JP2006506455A5 - - Google Patents
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- Publication number
- JP2006506455A5 JP2006506455A5 JP2005501534A JP2005501534A JP2006506455A5 JP 2006506455 A5 JP2006506455 A5 JP 2006506455A5 JP 2005501534 A JP2005501534 A JP 2005501534A JP 2005501534 A JP2005501534 A JP 2005501534A JP 2006506455 A5 JP2006506455 A5 JP 2006506455A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- tert
- butylbenzoyl
- pyrrolidine
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 57
- 125000003118 aryl group Chemical group 0.000 claims 48
- 229910052739 hydrogen Inorganic materials 0.000 claims 42
- 125000001072 heteroaryl group Chemical group 0.000 claims 33
- -1 3-methoxy-4-tert-butylbenzoyl Chemical group 0.000 claims 28
- 125000000623 heterocyclic group Chemical group 0.000 claims 28
- 239000001257 hydrogen Substances 0.000 claims 26
- 150000002431 hydrogen Chemical class 0.000 claims 24
- 125000003710 aryl alkyl group Chemical group 0.000 claims 21
- 125000004122 cyclic group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 18
- 125000004093 cyano group Chemical group *C#N 0.000 claims 17
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 17
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 16
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 16
- 125000004043 oxo group Chemical group O=* 0.000 claims 12
- 229920006395 saturated elastomer Polymers 0.000 claims 10
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 9
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 208000036142 Viral infection Diseases 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 4
- 125000005841 biaryl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000013160 medical therapy Methods 0.000 claims 2
- CNJOQLFWCMXPPG-CDPAUJCKSA-N (2s,4r,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-4-(1-hydroxyethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1=C(C(C)(C)C)C(OC)=CC(C(=O)N2[C@](C[C@H]([C@@H]2C=2SC=CN=2)C(C)O)(CC(C)C)C(O)=O)=C1 CNJOQLFWCMXPPG-CDPAUJCKSA-N 0.000 claims 1
- GNSKKEXPOIMGRA-ZOIIRCJOSA-N (2s,4r,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-4-(2-hydroxypropan-2-yl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1=C(C(C)(C)C)C(OC)=CC(C(=O)N2[C@](C[C@H]([C@@H]2C=2SC=CN=2)C(C)(C)O)(CC(C)C)C(O)=O)=C1 GNSKKEXPOIMGRA-ZOIIRCJOSA-N 0.000 claims 1
- PFZUXBHTBAMAOS-OFUUFJSKSA-N (2s,4s,5r)-1-(3-bromo-4-tert-butylbenzoyl)-4-(ethoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1([C@@H]2N([C@@](CC(C)C)(C[C@@H]2COCC)C(O)=O)C(=O)C=2C=C(Br)C(=CC=2)C(C)(C)C)=NC=CS1 PFZUXBHTBAMAOS-OFUUFJSKSA-N 0.000 claims 1
- BBDXRCVFTQOLNZ-OFUUFJSKSA-N (2s,4s,5r)-1-(4-tert-butyl-3-chlorobenzoyl)-4-(ethoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1([C@@H]2N([C@@](CC(C)C)(C[C@@H]2COCC)C(O)=O)C(=O)C=2C=C(Cl)C(=CC=2)C(C)(C)C)=NC=CS1 BBDXRCVFTQOLNZ-OFUUFJSKSA-N 0.000 claims 1
- FECFCUYXLBBKBO-XCIGCYOISA-N (2s,4s,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-2-(2-methylpropyl)-4-(prop-2-enoxymethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1=C(C(C)(C)C)C(OC)=CC(C(=O)N2[C@](C[C@H](COCC=C)[C@@H]2C=2SC=CN=2)(CC(C)C)C(O)=O)=C1 FECFCUYXLBBKBO-XCIGCYOISA-N 0.000 claims 1
- DHGFOQPHLMIWIF-XCIGCYOISA-N (2s,4s,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-2-(2-methylpropyl)-4-(propoxymethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1([C@@H]2N([C@@](CC(C)C)(C[C@@H]2COCCC)C(O)=O)C(=O)C=2C=C(OC)C(=CC=2)C(C)(C)C)=NC=CS1 DHGFOQPHLMIWIF-XCIGCYOISA-N 0.000 claims 1
