RU2227142C2 - Производные эпотилона и способы их получения, фармацевтическая композиция и способ лечения на их основе - Google Patents

Производные эпотилона и способы их получения, фармацевтическая композиция и способ лечения на их основе

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Publication number
RU2227142C2
RU2227142C2 RU2000132188/04A RU2000132188A RU2227142C2 RU 2227142 C2 RU2227142 C2 RU 2227142C2 RU 2000132188/04 A RU2000132188/04 A RU 2000132188/04A RU 2000132188 A RU2000132188 A RU 2000132188A RU 2227142 C2 RU2227142 C2 RU 2227142C2
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Prior art keywords
formula
absent
compound
salt
bond
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RU2000132188/04A
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English (en)
Russian (ru)
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RU2000132188A (ru
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Кир кос Коста НИКОЛАОУ (US)
Кирякос Коста НИКОЛАОУ
Найджел Пол КИНГ (US)
Найджел Пол КИНГ
Морис Реймонд Верскойл ФИНЛЕЙ (US)
Морис Реймонд Верскойл Финлей
Юнь ХЕ (US)
Юнь Хе
Франк РОШАНГАР (US)
Франк РОШАНГАР
Дионисиос ВОУРЛОУМИС (US)
Дионисиос ВОУРЛОУМИС
Ханс ВАЛЛБЕРГ (SE)
Ханс ВАЛЛБЕРГ
Антони БИГОТ (US)
Антони БИГОТ
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Новартис Аг
Дзе Скриппс Рисерч Инститьют
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2000132188/04A 1998-06-22 1999-06-21 Производные эпотилона и способы их получения, фармацевтическая композиция и способ лечения на их основе RU2227142C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/102,602 1998-06-22
US09/102,602 US6380394B1 (en) 1996-12-13 1998-06-22 Epothilone analogs

Publications (2)

Publication Number Publication Date
RU2000132188A RU2000132188A (ru) 2002-11-27
RU2227142C2 true RU2227142C2 (ru) 2004-04-20

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RU2000132188/04A RU2227142C2 (ru) 1998-06-22 1999-06-21 Производные эпотилона и способы их получения, фармацевтическая композиция и способ лечения на их основе

Country Status (27)

Country Link
US (3) US6380394B1 (enExample)
EP (2) EP1089998B1 (enExample)
JP (1) JP4681732B2 (enExample)
KR (3) KR20080045298A (enExample)
CN (1) CN1192031C (enExample)
AT (1) ATE343573T1 (enExample)
AU (1) AU757854B2 (enExample)
BR (1) BR9911420A (enExample)
CA (1) CA2334342C (enExample)
CY (1) CY1105863T1 (enExample)
CZ (1) CZ301783B6 (enExample)
DE (1) DE69933767T2 (enExample)
DK (1) DK1089998T3 (enExample)
ES (1) ES2273502T3 (enExample)
HU (1) HUP0102711A3 (enExample)
ID (1) ID28210A (enExample)
IL (3) IL139784A0 (enExample)
MX (1) MXPA00012443A (enExample)
NO (1) NO328417B1 (enExample)
NZ (1) NZ508622A (enExample)
PL (1) PL197648B1 (enExample)
PT (1) PT1089998E (enExample)
RU (1) RU2227142C2 (enExample)
SK (2) SK287864B6 (enExample)
TR (1) TR200003844T2 (enExample)
WO (1) WO1999067252A2 (enExample)
ZA (1) ZA200007059B (enExample)

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