EA200801505A1 - Способ получения фармацевтического промежуточного соединения - Google Patents

Способ получения фармацевтического промежуточного соединения

Info

Publication number
EA200801505A1
EA200801505A1 EA200801505A EA200801505A EA200801505A1 EA 200801505 A1 EA200801505 A1 EA 200801505A1 EA 200801505 A EA200801505 A EA 200801505A EA 200801505 A EA200801505 A EA 200801505A EA 200801505 A1 EA200801505 A1 EA 200801505A1
Authority
EA
Eurasian Patent Office
Prior art keywords
obtaining
intermediate compound
pharmaceutical intermediate
enantiomers
formula
Prior art date
Application number
EA200801505A
Other languages
English (en)
Other versions
EA014530B1 (ru
Inventor
Петер Тринка
Тибор Мезеи
Йожеф Реитер
Ференц Барта
Зольтан Катона
Донат Дьёрди Верецкеине
Кальман Надь
Ласло Понго
Original Assignee
Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг filed Critical Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Publication of EA200801505A1 publication Critical patent/EA200801505A1/ru
Publication of EA014530B1 publication Critical patent/EA014530B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к способу получения {2-[4-(α-фенил-n-хлорбензил)пиперазин-1-ил]этокси}уксусной кислоты N,N-диметиламида формулы (I) и его энантиомеров. Соединение формулы (I) или его энантиомеры представляют собой важные фармацевтические промежуточные соединения, пригодные для прямого преобразования в активные фармацевтические ингредиенты неседативного антигистаминного типа - цетиризин и левоцетиризин.
EA200801505A 2005-12-08 2006-12-08 Способ получения фармацевтического промежуточного соединения EA014530B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0501138A HU227325B1 (en) 2005-12-08 2005-12-08 Process for the production of an intermediate of (dextro- and levo)- cetirizine
PCT/HU2006/000108 WO2007066162A1 (en) 2005-12-08 2006-12-08 Process for the preparation of a pharmaceutical intermediate

Publications (2)

Publication Number Publication Date
EA200801505A1 true EA200801505A1 (ru) 2008-10-30
EA014530B1 EA014530B1 (ru) 2010-12-30

Family

ID=89986438

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801505A EA014530B1 (ru) 2005-12-08 2006-12-08 Способ получения фармацевтического промежуточного соединения

Country Status (11)

Country Link
US (1) US20090018337A1 (ru)
EP (1) EP1971585B1 (ru)
JP (1) JP2009518378A (ru)
CN (1) CN101360727A (ru)
AT (1) ATE501131T1 (ru)
DE (1) DE602006020624D1 (ru)
EA (1) EA014530B1 (ru)
HU (1) HU227325B1 (ru)
NO (1) NO20083064L (ru)
UA (1) UA92770C2 (ru)
WO (1) WO2007066162A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7880761B2 (en) 2005-07-20 2011-02-01 Lab Partners Associates, Inc. Wireless photographic communication system and method
EP2162792A4 (en) 2007-05-29 2011-08-24 Lab Partners Associates Inc SYSTEM AND METHOD FOR MAINTAINING FLASH CONTACT COMMUNICATIONS BETWEEN A CAMERA AND A WIRELESS DEVICE
US20110230496A1 (en) * 2007-08-15 2011-09-22 Chemagis Ltd. Novel process for preparing highly pure levocetirizine and salts thereof
CN103044355A (zh) * 2011-10-13 2013-04-17 湖南九典制药有限公司 合成左西替利嗪的关键中间体及其制备方法
CN110988163B (zh) * 2019-11-29 2022-04-19 重庆华邦胜凯制药有限公司 一种hplc法分离测定盐酸左西替利嗪及其基因毒性杂质e的方法
CN111205247B (zh) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 左旋西替利嗪的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154078C (da) * 1981-02-06 1989-05-22 Ucb Sa Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
US20030064995A1 (en) * 2001-10-03 2003-04-03 Merck Patent Gmbh Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
EP1233954B1 (en) * 1999-11-30 2004-10-20 Egis Gyogyszergyar Rt. A process for the preparation of 2- 4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy acetic acid and novel intermediates therefor

Also Published As

Publication number Publication date
HU0501138D0 (en) 2006-02-28
EA014530B1 (ru) 2010-12-30
EP1971585A1 (en) 2008-09-24
UA92770C2 (ru) 2010-12-10
US20090018337A1 (en) 2009-01-15
JP2009518378A (ja) 2009-05-07
WO2007066162A1 (en) 2007-06-14
NO20083064L (no) 2008-07-08
EP1971585B1 (en) 2011-03-09
DE602006020624D1 (de) 2011-04-21
HUP0501138A2 (en) 2007-08-28
HU227325B1 (en) 2011-03-28
CN101360727A (zh) 2009-02-04
ATE501131T1 (de) 2011-03-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU