UA92770C2 - СПОСОБ ПОЛУЧЕНИЯ {2-[4-(а-ФЕНИЛ-п-ХЛОРБЕНЗИЛ)-ПИПЕРАЗИН-1-ИЛ]-ЭТОКСИ}-УКСУСНОЙ КИСЛОТЫ N,N-ДИМЕТИЛАМИДА ИЛИ ЕГО ЭНАНТИОМЕРОВ - Google Patents
СПОСОБ ПОЛУЧЕНИЯ {2-[4-(а-ФЕНИЛ-п-ХЛОРБЕНЗИЛ)-ПИПЕРАЗИН-1-ИЛ]-ЭТОКСИ}-УКСУСНОЙ КИСЛОТЫ N,N-ДИМЕТИЛАМИДА ИЛИ ЕГО ЭНАНТИОМЕРОВInfo
- Publication number
- UA92770C2 UA92770C2 UAA200808850A UAA200808850A UA92770C2 UA 92770 C2 UA92770 C2 UA 92770C2 UA A200808850 A UAA200808850 A UA A200808850A UA A200808850 A UAA200808850 A UA A200808850A UA 92770 C2 UA92770 C2 UA 92770C2
- Authority
- UA
- Ukraine
- Prior art keywords
- enantiomers
- dimethylamide
- chlorobenzyl
- piperazin
- ethoxy
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 3
- LCUYPSMMXOBVHQ-UHFFFAOYSA-N 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]-n,n-dimethylacetamide Chemical compound C1CN(CCOCC(=O)N(C)C)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 LCUYPSMMXOBVHQ-UHFFFAOYSA-N 0.000 abstract 1
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 abstract 1
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229960001803 cetirizine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960001508 levocetirizine Drugs 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0501138A HU227325B1 (en) | 2005-12-08 | 2005-12-08 | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA92770C2 true UA92770C2 (ru) | 2010-12-10 |
Family
ID=89986438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200808850A UA92770C2 (ru) | 2005-12-08 | 2006-08-12 | СПОСОБ ПОЛУЧЕНИЯ {2-[4-(а-ФЕНИЛ-п-ХЛОРБЕНЗИЛ)-ПИПЕРАЗИН-1-ИЛ]-ЭТОКСИ}-УКСУСНОЙ КИСЛОТЫ N,N-ДИМЕТИЛАМИДА ИЛИ ЕГО ЭНАНТИОМЕРОВ |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090018337A1 (ru) |
| EP (1) | EP1971585B1 (ru) |
| JP (1) | JP2009518378A (ru) |
| CN (1) | CN101360727A (ru) |
| AT (1) | ATE501131T1 (ru) |
| DE (1) | DE602006020624D1 (ru) |
| EA (1) | EA014530B1 (ru) |
| HU (1) | HU227325B1 (ru) |
| NO (1) | NO20083064L (ru) |
| UA (1) | UA92770C2 (ru) |
| WO (1) | WO2007066162A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7880761B2 (en) | 2005-07-20 | 2011-02-01 | Lab Partners Associates, Inc. | Wireless photographic communication system and method |
| EP2162792A4 (en) | 2007-05-29 | 2011-08-24 | Lab Partners Associates Inc | SYSTEM AND METHOD FOR MAINTAINING FLASH CONTACT COMMUNICATIONS BETWEEN A CAMERA AND A WIRELESS DEVICE |
| US20110230496A1 (en) * | 2007-08-15 | 2011-09-22 | Chemagis Ltd. | Novel process for preparing highly pure levocetirizine and salts thereof |
| CN103044355A (zh) * | 2011-10-13 | 2013-04-17 | 湖南九典制药有限公司 | 合成左西替利嗪的关键中间体及其制备方法 |
| CN110988163B (zh) * | 2019-11-29 | 2022-04-19 | 重庆华邦胜凯制药有限公司 | 一种hplc法分离测定盐酸左西替利嗪及其基因毒性杂质e的方法 |
| CN111205247B (zh) * | 2020-04-22 | 2020-08-14 | 湖南九典宏阳制药有限公司 | 左旋西替利嗪的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154078C (da) * | 1981-02-06 | 1989-05-22 | Ucb Sa | Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf |
| GB8827391D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| US20030064995A1 (en) * | 2001-10-03 | 2003-04-03 | Merck Patent Gmbh | Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
| EP1233954B1 (en) * | 1999-11-30 | 2004-10-20 | Egis Gyogyszergyar Rt. | A process for the preparation of 2- 4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy acetic acid and novel intermediates therefor |
-
2005
- 2005-12-08 HU HU0501138A patent/HU227325B1/hu not_active IP Right Cessation
-
2006
- 2006-08-12 UA UAA200808850A patent/UA92770C2/ru unknown
- 2006-12-08 CN CNA2006800455299A patent/CN101360727A/zh active Pending
- 2006-12-08 EP EP06842191A patent/EP1971585B1/en active Active
- 2006-12-08 DE DE602006020624T patent/DE602006020624D1/de active Active
- 2006-12-08 JP JP2008543922A patent/JP2009518378A/ja not_active Withdrawn
- 2006-12-08 AT AT06842191T patent/ATE501131T1/de not_active IP Right Cessation
- 2006-12-08 EA EA200801505A patent/EA014530B1/ru not_active IP Right Cessation
- 2006-12-08 WO PCT/HU2006/000108 patent/WO2007066162A1/en active Application Filing
- 2006-12-08 US US12/096,630 patent/US20090018337A1/en not_active Abandoned
-
2008
- 2008-07-08 NO NO20083064A patent/NO20083064L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU0501138D0 (en) | 2006-02-28 |
| EA014530B1 (ru) | 2010-12-30 |
| EP1971585A1 (en) | 2008-09-24 |
| US20090018337A1 (en) | 2009-01-15 |
| JP2009518378A (ja) | 2009-05-07 |
| WO2007066162A1 (en) | 2007-06-14 |
| NO20083064L (no) | 2008-07-08 |
| EP1971585B1 (en) | 2011-03-09 |
| DE602006020624D1 (de) | 2011-04-21 |
| HUP0501138A2 (en) | 2007-08-28 |
| HU227325B1 (en) | 2011-03-28 |
| CN101360727A (zh) | 2009-02-04 |
| EA200801505A1 (ru) | 2008-10-30 |
| ATE501131T1 (de) | 2011-03-15 |
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