ATE501131T1 - Verfahren zur herstellung eines pharmazeutischen zwischenprodukts - Google Patents
Verfahren zur herstellung eines pharmazeutischen zwischenproduktsInfo
- Publication number
- ATE501131T1 ATE501131T1 AT06842191T AT06842191T ATE501131T1 AT E501131 T1 ATE501131 T1 AT E501131T1 AT 06842191 T AT06842191 T AT 06842191T AT 06842191 T AT06842191 T AT 06842191T AT E501131 T1 ATE501131 T1 AT E501131T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- intermediate product
- pharmaceutical intermediate
- enantiomers
- formula
- Prior art date
Links
- 239000012450 pharmaceutical intermediate Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000047 product Substances 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- LCUYPSMMXOBVHQ-UHFFFAOYSA-N 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]-n,n-dimethylacetamide Chemical compound C1CN(CCOCC(=O)N(C)C)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 LCUYPSMMXOBVHQ-UHFFFAOYSA-N 0.000 abstract 1
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 abstract 1
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229960001803 cetirizine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960001508 levocetirizine Drugs 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0501138A HU227325B1 (en) | 2005-12-08 | 2005-12-08 | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
| PCT/HU2006/000108 WO2007066162A1 (en) | 2005-12-08 | 2006-12-08 | Process for the preparation of a pharmaceutical intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501131T1 true ATE501131T1 (de) | 2011-03-15 |
Family
ID=89986438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06842191T ATE501131T1 (de) | 2005-12-08 | 2006-12-08 | Verfahren zur herstellung eines pharmazeutischen zwischenprodukts |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090018337A1 (de) |
| EP (1) | EP1971585B1 (de) |
| JP (1) | JP2009518378A (de) |
| CN (1) | CN101360727A (de) |
| AT (1) | ATE501131T1 (de) |
| DE (1) | DE602006020624D1 (de) |
| EA (1) | EA014530B1 (de) |
| HU (1) | HU227325B1 (de) |
| NO (1) | NO20083064L (de) |
| UA (1) | UA92770C2 (de) |
| WO (1) | WO2007066162A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007012041A2 (en) | 2005-07-20 | 2007-01-25 | Lab Partners Associates, Inc. | Wireless photographic communication system and method |
| JP5220104B2 (ja) | 2007-05-29 | 2013-06-26 | ラブ・パートナーズ・アソシエイツ・インコーポレーテッド | カメラとワイヤレスデバイスとの間のホットシュー通信を維持するためのシステムおよび方法 |
| US20110230496A1 (en) * | 2007-08-15 | 2011-09-22 | Chemagis Ltd. | Novel process for preparing highly pure levocetirizine and salts thereof |
| CN103044355A (zh) * | 2011-10-13 | 2013-04-17 | 湖南九典制药有限公司 | 合成左西替利嗪的关键中间体及其制备方法 |
| CN110988163B (zh) * | 2019-11-29 | 2022-04-19 | 重庆华邦胜凯制药有限公司 | 一种hplc法分离测定盐酸左西替利嗪及其基因毒性杂质e的方法 |
| CN111205247B (zh) * | 2020-04-22 | 2020-08-14 | 湖南九典宏阳制药有限公司 | 左旋西替利嗪的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO155805C (no) * | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
| GB8827391D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| US20030064995A1 (en) * | 2001-10-03 | 2003-04-03 | Merck Patent Gmbh | Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
| ATE280165T1 (de) * | 1999-11-30 | 2004-11-15 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung von 2-(4-(alpha-phenyl- p-chlorobenzyl)piperazin-1-yl)ethoxyessigsäure und zwischenprodukte dafür |
-
2005
- 2005-12-08 HU HU0501138A patent/HU227325B1/hu not_active IP Right Cessation
-
2006
- 2006-08-12 UA UAA200808850A patent/UA92770C2/ru unknown
- 2006-12-08 EP EP06842191A patent/EP1971585B1/de active Active
- 2006-12-08 EA EA200801505A patent/EA014530B1/ru not_active IP Right Cessation
- 2006-12-08 AT AT06842191T patent/ATE501131T1/de not_active IP Right Cessation
- 2006-12-08 CN CNA2006800455299A patent/CN101360727A/zh active Pending
- 2006-12-08 US US12/096,630 patent/US20090018337A1/en not_active Abandoned
- 2006-12-08 JP JP2008543922A patent/JP2009518378A/ja not_active Withdrawn
- 2006-12-08 WO PCT/HU2006/000108 patent/WO2007066162A1/en active Application Filing
- 2006-12-08 DE DE602006020624T patent/DE602006020624D1/de active Active
-
2008
- 2008-07-08 NO NO20083064A patent/NO20083064L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101360727A (zh) | 2009-02-04 |
| EA200801505A1 (ru) | 2008-10-30 |
| UA92770C2 (ru) | 2010-12-10 |
| EA014530B1 (ru) | 2010-12-30 |
| WO2007066162A1 (en) | 2007-06-14 |
| NO20083064L (no) | 2008-07-08 |
| EP1971585B1 (de) | 2011-03-09 |
| JP2009518378A (ja) | 2009-05-07 |
| EP1971585A1 (de) | 2008-09-24 |
| DE602006020624D1 (de) | 2011-04-21 |
| HU227325B1 (en) | 2011-03-28 |
| HUP0501138A2 (en) | 2007-08-28 |
| US20090018337A1 (en) | 2009-01-15 |
| HU0501138D0 (en) | 2006-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |