ATE283273T1 - Hemisynthetisches verfahren und dessen zwischenprudukte - Google Patents

Hemisynthetisches verfahren und dessen zwischenprudukte

Info

Publication number
ATE283273T1
ATE283273T1 AT00927582T AT00927582T ATE283273T1 AT E283273 T1 ATE283273 T1 AT E283273T1 AT 00927582 T AT00927582 T AT 00927582T AT 00927582 T AT00927582 T AT 00927582T AT E283273 T1 ATE283273 T1 AT E283273T1
Authority
AT
Austria
Prior art keywords
intermediate products
hemisynthetic process
hemisynthetic
products
Prior art date
Application number
AT00927582T
Other languages
English (en)
Inventor
Carmen Cuevas
Marta Perez
Andres Francesch
Carolina Fernandez
Jose Luis Chicharro
Pilar Gallego
Maria Zarzuelo
La Calle Fernando De
Ignacio Manzanares
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911345.8A external-priority patent/GB9911345D0/en
Priority claimed from GBGB9918178.6A external-priority patent/GB9918178D0/en
Priority claimed from GBGB9923632.5A external-priority patent/GB9923632D0/en
Priority claimed from GB0001063A external-priority patent/GB0001063D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE283273T1 publication Critical patent/ATE283273T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00927582T 1999-05-14 2000-05-15 Hemisynthetisches verfahren und dessen zwischenprudukte ATE283273T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9911345.8A GB9911345D0 (de) 1999-05-14 1999-05-14
GBGB9918178.6A GB9918178D0 (en) 2000-05-15 1999-08-02 Synthetic methods
GBGB9923632.5A GB9923632D0 (en) 1999-10-06 1999-10-06 Hemisynthetic process towards ecteinascidin and phtalscidin compounds
GB0001063A GB0001063D0 (en) 2000-01-17 2000-01-17 Hemisynthetic process towards ecteinascidin and phtalascidin
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE283273T1 true ATE283273T1 (de) 2004-12-15

Family

ID=42632476

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00927582T ATE283273T1 (de) 1999-05-14 2000-05-15 Hemisynthetisches verfahren und dessen zwischenprudukte

Country Status (29)