- GNSKKEXPOIMGRA-FCDUAZGNSA-N (2s,4s,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-4-(2-hydroxypropan-2-yl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1=C(C(C)(C)C)C(OC)=CC(C(=O)N2[C@](C[C@@H]([C@@H]2C=2SC=CN=2)C(C)(C)O)(CC(C)C)C(O)=O)=C1 GNSKKEXPOIMGRA-FCDUAZGNSA-N 0.000 claims 1
- BSBUQUPCVMXAIX-ZHCYEPILSA-N (2s,4s,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-4-(ethoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1([C@@H]2N([C@@](CC(C)C)(C[C@@H]2COCC)C(O)=O)C(=O)C=2C=C(OC)C(=CC=2)C(C)(C)C)=NC=CS1 BSBUQUPCVMXAIX-ZHCYEPILSA-N 0.000 claims 1
- URHNVEKBTOYPNA-OFUUFJSKSA-N (2s,4s,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-4-(methoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1([C@@H]2N([C@@](CC(C)C)(C[C@@H]2COC)C(O)=O)C(=O)C=2C=C(OC)C(=CC=2)C(C)(C)C)=NC=CS1 URHNVEKBTOYPNA-OFUUFJSKSA-N 0.000 claims 1
- MVXLYYMOZKDDSX-GDRRSRKRSA-N (2s,4s,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-4-(methoxymethyl)-2-(2-methylpropyl)-5-pyridin-2-ylpyrrolidine-2-carboxylic acid Chemical compound C1([C@@H]2N([C@@](CC(C)C)(C[C@@H]2COC)C(O)=O)C(=O)C=2C=C(OC)C(=CC=2)C(C)(C)C)=CC=CC=N1 MVXLYYMOZKDDSX-GDRRSRKRSA-N 0.000 claims 1
- QUEDXIIQZYWKOH-NTOOTBGVSA-N (2s,4s,5r)-1-(4-tert-butyl-3-methylbenzoyl)-4-(ethoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C1([C@@H]2N([C@@](CC(C)C)(C[C@@H]2COCC)C(O)=O)C(=O)C=2C=C(C)C(=CC=2)C(C)(C)C)=NC=CS1 QUEDXIIQZYWKOH-NTOOTBGVSA-N 0.000 claims 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- XGQJFVPSDZWOII-UHFFFAOYSA-N 1-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound OC(=O)C1CCCN1C1=NC=CS1 XGQJFVPSDZWOII-UHFFFAOYSA-N 0.000 claims 1
- JQCSUVJDBHJKNG-UHFFFAOYSA-N 1-methoxy-ethyl Chemical group C[CH]OC JQCSUVJDBHJKNG-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- VDNWMJNXQUIRGC-UHFFFAOYSA-N diethyl 1-(2-aminobenzoyl)-4-(1-hydroxyethyl)pyrrolidine-2,2-dicarboxylate Chemical compound CCOC(=O)C1(C(=O)OCC)CC(C(C)O)CN1C(=O)C1=CC=CC=C1N VDNWMJNXQUIRGC-UHFFFAOYSA-N 0.000 claims 1
- RXKSUQZUBGLJQC-UHFFFAOYSA-N diethyl 4-(1-hydroxyethyl)-1-(2-nitrobenzoyl)pyrrolidine-2,2-dicarboxylate Chemical compound CCOC(=O)C1(C(=O)OCC)CC(C(C)O)CN1C(=O)C1=CC=CC=C1[N+]([O-])=O RXKSUQZUBGLJQC-UHFFFAOYSA-N 0.000 claims 1
- LHTLMSMNROQTDU-UHFFFAOYSA-N diethyl 4-ethenyl-1-(2-nitrobenzoyl)pyrrolidine-2,2-dicarboxylate Chemical compound CCOC(=O)C1(C(=O)OCC)CC(C=C)CN1C(=O)C1=CC=CC=C1[N+]([O-])=O LHTLMSMNROQTDU-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 0 *C(C(CC(C1N)N)(*1C(O)=O)I)=O Chemical compound *C(C(CC(C1N)N)(*1C(O)=O)I)=O 0.000 description 5
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0224774A GB0224774D0 (en) | 2002-10-24 | 2002-10-24 | Compounds |
| GB0229470A GB0229470D0 (en) | 2002-12-18 | 2002-12-18 | Compounds |
| GB0317141A GB0317141D0 (en) | 2003-07-22 | 2003-07-22 | Compounds |
| PCT/EP2003/011813 WO2004037818A1 (en) | 2002-10-24 | 2003-10-22 | 1-acyl-pyrrolidine derivatives for the treatment of viral infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506455A JP2006506455A (ja) | 2006-02-23 |
| JP2006506455A5 true JP2006506455A5 (enExample) | 2006-12-07 |
Family
ID=32180212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501534A Withdrawn JP2006506455A (ja) | 2002-10-24 | 2003-10-22 | ウイルス感染症の治療のための１−アシル−ピロリジン誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7304087B2 (enExample) |
