DK1185536T3 - Hemisyntesefremgangsmåde og mellemprodukter deraf - Google Patents

Hemisyntesefremgangsmåde og mellemprodukter deraf

Info

Publication number
DK1185536T3
DK1185536T3 DK00927582T DK00927582T DK1185536T3 DK 1185536 T3 DK1185536 T3 DK 1185536T3 DK 00927582 T DK00927582 T DK 00927582T DK 00927582 T DK00927582 T DK 00927582T DK 1185536 T3 DK1185536 T3 DK 1185536T3
Authority
DK
Denmark
Prior art keywords
hemisynthesis
intermediates
hemisynthesis method
Prior art date
Application number
DK00927582T
Other languages
Danish (da)
English (en)
Inventor
Carmen Cuevas
Marta Perez
Andres Francesch
Carolina Fernandez
Jose Luis Chicharro
Pilar Gallego
Maria Zarzuelo
La Calle Fernando De
Ignacio Manzanares
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911345.8A external-priority patent/GB9911345D0/en
Priority claimed from GBGB9918178.6A external-priority patent/GB9918178D0/en
Priority claimed from GBGB9923632.5A external-priority patent/GB9923632D0/en
Priority claimed from GB0001063A external-priority patent/GB0001063D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of DK1185536T3 publication Critical patent/DK1185536T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
DK00927582T 1999-05-14 2000-05-15 Hemisyntesefremgangsmåde og mellemprodukter deraf DK1185536T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9911345.8A GB9911345D0 (cs) 1999-05-14 1999-05-14
GBGB9918178.6A GB9918178D0 (en) 2000-05-15 1999-08-02 Synthetic methods
GBGB9923632.5A GB9923632D0 (en) 1999-10-06 1999-10-06 Hemisynthetic process towards ecteinascidin and phtalscidin compounds
GB0001063A GB0001063D0 (en) 2000-01-17 2000-01-17 Hemisynthetic process towards ecteinascidin and phtalascidin
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof

Publications (1)

Publication Number Publication Date
DK1185536T3 true DK1185536T3 (da) 2005-04-04

Family

ID=42632476

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00927582T DK1185536T3 (da) 1999-05-14 2000-05-15 Hemisyntesefremgangsmåde og mellemprodukter deraf

Country Status (29)

Country Link
US (3) US7241892B1 (cs)
EP (1) EP1185536B1 (cs)
JP (1) JP4445136B2 (cs)
KR (1) KR100834601B1 (cs)
CN (3) CN1229382C (cs)
AR (1) AR035842A1 (cs)
AT (1) ATE283273T1 (cs)
AU (2) AU775580B2 (cs)
BG (1) BG65896B1 (cs)
BR (3) BRPI0010559B8 (cs)
CA (2) CA2372058C (cs)
CY (1) CY1108095T1 (cs)
CZ (3) CZ303536B6 (cs)
DE (1) DE60016209T2 (cs)
DK (1) DK1185536T3 (cs)
ES (2) ES2233367T3 (cs)
HU (1) HU230646B1 (cs)
MX (1) MXPA01011631A (cs)
MY (1) MY130271A (cs)
NO (2) NO322016B1 (cs)
NZ (1) NZ515424A (cs)
PL (1) PL226890B1 (cs)
PT (1) PT1185536E (cs)
RU (1) RU2237063C9 (cs)
SI (2) SI1185536T1 (cs)
SK (2) SK287835B6 (cs)
TR (1) TR200103273T2 (cs)
UA (1) UA75333C2 (cs)
WO (3) WO2000069862A2 (cs)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US6316214B1 (en) 1998-05-11 2001-11-13 The Board Of Trustees Of The University Of Illinois ETM-775 metabolite of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
IL152094A (en) 2000-04-12 2011-10-31 Pharma Mar Sa History of actinacidin and pharmaceutical preparations containing them as anti-cancer substances
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
IL152125A (en) * 2000-05-15 2008-04-13 Pharma Mar Sa Process for the manufacture of ecteinascidin derivatives
AU2002239565B2 (en) 2000-11-03 2007-11-15 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
JP4391083B2 (ja) * 2000-11-06 2009-12-24 ファルマ・マール・ソシエダード・アノニマ 効果的な抗腫瘍治療
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
CN1606449A (zh) * 2001-10-19 2005-04-13 法马马有限公司 抗肿瘤化合物在癌症治疗中的改良用途
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) * 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CA2545054A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
JP2008514688A (ja) * 2004-09-29 2008-05-08 ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル 抗炎症剤としてのエクテイナシジン化合物
KR101287918B1 (ko) * 2004-10-26 2013-07-19 오르토 바이오테크 프로덕츠 엘.피. 엑티나시딘 ７４３과 조합된 페길화된 리포좀 독소루비신
RS50510B (sr) * 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
KR100712667B1 (ko) 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
GB0708691D0 (en) * 2007-05-04 2007-06-13 Pharma Mar Sa Anticancer treatments a
US20090076017A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched trabectedin
EP2201141A1 (en) * 2007-10-19 2010-06-30 Pharma Mar S.A. Prognostic molecular markers for et-743 treatment
EP2303274A1 (en) * 2008-05-16 2011-04-06 Pharma Mar S.A. Multiple myeloma treatments
CN102099025A (zh) * 2008-05-16 2011-06-15 马尔药品公司 Pm00104与另一抗肿瘤剂的联合疗法
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
EP2576569B1 (en) * 2010-05-25 2015-01-14 Pharma Mar S.A. Synthetic process for the manufacture of ecteinascidin compounds and intermediates
ES2719091T3 (es) * 2010-11-12 2019-07-08 Pharma Mar Sa Terapia de combinación con un inhibidor mitótico
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN107739387B (zh) * 2017-10-16 2020-01-03 上海皓元生物医药科技有限公司 一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) * 2017-12-13 2021-12-24 浙江中科创越药业有限公司 天然产物Trabectedin的制备
TWI824043B (zh) 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
CN111518110B (zh) * 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN111620792B (zh) * 2019-02-28 2023-01-03 兰州大学 一种n,n-二取代氰基甲酰胺的合成方法
CN118924688A (zh) 2019-11-21 2024-11-12 法马马有限公司 用鲁比卡丁制剂治疗小细胞肺癌的方法
CN116217584A (zh) * 2021-12-06 2023-06-06 南通诺泰生物医药技术有限公司 Et743及其中间体的光催化合成方法
AU2024210894A1 (en) * 2023-01-17 2025-07-17 Adcytherix Sas Ecteinascidin derivative antibody drug conjugates
WO2025077996A1 (en) 2023-10-09 2025-04-17 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
WO2025233522A1 (en) 2024-05-10 2025-11-13 Pharma Mar, S.A. Synthetic process for an ecteinascidin

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US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
WO1987007610A2 (en) 1986-06-09 1987-12-17 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
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US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
IL138856A0 (en) 1998-04-06 2001-10-31 Univ Illinois Semi-synthetic ecteinascidins
US6316214B1 (en) 1998-05-11 2001-11-13 The Board Of Trustees Of The University Of Illinois ETM-775 metabolite of ecteinascidin 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
JP2003520801A (ja) 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
IL152094A (en) 2000-04-12 2011-10-31 Pharma Mar Sa History of actinacidin and pharmaceutical preparations containing them as anti-cancer substances
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
PL353002A1 (en) 2003-09-22
BRPI0110443B8 (pt) 2021-05-25
CZ303536B6 (cs) 2012-11-21
NZ515424A (en) 2004-06-25
WO2000069862A2 (en) 2000-11-23
ES2231486T3 (es) 2005-05-16
MY130271A (en) 2007-06-29
BRPI0110801B8 (pt) 2021-05-25
SI1287004T1 (sl) 2005-12-31
CZ304973B6 (cs) 2015-02-25
NO20015547L (no) 2002-01-14
SK287879B6 (sk) 2012-02-03
BRPI0010559B8 (pt) 2021-05-25
CY1108095T1 (el) 2014-02-12
HU230646B1 (hu) 2017-05-29
JP2002544280A (ja) 2002-12-24
CN1211386C (zh) 2005-07-20
NO20015547D0 (no) 2001-11-13
NO20025186L (no) 2003-01-14
AU775580B2 (en) 2004-08-05
WO2001087895A1 (en) 2001-11-22
RU2237063C2 (ru) 2004-09-27
JP4445136B2 (ja) 2010-04-07
CZ20023746A3 (cs) 2003-04-16
DE60016209D1 (de) 2004-12-30
BRPI0110443B1 (pt) 2018-06-26
US20080045713A1 (en) 2008-02-21
TR200103273T2 (tr) 2002-04-22
AR035842A1 (es) 2004-07-21
AU4597300A (en) 2000-12-05
BRPI0110801B1 (pt) 2018-02-27
CA2372058A1 (en) 2000-11-23
CN1360588A (zh) 2002-07-24
CN100475822C (zh) 2009-04-08
DE60016209T2 (de) 2005-12-15
KR20020021636A (ko) 2002-03-21
PL226890B1 (pl) 2017-09-29
CA2406095C (en) 2010-02-16
NO328301B1 (no) 2010-01-25
SK15272002A3 (sk) 2003-06-03
BR0110443A (pt) 2003-04-08
SK287835B6 (sk) 2011-12-05
AU5649601A (en) 2001-11-26
SI1185536T1 (en) 2005-06-30
US7524956B2 (en) 2009-04-28
RU2237063C9 (ru) 2008-10-10
CA2372058C (en) 2010-10-26
SK16502001A3 (sk) 2002-06-04
BR0110801A (pt) 2003-02-11
US7241892B1 (en) 2007-07-10
HUP0201188A2 (en) 2002-07-29
CZ20014102A3 (cs) 2002-06-12
NO20025186D0 (no) 2002-10-29
PT1185536E (pt) 2005-04-29
CZ20023751A3 (en) 2004-05-12
MXPA01011631A (es) 2002-07-30
CA2406095A1 (en) 2001-11-22
NO322016B1 (no) 2006-08-07
CN1441805A (zh) 2003-09-10
EP1185536A2 (en) 2002-03-13
BG107301A (bg) 2003-07-31
BRPI0010559B1 (pt) 2016-08-30
HK1047432A1 (en) 2003-02-21
UA75333C2 (uk) 2006-04-17
ES2233367T3 (es) 2005-06-16
KR100834601B1 (ko) 2008-06-02
BG65896B1 (bg) 2010-04-30
CN1440414A (zh) 2003-09-03
EP1185536B1 (en) 2004-11-24
CN1229382C (zh) 2005-11-30
ATE283273T1 (de) 2004-12-15
WO2000069862A3 (en) 2001-03-22
US20040002602A1 (en) 2004-01-01
CZ304966B6 (cs) 2015-02-18
BR0010559A (pt) 2002-07-02
WO2001087894A1 (en) 2001-11-22

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