RU2226216C2 - Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты, пищевые продукты, содержащие эти кислоты, и штамм ulkenia sp.sam2179 - продуцент этих кислот - Google Patents

Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты, пищевые продукты, содержащие эти кислоты, и штамм ulkenia sp.sam2179 - продуцент этих кислот Download PDF

Info

Publication number
RU2226216C2
RU2226216C2 RU99103073/13A RU99103073A RU2226216C2 RU 2226216 C2 RU2226216 C2 RU 2226216C2 RU 99103073/13 A RU99103073/13 A RU 99103073/13A RU 99103073 A RU99103073 A RU 99103073A RU 2226216 C2 RU2226216 C2 RU 2226216C2
Authority
RU
Russia
Prior art keywords
lipids
acid
exceed
content
food product
Prior art date
Application number
RU99103073/13A
Other languages
English (en)
Other versions
RU99103073A (ru
Inventor
Сатохиро ТАНАКА (JP)
Сатохиро Танака
Тошиаки ЯГУЧИ (JP)
Тошиаки Ягучи
Сакаю ШИМИЦУ (JP)
Сакаю Шимицу
Цутому СОГО (JP)
Цутому Сого
Шигеаки ФУДЖИКАВА (JP)
Шигеаки Фуджикава
Original Assignee
Нагасе Кемтекс Корпорейшн
Сунтори Лимитед
НАГАСЕ энд КО., ЛТД.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Нагасе Кемтекс Корпорейшн, Сунтори Лимитед, НАГАСЕ энд КО., ЛТД. filed Critical Нагасе Кемтекс Корпорейшн
Publication of RU99103073A publication Critical patent/RU99103073A/ru
Application granted granted Critical
Publication of RU2226216C2 publication Critical patent/RU2226216C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
    • C11C1/04—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis
    • C11C1/045—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis using enzymes or microorganisms, living or dead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C12N1/125—Unicellular algae isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/89—Algae ; Processes using algae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Animal Husbandry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к биотехнологии. Способ включает в себя стадии культивирования в среде микроорганизма, который принадлежит к роду Ulkenia, обладающему способностью продуцировать докозагексаеновую (ДГК) и/или докозапентаеновую (ДПА) кислоты, и извлечения липидов из культуры. Способ может дополнительно включать в себя стадию отделения ДГК и/или ДПК из липидов. Штамм Ulkenia sp.SAM2179 обладает способностью продуцировать липиды, содержащие докозагексаеновую кислоту и докозапентаеновую кислоту. Пищевые продукты и корма, содержащие липиды, полученные описанным способом, обладают биологической активностью и регулируют широкий спектр физиологических процессов организма. 12 с. и 10 з.п. ф-лы, 1 ил., 6 табл.

Description

Текст описания в факсимильном виде (см. графическую часть).

Claims (22)

1. Способ получения липидов, содержащих докозагексаеновую кислоту и/или докозапентаеновую кислоту, включающий культивирование в среде микроорганизма, принадлежащего к роду Ulkenia, обладающего способностью продуцировать липиды, содержащие докозагексаеновую кислоту и/или докозапентаеновую кислоту, и извлечение этих липидов из культуры.
2. Способ по п.1, дополнительно включающий выделение докозагексаеновой кислоты из этих липидов.
3. Способ по п.1, дополнительно включающий выделение докозапентаеновой кислоты из этих липидов.
4. Способ по п.1, дополнительно включающий обработку этих липидов грибковой липазой для превращения жирных кислот в положениях 1 и 3 в среднецепочные жирные кислоты с получением структурированных липидов.
5. Штамм Ulkenia sp. SAM2179 (FERM BP-5601), обладающий способностью продуцировать липиды, содержащие докозагексаеновую кислоту и докозапентаеновую кислоту.
6. Пищевой продукт повышенной питательности, содержащий липиды, полученные способом по любому из пп.1-3.
7. Пищевой продукт по п.6, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
8. Пищевой продукт для младенцев, содержащий липиды, полученные способом по любому из пп.1-3.
9. Пищевой продукт для младенцев по п.8, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
10. Пищевой продукт для недоношенных младенцев, содержащий липиды, полученные по способу любого из пп.1-3.
11. Пищевой продукт для недоношенных младенцев по п.10, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
12. Детское питание, содержащее липиды, полученные способом по любому из пп.1-3.
13. Детское питание по п.12, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
14. Питание для пожилых людей, содержащее липиды, полученные способом по любому из пп.1-3.
15. Питание для пожилых людей по п.14, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
16. Парентеральный агент для улучшения питания, содержащий липиды, полученные способом по любому из пп.1-3.
17. Парентеральный агент по п.16, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
18. Корм для животных, содержащий липиды, полученные способом по любому из пп.1-3.
19. Добавка к корму для животных, содержащая липиды, полученные способом по любому из пп.1-3.
20. Питательный компонент для микроорганизмов, служащих кормом для животных, содержащий липиды, полученные способом по любому из пп.1-3.
21. Питание для беременных женщин или кормящих матерей, содержащее липиды, полученные способом по любому из пп.1-3.
22. Питание для беременных женщин или кормящих матерей по п.21, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
RU99103073/13A 1996-07-23 1997-06-06 Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты, пищевые продукты, содержащие эти кислоты, и штамм ulkenia sp.sam2179 - продуцент этих кислот RU2226216C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8/193516 1996-07-23
JP19351696 1996-07-23

