RU2237063C9 - Полусинтетический способ и новые соединения - Google Patents

Полусинтетический способ и новые соединения Download PDF

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Publication number
RU2237063C9
RU2237063C9 RU2001133386/04A RU2001133386A RU2237063C9 RU 2237063 C9 RU2237063 C9 RU 2237063C9 RU 2001133386/04 A RU2001133386/04 A RU 2001133386/04A RU 2001133386 A RU2001133386 A RU 2001133386A RU 2237063 C9 RU2237063 C9 RU 2237063C9
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RU
Russia
Prior art keywords
group
compound
formula
ring
saframycin
Prior art date
Application number
RU2001133386/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2001133386A (ru
RU2237063C2 (ru
Inventor
Кармен КУЭВАС (ES)
Кармен Куэвас
Марта ПЕРЕС (ES)
Марта ПЕРЕС
Андрес ФРАНСЕСЧ (ES)
Андрес ФРАНСЕСЧ
Каролина ФЕРНАНДЕС (ES)
Каролина ФЕРНАНДЕС
Хосе Луис ЧИЧАРРО (ES)
Хосе Луис ЧИЧАРРО
Пилар ГАЛЬЕГО (ES)
Пилар ГАЛЬЕГО
Мари САРСУЭЛО (ES)
Мария САРСУЭЛО
ЛА КАЛЬЕ Фернандо ДЕ (ES)
ЛА КАЛЬЕ Фернандо ДЕ
Игнасио МАНСАНАРЕС (ES)
Игнасио МАНСАНАРЕС
Original Assignee
Фарма Мар, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911345.8A external-priority patent/GB9911345D0/en
Priority claimed from GBGB9918178.6A external-priority patent/GB9918178D0/en
Priority claimed from GBGB9923632.5A external-priority patent/GB9923632D0/en
Priority claimed from GB0001063A external-priority patent/GB0001063D0/en
Application filed by Фарма Мар, С.А. filed Critical Фарма Мар, С.А.
Publication of RU2001133386A publication Critical patent/RU2001133386A/ru
Application granted granted Critical
Publication of RU2237063C2 publication Critical patent/RU2237063C2/ru
Publication of RU2237063C9 publication Critical patent/RU2237063C9/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
RU2001133386/04A 1999-05-14 2000-05-15 Полусинтетический способ и новые соединения RU2237063C9 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB9911345.8A GB9911345D0 (cs) 1999-05-14 1999-05-14
GB9911345.8 1999-05-14
GB9918178.6 1999-08-02
GBGB9918178.6A GB9918178D0 (en) 2000-05-15 1999-08-02 Synthetic methods
GB9923632.5 1999-10-06
GBGB9923632.5A GB9923632D0 (en) 1999-10-06 1999-10-06 Hemisynthetic process towards ecteinascidin and phtalscidin compounds
GB0001063A GB0001063D0 (en) 2000-01-17 2000-01-17 Hemisynthetic process towards ecteinascidin and phtalascidin
GB0001063.7 2000-01-17
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof

Publications (3)

Publication Number Publication Date
RU2001133386A RU2001133386A (ru) 2003-06-27
RU2237063C2 RU2237063C2 (ru) 2004-09-27
RU2237063C9 true RU2237063C9 (ru) 2008-10-10

Family

ID=42632476

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001133386/04A RU2237063C9 (ru) 1999-05-14 2000-05-15 Полусинтетический способ и новые соединения

Country Status (29)

