NO20083064L - Fremgangsmate for fremstilling av et farmasoytisk mellomprodukt - Google Patents
Fremgangsmate for fremstilling av et farmasoytisk mellomproduktInfo
- Publication number
- NO20083064L NO20083064L NO20083064A NO20083064A NO20083064L NO 20083064 L NO20083064 L NO 20083064L NO 20083064 A NO20083064 A NO 20083064A NO 20083064 A NO20083064 A NO 20083064A NO 20083064 L NO20083064 L NO 20083064L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- enantiomers
- formula
- pharmaceutical intermediate
- levocetirizine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000012450 pharmaceutical intermediate Substances 0.000 title abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 abstract 1
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 abstract 1
- 206010039897 Sedation Diseases 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229960001803 cetirizine Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960001508 levocetirizine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Abstract
Fremgangsmåte for fremstilling av {2-[4-(a-fenyl-/?-klorbenzyl)-piperazin-l-yl]-etoksy}-eddiksyre-A^7V-dimetylamid av formel (I) og enantiomerer derav. Forbindelsen av formel (Kl) eller enantiomerer derav er viktige farmasøytiske mellomprodukter egnet for direkte omdannelse til ikke-sedasjonsgivende farmasøytisk aktive ingredienser av antihistamintypen cetirizin og levocetirizin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0501138A HU227325B1 (en) | 2005-12-08 | 2005-12-08 | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
PCT/HU2006/000108 WO2007066162A1 (en) | 2005-12-08 | 2006-12-08 | Process for the preparation of a pharmaceutical intermediate |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20083064L true NO20083064L (no) | 2008-07-08 |
Family
ID=89986438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20083064A NO20083064L (no) | 2005-12-08 | 2008-07-08 | Fremgangsmate for fremstilling av et farmasoytisk mellomprodukt |
Country Status (11)
Country | Link |
---|---|
US (1) | US20090018337A1 (no) |
EP (1) | EP1971585B1 (no) |
JP (1) | JP2009518378A (no) |
CN (1) | CN101360727A (no) |
AT (1) | ATE501131T1 (no) |
DE (1) | DE602006020624D1 (no) |
EA (1) | EA014530B1 (no) |
HU (1) | HU227325B1 (no) |
NO (1) | NO20083064L (no) |
UA (1) | UA92770C2 (no) |
WO (1) | WO2007066162A1 (no) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2616030A1 (en) | 2005-07-20 | 2007-01-25 | Lab Partners Associates, Inc. | Wireless photographic communication system and method |
EP2162792A4 (en) | 2007-05-29 | 2011-08-24 | Lab Partners Associates Inc | SYSTEM AND METHOD FOR MAINTAINING FLASH CONTACT COMMUNICATIONS BETWEEN A CAMERA AND A WIRELESS DEVICE |
EP2175856A4 (en) * | 2007-08-15 | 2011-08-24 | Chemagis Ltd | NOVEL PROCESS FOR THE PREPARATION OF HIGH-PURITY LEVOCETRIXIN AND ITS SALTS |
CN103044355A (zh) * | 2011-10-13 | 2013-04-17 | 湖南九典制药有限公司 | 合成左西替利嗪的关键中间体及其制备方法 |
CN110988163B (zh) * | 2019-11-29 | 2022-04-19 | 重庆华邦胜凯制药有限公司 | 一种hplc法分离测定盐酸左西替利嗪及其基因毒性杂质e的方法 |
CN111205247B (zh) * | 2020-04-22 | 2020-08-14 | 湖南九典宏阳制药有限公司 | 左旋西替利嗪的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK154078C (da) * | 1981-02-06 | 1989-05-22 | Ucb Sa | Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf |
GB8827391D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
US20030064995A1 (en) * | 2001-10-03 | 2003-04-03 | Merck Patent Gmbh | Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands |
IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
RU2248974C2 (ru) * | 1999-11-30 | 2005-03-27 | Эгиш Дьёдьсердьяр Рт. | Способ получения {2-[4-(альфа-фенил-п-хлорбензил)пиперазин-1-ил]-этокси}-уксусной кислоты и новые промежуточные соединения |
-
2005
- 2005-12-08 HU HU0501138A patent/HU227325B1/hu not_active IP Right Cessation
-
2006
- 2006-08-12 UA UAA200808850A patent/UA92770C2/ru unknown
- 2006-12-08 DE DE602006020624T patent/DE602006020624D1/de active Active
- 2006-12-08 US US12/096,630 patent/US20090018337A1/en not_active Abandoned
- 2006-12-08 AT AT06842191T patent/ATE501131T1/de not_active IP Right Cessation
- 2006-12-08 WO PCT/HU2006/000108 patent/WO2007066162A1/en active Application Filing
- 2006-12-08 JP JP2008543922A patent/JP2009518378A/ja not_active Withdrawn
- 2006-12-08 EA EA200801505A patent/EA014530B1/ru not_active IP Right Cessation
- 2006-12-08 CN CNA2006800455299A patent/CN101360727A/zh active Pending
- 2006-12-08 EP EP06842191A patent/EP1971585B1/en active Active
-
2008
- 2008-07-08 NO NO20083064A patent/NO20083064L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1971585A1 (en) | 2008-09-24 |
DE602006020624D1 (de) | 2011-04-21 |
EA200801505A1 (ru) | 2008-10-30 |
HU0501138D0 (en) | 2006-02-28 |
ATE501131T1 (de) | 2011-03-15 |
JP2009518378A (ja) | 2009-05-07 |
WO2007066162A1 (en) | 2007-06-14 |
EP1971585B1 (en) | 2011-03-09 |
HU227325B1 (en) | 2011-03-28 |
HUP0501138A2 (en) | 2007-08-28 |
CN101360727A (zh) | 2009-02-04 |
EA014530B1 (ru) | 2010-12-30 |
UA92770C2 (ru) | 2010-12-10 |
US20090018337A1 (en) | 2009-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |