RU2271809C2 - Применение антагониста рецептора at-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2 - Google Patents
Применение антагониста рецептора at-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2 Download PDFInfo
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- RU2271809C2 RU2271809C2 RU2001119990/15A RU2001119990A RU2271809C2 RU 2271809 C2 RU2271809 C2 RU 2271809C2 RU 2001119990/15 A RU2001119990/15 A RU 2001119990/15A RU 2001119990 A RU2001119990 A RU 2001119990A RU 2271809 C2 RU2271809 C2 RU 2271809C2
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- receptor
- receptors
- valsartan
- lung
- carcinoma
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Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98811258.7 | 1998-12-23 | ||
| EP98811257 | 1998-12-23 | ||
| EP98811258A EP1013273A1 (en) | 1998-12-23 | 1998-12-23 | Use of AT-1 receptor antagonist or AT-2 receptor modulator for treating diseases associated with an increase of AT-1 or AT-2 receptors |
| EP98811257.9 | 1998-12-23 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005124363/15A Division RU2361575C2 (ru) | 1998-12-23 | 2005-08-01 | Твердые пероральные дозируемые формы валсартана |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001119990A RU2001119990A (ru) | 2003-05-20 |
| RU2271809C2 true RU2271809C2 (ru) | 2006-03-20 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001119990/15A RU2271809C2 (ru) | 1998-12-23 | 1999-12-22 | Применение антагониста рецептора at-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2 |
| RU2005124363/15A RU2361575C2 (ru) | 1998-12-23 | 2005-08-01 | Твердые пероральные дозируемые формы валсартана |
| RU2008143545/15A RU2008143545A (ru) | 1998-12-23 | 2008-11-05 | Применение антагониста рецептора ат-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005124363/15A RU2361575C2 (ru) | 1998-12-23 | 2005-08-01 | Твердые пероральные дозируемые формы валсартана |
| RU2008143545/15A RU2008143545A (ru) | 1998-12-23 | 2008-11-05 | Применение антагониста рецептора ат-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2 |
Country Status (26)
| Country | Link |
|---|---|
| EP (3) | EP2298298A3 (https=) |
| JP (2) | JP2002533390A (https=) |
| KR (1) | KR100646716B1 (https=) |
| CN (2) | CN1304000C (https=) |
| AT (2) | ATE524176T1 (https=) |
| AU (4) | AU3043000A (https=) |
| BR (1) | BR9916576A (https=) |
| CA (2) | CA2351357A1 (https=) |
| CY (2) | CY1106581T1 (https=) |
| CZ (2) | CZ297795B6 (https=) |
| DE (1) | DE69935249T2 (https=) |
| DK (2) | DK1588706T3 (https=) |
| ES (2) | ES2373556T3 (https=) |
| HK (1) | HK1038888B (https=) |
| HU (1) | HUP0104780A3 (https=) |
| ID (1) | ID29856A (https=) |
| IL (5) | IL143233A0 (https=) |
| NO (2) | NO328775B1 (https=) |
| NZ (3) | NZ587909A (https=) |
| PL (1) | PL199100B1 (https=) |
| PT (2) | PT1140071E (https=) |
| RU (3) | RU2271809C2 (https=) |
| SI (2) | SI1588706T1 (https=) |
| SK (1) | SK9132001A3 (https=) |
| TR (7) | TR200200764T2 (https=) |
| WO (1) | WO2000038676A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2512071C2 (ru) * | 2008-02-18 | 2014-04-10 | Квин Мэри Энд Вестфилд Колледж | Scfv cинтетический аналог вариабельных участков моноклонального антитела 6313/g2 к рецептору ангиотензина ii типа 1 |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ522953A (en) * | 2000-06-22 | 2005-10-28 | Novartis Ag | Tablet containing valsartan, microcrystalline cellulose, crospovidone, colloidal anhydrous silica/colloidal silicon dioxide and magnesium stearate |
| JP4972847B2 (ja) * | 2000-10-11 | 2012-07-11 | 住友化学株式会社 | コラーゲン蓄積抑制剤 |
| JPWO2002083127A1 (ja) * | 2001-04-09 | 2004-09-30 | 宮田 敏男 | 蛋白修飾物生成抑制組成物 |
| CN1529697B (zh) | 2001-05-31 | 2010-09-22 | 维科尔药物公司 | 用作血管紧张素ⅱ激动剂的三环化合物 |
| US7812044B2 (en) | 2001-11-13 | 2010-10-12 | Takeda Pharmaceutical Company Limited | Anticancer agents |
| EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
| WO2005041941A2 (en) * | 2003-11-03 | 2005-05-12 | Zentiva, A.S. | Valsartan containing formulation |
| DK2033629T3 (da) | 2004-12-24 | 2013-02-04 | Krka | Fast farmaceutisk sammensætning omfattende valsartan |
| WO2006066361A1 (en) * | 2004-12-24 | 2006-06-29 | The University Of Queensland | Method of treatment or prophylaxis |
| WO2006136916A2 (en) * | 2005-06-20 | 2006-12-28 | Glenmark Pharmaceuticals Limited | Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same |
| GT200600371A (es) | 2005-08-17 | 2007-03-21 | Formas de dosis sólidas de valsartan y amlodipina y método para hacer las mismas | |
