ATE359773T1 - Verfahren zur behandlung von erkrankungen mit malonyl coa-decarboxylase-inhibitoren - Google Patents

Verfahren zur behandlung von erkrankungen mit malonyl coa-decarboxylase-inhibitoren

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Publication number
ATE359773T1
ATE359773T1 AT02703196T AT02703196T ATE359773T1 AT E359773 T1 ATE359773 T1 AT E359773T1 AT 02703196 T AT02703196 T AT 02703196T AT 02703196 T AT02703196 T AT 02703196T AT E359773 T1 ATE359773 T1 AT E359773T1
Authority
AT
Austria
Prior art keywords
malonyl
treating diseases
coa decarboxylase
malonyl coa
decarboxylase inhibitors
Prior art date
Application number
AT02703196T
Other languages
English (en)
Inventor
Thomas Arrhenius
Mi Chen
Jie Fei Cheng
Masayuki Haramura
Yujin Huang
Alex Nadzan
Sovouthy Tith
David Wallace
Lin Zhang
Steve Brown
Charles Harmon
Gary Lopaschuk
Jason Dyck
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE359773T1 publication Critical patent/ATE359773T1/de

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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AT02703196T 2001-01-26 2002-01-22 Verfahren zur behandlung von erkrankungen mit malonyl coa-decarboxylase-inhibitoren ATE359773T1 (de)

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