Publications (2)

Publication Number Publication Date
RU99103073A RU99103073A (ru) 2000-12-27
RU2226216C2 true RU2226216C2 (ru) 2004-03-27

Family

ID=16309374

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99103073/13A RU2226216C2 (ru) 1996-07-23 1997-06-06 Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты, пищевые продукты, содержащие эти кислоты, и штамм ulkenia sp.sam2179 - продуцент этих кислот

Country Status (24)

Country Link
US (2) US6509178B1 (ru)
EP (3) EP1785492B1 (ru)
JP (2) JP3343358B2 (ru)
AT (2) ATE347607T1 (ru)
AU (1) AU723553C (ru)
BR (1) BR9710394A (ru)
CA (1) CA2261231C (ru)
CZ (2) CZ300277B6 (ru)
DE (2) DE69737063T2 (ru)
DK (2) DK1785492T3 (ru)
EE (1) EE04063B1 (ru)
ES (2) ES2281913T3 (ru)
HU (1) HU229062B1 (ru)
ID (1) ID17466A (ru)
IL (2) IL128166A (ru)
LT (1) LT4550B (ru)
LV (1) LV12329B (ru)
NO (2) NO323173B1 (ru)
PL (1) PL193818B1 (ru)
PT (2) PT935667E (ru)
RU (1) RU2226216C2 (ru)
SI (1) SI0935667T1 (ru)
TR (1) TR199900130T2 (ru)
WO (1) WO1998003671A1 (ru)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2457836C2 (ru) * 2006-05-23 2012-08-10 Нестек С.А. Добавка к материнскому рациону
RU2537252C1 (ru) * 2013-06-29 2014-12-27 Федеральное государственное бюджетное учреждение науки Институт биологии моря им. А.В. Жирмунского Дальневосточного отделения Российской академии наук Способ получения докозагексаеновой кислоты

