WO2009106599A3 - Substituted piperidines as therapeutic compounds - Google Patents

Substituted piperidines as therapeutic compounds Download PDF

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Publication number
WO2009106599A3
WO2009106599A3 PCT/EP2009/052335 EP2009052335W WO2009106599A3 WO 2009106599 A3 WO2009106599 A3 WO 2009106599A3 EP 2009052335 W EP2009052335 W EP 2009052335W WO 2009106599 A3 WO2009106599 A3 WO 2009106599A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic compounds
substituted piperidines
compounds
piperidines
substituted
Prior art date
Application number
PCT/EP2009/052335
Other languages
French (fr)
Other versions
WO2009106599A2 (en
Inventor
Peter Herold
Robert Mah
Stefan Stutz
Vincenzo Tschinke
Isabelle Lyothier
Stjepan Jelakovic
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of WO2009106599A2 publication Critical patent/WO2009106599A2/en
Publication of WO2009106599A3 publication Critical patent/WO2009106599A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Use of compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R, R1 and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin Il and/or HIV protease inhibitors.
PCT/EP2009/052335 2008-02-29 2009-02-27 Substituted piperidines as therapeutic compounds WO2009106599A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08152186 2008-02-29
EP08152186.6 2008-02-29

Publications (2)

Publication Number Publication Date
WO2009106599A2 WO2009106599A2 (en) 2009-09-03
WO2009106599A3 true WO2009106599A3 (en) 2009-12-03

Family

ID=40852854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/052335 WO2009106599A2 (en) 2008-02-29 2009-02-27 Substituted piperidines as therapeutic compounds

Country Status (1)

Country Link
WO (1) WO2009106599A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012068560A2 (en) * 2010-11-18 2012-05-24 Jenrin Discovery 4-quinolinemethanols as anti-malarial agents
CN112500338A (en) 2013-03-15 2021-03-16 全球血液疗法股份有限公司 Compounds and their use for modulating hemoglobin
WO2015009731A2 (en) * 2013-07-15 2015-01-22 The Regents Of The University Of California Azacyclic constrained analogs of fty720
EA202092627A1 (en) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION
JP6853539B2 (en) 2015-09-24 2021-03-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ Synthetic sphingolipid-like molecules, drugs, methods of synthesizing them, and methods of treatment
AU2020412429A1 (en) 2019-12-27 2022-08-18 Lupin Limited Substituted tricyclic compounds

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009311A1 (en) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
WO2002024649A1 (en) * 2000-09-25 2002-03-28 Actelion Pharmaceuticals Ltd Substituted amino-aza-cycloalkanes useful against malaria
WO2002076440A2 (en) * 2001-03-23 2002-10-03 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease with piperidin derivates
WO2005061457A1 (en) * 2003-10-01 2005-07-07 Speedel Experimenta Ag Organic compounds
WO2005070870A2 (en) * 2004-01-23 2005-08-04 Speedel Experimenta Ag Amino alcohol derivatives and their use as renin inhibitors
WO2005108391A1 (en) * 2004-04-22 2005-11-17 Eli Lilly And Company Amides as bace inhibitors
WO2006005741A2 (en) * 2004-07-09 2006-01-19 Speedel Experimenta Ag Piperdine derivatives as renin inhibitors
EP1707202A1 (en) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organic compounds
EP1745776A1 (en) * 2005-07-20 2007-01-24 Speedel Experimenta AG Aminoalcohols as therapeutic compounds
WO2007010390A1 (en) * 2005-07-22 2007-01-25 Pfizer Japan Inc. Indazolecarboxamide derivatives as 5ht4 receptor agonists
EP1816122A2 (en) * 2006-01-19 2007-08-08 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
WO2007141318A1 (en) * 2006-06-08 2007-12-13 Speedel Experimenta Ag 2,5-disubstituted piperidines

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009311A1 (en) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
WO2002024649A1 (en) * 2000-09-25 2002-03-28 Actelion Pharmaceuticals Ltd Substituted amino-aza-cycloalkanes useful against malaria
WO2002076440A2 (en) * 2001-03-23 2002-10-03 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease with piperidin derivates
WO2005061457A1 (en) * 2003-10-01 2005-07-07 Speedel Experimenta Ag Organic compounds
WO2005070870A2 (en) * 2004-01-23 2005-08-04 Speedel Experimenta Ag Amino alcohol derivatives and their use as renin inhibitors
WO2005108391A1 (en) * 2004-04-22 2005-11-17 Eli Lilly And Company Amides as bace inhibitors
WO2006005741A2 (en) * 2004-07-09 2006-01-19 Speedel Experimenta Ag Piperdine derivatives as renin inhibitors
EP1707202A1 (en) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organic compounds
EP1745776A1 (en) * 2005-07-20 2007-01-24 Speedel Experimenta AG Aminoalcohols as therapeutic compounds
WO2007010390A1 (en) * 2005-07-22 2007-01-25 Pfizer Japan Inc. Indazolecarboxamide derivatives as 5ht4 receptor agonists
EP1816122A2 (en) * 2006-01-19 2007-08-08 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
WO2007141318A1 (en) * 2006-06-08 2007-12-13 Speedel Experimenta Ag 2,5-disubstituted piperidines

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AMOUYEL P ET AL: "The Renin Angiotensin System and Alzheimer's Disease", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 903, 1 January 2000 (2000-01-01), pages 437 - 441, XP002402224 *
DASH C ET AL: "Aspartic Peptidase Inhibitors: Implications in Drug Development", CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, CRC PRESS, BOCA RATON, FL, US, vol. 38, no. 2, 1 January 2003 (2003-01-01), pages 89 - 119, XP002472134, ISSN: 1040-9238 *
ECKSTEIN J W: "Malarial proteinases: A review of the recent patent literature", IDRUGS, CURRENT DRUGS LTD, GB, vol. 5, no. 4, 1 January 2002 (2002-01-01), pages 342 - 348, XP002407307, ISSN: 1369-7056 *
GULLER R ET AL: "Piperidine-renin inhibitors compounds with improved physicochemical properties", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 9, no. 10, 17 May 1999 (1999-05-17), pages 1403 - 1408, XP004164901, ISSN: 0960-894X *
SILVA AM ET AL: "Structural analysis of plasmepsin II. A comparison with human aspartic proteases", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRINGER, US, vol. 436, 1 January 1998 (1998-01-01), pages 363 - 373, XP009101605, ISSN: 0065-2598 *

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