| EP (1) | EP1554274B1 (enExample) |
| JP (1) | JP2006506455A (enExample) |
| KR (1) | KR20050057670A (enExample) |
| AR (1) | AR041816A1 (enExample) |
| AT (1) | ATE418554T1 (enExample) |
| AU (1) | AU2003276172A1 (enExample) |
| BR (1) | BR0315417A (enExample) |
| CA (1) | CA2503471A1 (enExample) |
| CO (1) | CO5550450A2 (enExample) |
| DE (1) | DE60325498D1 (enExample) |
| IS (1) | IS7851A (enExample) |
| MA (1) | MA27524A1 (enExample) |
| MX (1) | MXPA05004435A (enExample) |
| NO (1) | NO20052472L (enExample) |
| PL (1) | PL376454A1 (enExample) |
| TW (1) | TW200418848A (enExample) |
| WO (1) | WO2004037818A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0304494D0 (en) * | 2003-02-27 | 2003-04-02 | Glaxo Group Ltd | Compounds |
| GB0408995D0 (en) * | 2004-04-22 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| GB0423672D0 (en) * | 2004-10-25 | 2004-11-24 | Glaxo Group Ltd | Compounds |
| GB0423673D0 (en) * | 2004-10-25 | 2004-11-24 | Glaxo Group Ltd | Compounds |
| US7115749B2 (en) | 2004-10-29 | 2006-10-03 | Schering Corporation | Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents |
| GB0519478D0 (en) * | 2005-09-23 | 2005-11-02 | Glaxo Group Ltd | Compounds |
| GB0519488D0 (en) * | 2005-09-23 | 2005-11-02 | Glaxo Group Ltd | Compounds |
| GB0519486D0 (en) * | 2005-09-23 | 2005-11-02 | Glaxo Group Ltd | Compounds |
| GB0519485D0 (en) * | 2005-09-23 | 2005-11-02 | Glaxo Group Ltd | Compounds |
| ATE525068T1 (de) | 2007-02-28 | 2011-10-15 | Conatus Pharmaceuticals Inc | Verfahren zur behandlung von chronischer viraler hepatitis c mithilfe von ro 113-0830 |
| NZ580917A (en) | 2007-05-04 | 2012-06-29 | Vertex Pharma | Combinations of protease inhibitors such as VX-950 and polymerase inhibitors for the treatment of HCV infection |
| US20090053175A1 (en) * | 2007-08-24 | 2009-02-26 | Yat Sun Or | Substitute pyrrolidine derivatives |
| KR101269393B1 (ko) | 2008-04-28 | 2013-05-29 | 아사히 가세이 파마 가부시키가이샤 | 페닐프로피온산 유도체 및 이의 용도 |
| MX2011001662A (es) | 2008-08-11 | 2011-03-24 | Glaxosmithkline Llc | Derivados de purina para usarse en el tratamiento de enfermedades alergicas, inflamatorias e infecciosas. |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| CN102176911B (zh) | 2008-08-11 | 2014-12-10 | 葛兰素史密丝克莱恩有限责任公司 | 新的腺嘌呤衍生物 |
| WO2011098451A1 (en) | 2010-02-10 | 2011-08-18 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
| SI2534149T1 (sl) | 2010-02-10 | 2015-02-27 | Glaxosmithkline Llc Corporation Service Company | 6-amino-2-((1S)-1-metilbutil)oksi)-9-(5-(1-pipridinil)pentil)-7,9- dihidro-8H purin-8-on maleat |
| US9340530B2 (en) | 2012-03-06 | 2016-05-17 | Merck Sharp & Dohme Corp. | Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists |
| CN106029668B (zh) | 2014-02-20 | 2018-02-23 | 葛兰素史克知识产权第二有限公司 | 吡咯并[3,2]嘧啶衍生物作为人类干扰素诱导剂 |
| MX2017006302A (es) | 2014-11-13 | 2018-02-16 | Glaxosmithkline Biologicals Sa | Derivados de adenina que son utiles en el tratamiento de enfermedades alergicas u otras afecciones inflamatorias. |
| PE20181297A1 (es) | 2015-12-03 | 2018-08-07 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos de purino ciclico como moduladores de sting |
| WO2017175156A1 (en) | 2016-04-07 | 2017-10-12 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
| CN113549110B (zh) | 2016-04-07 | 2024-08-16 | 葛兰素史密斯克莱知识产权发展有限公司 | 用作蛋白质调节剂的杂环酰胺 |
