BR0107804A - Processo para a preparação de acetil-amidiniofenilalanil-ciclohexilglicil-piridinioa laninamidas - Google Patents

Processo para a preparação de acetil-amidiniofenilalanil-ciclohexilglicil-piridinioa laninamidas

Info

Publication number
BR0107804A
BR0107804A BR0107804-6A BR0107804A BR0107804A BR 0107804 A BR0107804 A BR 0107804A BR 0107804 A BR0107804 A BR 0107804A BR 0107804 A BR0107804 A BR 0107804A
Authority
BR
Brazil
Prior art keywords
acetyl
preparation
salt
amidiniophenylalanyl
cyclohexylglycyl
Prior art date
Application number
BR0107804-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Gerhard Breipohl
Wolfgang Holla
Heiner Jendralla
Gerhard Beck
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0107804A publication Critical patent/BR0107804A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BR0107804-6A 2000-01-28 2001-01-18 Processo para a preparação de acetil-amidiniofenilalanil-ciclohexilglicil-piridinioa laninamidas BR0107804A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28
PCT/EP2001/000523 WO2001055175A2 (en) 2000-01-28 2001-01-18 Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides

Publications (1)

Publication Number Publication Date
BR0107804A true BR0107804A (pt) 2002-10-22

Family

ID=7628946

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0107804-6A BR0107804A (pt) 2000-01-28 2001-01-18 Processo para a preparação de acetil-amidiniofenilalanil-ciclohexilglicil-piridinioa laninamidas

Country Status (29)

Country Link
US (2) US20010031858A1 (enExample)
EP (1) EP1254159B9 (enExample)
JP (1) JP4778181B2 (enExample)
KR (1) KR100758141B1 (enExample)
CN (1) CN1176104C (enExample)
AR (1) AR027246A1 (enExample)
AT (1) ATE325810T1 (enExample)
AU (1) AU779722B2 (enExample)
BR (1) BR0107804A (enExample)
CA (1) CA2398497C (enExample)
CZ (1) CZ20022583A3 (enExample)
DE (1) DE60119491T2 (enExample)
DK (1) DK1254159T3 (enExample)
EE (1) EE200200410A (enExample)
ES (1) ES2262632T3 (enExample)
HR (1) HRP20020631A2 (enExample)
HU (1) HUP0301986A2 (enExample)
IL (2) IL150897A0 (enExample)
MX (1) MXPA02006762A (enExample)
NO (1) NO20023577L (enExample)
NZ (1) NZ520427A (enExample)
PL (1) PL356801A1 (enExample)
PT (1) PT1254159E (enExample)
RU (1) RU2250212C2 (enExample)
SK (1) SK10842002A3 (enExample)
TW (1) TWI236481B (enExample)
WO (1) WO2001055175A2 (enExample)
YU (1) YU51202A (enExample)
ZA (1) ZA200205990B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
US8558023B2 (en) * 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
EP2646150A4 (en) * 2010-11-29 2014-10-08 Takasago Perfumery Co Ltd CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR PRODUCING AN OPTICALLY ACTIVE CARBONYL COMPOUND THEREWITH
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用
CN115612702A (zh) * 2022-10-09 2023-01-17 深圳市茵诺圣生物科技有限公司 L-丙氨酸类非天然氨基酸3-(3-吡啶基)-l-丙氨酸的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5866685A (en) * 1993-10-15 1999-02-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
ZA953361B (en) * 1994-04-26 1996-01-12 Selectide Corp Factor Xa inhibitors
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
SK281432B6 (sk) * 1995-12-20 2001-03-12 Hoechst Marion Roussel, Inc. Spôsob prípravy n-acetyl-(l)-4-kyanofenylalanínu ac-(l)-phe(4- -cn)-oh a n-acetyl-(l)-p-amidinofenylalanín-cyklohexylglycín- -beta-(3-n-metylpyridínium)-alanínu ac-(l)-paph-chg-palme(3)-nh2
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Also Published As

