WO2008139492A3 - A process for the preparation of highly pure ranolazine base - Google Patents

A process for the preparation of highly pure ranolazine base Download PDF

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Publication number
WO2008139492A3
WO2008139492A3 PCT/IN2008/000289 IN2008000289W WO2008139492A3 WO 2008139492 A3 WO2008139492 A3 WO 2008139492A3 IN 2008000289 W IN2008000289 W IN 2008000289W WO 2008139492 A3 WO2008139492 A3 WO 2008139492A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
highly pure
ranolazine base
pure ranolazine
base
Prior art date
Application number
PCT/IN2008/000289
Other languages
French (fr)
Other versions
WO2008139492A2 (en
Inventor
Amala Kishan Kompella
Kali Satya Bhujanga Rao Adibhatla
Chowdary Nannapaneni Venkaiah
Original Assignee
Natco Pharma Ltd
Amala Kishan Kompella
Adibhatla Kali Satya Bhujanga
Chowdary Nannapaneni Venkaiah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd, Amala Kishan Kompella, Adibhatla Kali Satya Bhujanga, Chowdary Nannapaneni Venkaiah filed Critical Natco Pharma Ltd
Publication of WO2008139492A2 publication Critical patent/WO2008139492A2/en
Publication of WO2008139492A3 publication Critical patent/WO2008139492A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved and novel process for the preparation of highly pure (>99.8) N-(2,6-Dimethyl phenyl)-4-[2-hydroxy-3-(2-methoxy phenoxy) propyl]-1-piperazine acetamide (Ranolazine) of formula (I) and its pharmaceutically acceptable salts process for preparation thereof.
PCT/IN2008/000289 2007-05-15 2008-05-09 A process for the preparation of highly pure ranolazine base WO2008139492A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1022CH2007 2007-05-15
IN1022/CHE/2007 2007-05-15

Publications (2)

Publication Number Publication Date
WO2008139492A2 WO2008139492A2 (en) 2008-11-20
WO2008139492A3 true WO2008139492A3 (en) 2009-03-12

Family

ID=40002739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000289 WO2008139492A2 (en) 2007-05-15 2008-05-09 A process for the preparation of highly pure ranolazine base

Country Status (1)

Country Link
WO (1) WO2008139492A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110223213A1 (en) * 2008-10-15 2011-09-15 Actavis Group Ptc Ehf Highly pure ranolazine or a pharmaceutically acceptable salt thereof
WO2010097805A1 (en) 2009-02-24 2010-09-02 Lupin Limited A process for the preparation of ranolazine
WO2010136522A2 (en) * 2009-05-27 2010-12-02 Medichem S.A. A piperazine derivative free, or essentially free, of potential genotoxicity, and a process for preparing the same
CN102295622A (en) 2010-06-25 2011-12-28 上海冠杰生物医药科技有限公司 Preparation method of ranolazine
EP3782992A1 (en) 2015-03-10 2021-02-24 Unichem Laboratories Limited Novel process for the preparation of ranolazine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126449A1 (en) * 1983-05-18 1984-11-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry
EP0483932A1 (en) * 1990-10-31 1992-05-06 Richter Gedeon Vegyeszeti Gyar R.T. Process for the preparation of piperazine derivatives
WO2006008753A1 (en) * 2004-07-19 2006-01-26 Unichem Laboratories Limited Crystalline and amorphous form of ranolazine and the process for manufacturing them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126449A1 (en) * 1983-05-18 1984-11-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry
EP0483932A1 (en) * 1990-10-31 1992-05-06 Richter Gedeon Vegyeszeti Gyar R.T. Process for the preparation of piperazine derivatives
WO2006008753A1 (en) * 2004-07-19 2006-01-26 Unichem Laboratories Limited Crystalline and amorphous form of ranolazine and the process for manufacturing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
QIN B ET AL: "NMR study on (+/-)-1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-d imethylphenyl)aminoc arbonylmethyl]piperazine dihydrochloride salt", SPECTROCHIMICA ACTA. PART A: MOLECULAR AND BIOMOLECULARSPECTROSCOPY, ELSEVIER, AMSTERDAM, NL, vol. 61, no. 4, 1 February 2005 (2005-02-01), pages 665 - 671, XP004710741, ISSN: 1386-1425 *

Also Published As

Publication number Publication date
WO2008139492A2 (en) 2008-11-20

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