DE60016209D1 - Hemisynthetisches verfahren und dessen zwischenprudukte - Google Patents

Hemisynthetisches verfahren und dessen zwischenprudukte

Info

Publication number
DE60016209D1
DE60016209D1 DE60016209T DE60016209T DE60016209D1 DE 60016209 D1 DE60016209 D1 DE 60016209D1 DE 60016209 T DE60016209 T DE 60016209T DE 60016209 T DE60016209 T DE 60016209T DE 60016209 D1 DE60016209 D1 DE 60016209D1
Authority
DE
Germany
Prior art keywords
interim products
hemisynthetic
hemisynthetic method
interim
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60016209T
Other languages
English (en)
Other versions
DE60016209T2 (de
Inventor
Carmen Cuevas
Marta Perez
Andres Francesch
Carolina Fernandez
Jose Luis Chicharro
Pilar Gallego
Maria Zarzuelo
La Calle Fernando De
Ignacio Manzanares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911345.8A external-priority patent/GB9911345D0/en
Priority claimed from GBGB9918178.6A external-priority patent/GB9918178D0/en
Priority claimed from GBGB9923632.5A external-priority patent/GB9923632D0/en
Priority claimed from GB0001063A external-priority patent/GB0001063D0/en
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of DE60016209D1 publication Critical patent/DE60016209D1/de
Application granted granted Critical
Publication of DE60016209T2 publication Critical patent/DE60016209T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE60016209T 1999-05-14 2000-05-15 Hemisynthetisches verfahren und dessen zwischenprudukte Expired - Lifetime DE60016209T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB9911345 1999-05-14
GBGB9911345.8A GB9911345D0 (de) 1999-05-14 1999-05-14
GBGB9918178.6A GB9918178D0 (en) 2000-05-15 1999-08-02 Synthetic methods
GB9918178 1999-08-02
GBGB9923632.5A GB9923632D0 (en) 1999-10-06 1999-10-06 Hemisynthetic process towards ecteinascidin and phtalscidin compounds
GB9923632 1999-10-06
GB0001063 2000-01-17
GB0001063A GB0001063D0 (en) 2000-01-17 2000-01-17 Hemisynthetic process towards ecteinascidin and phtalascidin
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof

Publications (2)

Publication Number Publication Date
DE60016209D1 true DE60016209D1 (de) 2004-12-30
DE60016209T2 DE60016209T2 (de) 2005-12-15

Family

ID=42632476

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60016209T Expired - Lifetime DE60016209T2 (de) 1999-05-14 2000-05-15 Hemisynthetisches verfahren und dessen zwischenprudukte

Country Status (30)

Country Link
US (3) US7241892B1 (de)
EP (1) EP1185536B1 (de)
JP (1) JP4445136B2 (de)
KR (1) KR100834601B1 (de)
CN (3) CN1229382C (de)
AR (1) AR035842A1 (de)
AT (1) ATE283273T1 (de)
AU (2) AU775580B2 (de)
BG (1) BG65896B1 (de)
BR (3) BRPI0010559B8 (de)
CA (2) CA2372058C (de)
CY (1) CY1108095T1 (de)
CZ (3) CZ303536B6 (de)
DE (1) DE60016209T2 (de)
DK (1) DK1185536T3 (de)
ES (2) ES2233367T3 (de)
HK (1) HK1047432A1 (de)
HU (1) HU230646B1 (de)
MX (1) MXPA01011631A (de)
MY (1) MY130271A (de)
NO (2) NO322016B1 (de)
NZ (1) NZ515424A (de)
PL (1) PL226890B1 (de)
PT (1) PT1185536E (de)
RU (1) RU2237063C9 (de)
SI (2) SI1185536T1 (de)
SK (2) SK287835B6 (de)
TR (1) TR200103273T2 (de)
UA (1) UA75333C2 (de)
WO (3) WO2000069862A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK285069B6 (sk) 1998-05-11 2006-05-04 Pharma Mar, S. A. Zlúčeniny, ktoré sú metabolitmi ekteinascidínu 743, farmaceutické prostriedky s ich obsahom a ich použitie
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
CA2406080C (en) 2000-04-12 2011-11-29 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
IL152125A (en) * 2000-05-15 2008-04-13 Pharma Mar Sa Process for the manufacture of ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CA2447553A1 (en) 2000-11-03 2002-05-23 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
WO2002036135A2 (en) * 2000-11-06 2002-05-10 Pharma Mar, S.A. Compositions for antitumour treatment containing ecteinascidin 743
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
IL161430A0 (en) * 2001-10-19 2004-09-27 Pharma Mar Sa Pharmaceutical compositions containing ecteinascidin 743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
JP2007511499A (ja) * 2003-11-13 2007-05-10 ファーマ・マール・エス・アー・ウー コンビネーション
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (de) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Kombinationstherapie mit verwendung von et-743 und paclitaxel zur behandlung von krebs
US20080242670A2 (en) * 2004-09-29 2008-10-02 Pharma Mar S.A., Sociedad Unipersonal Anti-Inflammatory Agents
CN101119750B (zh) * 2004-10-26 2013-03-06 法马马私人股份有限公司 抗癌治疗
DK1658848T3 (da) * 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
KR100712667B1 (ko) 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
GB0708691D0 (en) * 2007-05-04 2007-06-13 Pharma Mar Sa Anticancer treatments a
US20090076017A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched trabectedin
AU2008313634A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
AU2009248039B2 (en) * 2008-05-16 2014-07-31 Pharma Mar, S.A. Multiple myeloma treatments
US20110070232A1 (en) * 2008-05-16 2011-03-24 Pharma Mar, S.A. Combination Therapy with an Antitumor Alkaloid
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
AU2011257277B2 (en) * 2010-05-25 2016-02-25 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
ES2569180T3 (es) 2010-11-12 2016-05-09 Pharma Mar S.A. Terapia de combinación con un alcaloide antitumoral
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN107739387B (zh) * 2017-10-16 2020-01-03 上海皓元生物医药科技有限公司 一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) * 2017-12-13 2021-12-24 浙江中科创越药业有限公司 天然产物Trabectedin的制备
TWI824043B (zh) 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
CN111518110B (zh) * 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN111620792B (zh) * 2019-02-28 2023-01-03 兰州大学 一种n,n-二取代氰基甲酰胺的合成方法
CN116217584A (zh) * 2021-12-06 2023-06-06 南通诺泰生物医药技术有限公司 Et743及其中间体的光催化合成方法

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FR2461995A1 (fr) * 1979-07-20 1981-02-06 Lcc Cice Cie Europ Compo Elect Transducteur magneto-electrique pour systeme d'enregistrement magnetique, et systeme d'enregistrement comportant un tel transducteur
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6054386A (ja) * 1983-09-02 1985-03-28 Yoshitomi Pharmaceut Ind Ltd サフラシン誘導体
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
DE3774435D1 (de) 1986-06-09 1991-12-12 Univ Pennsylvania Ekteinascidine 729, 743, 745, 759a, 759b and 770.
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
HUP0104273A3 (en) 1998-04-06 2003-12-29 Univ Illinois Semi-synthetic ecteinascidins and pharmaceutical compositions containing them
SK285069B6 (sk) 1998-05-11 2006-05-04 Pharma Mar, S. A. Zlúčeniny, ktoré sú metabolitmi ekteinascidínu 743, farmaceutické prostriedky s ich obsahom a ich použitie
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
CA2397597A1 (en) 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
CA2406080C (en) 2000-04-12 2011-11-29 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
BG107301A (bg) 2003-07-31
US7241892B1 (en) 2007-07-10
JP2002544280A (ja) 2002-12-24
AU4597300A (en) 2000-12-05
BG65896B1 (bg) 2010-04-30
CN1441805A (zh) 2003-09-10
HK1047432A1 (en) 2003-02-21
CZ20023746A3 (cs) 2003-04-16
PL353002A1 (en) 2003-09-22
NO20025186L (no) 2003-01-14
BRPI0010559B8 (pt) 2021-05-25
BR0110443A (pt) 2003-04-08
KR20020021636A (ko) 2002-03-21
NZ515424A (en) 2004-06-25
CA2372058C (en) 2010-10-26
CN1229382C (zh) 2005-11-30
NO20025186D0 (no) 2002-10-29
BRPI0110443B8 (pt) 2021-05-25
ES2231486T3 (es) 2005-05-16
SK15272002A3 (sk) 2003-06-03
CN100475822C (zh) 2009-04-08
US20080045713A1 (en) 2008-02-21
WO2001087895A1 (en) 2001-11-22
ATE283273T1 (de) 2004-12-15
SI1287004T1 (sl) 2005-12-31
PT1185536E (pt) 2005-04-29
HU230646B1 (hu) 2017-05-29
EP1185536A2 (de) 2002-03-13
BRPI0110801B1 (pt) 2018-02-27
WO2000069862A2 (en) 2000-11-23
CZ20014102A3 (cs) 2002-06-12
AR035842A1 (es) 2004-07-21
NO322016B1 (no) 2006-08-07
EP1185536B1 (de) 2004-11-24
US7524956B2 (en) 2009-04-28
MY130271A (en) 2007-06-29
SK287879B6 (sk) 2012-02-03
KR100834601B1 (ko) 2008-06-02
RU2237063C9 (ru) 2008-10-10
PL226890B1 (pl) 2017-09-29
CZ20023751A3 (en) 2004-05-12
CA2406095C (en) 2010-02-16
CN1440414A (zh) 2003-09-03
SI1185536T1 (en) 2005-06-30
SK287835B6 (sk) 2011-12-05
BRPI0110801B8 (pt) 2021-05-25
CN1211386C (zh) 2005-07-20
NO328301B1 (no) 2010-01-25
DE60016209T2 (de) 2005-12-15
AU5649601A (en) 2001-11-26
NO20015547L (no) 2002-01-14
BRPI0110443B1 (pt) 2018-06-26
BRPI0010559B1 (pt) 2016-08-30
RU2237063C2 (ru) 2004-09-27
BR0110801A (pt) 2003-02-11
AU775580B2 (en) 2004-08-05
UA75333C2 (uk) 2006-04-17
MXPA01011631A (es) 2002-07-30
WO2000069862A3 (en) 2001-03-22
CY1108095T1 (el) 2014-02-12
CA2406095A1 (en) 2001-11-22
SK16502001A3 (sk) 2002-06-04
ES2233367T3 (es) 2005-06-16
CZ303536B6 (cs) 2012-11-21
US20040002602A1 (en) 2004-01-01
CZ304966B6 (cs) 2015-02-18
NO20015547D0 (no) 2001-11-13
DK1185536T3 (da) 2005-04-04
TR200103273T2 (tr) 2002-04-22
CZ304973B6 (cs) 2015-02-25
BR0010559A (pt) 2002-07-02
HUP0201188A2 (en) 2002-07-29
WO2001087894A1 (en) 2001-11-22
JP4445136B2 (ja) 2010-04-07
CA2372058A1 (en) 2000-11-23
CN1360588A (zh) 2002-07-24

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