PT1254159E - Processo para a preparacao de acetil-amidiniofenilalanil-ciclo-hexilglicil-piridilalaninamidas - Google Patents

Processo para a preparacao de acetil-amidiniofenilalanil-ciclo-hexilglicil-piridilalaninamidas

Info

Publication number
PT1254159E
PT1254159E PT01911497T PT01911497T PT1254159E PT 1254159 E PT1254159 E PT 1254159E PT 01911497 T PT01911497 T PT 01911497T PT 01911497 T PT01911497 T PT 01911497T PT 1254159 E PT1254159 E PT 1254159E
Authority
PT
Portugal
Prior art keywords
cyclohexylglycyl
acetyl
salt
preparation
amidiniophenylalanyl
Prior art date
Application number
PT01911497T
Other languages
English (en)
Portuguese (pt)
Inventor
Breipohl Dr Gerhard
Holla Wolfgang
Jendralla Heiner
Gerhard Beck
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PT1254159E publication Critical patent/PT1254159E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PT01911497T 2000-01-28 2001-01-18 Processo para a preparacao de acetil-amidiniofenilalanil-ciclo-hexilglicil-piridilalaninamidas PT1254159E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28

Publications (1)

Publication Number Publication Date
PT1254159E true PT1254159E (pt) 2006-07-31

Family

ID=7628946

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01911497T PT1254159E (pt) 2000-01-28 2001-01-18 Processo para a preparacao de acetil-amidiniofenilalanil-ciclo-hexilglicil-piridilalaninamidas

Country Status (29)

Country Link
US (2) US20010031858A1 (enExample)
EP (1) EP1254159B9 (enExample)
JP (1) JP4778181B2 (enExample)
KR (1) KR100758141B1 (enExample)
CN (1) CN1176104C (enExample)
AR (1) AR027246A1 (enExample)
AT (1) ATE325810T1 (enExample)
AU (1) AU779722B2 (enExample)
BR (1) BR0107804A (enExample)
CA (1) CA2398497C (enExample)
CZ (1) CZ20022583A3 (enExample)
DE (1) DE60119491T2 (enExample)
DK (1) DK1254159T3 (enExample)
EE (1) EE200200410A (enExample)
ES (1) ES2262632T3 (enExample)
HR (1) HRP20020631A2 (enExample)
HU (1) HUP0301986A2 (enExample)
IL (2) IL150897A0 (enExample)
MX (1) MXPA02006762A (enExample)
NO (1) NO20023577L (enExample)
NZ (1) NZ520427A (enExample)
PL (1) PL356801A1 (enExample)
PT (1) PT1254159E (enExample)
RU (1) RU2250212C2 (enExample)
SK (1) SK10842002A3 (enExample)
TW (1) TWI236481B (enExample)
WO (1) WO2001055175A2 (enExample)
YU (1) YU51202A (enExample)
ZA (1) ZA200205990B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
US8558023B2 (en) * 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
EP2646150A4 (en) * 2010-11-29 2014-10-08 Takasago Perfumery Co Ltd CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR PRODUCING AN OPTICALLY ACTIVE CARBONYL COMPOUND THEREWITH
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用
CN115612702A (zh) * 2022-10-09 2023-01-17 深圳市茵诺圣生物科技有限公司 L-丙氨酸类非天然氨基酸3-(3-吡啶基)-l-丙氨酸的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5866685A (en) * 1993-10-15 1999-02-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
ZA953361B (en) * 1994-04-26 1996-01-12 Selectide Corp Factor Xa inhibitors
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
SK281432B6 (sk) * 1995-12-20 2001-03-12 Hoechst Marion Roussel, Inc. Spôsob prípravy n-acetyl-(l)-4-kyanofenylalanínu ac-(l)-phe(4- -cn)-oh a n-acetyl-(l)-p-amidinofenylalanín-cyklohexylglycín- -beta-(3-n-metylpyridínium)-alanínu ac-(l)-paph-chg-palme(3)-nh2
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Also Published As

Publication number Publication date
WO2001055175A2 (en) 2001-08-02
JP4778181B2 (ja) 2011-09-21
CN1176104C (zh) 2004-11-17
NO20023577D0 (no) 2002-07-26
SK10842002A3 (sk) 2003-04-01
CA2398497A1 (en) 2001-08-02
WO2001055175A3 (en) 2002-02-21
ZA200205990B (en) 2003-04-30
EP1254159B1 (en) 2006-05-10
AR027246A1 (es) 2003-03-19
PL356801A1 (en) 2004-07-12
IL150897A0 (en) 2003-02-12
MXPA02006762A (es) 2002-10-23
DE60119491D1 (de) 2006-06-14
CN1396928A (zh) 2003-02-12
KR20030019306A (ko) 2003-03-06
RU2250212C2 (ru) 2005-04-20
JP2003523364A (ja) 2003-08-05
EP1254159A2 (en) 2002-11-06
AU4051601A (en) 2001-08-07
KR100758141B1 (ko) 2007-09-13
DE60119491T2 (de) 2006-11-16
NZ520427A (en) 2004-02-27
BR0107804A (pt) 2002-10-22
ATE325810T1 (de) 2006-06-15
ES2262632T3 (es) 2006-12-01
US20040225109A1 (en) 2004-11-11
US20010031858A1 (en) 2001-10-18
TWI236481B (en) 2005-07-21
HK1051866A1 (en) 2003-08-22
RU2002123046A (ru) 2004-01-10
IL150897A (en) 2008-08-07
NO20023577L (no) 2002-08-28
US7084250B2 (en) 2006-08-01
CZ20022583A3 (cs) 2002-10-16
HRP20020631A2 (en) 2004-12-31
CA2398497C (en) 2011-04-26
EP1254159B9 (en) 2006-06-28
AU779722B2 (en) 2005-02-10
DK1254159T3 (da) 2006-09-11
HUP0301986A2 (hu) 2003-09-29
YU51202A (sh) 2005-11-28
EE200200410A (et) 2003-12-15

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