RU2250212C2 - Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов - Google Patents

Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов Download PDF

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Publication number
RU2250212C2
RU2250212C2 RU2002123046/04A RU2002123046A RU2250212C2 RU 2250212 C2 RU2250212 C2 RU 2250212C2 RU 2002123046/04 A RU2002123046/04 A RU 2002123046/04A RU 2002123046 A RU2002123046 A RU 2002123046A RU 2250212 C2 RU2250212 C2 RU 2250212C2
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RU
Russia
Prior art keywords
formula
compound
salt
acid
compounds
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Application number
RU2002123046/04A
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English (en)
Russian (ru)
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RU2002123046A (ru
Inventor
Герхард БРАЙПОЛЬ (DE)
Герхард Брайполь
Вольфганг ХОЛЛА (DE)
Вольфганг ХОЛЛА
Хайнер ЙЕНДРАЛЛА (DE)
Хайнер ЙЕНДРАЛЛА
Герхард БЕК (DE)
Герхард БЕК
Original Assignee
Авентис Фарма Дойчланд Гмбх
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Publication of RU2002123046A publication Critical patent/RU2002123046A/ru
Application granted granted Critical
Publication of RU2250212C2 publication Critical patent/RU2250212C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
RU2002123046/04A 2000-01-28 2001-01-18 Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов RU2250212C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28
DE10003586.8 2000-01-28

Publications (2)

Publication Number Publication Date
RU2002123046A RU2002123046A (ru) 2004-01-10
RU2250212C2 true RU2250212C2 (ru) 2005-04-20

Family

ID=7628946

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002123046/04A RU2250212C2 (ru) 2000-01-28 2001-01-18 Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов

Country Status (29)

Country Link
US (2) US20010031858A1 (enExample)
EP (1) EP1254159B9 (enExample)
JP (1) JP4778181B2 (enExample)
KR (1) KR100758141B1 (enExample)
CN (1) CN1176104C (enExample)
AR (1) AR027246A1 (enExample)
AT (1) ATE325810T1 (enExample)
AU (1) AU779722B2 (enExample)
BR (1) BR0107804A (enExample)
CA (1) CA2398497C (enExample)
CZ (1) CZ20022583A3 (enExample)
DE (1) DE60119491T2 (enExample)
DK (1) DK1254159T3 (enExample)
EE (1) EE200200410A (enExample)
ES (1) ES2262632T3 (enExample)
HR (1) HRP20020631A2 (enExample)
HU (1) HUP0301986A2 (enExample)
IL (2) IL150897A0 (enExample)
MX (1) MXPA02006762A (enExample)
NO (1) NO20023577L (enExample)
NZ (1) NZ520427A (enExample)
PL (1) PL356801A1 (enExample)
PT (1) PT1254159E (enExample)
RU (1) RU2250212C2 (enExample)
SK (1) SK10842002A3 (enExample)
TW (1) TWI236481B (enExample)
WO (1) WO2001055175A2 (enExample)
YU (1) YU51202A (enExample)
ZA (1) ZA200205990B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
US8558023B2 (en) * 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
EP2646150A4 (en) * 2010-11-29 2014-10-08 Takasago Perfumery Co Ltd CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR PRODUCING AN OPTICALLY ACTIVE CARBONYL COMPOUND THEREWITH
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用
CN115612702A (zh) * 2022-10-09 2023-01-17 深圳市茵诺圣生物科技有限公司 L-丙氨酸类非天然氨基酸3-(3-吡啶基)-l-丙氨酸的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2134695C1 (ru) * 1993-10-15 1999-08-20 Рон-Пуленк Рорер Фармасьютикалз Инк. Антитромботические азациклоалкилалканоилпептиды
RU2142469C1 (ru) * 1993-06-03 1999-12-10 Астра Актиеболаг Пептидные производные, их стереоизомеры или физиологически приемлемые соли, обладающие противотромбозной, противосвертывающей или противовоспалительной активностью, способ их получения, фармацевтическая композиция, способ подавления тромбина, способ подавления кининогеназ, применение соединений в качестве исходных в синтезе ингибитора тромбина

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
ZA953361B (en) * 1994-04-26 1996-01-12 Selectide Corp Factor Xa inhibitors
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
SK281432B6 (sk) * 1995-12-20 2001-03-12 Hoechst Marion Roussel, Inc. Spôsob prípravy n-acetyl-(l)-4-kyanofenylalanínu ac-(l)-phe(4- -cn)-oh a n-acetyl-(l)-p-amidinofenylalanín-cyklohexylglycín- -beta-(3-n-metylpyridínium)-alanínu ac-(l)-paph-chg-palme(3)-nh2
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2142469C1 (ru) * 1993-06-03 1999-12-10 Астра Актиеболаг Пептидные производные, их стереоизомеры или физиологически приемлемые соли, обладающие противотромбозной, противосвертывающей или противовоспалительной активностью, способ их получения, фармацевтическая композиция, способ подавления тромбина, способ подавления кининогеназ, применение соединений в качестве исходных в синтезе ингибитора тромбина
RU2134695C1 (ru) * 1993-10-15 1999-08-20 Рон-Пуленк Рорер Фармасьютикалз Инк. Антитромботические азациклоалкилалканоилпептиды

Also Published As

Publication number Publication date
WO2001055175A2 (en) 2001-08-02
JP4778181B2 (ja) 2011-09-21
CN1176104C (zh) 2004-11-17
NO20023577D0 (no) 2002-07-26
SK10842002A3 (sk) 2003-04-01
CA2398497A1 (en) 2001-08-02
WO2001055175A3 (en) 2002-02-21
ZA200205990B (en) 2003-04-30
EP1254159B1 (en) 2006-05-10
AR027246A1 (es) 2003-03-19
PL356801A1 (en) 2004-07-12
IL150897A0 (en) 2003-02-12
MXPA02006762A (es) 2002-10-23
DE60119491D1 (de) 2006-06-14
CN1396928A (zh) 2003-02-12
KR20030019306A (ko) 2003-03-06
JP2003523364A (ja) 2003-08-05
EP1254159A2 (en) 2002-11-06
AU4051601A (en) 2001-08-07
KR100758141B1 (ko) 2007-09-13
DE60119491T2 (de) 2006-11-16
NZ520427A (en) 2004-02-27
BR0107804A (pt) 2002-10-22
PT1254159E (pt) 2006-07-31
ATE325810T1 (de) 2006-06-15
ES2262632T3 (es) 2006-12-01
US20040225109A1 (en) 2004-11-11
US20010031858A1 (en) 2001-10-18
TWI236481B (en) 2005-07-21
HK1051866A1 (en) 2003-08-22
RU2002123046A (ru) 2004-01-10
IL150897A (en) 2008-08-07
NO20023577L (no) 2002-08-28
US7084250B2 (en) 2006-08-01
CZ20022583A3 (cs) 2002-10-16
HRP20020631A2 (en) 2004-12-31
CA2398497C (en) 2011-04-26
EP1254159B9 (en) 2006-06-28
AU779722B2 (en) 2005-02-10
DK1254159T3 (da) 2006-09-11
HUP0301986A2 (hu) 2003-09-29
YU51202A (sh) 2005-11-28
EE200200410A (et) 2003-12-15

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Effective date: 20070119