DE602006020624D1 - Verfahren zur herstellung eines pharmazeutischen zwischenprodukts - Google Patents
Verfahren zur herstellung eines pharmazeutischen zwischenproduktsInfo
- Publication number
- DE602006020624D1 DE602006020624D1 DE602006020624T DE602006020624T DE602006020624D1 DE 602006020624 D1 DE602006020624 D1 DE 602006020624D1 DE 602006020624 T DE602006020624 T DE 602006020624T DE 602006020624 T DE602006020624 T DE 602006020624T DE 602006020624 D1 DE602006020624 D1 DE 602006020624D1
- Authority
- DE
- Germany
- Prior art keywords
- preparing
- intermediate product
- pharmaceutical intermediate
- enantiomers
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012450 pharmaceutical intermediate Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000047 product Substances 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- LCUYPSMMXOBVHQ-UHFFFAOYSA-N 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]-n,n-dimethylacetamide Chemical compound C1CN(CCOCC(=O)N(C)C)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 LCUYPSMMXOBVHQ-UHFFFAOYSA-N 0.000 abstract 1
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 abstract 1
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229960001803 cetirizine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960001508 levocetirizine Drugs 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0501138A HU227325B1 (en) | 2005-12-08 | 2005-12-08 | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
| PCT/HU2006/000108 WO2007066162A1 (en) | 2005-12-08 | 2006-12-08 | Process for the preparation of a pharmaceutical intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006020624D1 true DE602006020624D1 (de) | 2011-04-21 |
Family
ID=89986438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006020624T Active DE602006020624D1 (de) | 2005-12-08 | 2006-12-08 | Verfahren zur herstellung eines pharmazeutischen zwischenprodukts |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090018337A1 (de) |
| EP (1) | EP1971585B1 (de) |
| JP (1) | JP2009518378A (de) |
| CN (1) | CN101360727A (de) |
| AT (1) | ATE501131T1 (de) |
| DE (1) | DE602006020624D1 (de) |
| EA (1) | EA014530B1 (de) |
| HU (1) | HU227325B1 (de) |
| NO (1) | NO20083064L (de) |
| UA (1) | UA92770C2 (de) |
| WO (1) | WO2007066162A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2616030A1 (en) | 2005-07-20 | 2007-01-25 | Lab Partners Associates, Inc. | Wireless photographic communication system and method |
| US7783188B2 (en) | 2007-05-29 | 2010-08-24 | Lab Partners Associates, Inc. | System and method for maintaining hot shoe communications between a camera and a wireless device |
| EP2175856A4 (de) * | 2007-08-15 | 2011-08-24 | Chemagis Ltd | Neues verfahren für die herstellung von hochreinem levocetirizin und salzen daraus |
| CN103044355A (zh) * | 2011-10-13 | 2013-04-17 | 湖南九典制药有限公司 | 合成左西替利嗪的关键中间体及其制备方法 |
| CN110988163B (zh) * | 2019-11-29 | 2022-04-19 | 重庆华邦胜凯制药有限公司 | 一种hplc法分离测定盐酸左西替利嗪及其基因毒性杂质e的方法 |
| CN111205247B (zh) * | 2020-04-22 | 2020-08-14 | 湖南九典宏阳制药有限公司 | 左旋西替利嗪的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO155805C (no) * | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
| GB8827391D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| US20030064995A1 (en) * | 2001-10-03 | 2003-04-03 | Merck Patent Gmbh | Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
| US6908999B2 (en) * | 1999-11-30 | 2005-06-21 | Egis Gyogyszergyar Rt. | Process for the preparation of {2-[4-α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor |
-
2005
- 2005-12-08 HU HU0501138A patent/HU227325B1/hu not_active IP Right Cessation
-
2006
- 2006-08-12 UA UAA200808850A patent/UA92770C2/ru unknown
- 2006-12-08 EP EP06842191A patent/EP1971585B1/de active Active
- 2006-12-08 WO PCT/HU2006/000108 patent/WO2007066162A1/en active Application Filing
- 2006-12-08 JP JP2008543922A patent/JP2009518378A/ja not_active Withdrawn
- 2006-12-08 US US12/096,630 patent/US20090018337A1/en not_active Abandoned
- 2006-12-08 AT AT06842191T patent/ATE501131T1/de not_active IP Right Cessation
- 2006-12-08 DE DE602006020624T patent/DE602006020624D1/de active Active
- 2006-12-08 CN CNA2006800455299A patent/CN101360727A/zh active Pending
- 2006-12-08 EA EA200801505A patent/EA014530B1/ru not_active IP Right Cessation
-
2008
- 2008-07-08 NO NO20083064A patent/NO20083064L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1971585B1 (de) | 2011-03-09 |
| WO2007066162A1 (en) | 2007-06-14 |
| US20090018337A1 (en) | 2009-01-15 |
| EA014530B1 (ru) | 2010-12-30 |
| HUP0501138A2 (en) | 2007-08-28 |
| HU227325B1 (en) | 2011-03-28 |
| NO20083064L (no) | 2008-07-08 |
| ATE501131T1 (de) | 2011-03-15 |
| EA200801505A1 (ru) | 2008-10-30 |
| UA92770C2 (ru) | 2010-12-10 |
| HU0501138D0 (en) | 2006-02-28 |
| EP1971585A1 (de) | 2008-09-24 |
| JP2009518378A (ja) | 2009-05-07 |
| CN101360727A (zh) | 2009-02-04 |
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