ATE283273T1 - Hemisynthetisches verfahren und dessen zwischenprudukte - Google Patents

Hemisynthetisches verfahren und dessen zwischenprudukte

Info

Publication number
ATE283273T1
ATE283273T1 AT00927582T AT00927582T ATE283273T1 AT E283273 T1 ATE283273 T1 AT E283273T1 AT 00927582 T AT00927582 T AT 00927582T AT 00927582 T AT00927582 T AT 00927582T AT E283273 T1 ATE283273 T1 AT E283273T1
Authority
AT
Austria
Prior art keywords
intermediate products
hemisynthetic process
hemisynthetic
products
Prior art date
Application number
AT00927582T
Other languages
English (en)
Inventor
Carmen Cuevas
Marta Perez
Andres Francesch
Carolina Fernandez
Jose Luis Chicharro
Pilar Gallego
Maria Zarzuelo
La Calle Fernando De
Ignacio Manzanares
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911345.8A external-priority patent/GB9911345D0/en
Priority claimed from GBGB9918178.6A external-priority patent/GB9918178D0/en
Priority claimed from GBGB9923632.5A external-priority patent/GB9923632D0/en
Priority claimed from GB0001063A external-priority patent/GB0001063D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE283273T1 publication Critical patent/ATE283273T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT00927582T 1999-05-14 2000-05-15 Hemisynthetisches verfahren und dessen zwischenprudukte ATE283273T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9911345.8A GB9911345D0 (de) 1999-05-14 1999-05-14
GBGB9918178.6A GB9918178D0 (en) 2000-05-15 1999-08-02 Synthetic methods
GBGB9923632.5A GB9923632D0 (en) 1999-10-06 1999-10-06 Hemisynthetic process towards ecteinascidin and phtalscidin compounds
GB0001063A GB0001063D0 (en) 2000-01-17 2000-01-17 Hemisynthetic process towards ecteinascidin and phtalascidin
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE283273T1 true ATE283273T1 (de) 2004-12-15

Family

ID=42632476

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00927582T ATE283273T1 (de) 1999-05-14 2000-05-15 Hemisynthetisches verfahren und dessen zwischenprudukte

Country Status (29)

Country Link
US (3) US7241892B1 (de)
EP (1) EP1185536B1 (de)
JP (1) JP4445136B2 (de)
KR (1) KR100834601B1 (de)
CN (3) CN1229382C (de)
AR (1) AR035842A1 (de)
AT (1) ATE283273T1 (de)
AU (2) AU775580B2 (de)
BG (1) BG65896B1 (de)
BR (3) BRPI0010559B8 (de)
CA (2) CA2372058C (de)
CY (1) CY1108095T1 (de)
CZ (3) CZ303536B6 (de)
DE (1) DE60016209T2 (de)
DK (1) DK1185536T3 (de)
ES (2) ES2233367T3 (de)
HU (1) HU230646B1 (de)
MX (1) MXPA01011631A (de)
MY (1) MY130271A (de)
NO (2) NO322016B1 (de)
NZ (1) NZ515424A (de)
PL (1) PL226890B1 (de)
PT (1) PT1185536E (de)
RU (1) RU2237063C9 (de)
SI (2) SI1185536T1 (de)
SK (2) SK287835B6 (de)
TR (1) TR200103273T2 (de)
UA (1) UA75333C2 (de)
WO (3) WO2000069862A2 (de)

Families Citing this family (48)

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KR100643092B1 (ko) 1998-05-11 2006-11-10 파르마 마르, 에스.에이. 엑테인아시딘 743의 대사산물
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
JP5219323B2 (ja) * 2000-04-12 2013-06-26 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍性エクチナサイジン誘導体
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
IL152125A (en) * 2000-05-15 2008-04-13 Pharma Mar Sa Process for the manufacture of ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CA2447553A1 (en) 2000-11-03 2002-05-23 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
EA005564B1 (ru) * 2000-11-06 2005-04-28 Фарма Мар, С.А. Эффективные противоопухолевые лекарственные средства
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
KR20050038578A (ko) * 2001-10-19 2005-04-27 파르마 마르, 에스.에이. 항종양성 화합물의 암치료에 있어서의 향상된 용도
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) * 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CN1897949A (zh) * 2003-11-14 2007-01-17 马尔药品公司 包含使用et－743和紫杉醇来治疗癌症的联合疗法
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
RU2359700C2 (ru) * 2004-10-26 2009-06-27 Фарма Мар С.А., Сосьедад Униперсональ Пегилированный липосомальный доксорубицин в комбинации с эктеинасцидином 743 (ecteinescidin 743)
KR101188691B1 (ko) 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
KR100712667B1 (ko) 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
GB0708691D0 (en) * 2007-05-04 2007-06-13 Pharma Mar Sa Anticancer treatments a
US20090076017A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched trabectedin
CA2703026A1 (en) * 2007-10-19 2009-04-23 Rafael Rosell Costa Prognostic molecular markers for et-743 treatment
KR20110025178A (ko) * 2008-05-16 2011-03-09 파르마 마르 에스.에이. Ｐｍ00104 및 다른 항종양제를 이용한 복합 치료법
NZ589270A (en) * 2008-05-16 2011-12-22 Pharma Mar Sa Multiple myeloma treatments
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
AU2011257277B2 (en) * 2010-05-25 2016-02-25 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
DK2786753T3 (en) 2010-11-12 2019-04-15 Pharma Mar Sa Combination therapy with an antitumor antibiotic
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
CN107739387B (zh) * 2017-10-16 2020-01-03 上海皓元生物医药科技有限公司 一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) * 2017-12-13 2021-12-24 浙江中科创越药业有限公司 天然产物Trabectedin的制备
TWI824043B (zh) 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
CN111518110B (zh) 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN111620792B (zh) * 2019-02-28 2023-01-03 兰州大学 一种n,n-二取代氰基甲酰胺的合成方法
WO2021098992A1 (en) 2019-11-21 2021-05-27 Pharma Mar, S.A. Methods of treating small cell lung cancer with lurbinectedin formulations
CN116217584A (zh) * 2021-12-06 2023-06-06 南通诺泰生物医药技术有限公司 Et743及其中间体的光催化合成方法
CN117659032A (zh) * 2022-08-29 2024-03-08 南通诺泰生物医药技术有限公司 海鞘素类衍生物的中间体及其的合成方法
EP4651871A2 (de) * 2023-01-17 2025-11-26 Adcytherix SAS Ecteinascidinderivat-antikörper-wirkstoffkonjugate
CN121986103A (zh) 2023-10-09 2026-05-05 法马马有限公司 用于制造海鞘素化合物的合成方法
WO2025233522A1 (en) 2024-05-10 2025-11-13 Pharma Mar, S.A. Synthetic process for an ecteinascidin
WO2026022359A2 (en) 2024-07-26 2026-01-29 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
CN119613425B (zh) * 2024-10-31 2026-04-03 深圳创元生物医药科技有限公司 一种曲贝替定五环核心骨架的合成方法

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US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
AU589282B2 (en) 1986-06-09 1989-10-05 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
CZ301083B6 (cs) 1998-04-06 2009-11-04 The Board Of Trustees Of The University Of Illinois Ekteinascidinová sloucenina, farmaceutický prostredek ji obsahující a její použití
KR100643092B1 (ko) 1998-05-11 2006-11-10 파르마 마르, 에스.에이. 엑테인아시딘 743의 대사산물
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
JP2003520801A (ja) 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
JP5219323B2 (ja) 2000-04-12 2013-06-26 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍性エクチナサイジン誘導体
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
BRPI0010559B1 (pt) 2016-08-30
EP1185536A2 (de) 2002-03-13
WO2000069862A2 (en) 2000-11-23
HUP0201188A2 (en) 2002-07-29
KR100834601B1 (ko) 2008-06-02
DE60016209T2 (de) 2005-12-15
NO20015547L (no) 2002-01-14
BR0110801A (pt) 2003-02-11
WO2000069862A3 (en) 2001-03-22
AR035842A1 (es) 2004-07-21
US7241892B1 (en) 2007-07-10
DK1185536T3 (da) 2005-04-04
SK287835B6 (sk) 2011-12-05
CA2406095C (en) 2010-02-16
NO20025186L (no) 2003-01-14
SK287879B6 (sk) 2012-02-03
US7524956B2 (en) 2009-04-28
BG107301A (bg) 2003-07-31
HK1047432A1 (en) 2003-02-21
SK15272002A3 (sk) 2003-06-03
CZ20023746A3 (cs) 2003-04-16
UA75333C2 (uk) 2006-04-17
ES2233367T3 (es) 2005-06-16
US20040002602A1 (en) 2004-01-01
SK16502001A3 (sk) 2002-06-04
CN1440414A (zh) 2003-09-03
RU2237063C9 (ru) 2008-10-10
US20080045713A1 (en) 2008-02-21
BRPI0110801B8 (pt) 2021-05-25
BRPI0110443B8 (pt) 2021-05-25
NO322016B1 (no) 2006-08-07
BRPI0010559B8 (pt) 2021-05-25
CN1360588A (zh) 2002-07-24
MXPA01011631A (es) 2002-07-30
KR20020021636A (ko) 2002-03-21
BR0110443A (pt) 2003-04-08
SI1185536T1 (en) 2005-06-30
SI1287004T1 (sl) 2005-12-31
CY1108095T1 (el) 2014-02-12
CA2406095A1 (en) 2001-11-22
MY130271A (en) 2007-06-29
AU5649601A (en) 2001-11-26
NO20025186D0 (no) 2002-10-29
CZ304966B6 (cs) 2015-02-18
CZ20014102A3 (cs) 2002-06-12
CZ20023751A3 (en) 2004-05-12
CN1211386C (zh) 2005-07-20
PL353002A1 (en) 2003-09-22
NO20015547D0 (no) 2001-11-13
AU775580B2 (en) 2004-08-05
CA2372058A1 (en) 2000-11-23
RU2237063C2 (ru) 2004-09-27
BG65896B1 (bg) 2010-04-30
DE60016209D1 (de) 2004-12-30
HU230646B1 (hu) 2017-05-29
NZ515424A (en) 2004-06-25
JP2002544280A (ja) 2002-12-24
CA2372058C (en) 2010-10-26
CN100475822C (zh) 2009-04-08
CN1229382C (zh) 2005-11-30
ES2231486T3 (es) 2005-05-16
CZ303536B6 (cs) 2012-11-21
WO2001087895A1 (en) 2001-11-22
BR0010559A (pt) 2002-07-02
BRPI0110443B1 (pt) 2018-06-26
BRPI0110801B1 (pt) 2018-02-27
EP1185536B1 (de) 2004-11-24
AU4597300A (en) 2000-12-05
TR200103273T2 (tr) 2002-04-22
PT1185536E (pt) 2005-04-29
PL226890B1 (pl) 2017-09-29
NO328301B1 (no) 2010-01-25
JP4445136B2 (ja) 2010-04-07
WO2001087894A1 (en) 2001-11-22
CN1441805A (zh) 2003-09-10
CZ304973B6 (cs) 2015-02-25

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