Country Link
US (3) US7241892B1 (de)
EP (1) EP1185536B1 (de)
JP (1) JP4445136B2 (de)
KR (1) KR100834601B1 (de)
CN (3) CN1229382C (de)
AR (1) AR035842A1 (de)
AT (1) ATE283273T1 (de)
AU (2) AU775580B2 (de)
BG (1) BG65896B1 (de)
BR (3) BRPI0010559B8 (de)
CA (2) CA2372058C (de)
CY (1) CY1108095T1 (de)
CZ (3) CZ303536B6 (de)
DE (1) DE60016209T2 (de)
DK (1) DK1185536T3 (de)
ES (2) ES2233367T3 (de)
HU (1) HU230646B1 (de)
MX (1) MXPA01011631A (de)
MY (1) MY130271A (de)
NO (2) NO322016B1 (de)
NZ (1) NZ515424A (de)
PL (1) PL226890B1 (de)
PT (1) PT1185536E (de)
RU (1) RU2237063C9 (de)
SI (2) SI1185536T1 (de)
SK (2) SK287835B6 (de)
TR (1) TR200103273T2 (de)
UA (1) UA75333C2 (de)
WO (3) WO2000069862A2 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1077698B1 (de) 1998-05-11 2005-03-02 Pharma Mar, S.A. Ecteinascidinderivate
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
JP5219323B2 (ja) 2000-04-12 2013-06-26 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍性エクチナサイジン誘導体
IL152125A (en) * 2000-05-15 2008-04-13 Pharma Mar Sa Process for the manufacture of ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
EP1339713A2 (de) 2000-11-03 2003-09-03 President And Fellows Of Harvard College Saframycine, analogen und deren verwendung
EP1365808B1 (de) * 2000-11-06 2011-01-19 Pharma Mar, S.A. Antitumorzusammensetzungen welche ecteinascidin 743 enthalten
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
BR0213424A (pt) * 2001-10-19 2004-12-14 Pharma Mar Sa Uso aperfeiçoado de composto antitumoral na terapia contra câncer
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DE602004016376D1 (de) * 2003-11-13 2008-10-16 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CA2545054A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
DK1827500T3 (da) * 2004-10-26 2009-08-31 Pharma Mar Sa Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
KR100712667B1 (ko) 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
GB0708691D0 (en) * 2007-05-04 2007-06-13 Pharma Mar Sa Anticancer treatments a
US20090076017A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched trabectedin
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
CA2724206A1 (en) * 2008-05-16 2009-11-19 Pharma Mar S.A. Multiple myeloma treatments
CA2724325A1 (en) * 2008-05-16 2009-11-19 Pharma Mar, S.A. Combination therapy with an antitumor alkaloid
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
CN107033164A (zh) * 2010-05-25 2017-08-11 法马马有限公司 制备海鞘素化合物的合成方法
ME02395B (de) 2010-11-12 2016-09-20 Pharma Mar Sa Kombinationstherapie mit einem antitumoralen alkaloid
HRP20231233T1 (hr) 2017-04-27 2024-01-19 Pharma Mar, S.A. Antitumorski spojevi
CN107739387B (zh) * 2017-10-16 2020-01-03 上海皓元生物医药科技有限公司 一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) * 2017-12-13 2021-12-24 浙江中科创越药业有限公司 天然产物Trabectedin的制备
TWI824043B (zh) 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
CN111518110B (zh) 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN111620792B (zh) * 2019-02-28 2023-01-03 兰州大学 一种n,n-二取代氰基甲酰胺的合成方法
JP2023503318A (ja) 2019-11-21 2023-01-27 ファルマ、マール、ソシエダード、アノニマ ルルビネクテジン製剤で小細胞肺がんを処置する方法
CN116217584A (zh) * 2021-12-06 2023-06-06 南通诺泰生物医药技术有限公司 Et743及其中间体的光催化合成方法
CN117659032A (zh) * 2022-08-29 2024-03-08 南通诺泰生物医药技术有限公司 海鞘素类衍生物的中间体及其的合成方法
WO2024155565A2 (en) * 2023-01-17 2024-07-25 Yarrow Therapeutics, Inc. Ecteinascidin derivative antibody drug conjugates
WO2025077996A1 (en) 2023-10-09 2025-04-17 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
WO2025233522A1 (en) 2024-05-10 2025-11-13 Pharma Mar, S.A. Synthetic process for an ecteinascidin
WO2026022359A2 (en) 2024-07-26 2026-01-29 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
CN119613425B (zh) * 2024-10-31 2026-04-03 深圳创元生物医药科技有限公司 一种曲贝替定五环核心骨架的合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2461995A1 (fr) * 1979-07-20 1981-02-06 Lcc Cice Cie Europ Compo Elect Transducteur magneto-electrique pour systeme d'enregistrement magnetique, et systeme d'enregistrement comportant un tel transducteur
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6054386A (ja) * 1983-09-02 1985-03-28 Yoshitomi Pharmaceut Ind Ltd サフラシン誘導体
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
JP2562162B2 (ja) 1986-06-09 1996-12-11 ユニバーシティ・オブ・イリノイ エクテインアシジン７２９、７４３、７４５、７５９ａ、７５９ｂおよび７７０
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
CN1157189C (zh) 1998-04-06 2004-07-14 伊利诺伊大学评议会 半合成海鞘素
EP1077698B1 (de) 1998-05-11 2005-03-02 Pharma Mar, S.A. Ecteinascidinderivate
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
JP2003520801A (ja) 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
JP5219323B2 (ja) 2000-04-12 2013-06-26 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍性エクチナサイジン誘導体
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
ES2233367T3 (es) 2005-06-16
CZ304973B6 (cs) 2015-02-25
ES2231486T3 (es) 2005-05-16
RU2237063C2 (ru) 2004-09-27
NO20025186L (no) 2003-01-14
CZ20023746A3 (cs) 2003-04-16
BG65896B1 (bg) 2010-04-30
SI1287004T1 (sl) 2005-12-31
WO2000069862A3 (en) 2001-03-22
US20080045713A1 (en) 2008-02-21
CA2372058C (en) 2010-10-26
BRPI0010559B1 (pt) 2016-08-30
NO322016B1 (no) 2006-08-07
CN1229382C (zh) 2005-11-30
MXPA01011631A (es) 2002-07-30
HK1047432A1 (en) 2003-02-21
WO2000069862A2 (en) 2000-11-23
CZ304966B6 (cs) 2015-02-18
UA75333C2 (uk) 2006-04-17
SK287879B6 (sk) 2012-02-03
AR035842A1 (es) 2004-07-21
US7241892B1 (en) 2007-07-10
AU4597300A (en) 2000-12-05
CA2406095C (en) 2010-02-16
NO328301B1 (no) 2010-01-25
CN100475822C (zh) 2009-04-08
WO2001087894A1 (en) 2001-11-22
NO20015547D0 (no) 2001-11-13
SK15272002A3 (sk) 2003-06-03
CA2372058A1 (en) 2000-11-23
US20040002602A1 (en) 2004-01-01
BG107301A (bg) 2003-07-31
BRPI0110443B1 (pt) 2018-06-26
DE60016209T2 (de) 2005-12-15
EP1185536B1 (de) 2004-11-24
BRPI0010559B8 (pt) 2021-05-25
BRPI0110801B8 (pt) 2021-05-25
CZ303536B6 (cs) 2012-11-21
BR0110443A (pt) 2003-04-08
AU5649601A (en) 2001-11-26
KR100834601B1 (ko) 2008-06-02
NO20025186D0 (no) 2002-10-29
CA2406095A1 (en) 2001-11-22
NZ515424A (en) 2004-06-25
NO20015547L (no) 2002-01-14
TR200103273T2 (tr) 2002-04-22
AU775580B2 (en) 2004-08-05
CY1108095T1 (el) 2014-02-12
CN1360588A (zh) 2002-07-24
JP2002544280A (ja) 2002-12-24
BRPI0110801B1 (pt) 2018-02-27
CZ20014102A3 (cs) 2002-06-12
BR0110801A (pt) 2003-02-11
DE60016209D1 (de) 2004-12-30
EP1185536A2 (de) 2002-03-13
PL226890B1 (pl) 2017-09-29
BRPI0110443B8 (pt) 2021-05-25
DK1185536T3 (da) 2005-04-04
US7524956B2 (en) 2009-04-28
SI1185536T1 (en) 2005-06-30
RU2237063C9 (ru) 2008-10-10
CN1440414A (zh) 2003-09-03
SK16502001A3 (sk) 2002-06-04
CN1441805A (zh) 2003-09-10
HU230646B1 (hu) 2017-05-29
KR20020021636A (ko) 2002-03-21
MY130271A (en) 2007-06-29
BR0010559A (pt) 2002-07-02
CN1211386C (zh) 2005-07-20
CZ20023751A3 (en) 2004-05-12
WO2001087895A1 (en) 2001-11-22
SK287835B6 (sk) 2011-12-05
PL353002A1 (en) 2003-09-22
JP4445136B2 (ja) 2010-04-07
HUP0201188A2 (en) 2002-07-29
PT1185536E (pt) 2005-04-29