| ES2246742B1 (es) * | 2005-09-06 | 2007-02-01 | Prous Institute For Biomedical Research S.A. | Uso de un derivado de imidazol. |
| US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| WO2008120242A1 (en) * | 2007-03-29 | 2008-10-09 | Alembic Limited | Valsartan tablet formulations |
| TR200703568A1 (tr) | 2007-05-24 | 2008-07-21 | Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� | Valsartan formülasyonları |
| CN101888829A (zh) | 2007-10-09 | 2010-11-17 | 诺瓦提斯公司 | 缬沙坦的药物制剂 |
| NZ584686A (en) * | 2007-11-06 | 2013-03-28 | Novartis Ag | Compositions of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate(S)-3'-methyl-2' -(pentanoyl{ 2 -(tetrazol-5-ylate)biphenyl-4'-ylmethyl} amino)butyrate]hemipentahydrate |
| US20110104166A1 (en) | 2008-01-18 | 2011-05-05 | Stankovic Konstantina M | Methods and Compositions for Treating Polyps |
| WO2010104485A2 (en) | 2009-03-11 | 2010-09-16 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Valsartan formulations |
| SI2536396T1 (sl) | 2010-02-16 | 2017-01-31 | KRKA, tovarna zdravil, d.d.,Novo mesto | Postopek za pripravo oralnih trdnih odmernih oblik, ki obsegajo valsartan |
| EP2455388A1 (en) | 2010-11-23 | 2012-05-23 | LanthioPep B.V. | Novel angiotensin type 2 (AT2) receptor agonists and uses thereof. |
| CN102266307B (zh) * | 2011-08-01 | 2012-10-24 | 海南锦瑞制药股份有限公司 | 一种缬沙坦胶囊及其制备方法 |
| WO2013098578A1 (en) | 2011-12-31 | 2013-07-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Immediate release pharmaceutical composition of valsartan hydrochlorothiazide |
| WO2013098576A1 (en) | 2011-12-31 | 2013-07-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Immediate release pharmaceutical composition of valsartan |
| EA018867B1 (ru) * | 2012-11-01 | 2013-11-29 | Лаборатория Тютор С.А.С.И.Ф.И.А. | Способ получения фармацевтической композиции и продукт способа |
| EP4007592A1 (en) | 2019-08-02 | 2022-06-08 | LanthioPep B.V. | Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer |
| EP4295839A1 (en) | 2022-06-20 | 2023-12-27 | KRKA, d.d., Novo mesto | Combination of valsartan and indapamide |
| WO2024026528A1 (en) * | 2022-08-02 | 2024-02-08 | Dimerix Bioscience Pty Ltd | Dosage regimen for the treatment of copd |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| US5399578A (en) * | 1990-02-19 | 1995-03-21 | Ciba-Geigy Corp | Acyl compounds |
| WO1997031634A1 (en) * | 1996-02-29 | 1997-09-04 | Novartis Ag | At1 receptor antagonist for the stimulation of apoptosis |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3146168A (en) | 1962-04-10 | 1964-08-25 | Fmc Corp | Manufacture of pharmaceutical preparations containing cellulose crystallite aggregates |
| CA1334092C (en) | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| EP0330284B1 (en) * | 1988-02-25 | 1994-07-27 | Yamanouchi Europe B.V. | Process for the preparation of a pharmaceutical granulate |
| DK0403159T3 (da) | 1989-06-14 | 2000-08-14 | Smithkline Beecham Corp | Imidazolylalkensyrer |
| IE70593B1 (en) | 1989-09-29 | 1996-12-11 | Eisai Co Ltd | Biphenylmethane derivative the use of it and pharmacological compositions containing same |
| TW201738B (https=) | 1990-03-20 | 1993-03-11 | Sanofi Co | |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| IL99246A0 (en) | 1990-09-10 | 1992-07-15 | Abbott Lab | Angiotensin ii receptor antagonists and pharmaceutical compositions containing them |
| CA2093125C (en) * | 1990-10-02 | 2003-12-16 | Warner-Lambert Company | Angiotensin ii antagonists |
| DE4038335A1 (de) * | 1990-12-01 | 1992-06-04 | Boehringer Mannheim Gmbh | Neue pyridinderivate, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| SI9210098B (sl) * | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo |
| US5591762A (en) * | 1991-02-06 | 1997-01-07 | Dr. Karl Thomae Gmbh | Benzimidazoles useful as angiotensin-11 antagonists |
| US5196537A (en) | 1991-03-21 | 1993-03-23 | G. D. Searle & Co. | 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders |
| GB9110636D0 (en) | 1991-05-16 | 1991-07-03 | Glaxo Group Ltd | Chemical compounds |
| DE4132632A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Substituierte imidazolyl-propensaeurederivate |
| DE4309968A1 (de) * | 1993-03-26 | 1994-09-29 | Bayer Ag | Phenylglycinamide von heterocyclisch substituierten Phenylessigsäurederivaten |
| AU675935B2 (en) | 1992-04-13 | 1997-02-27 | Astrazeneca Ab | Angiotensin II antagonists against disorders associated withimpaired neuronal conduction velocity, especially diabetic neuropathy |
