ATE545638T1 - Optisch aktive carbamate, verfahren zu deren herstellung und deren anwendung als pharmazeutische zwischenprodukte - Google Patents

Optisch aktive carbamate, verfahren zu deren herstellung und deren anwendung als pharmazeutische zwischenprodukte

Info

Publication number
ATE545638T1
ATE545638T1 AT06831510T AT06831510T ATE545638T1 AT E545638 T1 ATE545638 T1 AT E545638T1 AT 06831510 T AT06831510 T AT 06831510T AT 06831510 T AT06831510 T AT 06831510T AT E545638 T1 ATE545638 T1 AT E545638T1
Authority
AT
Austria
Prior art keywords
production
optically active
intermediate products
pharmaceutical intermediate
phenylmethyl
Prior art date
Application number
AT06831510T
Other languages
English (en)
Inventor
Tibor Mezei
Enikoe Molnar
Peter Trinka
Ferenc Bartha
Zoltan Katona
Donath Gyoergyi Vereczkeyne
Kalman Nagy
Laszlo Ponga
Gyula Lukacs
Marta Porcs-Makkay
Zsuzsanna Evinger
Gyula Simig
Original Assignee
Egis Gyogyszergyar Nyilvanosan Mukoedoe Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan Mukoedoe Reszvenytarsasag filed Critical Egis Gyogyszergyar Nyilvanosan Mukoedoe Reszvenytarsasag
Application granted granted Critical
Publication of ATE545638T1 publication Critical patent/ATE545638T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT06831510T 2005-12-08 2006-12-08 Optisch aktive carbamate, verfahren zu deren herstellung und deren anwendung als pharmazeutische zwischenprodukte ATE545638T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0501139A HU227074B1 (en) 2005-12-08 2005-12-08 An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate
PCT/HU2006/000109 WO2007066163A2 (en) 2005-12-08 2006-12-08 Optically active carbamates, process for preparation thereof and use thereof as pharmaceutical intermediates

Publications (1)

Publication Number Publication Date
ATE545638T1 true ATE545638T1 (de) 2012-03-15

Family

ID=89986439

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06831510T ATE545638T1 (de) 2005-12-08 2006-12-08 Optisch aktive carbamate, verfahren zu deren herstellung und deren anwendung als pharmazeutische zwischenprodukte

Country Status (10)

Country Link
US (1) US7851627B2 (de)
EP (1) EP1963296B1 (de)
JP (1) JP2009518379A (de)
CN (1) CN101356162A (de)
AT (1) ATE545638T1 (de)
EA (1) EA015801B1 (de)
HU (1) HU227074B1 (de)
NO (1) NO20083068L (de)
UA (1) UA92195C2 (de)
WO (1) WO2007066163A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100928776B1 (ko) * 2007-09-07 2009-11-25 한미약품 주식회사 (ｒ)-1-[(4-클로로페닐)페닐메틸]피페라진 또는 이의 염의제조방법
KR101427100B1 (ko) 2007-10-23 2014-08-08 주식회사 씨트리 광학활성을 갖는 1-[(4-클로로페닐)페닐메틸]-피페라진의제조방법
US7989623B2 (en) * 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
PL2062881T3 (pl) * 2007-11-21 2011-07-29 Synthon Bv Sposób wytwarzania N-(difenylometylo)piperazyn
AU2009254959B2 (en) * 2008-06-02 2014-01-30 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein
WO2010057515A1 (en) * 2008-11-21 2010-05-27 Synthon B.V. Levocetirizine by menthyl intermediate
US20100145049A1 (en) * 2008-11-21 2010-06-10 Jie Zhu Process for making n-(diphenylmethyl)piperazines
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
US8580886B2 (en) 2011-09-20 2013-11-12 Dow Corning Corporation Method for the preparation and use of bis (alkoxysilylorgano)-dicarboxylates
CN104024265B (zh) 2011-12-02 2017-03-01 道康宁公司 酯官能化硅烷及其制备和用途；以及亚胺化合物作为相转移催化剂的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2709169A (en) * 1955-05-24 X c chs
BE508650A (de) *
BE501277A (fr) * 1951-02-15 1952-05-09 H Morren Procede de preparation de 1,4-aralcoyl-piperazines.
IT1140978B (it) * 1980-05-23 1986-10-10 Selvi & C Spa 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
JP2002249487A (ja) * 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。