Country Link
US (3) US7241892B1 (cs)
EP (1) EP1185536B1 (cs)
JP (1) JP4445136B2 (cs)
KR (1) KR100834601B1 (cs)
CN (3) CN1229382C (cs)
AR (1) AR035842A1 (cs)
AT (1) ATE283273T1 (cs)
AU (2) AU775580B2 (cs)
BG (1) BG65896B1 (cs)
BR (3) BRPI0010559B8 (cs)
CA (2) CA2372058C (cs)
CY (1) CY1108095T1 (cs)
CZ (3) CZ303536B6 (cs)
DE (1) DE60016209T2 (cs)
DK (1) DK1185536T3 (cs)
ES (2) ES2233367T3 (cs)
HU (1) HU230646B1 (cs)
MX (1) MXPA01011631A (cs)
MY (1) MY130271A (cs)
NO (2) NO322016B1 (cs)
NZ (1) NZ515424A (cs)
PL (1) PL226890B1 (cs)
PT (1) PT1185536E (cs)
RU (1) RU2237063C9 (cs)
SI (2) SI1185536T1 (cs)
SK (2) SK287835B6 (cs)
TR (1) TR200103273T2 (cs)
UA (1) UA75333C2 (cs)
WO (3) WO2000069862A2 (cs)

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MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
HU230918B1 (hu) 2000-04-12 2019-03-28 Pharma Mar, S.A. Tumorellenes ekteinaszcidinszármazékok
NZ521808A (en) * 2000-05-15 2004-07-30 Pharma Mar S Synthetic process for the manufacture of an ecteinaschidin compound
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
AU2002239565B2 (en) 2000-11-03 2007-11-15 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
AU2002212499B2 (en) * 2000-11-06 2006-11-02 Pharma Mar, S.A. Compositions for antitumour treatment containing ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
BR0213424A (pt) * 2001-10-19 2004-12-14 Pharma Mar Sa Uso aperfeiçoado de composto antitumoral na terapia contra câncer
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
RS50692B (sr) * 2003-11-13 2010-06-30 Pharma Mar S.A.U. Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (en) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
US20080242670A2 (en) * 2004-09-29 2008-10-02 Pharma Mar S.A., Sociedad Unipersonal Anti-Inflammatory Agents
NZ554765A (en) * 2004-10-26 2010-01-29 Pharma Mar Sa Pegylated Liposomal Doxorubicin In Combination With Ecteinescidin 743
BRPI0517238B1 (pt) * 2004-10-29 2021-11-09 Pharma Mar, S.A. Composições que compreendem ecteinascidina e um dissacarídeo, método para produzir um frasco que contém a referida composição e para preparar uma solução para infusão intravenosa e uso da referida solução
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
KR100712667B1 (ko) 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
GB0708691D0 (en) * 2007-05-04 2007-06-13 Pharma Mar Sa Anticancer treatments a
US20090076017A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched trabectedin
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
AU2009246130A1 (en) * 2008-05-16 2009-11-19 Pharma Mar, S.A. Combination therapy with PM00 104 and another antitumor agent
WO2009138509A1 (en) * 2008-05-16 2009-11-19 Pharma Mar, S.A. Multiple myeloma treatments
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
CN107033164A (zh) * 2010-05-25 2017-08-11 法马马有限公司 制备海鞘素化合物的合成方法
BR122017028568B1 (pt) 2010-11-12 2022-03-03 Pharma Mar, S.A Uso de pm01183, ou um sal farmaceuticamente aceitável do mesmo, em combinação sinérgica com um inibidor mitótico e kit
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN107739387B (zh) * 2017-10-16 2020-01-03 上海皓元生物医药科技有限公司 一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) * 2017-12-13 2021-12-24 浙江中科创越药业有限公司 天然产物Trabectedin的制备
TWI824043B (zh) 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
CN111518110B (zh) * 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN111620792B (zh) * 2019-02-28 2023-01-03 兰州大学 一种n,n-二取代氰基甲酰胺的合成方法
WO2021098992A1 (en) 2019-11-21 2021-05-27 Pharma Mar, S.A. Methods of treating small cell lung cancer with lurbinectedin formulations
CN116217584A (zh) * 2021-12-06 2023-06-06 南通诺泰生物医药技术有限公司 Et743及其中间体的光催化合成方法
IL322039A (en) * 2023-01-17 2025-09-01 Adcytherix Sas The breads of ECTEINASCIDIN and antibodies
WO2025077996A1 (en) 2023-10-09 2025-04-17 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
WO2025233522A1 (en) 2024-05-10 2025-11-13 Pharma Mar, S.A. Synthetic process for an ecteinascidin