Publication number Publication date
WO2001055175A2 (en) 2001-08-02
JP4778181B2 (ja) 2011-09-21
CN1176104C (zh) 2004-11-17
NO20023577D0 (no) 2002-07-26
SK10842002A3 (sk) 2003-04-01
CA2398497A1 (en) 2001-08-02
WO2001055175A3 (en) 2002-02-21
ZA200205990B (en) 2003-04-30
EP1254159B1 (en) 2006-05-10
AR027246A1 (es) 2003-03-19
PL356801A1 (en) 2004-07-12
IL150897A0 (en) 2003-02-12
MXPA02006762A (es) 2002-10-23
DE60119491D1 (de) 2006-06-14
CN1396928A (zh) 2003-02-12
KR20030019306A (ko) 2003-03-06
RU2250212C2 (ru) 2005-04-20
JP2003523364A (ja) 2003-08-05
EP1254159A2 (en) 2002-11-06
AU4051601A (en) 2001-08-07
KR100758141B1 (ko) 2007-09-13
DE60119491T2 (de) 2006-11-16
NZ520427A (en) 2004-02-27
PT1254159E (pt) 2006-07-31
ATE325810T1 (de) 2006-06-15
ES2262632T3 (es) 2006-12-01
US20040225109A1 (en) 2004-11-11
US20010031858A1 (en) 2001-10-18
TWI236481B (en) 2005-07-21
HK1051866A1 (en) 2003-08-22
RU2002123046A (ru) 2004-01-10
IL150897A (en) 2008-08-07
NO20023577L (no) 2002-08-28
US7084250B2 (en) 2006-08-01
CZ20022583A3 (cs) 2002-10-16
HRP20020631A2 (en) 2004-12-31
CA2398497C (en) 2011-04-26
EP1254159B9 (en) 2006-06-28
AU779722B2 (en) 2005-02-10
DK1254159T3 (da) 2006-09-11
HUP0301986A2 (hu) 2003-09-29
YU51202A (sh) 2005-11-28
EE200200410A (et) 2003-12-15

Similar Documents

Publication Publication Date Title
ES2254385T3 (es) Benzamidas e inhibidores relacionados del factor xa.
BRPI0111596B8 (pt) Composto piridona, processo de produção do composto, composição farmacêutica, e uso do dito composto
ES2316383T3 (es) Benzamidas e inhibidores relacionados del factor xa.
BR9713465A (pt) Inibidores metalotprotease de amina cìclica sibstituìda
BR0203644A (pt) Derivados heteroarìlicos dissubstituìdos com ácido como inibidores de metaloproteinase de matriz
NO20021542D0 (no) Nye <alfa>-aminosyresulfonylforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdendedem
ATE251176T1 (de) Intermediate zur herstellung von thrombininhibitoren als anticoagulantien
PT89122A (pt) Processo para a preparacao de tiazolidinodionas uteis como agentes hipoglicemicos e anti-aterosclerose
BR0009411A (pt) Composto de anilina substituìda, e, processo para a preparação e uso de compostos
BR0113039A (pt) Composto ou um seu sal ou solvato fisiologicamente aceitável, uso do mesmo, composição farmacêutica, formulação farmacêutica em aerossol, método para o tratamento de um indivìduo humano ou animal com uma condição antiinflamatória e/ou alérgica, e, processo para preparar um composto
BR9813028A (pt) Agonistas de prostaglandina e seu uso para tratar distúrbios nos ossos
WO2006034833A1 (en) Cyclic diarly ureas suitable as tyrosine kinase inhibitors
BR0015202A (pt) Processo para a purificação de uma solução contendo aminoácido por meio de eletrodiálise, e processo integrado para a produção de um aminoácido livre
BR0213760A (pt) Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição
BR0214466A (pt) Composições de pró-perfume usadas em produtos de limpeza ou de tratamento de tecidos
DE60228724D1 (de) Verfahren zur herstellung von beraprost und dessen salzen
AU2019231208B2 (en) Imidazodiazepinediones and methods of use thereof
BR0012631A (pt) Processo para a preparação de compostos de amina
BR0313179A (pt) Pró-drogas de (n-2-piridil-n-2-hidroxicarboniletil)-amida de ácido 1-metil-2-(4-amidinofenilaminometil)-benzimidazol-5-il -carboxìlico, sua preparação e seu emprego como medicamento
PT1254159E (pt) Processo para a preparacao de acetil-amidiniofenilalanil-ciclo-hexilglicil-piridilalaninamidas
EA015918B1 (ru) УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
BR0011246A (pt) Processos para o preparo de novos derivados de propenona substituìda
BR0115262A (pt) Derivados de amina opticamente ativos e processo de preparação destes
DE60125082D1 (de) Verfahren zur Herstellung von optisch aktiven 3,7-Dimethyl-6-octenol und Verfahren zur Herstellung von Zwischenprodukt dafür
ATE349545T1 (de) Enzymatisches verfahren zur herstellung von substituierter 2-amino-3-(2-amino-phenylsulfanyl)-propionsäure

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements