксазолидинона, обладающие антибактериальной активностью, способ получения (варианты) и фармацевтическая композиция на их основе Download PDF

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Publication number
RU2322444C2
RU2322444C2 RU2003123104/04A RU2003123104A RU2322444C2 RU 2322444 C2 RU2322444 C2 RU 2322444C2 RU 2003123104/04 A RU2003123104/04 A RU 2003123104/04A RU 2003123104 A RU2003123104 A RU 2003123104A RU 2322444 C2 RU2322444 C2 RU 2322444C2
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RU
Russia
Prior art keywords
oxazolan
oxo
phenyl
salts
ylmethyl
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RU2003123104/04A
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English (en)
Russian (ru)
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RU2003123104A (ru
Inventor
Сельвакумар НАТЕСАН (IN)
Сельвакумар НАТЕСАН
Джагаттаран ДАС (IN)
Джагаттаран Дас
Джавед ИКБАЛ (IN)
Джавед Икбал
Ситарам Кумар МАГАДИ (IN)
Ситарам Кумар Магади
Нага Венката Сриниваса Рао МАМИДИ (IN)
Нага Венката Сриниваса Рао МАМИДИ
Раджагопалан РАМАНУДЖАМ (IN)
Раджагопалан Рамануджам
Баскаран СУНДАРАБАБУ (IN)
Баскаран СУНДАРАБАБУ
Брадж Бхушан ЛОХРЭЙ (IN)
Брадж Бхушан ЛОХРЭЙ
Original Assignee
Др. Редди`З Лабораториз Лтд.
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Publication of RU2003123104A publication Critical patent/RU2003123104A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2003123104/04A 2000-12-26 2001-12-26 Соединения оксазолидинона, обладающие антибактериальной активностью, способ получения (варианты) и фармацевтическая композиция на их основе RU2322444C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1124MA2000 2000-12-26
IN1124/MAS/2000 2000-12-26
IN15/MAS/2001 2001-01-04
IN15MA2001 2001-01-15

Publications (2)

Publication Number Publication Date
RU2003123104A RU2003123104A (ru) 2005-03-10
RU2322444C2 true RU2322444C2 (ru) 2008-04-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003123104/04A RU2322444C2 (ru) 2000-12-26 2001-12-26 Соединения оксазолидинона, обладающие антибактериальной активностью, способ получения (варианты) и фармацевтическая композиция на их основе

Country Status (21)

Country Link
US (2) US7030148B2 (enExample)
EP (1) EP1345913A2 (enExample)
JP (1) JP2004525876A (enExample)
KR (1) KR20030063472A (enExample)
CN (1) CN1656083A (enExample)
BG (1) BG108022A (enExample)
BR (1) BR0116571A (enExample)
CA (1) CA2433138A1 (enExample)
CZ (1) CZ20031799A3 (enExample)
EE (1) EE200300254A (enExample)
HR (1) HRP20030522A2 (enExample)
HU (1) HUP0302580A2 (enExample)
IL (1) IL156662A0 (enExample)
MX (1) MXPA03005822A (enExample)
NO (1) NO20032926L (enExample)
NZ (1) NZ526716A (enExample)
PL (1) PL363616A1 (enExample)
RU (1) RU2322444C2 (enExample)
SK (1) SK8202003A3 (enExample)
WO (1) WO2002051819A2 (enExample)
YU (1) YU52403A (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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US9163043B2 (en) 2003-12-18 2015-10-20 Dong-A St Co., Ltd. Oxazolidinone derivatives
US9624250B2 (en) 2009-02-03 2017-04-18 Merck Sharp & Dohme Corp. Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate

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GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
SI1427711T1 (sl) 2001-09-11 2005-12-31 Astrazeneca Ab Oksazolidinonski in/ali izoksazolinski derivati kot antibakterijska sredstva
US20060293315A1 (en) * 2001-12-21 2006-12-28 Dr. Reddy's Laboratories Ltd. Intermediates of novel heterocyclic compounds having antibacterial activity and process for their preparation
US6914058B2 (en) * 2002-01-18 2005-07-05 Dr. Reddy's Laboratories, Limited Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
DE10233817A1 (de) * 2002-07-25 2004-02-12 Aventis Pharma Deutschland Gmbh Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7141561B2 (en) 2002-07-25 2006-11-28 Sanofi-Aventis Deutschland Gmbh Substituted diaryl heterocycles, process for their preparation and their use as medicaments
AU2003215861A1 (en) * 2003-04-07 2004-11-01 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
ATE471937T1 (de) 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
US20070185132A1 (en) * 2003-07-02 2007-08-09 Yasumichi Fukuda Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo
WO2005035528A2 (en) * 2003-10-14 2005-04-21 Dr. Reddy's Laboratories Ltd. Triazole derivatives as antibacterial agents
WO2006091731A2 (en) * 2005-02-24 2006-08-31 Teva Pharmaceutical Industries Ltd. Processes for the preparation of linezolid intermediate
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
JP5455906B2 (ja) * 2007-08-06 2014-03-26 ミクウルク ファーマシューティカルズ，インコーポレイテッド 細菌感染症治療のための抗微生物性オルト−フルオロフェニルオキサゾリジノン
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
US20120040974A1 (en) * 2008-08-18 2012-02-16 Yale University Mif modulators
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
CN101798302B (zh) * 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
WO2014045292A1 (en) * 2012-09-20 2014-03-27 Symed Labs Limited Improved process for the preparation of linezolid intermediate
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US9382276B2 (en) 2014-02-21 2016-07-05 Micurx Pharmaceuticals, Inc. Water-soluble O-carbonyl phosphoramidate prodrugs for therapeutic administration
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
GB2550437B (en) * 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
WO2020021468A1 (en) 2018-07-25 2020-01-30 Cadila Healthcare Limited Substituted oxazolidinones for the treatment of mammalian infections
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections
CN110301433A (zh) * 2019-07-25 2019-10-08 河南精怡达生物科技有限公司 一种含有微量元素组合的猪精液体外常温保存剂

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WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1996013502A1 (en) * 1994-10-26 1996-05-09 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
WO1997027188A1 (en) * 1996-01-27 1997-07-31 Zeneca Limited Piperazinonephenyloxazolidinone derivatives and their use as antibacterial agents
RU2105003C1 (ru) * 1992-05-08 1998-02-20 Дзе Апджон Компани Производное оксазолидинона или его фармацевтически приемлемая соль, способ лечения микробных инфекций у теплокровных животных

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US6124334A (en) 1995-02-03 2000-09-26 Pharmacia & Upjohn Company Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
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RU2105003C1 (ru) * 1992-05-08 1998-02-20 Дзе Апджон Компани Производное оксазолидинона или его фармацевтически приемлемая соль, способ лечения микробных инфекций у теплокровных животных
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1996013502A1 (en) * 1994-10-26 1996-05-09 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
WO1997027188A1 (en) * 1996-01-27 1997-07-31 Zeneca Limited Piperazinonephenyloxazolidinone derivatives and their use as antibacterial agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9163043B2 (en) 2003-12-18 2015-10-20 Dong-A St Co., Ltd. Oxazolidinone derivatives
US9624250B2 (en) 2009-02-03 2017-04-18 Merck Sharp & Dohme Corp. Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US9988406B2 (en) 2009-02-03 2018-06-05 Merck Sharp & Dohme Corp. Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US10065947B1 (en) 2009-02-03 2018-09-04 Merck Sharp & Dohme Corp. Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US10442829B2 (en) 2009-02-03 2019-10-15 Merck Sharp & Dohme Corp. Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate

Also Published As

Publication number Publication date
NO20032926L (no) 2003-08-25
MXPA03005822A (es) 2004-05-04
EP1345913A2 (en) 2003-09-24
IL156662A0 (en) 2004-01-04
SK8202003A3 (en) 2004-07-07
US20030065175A1 (en) 2003-04-03
WO2002051819A3 (en) 2002-12-05
PL363616A1 (en) 2004-11-29
KR20030063472A (ko) 2003-07-28
RU2003123104A (ru) 2005-03-10
HUP0302580A2 (hu) 2003-11-28
CA2433138A1 (en) 2002-07-04
YU52403A (sh) 2006-03-03
HRP20030522A2 (en) 2005-06-30
WO2002051819A9 (en) 2003-08-07
BG108022A (bg) 2004-09-30
US7030148B2 (en) 2006-04-18
NO20032926D0 (no) 2003-06-25
US20040059120A1 (en) 2004-03-25
WO2002051819A2 (en) 2002-07-04
US7183301B2 (en) 2007-02-27
EE200300254A (et) 2003-12-15
CZ20031799A3 (cs) 2004-02-18
JP2004525876A (ja) 2004-08-26
CN1656083A (zh) 2005-08-17
BR0116571A (pt) 2004-03-02
NZ526716A (en) 2005-08-26

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Effective date: 20081227