NO20006378L - Epotilonderivater samt deres syntese og anvendelse - Google Patents

Epotilonderivater samt deres syntese og anvendelse

Info

Publication number
NO20006378L
NO20006378L NO20006378A NO20006378A NO20006378L NO 20006378 L NO20006378 L NO 20006378L NO 20006378 A NO20006378 A NO 20006378A NO 20006378 A NO20006378 A NO 20006378A NO 20006378 L NO20006378 L NO 20006378L
Authority
NO
Norway
Prior art keywords
absent
single bond
synthesis
alkyl
double bond
Prior art date
Application number
NO20006378A
Other languages
English (en)
Other versions
NO328417B1 (no
NO20006378D0 (no
Inventor
Kyriacos Costa Nicolaou
Nigel Paul King
Maurice Raymond Verscho Finlay
Yun He
Dionisios Vourloumis
Frank Roschangar
Antony Bigot
Original Assignee
Novartis Ag
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Scripps Research Inst filed Critical Novartis Ag
Publication of NO20006378D0 publication Critical patent/NO20006378D0/no
Publication of NO20006378L publication Critical patent/NO20006378L/no
Publication of NO328417B1 publication Critical patent/NO328417B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20006378A 1998-06-22 2000-12-14 Epotilonderivater samt deres syntese og anvendelse NO328417B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/102,602 US6380394B1 (en) 1996-12-13 1998-06-22 Epothilone analogs
PCT/EP1999/004287 WO1999067252A2 (en) 1998-06-22 1999-06-21 Epothilone derivatives and their synthesis and use

Publications (3)

Publication Number Publication Date
NO20006378D0 NO20006378D0 (no) 2000-12-14
NO20006378L true NO20006378L (no) 2001-02-21
NO328417B1 NO328417B1 (no) 2010-02-15

Family

ID=22290705

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006378A NO328417B1 (no) 1998-06-22 2000-12-14 Epotilonderivater samt deres syntese og anvendelse

Country Status (28)

Country Link
US (3) US6380394B1 (no)
EP (2) EP1741715A1 (no)
JP (1) JP4681732B2 (no)
KR (3) KR20090066332A (no)
CN (1) CN1192031C (no)
AT (1) ATE343573T1 (no)
AU (1) AU757854B2 (no)
BR (1) BR9911420A (no)
CA (1) CA2334342C (no)
CY (1) CY1105863T1 (no)
CZ (1) CZ301783B6 (no)
DE (1) DE69933767T2 (no)
DK (1) DK1089998T3 (no)
ES (1) ES2273502T3 (no)
HK (1) HK1038358A1 (no)
HU (1) HUP0102711A3 (no)
ID (1) ID28210A (no)
IL (3) IL139784A0 (no)
MX (1) MXPA00012443A (no)
NO (1) NO328417B1 (no)
NZ (1) NZ508622A (no)
PL (1) PL197648B1 (no)
PT (1) PT1089998E (no)
RU (1) RU2227142C2 (no)
SK (2) SK285647B6 (no)
TR (1) TR200003844T2 (no)
WO (1) WO1999067252A2 (no)
ZA (1) ZA200007059B (no)

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CN101535492A (zh) 2005-02-11 2009-09-16 南加州大学 表达含有二硫键的蛋白质的方法
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Birドメイン結合化合物
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CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
CN101600728A (zh) 2006-12-04 2009-12-09 伊利诺斯大学理事会 使用铜氧还蛋白和富含CpG的DNA治疗癌症的组合物和方法
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EP2070521A1 (en) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Surface-modified nanoparticles
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CN102985439B9 (zh) 2010-02-12 2016-08-03 制药科学股份有限公司 Iap bir结构域结合化合物
CN105797168A (zh) 2010-05-18 2016-07-27 天蓝制药公司 用于治疗自身免疫性疾病或其它疾病的组合物和方法
CN103442737B (zh) 2011-01-20 2017-03-29 得克萨斯系统大学董事会 Mri标记、递送和提取系统及其制造方法和用途
CN102863474A (zh) 2011-07-09 2013-01-09 陈小平 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用
CN102993239A (zh) 2011-09-19 2013-03-27 陈小平 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物
US9717803B2 (en) 2011-12-23 2017-08-01 Innate Pharma Enzymatic conjugation of polypeptides
US10132799B2 (en) 2012-07-13 2018-11-20 Innate Pharma Screening of conjugated antibodies
WO2014072482A1 (en) 2012-11-09 2014-05-15 Innate Pharma Recognition tags for tgase-mediated conjugation
CN104768962B (zh) 2012-11-17 2017-04-05 北京市丰硕维康技术开发有限责任公司 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物
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EP2968582B1 (en) 2013-03-15 2020-07-01 Innate Pharma Solid phase tgase-mediated conjugation of antibodies
WO2014202773A1 (en) 2013-06-20 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides
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Also Published As

Publication number Publication date
US6531497B1 (en) 2003-03-11
HK1038358A1 (en) 2002-03-15
TR200003844T2 (tr) 2001-04-20
KR100864742B1 (ko) 2008-10-22
DE69933767T2 (de) 2007-09-13
EP1089998A2 (en) 2001-04-11
KR20090066332A (ko) 2009-06-23
ZA200007059B (en) 2002-01-30
AU4774899A (en) 2000-01-10
NZ508622A (en) 2003-07-25
ID28210A (id) 2001-05-10
PL345327A1 (en) 2001-12-17
MXPA00012443A (es) 2004-12-03
WO1999067252A3 (en) 2000-03-16
IL182744A (en) 2010-05-17
HUP0102711A3 (en) 2002-09-30
KR20080045298A (ko) 2008-05-22
CZ301783B6 (cs) 2010-06-23
EP1741715A1 (en) 2007-01-10
DE69933767D1 (de) 2006-12-07
DK1089998T3 (da) 2007-01-15
CN1192031C (zh) 2005-03-09
US6380394B1 (en) 2002-04-30
RU2227142C2 (ru) 2004-04-20
CA2334342A1 (en) 1999-12-29
IL182744A0 (en) 2007-07-24
ES2273502T3 (es) 2007-05-01
IL139784A (en) 2010-05-17
CZ20004769A3 (cs) 2001-07-11
EP1089998B1 (en) 2006-10-25
CY1105863T1 (el) 2011-02-02
US7579366B2 (en) 2009-08-25
IL139784A0 (en) 2002-02-10
SK285647B6 (sk) 2007-05-03
KR20010083060A (ko) 2001-08-31
HUP0102711A2 (hu) 2001-12-28
PL197648B1 (pl) 2008-04-30
JP2002518504A (ja) 2002-06-25
JP4681732B2 (ja) 2011-05-11
NO328417B1 (no) 2010-02-15
CA2334342C (en) 2012-07-17
SK287864B6 (sk) 2012-02-03
US20030203938A1 (en) 2003-10-30
ATE343573T1 (de) 2006-11-15
PT1089998E (pt) 2007-01-31
NO20006378D0 (no) 2000-12-14
WO1999067252A2 (en) 1999-12-29
CN1306531A (zh) 2001-08-01
AU757854B2 (en) 2003-03-06
BR9911420A (pt) 2001-03-20
SK19712000A3 (sk) 2001-09-11

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