AU757854B2 - Epothilone derivatives and their synthesis and use - Google Patents

Epothilone derivatives and their synthesis and use Download PDF

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Publication number
AU757854B2
AU757854B2 AU47748/99A AU4774899A AU757854B2 AU 757854 B2 AU757854 B2 AU 757854B2 AU 47748/99 A AU47748/99 A AU 47748/99A AU 4774899 A AU4774899 A AU 4774899A AU 757854 B2 AU757854 B2 AU 757854B2
Authority
AU
Australia
Prior art keywords
formula
absent
compound
butyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47748/99A
Other languages
English (en)
Other versions
AU4774899A (en
Inventor
Antony Bigot
Maurice Raymond Verschoyle Finlay
Yun He
Nigel Paul King
Kyriacos Costa Nicolaou
Frank Roschangar
Hans Vallberg
Dionisios Vourloumis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Scripps Research Institute
Original Assignee
Novartis AG
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG, Scripps Research Institute filed Critical Novartis AG
Publication of AU4774899A publication Critical patent/AU4774899A/en
Application granted granted Critical
Publication of AU757854B2 publication Critical patent/AU757854B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU47748/99A 1998-06-22 1999-06-21 Epothilone derivatives and their synthesis and use Ceased AU757854B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/102602 1998-06-22
US09/102,602 US6380394B1 (en) 1996-12-13 1998-06-22 Epothilone analogs
PCT/EP1999/004287 WO1999067252A2 (en) 1998-06-22 1999-06-21 Epothilone derivatives and their synthesis and use

Publications (2)

Publication Number Publication Date
AU4774899A AU4774899A (en) 2000-01-10
AU757854B2 true AU757854B2 (en) 2003-03-06

Family

ID=22290705

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47748/99A Ceased AU757854B2 (en) 1998-06-22 1999-06-21 Epothilone derivatives and their synthesis and use

Country Status (27)

Country Link
US (3) US6380394B1 (enExample)
EP (2) EP1089998B1 (enExample)
JP (1) JP4681732B2 (enExample)
KR (3) KR20080045298A (enExample)
CN (1) CN1192031C (enExample)
AT (1) ATE343573T1 (enExample)
AU (1) AU757854B2 (enExample)
BR (1) BR9911420A (enExample)
CA (1) CA2334342C (enExample)
CY (1) CY1105863T1 (enExample)
CZ (1) CZ301783B6 (enExample)
DE (1) DE69933767T2 (enExample)
DK (1) DK1089998T3 (enExample)
ES (1) ES2273502T3 (enExample)
HU (1) HUP0102711A3 (enExample)
ID (1) ID28210A (enExample)
IL (3) IL139784A0 (enExample)
MX (1) MXPA00012443A (enExample)
NO (1) NO328417B1 (enExample)
NZ (1) NZ508622A (enExample)
PL (1) PL197648B1 (enExample)
PT (1) PT1089998E (enExample)
RU (1) RU2227142C2 (enExample)
SK (2) SK287864B6 (enExample)
TR (1) TR200003844T2 (enExample)
WO (1) WO1999067252A2 (enExample)
ZA (1) ZA200007059B (enExample)

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US20050043376A1 (en) * 1996-12-03 2005-02-24 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto, analogues and uses thereof
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US6660758B1 (en) * 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
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EP1135470A2 (en) 1998-11-20 2001-09-26 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
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Also Published As

Publication number Publication date
US6380394B1 (en) 2002-04-30
PT1089998E (pt) 2007-01-31
PL345327A1 (en) 2001-12-17
US7579366B2 (en) 2009-08-25
EP1089998B1 (en) 2006-10-25
CZ301783B6 (cs) 2010-06-23
EP1741715A1 (en) 2007-01-10
AU4774899A (en) 2000-01-10
CN1192031C (zh) 2005-03-09
IL139784A0 (en) 2002-02-10
ID28210A (id) 2001-05-10
JP2002518504A (ja) 2002-06-25
KR20080045298A (ko) 2008-05-22
JP4681732B2 (ja) 2011-05-11
HUP0102711A2 (hu) 2001-12-28
CA2334342A1 (en) 1999-12-29
CA2334342C (en) 2012-07-17
US20030203938A1 (en) 2003-10-30
ATE343573T1 (de) 2006-11-15
DK1089998T3 (da) 2007-01-15
EP1089998A2 (en) 2001-04-11
CZ20004769A3 (cs) 2001-07-11
WO1999067252A2 (en) 1999-12-29
KR20090066332A (ko) 2009-06-23
US6531497B1 (en) 2003-03-11
HK1038358A1 (en) 2002-03-15
TR200003844T2 (tr) 2001-04-20
NO328417B1 (no) 2010-02-15
CN1306531A (zh) 2001-08-01
BR9911420A (pt) 2001-03-20
WO1999067252A3 (en) 2000-03-16
CY1105863T1 (el) 2011-02-02
NZ508622A (en) 2003-07-25
DE69933767T2 (de) 2007-09-13
RU2227142C2 (ru) 2004-04-20
IL182744A (en) 2010-05-17
MXPA00012443A (es) 2004-12-03
ZA200007059B (en) 2002-01-30
SK287864B6 (sk) 2012-02-03
KR20010083060A (ko) 2001-08-31
IL139784A (en) 2010-05-17
KR100864742B1 (ko) 2008-10-22
IL182744A0 (en) 2007-07-24
ES2273502T3 (es) 2007-05-01
DE69933767D1 (de) 2006-12-07
NO20006378D0 (no) 2000-12-14
HUP0102711A3 (en) 2002-09-30
SK285647B6 (sk) 2007-05-03
PL197648B1 (pl) 2008-04-30
SK19712000A3 (sk) 2001-09-11
NO20006378L (no) 2001-02-21

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