EE200200410A - Meetod atsetüülamidiniofenüülalanüültsükloheksüülglütsüülpüridinioalaniinamiidide valmistamiseks ning selleks vajalikud lähte- ja vaheühendid - Google Patents

Meetod atsetüülamidiniofenüülalanüültsükloheksüülglütsüülpüridinioalaniinamiidide valmistamiseks ning selleks vajalikud lähte- ja vaheühendid

Info

Publication number
EE200200410A
EE200200410A EEP200200410A EEP200200410A EE200200410A EE 200200410 A EE200200410 A EE 200200410A EE P200200410 A EEP200200410 A EE P200200410A EE P200200410 A EEP200200410 A EE P200200410A EE 200200410 A EE200200410 A EE 200200410A
Authority
EE
Estonia
Prior art keywords
starting
preparation
intermediate compounds
compounds
Prior art date
Application number
EEP200200410A
Other languages
English (en)
Estonian (et)
Inventor
Breipohl Gerhard
Holla Wolfgang
Jendralla Heiner
Beck Gerhard
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of EE200200410A publication Critical patent/EE200200410A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EEP200200410A 2000-01-28 2001-01-18 Meetod atsetüülamidiniofenüülalanüültsükloheksüülglütsüülpüridinioalaniinamiidide valmistamiseks ning selleks vajalikud lähte- ja vaheühendid EE200200410A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28
PCT/EP2001/000523 WO2001055175A2 (en) 2000-01-28 2001-01-18 Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides

Publications (1)

Publication Number Publication Date
EE200200410A true EE200200410A (et) 2003-12-15

Family

ID=7628946

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200410A EE200200410A (et) 2000-01-28 2001-01-18 Meetod atsetüülamidiniofenüülalanüültsükloheksüülglütsüülpüridinioalaniinamiidide valmistamiseks ning selleks vajalikud lähte- ja vaheühendid

Country Status (29)

Country Link
US (2) US20010031858A1 (enExample)
EP (1) EP1254159B9 (enExample)
JP (1) JP4778181B2 (enExample)
KR (1) KR100758141B1 (enExample)
CN (1) CN1176104C (enExample)
AR (1) AR027246A1 (enExample)
AT (1) ATE325810T1 (enExample)
AU (1) AU779722B2 (enExample)
BR (1) BR0107804A (enExample)
CA (1) CA2398497C (enExample)
CZ (1) CZ20022583A3 (enExample)
DE (1) DE60119491T2 (enExample)
DK (1) DK1254159T3 (enExample)
EE (1) EE200200410A (enExample)
ES (1) ES2262632T3 (enExample)
HR (1) HRP20020631A2 (enExample)
HU (1) HUP0301986A2 (enExample)
IL (2) IL150897A0 (enExample)
MX (1) MXPA02006762A (enExample)
NO (1) NO20023577L (enExample)
NZ (1) NZ520427A (enExample)
PL (1) PL356801A1 (enExample)
PT (1) PT1254159E (enExample)
RU (1) RU2250212C2 (enExample)
SK (1) SK10842002A3 (enExample)
TW (1) TWI236481B (enExample)
WO (1) WO2001055175A2 (enExample)
YU (1) YU51202A (enExample)
ZA (1) ZA200205990B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) * 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
WO2011133651A1 (en) * 2010-04-20 2011-10-27 Chiral Quest , Inc. An enantioselective process for cycloalkenyl b-substituted alanines
US9000192B2 (en) 2010-11-29 2015-04-07 Takasago International Corporation Catalyst for asymmetric hydrogenation and method for manufacturing optically active carbonyl compound using the same
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
DE69426897T2 (de) * 1993-10-15 2001-07-05 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Antithrombotisch wirkende azacycloalkyl-alkanoyl-peptide und-pseudopeptide
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
DK0758341T3 (da) * 1994-04-26 2004-06-28 Aventis Pharma Inc Faktor Xa-inhibitorer
CN1087349C (zh) * 1995-12-20 2002-07-10 阿温蒂斯药物公司 N－乙酰基－(L)－4－氰基苯丙氨酸Ac-(L)-Phe(4－CN)－OH与N－乙酰基－(L)－对脒基苯丙氨酸－环己基甘氨酸－β－（3－N－甲基吡啶鎓）－丙氨酸AC－（L）－PAPh－chg－PaIMe(3)-NH2的新颖的制备方法
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Also Published As

Publication number Publication date
DK1254159T3 (da) 2006-09-11
US20040225109A1 (en) 2004-11-11
EP1254159A2 (en) 2002-11-06
ATE325810T1 (de) 2006-06-15
US7084250B2 (en) 2006-08-01
JP2003523364A (ja) 2003-08-05
PT1254159E (pt) 2006-07-31
EP1254159B1 (en) 2006-05-10
EP1254159B9 (en) 2006-06-28
MXPA02006762A (es) 2002-10-23
YU51202A (sh) 2005-11-28
NZ520427A (en) 2004-02-27
CA2398497C (en) 2011-04-26
AU4051601A (en) 2001-08-07
AR027246A1 (es) 2003-03-19
KR100758141B1 (ko) 2007-09-13
KR20030019306A (ko) 2003-03-06
AU779722B2 (en) 2005-02-10
BR0107804A (pt) 2002-10-22
HK1051866A1 (en) 2003-08-22
TWI236481B (en) 2005-07-21
PL356801A1 (en) 2004-07-12
NO20023577D0 (no) 2002-07-26
NO20023577L (no) 2002-08-28
HUP0301986A2 (hu) 2003-09-29
RU2250212C2 (ru) 2005-04-20
CZ20022583A3 (cs) 2002-10-16
US20010031858A1 (en) 2001-10-18
ES2262632T3 (es) 2006-12-01
HRP20020631A2 (en) 2004-12-31
CA2398497A1 (en) 2001-08-02
SK10842002A3 (sk) 2003-04-01
IL150897A0 (en) 2003-02-12
JP4778181B2 (ja) 2011-09-21
DE60119491T2 (de) 2006-11-16
IL150897A (en) 2008-08-07
DE60119491D1 (de) 2006-06-14
RU2002123046A (ru) 2004-01-10
WO2001055175A2 (en) 2001-08-02
ZA200205990B (en) 2003-04-30
CN1176104C (zh) 2004-11-17
WO2001055175A3 (en) 2002-02-21
CN1396928A (zh) 2003-02-12

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