| KR950704259A (ko) * | 1992-12-11 | 1995-11-17 | 베르너 발데크 | 치환된 벤즈아제피논(Substituted Benzazepinone) |
| AU685768B2 (en) | 1992-12-11 | 1998-01-29 | Novartis Ag | Benzazepinone derivatives |
| DE4309963A1 (de) * | 1993-03-26 | 1994-09-29 | Hubert Kamperschroer | Faß zum Austragen von Gülle |
| FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
| DE4408497A1 (de) * | 1994-03-14 | 1995-09-21 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| HUT76542A (en) | 1994-03-17 | 1997-09-29 | Ciba Geigy Ag | Use of valsartan for the preparation of pharmaceutical composition serving for the treatment of diabetic nephropathy |
| DE4432860A1 (de) * | 1994-09-15 | 1996-03-21 | Merck Patent Gmbh | Imidazopyridine |
| AU7213296A (en) | 1995-10-06 | 1997-04-30 | Ciba-Geigy Ag | At1-receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys |
| AU2316997A (en) | 1996-02-27 | 1997-09-16 | David H Thompson | Liposomal delivery system |
| GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| DE19628617A1 (de) * | 1996-07-16 | 1998-01-22 | Basf Ag | Direkttablettierhilfsmittel |
| TR200100062T2 (tr) | 1998-07-10 | 2001-06-21 | Novartis Ag | Valsartan ve kalsiyum kanalı bloklayıcısının anti-hipertensif kombinasyonu |
| IL144216A0 (en) * | 1999-01-26 | 2002-05-23 | Novartis Ag | Use of angiotensin ii receptor antagonists for treating acute myocardial infarction |
| NZ522953A (en) * | 2000-06-22 | 2005-10-28 | Novartis Ag | Tablet containing valsartan, microcrystalline cellulose, crospovidone, colloidal anhydrous silica/colloidal silicon dioxide and magnesium stearate |
| US20070123498A1 (en) | 2003-10-17 | 2007-05-31 | Shetty Suraj S | Combination of organic compounds |
| JP2009018990A (ja) | 2005-10-25 | 2009-01-29 | Univ Kurume | Ｃ型肝炎ウイルス由来ペプチド |
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1999
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- 1999-12-22 EP EP10010334A patent/EP2298298A3/en not_active Withdrawn
- 1999-12-22 NZ NZ587909A patent/NZ587909A/en not_active IP Right Cessation
- 1999-12-22 NZ NZ553010A patent/NZ553010A/en not_active IP Right Cessation
- 1999-12-22 KR KR1020017007996A patent/KR100646716B1/ko not_active Expired - Fee Related
- 1999-12-22 TR TR2002/00764T patent/TR200200764T2/xx unknown
- 1999-12-22 DK DK99964665T patent/DK1140071T3/da active
- 1999-12-22 PT PT99964665T patent/PT1140071E/pt unknown
- 1999-12-22 HK HK02100661.6A patent/HK1038888B/en not_active IP Right Cessation
- 1999-12-22 CN CNA200410087973XA patent/CN1636561A/zh active Pending
- 1999-12-22 AT AT05013209T patent/ATE524176T1/de active
- 1999-12-22 SI SI9931064T patent/SI1588706T1/sl unknown
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- 1999-12-22 SK SK913-2001A patent/SK9132001A3/sk unknown
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- 1999-12-22 PL PL349424A patent/PL199100B1/pl not_active IP Right Cessation
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- 1999-12-22 TR TR2001/01784T patent/TR200101784T2/xx unknown
- 1999-12-22 BR BR9916576-7A patent/BR9916576A/pt not_active IP Right Cessation
- 1999-12-22 EP EP99964665A patent/EP1140071B1/en not_active Revoked
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2001
- 2001-05-17 IL IL143233A patent/IL143233A/en not_active IP Right Cessation
- 2001-06-22 NO NO20013143A patent/NO328775B1/no not_active IP Right Cessation
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2003
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- 2010-01-18 JP JP2010008140A patent/JP5254258B2/ja not_active Expired - Lifetime
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399578A (en) * | 1990-02-19 | 1995-03-21 | Ciba-Geigy Corp | Acyl compounds |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| WO1997031634A1 (en) * | 1996-02-29 | 1997-09-04 | Novartis Ag | At1 receptor antagonist for the stimulation of apoptosis |
Non-Patent Citations (2)
| Title |
|---|
| БЕЛОУСОВ Ю.Б. и др. Клиническая фармакология и фармакотерапия. M.: Универсум паблишинг, 1997 с.140-141. * |
| РУКОВОДСТВО ПО МЕДИЦИНЕ «THE MERCK MANUAL». M.: Мир, 1997 ч.1 с.442-454. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2512071C2 (ru) * | 2008-02-18 | 2014-04-10 | Квин Мэри Энд Вестфилд Колледж | Scfv cинтетический аналог вариабельных участков моноклонального антитела 6313/g2 к рецептору ангиотензина ii типа 1 |
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