Also Published As

Publication number Publication date
EA015801B1 (ru) 2011-12-30
WO2007066163A2 (en) 2007-06-14
HU227074B1 (en) 2010-06-28
HU0501139D0 (en) 2006-02-28
UA92195C2 (ru) 2010-10-11
EA200801507A1 (ru) 2008-10-30
US7851627B2 (en) 2010-12-14
EP1963296A2 (de) 2008-09-03
US20090221823A1 (en) 2009-09-03
HUP0501139A2 (en) 2007-08-28
CN101356162A (zh) 2009-01-28
NO20083068L (no) 2008-07-08
WO2007066163A3 (en) 2007-08-02
JP2009518379A (ja) 2009-05-07
EP1963296B1 (de) 2012-02-15

Similar Documents

Publication Publication Date Title
ATE545638T1 (de) Optisch aktive carbamate, verfahren zu deren herstellung und deren anwendung als pharmazeutische zwischenprodukte
DE50307267D1 (de) Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
RU2436776C2 (ru) ДИАРИЛАМИН-СОДЕРЖАЩИЕ СОЕДИНЕНИЯ, КОМПОЗИЦИИ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРОВ с-КIT
RU2418792C2 (ru) Азольные соединения с нейтротерапевтической активностью
RU2424240C2 (ru) Антибактериальные производные пиперидина
NO20161634A1 (no) 3-Z-[1-(4-(N-((4-metyl-piperazin-1-yl)-metylkarbonyl)-N-metyl-amino)-anilino)-1-fenyl-metylen]-6-metoksykarbonyl-2-indolinon, tautomerene, diastereomerene, enantiomerene, blandinger derav og saltene derav, og i kombinasjon med en ytterligere farmakologisk aktiv substans, for anvendelse i forebygging eller behandling av fibrose ved revmatoid artritt
ATE553095T1 (de) Neue imidazolderivate, deren herstellung und deren verwendung als intermediate zur herstellung von arzneimitteln und pestiziden
ATE381559T1 (de) Adamantan- und azabicyclooctan- und - nonanderivate, verfahren zu deren herstellung und deren verwendung als dpp-iv-inhibitoren
AR051965A1 (es) Sales de la n-[2-( { (3r)-1-[trans-4-hidroxi-4-(6- metoxipiridin-3-il)-ciclohexil] pirrolidin-3- il} amino)-2- oxoetil]-3-(trifluormetil) benzamida
DE602004005886D1 (de) Derivate von n-äphenyl(alkylpiperidin-2-yl)methylübenzamid, verfahren zu deren herstellung und deren anwendung in therapeutika
NO20075365L (no) 3,4-substituerte pyrrolidinderivater for behandling av hypertensjon
BRPI0911476A2 (pt) compostos ativadores de glicoquinase de piridazinona, composição farmaceutica, uso dos compostos, método para tratamento de uma enfermidade e/ou distúbio metabólico e processo para a preparação dos compostos
ATE382049T1 (de) Neue 2-benzylaminodihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
ATE373009T1 (de) Verfahren zur vorbereitung von telithromycin
EA200800401A1 (ru) Промежуточное соединение для синтеза фармацевтического средства и способ его получения
NO20062453L (no) Tiozolidinoner, fremstilling og anvendelse derav som legemidler
ECSP045497A (es) "difenilazetidinonas sustituidas con grupos acidos, metodo para su producción, medicamentos que comprenden dichos compuestos y su uso"
RU2010108943A (ru) Новые пиперазинамидные производные
NO20085052L (no) 4-((fluorofenoksyl)fenylmetyl)piperidin metansulfonat: anvendelser, synteseprosess og farmasoytiske sammensetninger
ATE445617T1 (de) Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel
ATE528301T1 (de) Verfahren zur herstellung von substituierten sulfoxidzusammensetzungen
JP2024514366A (ja) 可溶性エポキシドヒドロラーゼ阻害剤としてのピペリジン尿素誘導体
PE20091579A1 (es) Derivados de sulfonamida sustituida
NO20076000L (no) Aminosyrederivater
EA200600760A1 (ru) Новые соединения фенилпиридилпиперазина, способ их получения и фармацевтические композиции, содержащие их