Similar Documents

Publication Publication Date Title
ATE283273T1 (de) Hemisynthetisches verfahren und dessen zwischenprudukte
DE60037857D1 (de) Saugfähiger Gegenstand und Verfahren zu dessen Herstellung
ATE379971T1 (de) Disinfektionsmittel und verfahren zu dessen herstellung
DE60027698D1 (de) Lasttragendes osteoimplantat und verfahren zu seiner herstellung
ATE555078T1 (de) Verfahren und zwischenprodukte
DE60026034D1 (de) Zusammendrückbeständiges mikriporöses material und verfahren zu seiner herstellung
DE60036294D1 (de) Umgossener transponder und verfahren zu dessen herstellung
DE60012839D1 (de) Spanholzwerkstoff und Verfahren zu seiner Herstellung
DE59913180D1 (de) Produktebestellungsverfahren und system
ATE348098T1 (de) Verfahren und zwischenprodukte zur herstellung von antikrebsmitteln
DE60039438D1 (de) Elektrostatischer ultraschallwandler und verfahren zu dessen herstellung
DE60044634D1 (de) Schalter und dessen Herstellungsverfahren
DE69816250D1 (de) Reinigungsprodukt und Verfahren zu seiner Herstellung
FI19992360L (fi) Tuote ja menetelmä sen valmistamiseksi
DE60018049D1 (de) Ionisationsstab und verfahren zu dessen herstellung
DE60017552D1 (de) Geschaeumte schokolade und verfahren zu dessen herstellung
DE60017012D1 (de) Orginalitätsverschluss und Herstellungverfahren
ATE286658T1 (de) Teigformmaschine und verfahren
DE60111904D1 (de) Biosensor und verfahren zu dessen herstellung
DE59914950D1 (de) Feldeffektgesteuerter transistor und verfahren zu dessen herstellung
EP1054607A4 (de) Mikrohaftverschluss und verfahren zu dessen herstellung
DE69905326D1 (de) Sollerschlitz und Verfahren zu dessen Herstellung
DE50010354D1 (de) Verbundteil und verfahren zu dessen herstellung
ATA75297A (de) Dekorlaminat und verfahren zu seiner herstellung
DE60100527D1 (de) Lederhänliches blattförmiges produkt und verfahren zu dessen herstellung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1185536

Country of ref document: EP