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RU96115394A (ru) * 1995-08-02 1998-12-27 Танабе Сейяку Ко., Лтд. Производные камптотецина

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US7524956B2 (en) 2009-04-28
HK1047432A1 (en) 2003-02-21
JP4445136B2 (ja) 2010-04-07
UA75333C2 (uk) 2006-04-17
NZ515424A (en) 2004-06-25
NO328301B1 (no) 2010-01-25
US20080045713A1 (en) 2008-02-21
BRPI0110801B8 (pt) 2021-05-25
SI1287004T1 (sl) 2005-12-31
SK15272002A3 (sk) 2003-06-03
BRPI0010559B8 (pt) 2021-05-25
CY1108095T1 (el) 2014-02-12
AR035842A1 (es) 2004-07-21
BR0110801A (pt) 2003-02-11
CZ303536B6 (cs) 2012-11-21
SK287835B6 (sk) 2011-12-05
CA2406095A1 (en) 2001-11-22
CA2372058C (en) 2010-10-26
CZ20014102A3 (cs) 2002-06-12
ES2231486T3 (es) 2005-05-16
CA2372058A1 (en) 2000-11-23
CN1360588A (zh) 2002-07-24
KR20020021636A (ko) 2002-03-21
PL226890B1 (pl) 2017-09-29
NO20025186D0 (no) 2002-10-29
MY130271A (en) 2007-06-29
NO322016B1 (no) 2006-08-07
AU5649601A (en) 2001-11-26
EP1185536A2 (en) 2002-03-13
ATE283273T1 (de) 2004-12-15
BR0010559A (pt) 2002-07-02
EP1185536B1 (en) 2004-11-24
HU230646B1 (hu) 2017-05-29
CN1211386C (zh) 2005-07-20
WO2001087895A1 (en) 2001-11-22
MXPA01011631A (es) 2002-07-30
BG65896B1 (bg) 2010-04-30
SK287879B6 (sk) 2012-02-03
ES2233367T3 (es) 2005-06-16
BR0110443A (pt) 2003-04-08
KR100834601B1 (ko) 2008-06-02
AU775580B2 (en) 2004-08-05
DE60016209D1 (de) 2004-12-30
PT1185536E (pt) 2005-04-29
CN1229382C (zh) 2005-11-30
BRPI0010559B1 (pt) 2016-08-30
CZ20023746A3 (cs) 2003-04-16
CZ20023751A3 (en) 2004-05-12
SI1185536T1 (en) 2005-06-30
NO20025186L (no) 2003-01-14
US7241892B1 (en) 2007-07-10
NO20015547L (no) 2002-01-14
RU2237063C2 (ru) 2004-09-27
SK16502001A3 (sk) 2002-06-04
BG107301A (bg) 2003-07-31
WO2000069862A3 (en) 2001-03-22
BRPI0110443B1 (pt) 2018-06-26
JP2002544280A (ja) 2002-12-24
WO2000069862A2 (en) 2000-11-23
BRPI0110801B1 (pt) 2018-02-27
BRPI0110443B8 (pt) 2021-05-25
US20040002602A1 (en) 2004-01-01
DK1185536T3 (da) 2005-04-04
PL353002A1 (en) 2003-09-22
CA2406095C (en) 2010-02-16
CZ304966B6 (cs) 2015-02-18
CN1441805A (zh) 2003-09-10
CZ304973B6 (cs) 2015-02-25
AU4597300A (en) 2000-12-05
NO20015547D0 (no) 2001-11-13
HUP0201188A2 (en) 2002-07-29
CN100475822C (zh) 2009-04-08
DE60016209T2 (de) 2005-12-15
TR200103273T2 (tr) 2002-04-22
CN1440414A (zh) 2003-09-03
WO2001087894A1 (en) 2001-11-22

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