| CN111417630B (zh) | 2017-10-05 | 2023-06-06 | 葛兰素史克知识产权开发有限公司 | 干扰素基因刺激因子(sting)的调节剂 |
| WO2019069269A1 (en) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | INTERFERON GENE STIMULATOR MODULATORS USEFUL IN THE TREATMENT OF HIV |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| US20220251079A1 (en) | 2019-05-16 | 2022-08-11 | Stingthera, Inc. | Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use |
| JP2022533390A (ja) | 2019-05-16 | 2022-07-22 | スティングセラ インコーポレイテッド | オキソアクリジニル酢酸誘導体および使用方法 |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| US12415785B2 (en) | 2019-12-18 | 2025-09-16 | Ctxt Pty Ltd | Compound modulators of sting |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977075A (en) | 1995-04-21 | 1999-11-02 | Novartis Ag | N-aroylamino acid amides as endothelin inhibitors |
| WO1999029705A2 (en) | 1997-12-08 | 1999-06-17 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
| EP1051104B1 (en) | 1998-01-26 | 2008-04-09 | Massachusetts Institute Of Technology | Fluorescence imaging endoscope |
| CA2329422A1 (en) * | 1998-04-23 | 1999-10-28 | Abbott Laboratories | Pyrrolidines as inhibitors of neuraminidases |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| EP1118287B1 (de) * | 2000-01-21 | 2004-11-24 | Alois Ing. Sampl | Steckbares Regalsystem |
| EP1278743A4 (en) | 2000-05-05 | 2003-05-14 | Smithkline Beecham Corp | NEW ANTI-INFECTIOUS ACTIVE SUBSTANCES |
| WO2002044168A2 (en) | 2000-11-20 | 2002-06-06 | Scios Inc. | Indole-type inhibitors of p38 kinase |
| WO2003037896A1 (en) | 2001-10-26 | 2003-05-08 | Pharmacia & Upjohn Company | N-azabicyclo-substituted hetero-bicyclic carboxamides as nachr agonists |
| WO2003037893A1 (en) | 2001-11-02 | 2003-05-08 | Glaxo Group Limited | Acyl dihydro pyrrole derivatives as hcv inhibitors |
| AU2002335950A1 (en) | 2002-10-28 | 2004-05-13 | Marquage Antivol Sherlock, Inc. | Method of preventing theft of vehicles using intensive marking |
-
2003
- 2003-10-22 CA CA002503471A patent/CA2503471A1/en not_active Abandoned
- 2003-10-22 TW TW092129213A patent/TW200418848A/zh unknown
- 2003-10-22 AT AT03809322T patent/ATE418554T1/de not_active IP Right Cessation
- 2003-10-22 MX MXPA05004435A patent/MXPA05004435A/es unknown
- 2003-10-22 KR KR1020057006957A patent/KR20050057670A/ko not_active Withdrawn
- 2003-10-22 EP EP03809322A patent/EP1554274B1/en not_active Expired - Lifetime
- 2003-10-22 PL PL03376454A patent/PL376454A1/xx not_active Application Discontinuation
- 2003-10-22 WO PCT/EP2003/011813 patent/WO2004037818A1/en not_active Ceased
- 2003-10-22 BR BR0315417-3A patent/BR0315417A/pt not_active IP Right Cessation
- 2003-10-22 JP JP2005501534A patent/JP2006506455A/ja not_active Withdrawn
- 2003-10-22 DE DE60325498T patent/DE60325498D1/de not_active Expired - Fee Related
- 2003-10-22 AU AU2003276172A patent/AU2003276172A1/en not_active Abandoned
- 2003-10-22 US US10/531,884 patent/US7304087B2/en not_active Expired - Fee Related
- 2003-10-22 AR ARP030103852A patent/AR041816A1/es not_active Application Discontinuation
-
2005
- 2005-04-25 CO CO05038997A patent/CO5550450A2/es not_active Application Discontinuation
- 2005-05-06 MA MA28263A patent/MA27524A1/fr unknown
- 2005-05-19 IS IS7851A patent/IS7851A/is unknown
- 2005-05-23 NO NO20052472A patent/NO20052472L/no not_active Application Discontinuation
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