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060094089A1 (en) * 1988-09-07 2006-05-04 Martek Biosciences Corporation Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
DK1785492T3 (da) * 1996-07-23 2010-07-26 Nagase Chemtex Corp Fremgangsmåde til fremstilling af docosahexaensyre og docosapentaensyre
EP0996740B1 (en) * 1997-08-01 2005-09-21 Martek Biosciences Corporation Dha-containing nutritional compositions and methods for their production
JP4283351B2 (ja) * 1998-08-27 2009-06-24 サントリー酒類株式会社 新規な油脂組成物の製造方法および用途
DE60034775T3 (de) * 1999-03-04 2016-11-24 Suntory Holdings Ltd. Verwendung von Docosapentsäure enthaltendem Material
AU2008229885B2 (en) * 2000-01-19 2011-11-17 Dsm Ip Assets B.V. Solventless extraction process
DK1252324T3 (da) * 2000-01-19 2010-12-20 Martek Biosciences Corp Solventfri ekstraktionsfremgangsmåde
KR20100116233A (ko) * 2000-01-28 2010-10-29 마텍 바이오싸이언스스 코포레이션 발효기 내에서 진핵 미생물의 고밀도 배양에 의한 고도불포화 지방산을 함유하는 지질의 증진된 생산 방법
KR100680906B1 (ko) * 2000-03-29 2007-02-08 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 트라우스토키트리드 진균에서 다불포화 지방산의 수준을증가시키는 방법
US6410282B1 (en) * 2000-03-30 2002-06-25 Council Of Scientific And Industrial Research Method for enhancing levels of polyunsaturated fatty acids in thraustochytrid fungi
EP1178118A1 (en) 2000-08-02 2002-02-06 Dsm N.V. Isolation of microbial oils
PT1322752E (pt) 2000-09-28 2010-05-06 Bioriginal Food & Science Corp Fad4, fad5, fad5-2 e fad6, novos membros da família de dessaturases de ácidos gordos e susas utilizações
US7419596B2 (en) 2001-12-12 2008-09-02 Martek Biosciences Corporation Extraction and winterization of lipids from oilseed and microbial sources
JP3840459B2 (ja) * 2003-03-20 2006-11-01 裕司 島田 グリセリドおよびその製造方法
US8921422B2 (en) * 2003-10-01 2014-12-30 The Iams Company Methods and kits for enhancing ability to learn in a puppy or kitten
KR101295390B1 (ko) 2003-10-02 2013-09-17 마텍 바이오싸이언스스 코포레이션 변형량의 염소 및 칼륨을 사용하는 미세조류 중에 고농도 디에치에이의 생산
DE10352838A1 (de) * 2003-11-10 2005-07-07 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Kultivierung von Mikroorganismen der Gattung Thraustochytriales unter Verwendung eines optimierten Niedrigsalzmediums
DE10352837A1 (de) * 2003-11-10 2005-07-07 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Prozess zur Kultivierung von Mikroorganismen der Gattung Thraustochytriales
EP1537871A1 (en) * 2003-12-04 2005-06-08 Aventis Pharma S.A. Enoxaparin for the treatment of cancer
DE102004017369A1 (de) 2004-04-08 2005-11-03 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Screeningverfahren zur Identifizierung von PUFA-PKS in Proben
DE102004022015A1 (de) * 2004-05-03 2005-12-01 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Fischfutter für Aquafarmen auf Basis fermentativ gewonnener mehrfach ungesättigter Fettsäuren
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
DE102004062141A1 (de) * 2004-12-23 2006-07-06 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Herstellung eines Rohöls aus Gemischen von Mikroorganismen und Pflanzen, das so hergestellte Öl sowie die spezifischen Verwendungen des so hergestellten und gegebenenfalls zusätzlich raffinierten Öls
DE102005003625A1 (de) * 2005-01-26 2006-07-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Herstellung einer DHA-haltigen Fettsäure-Zusammensetzung
DE102005003624A1 (de) * 2005-01-26 2006-07-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Herstellung und Anwendung eines antioxidativ wirksamen Extraktes aus Crypthecodinium sp.
EP1888081B1 (en) * 2005-05-23 2016-12-28 Massachusetts Institute of Technology Compositions containing pufa and methods of use thereof
DK2447356T3 (en) 2005-06-07 2016-06-06 Dsm Nutritional Products Ag Eukaryotic MICROORGANISMS FOR PRODUCTION OF LIPIDS AND ANTIOXIDANTS
RU2444356C2 (ru) * 2005-07-08 2012-03-10 Мартек Байосайенсиз Корпорейшн Полиненасыщенные жирные кислоты для лечения деменции и состояний, связанных с преддеменцией
EP1926834A4 (en) * 2005-09-20 2009-04-22 Prolacta Bioscience Inc METHOD FOR ANALYZING MILK
DE102005054577A1 (de) 2005-11-16 2007-05-24 Cognis Ip Management Gmbh Verwendung von Estern ungesättigter, physiologisch aktiver Fettsäuren als Nährmedien für Zellkulturen
US9265745B2 (en) 2005-12-21 2016-02-23 Brudy Technology S.L. Use of DHA, EPA or DHA-derived EPA for treating a pathology associated with cellular oxidative damage
ES2277557B1 (es) 2005-12-21 2008-07-01 Proyecto Empresarial Brudy, S.L. Utilizacion de acido docosahexaenoico para el tratamiento del daño celular oxidativo.
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US8097245B2 (en) 2005-12-28 2012-01-17 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
EP2010140A2 (en) * 2006-04-03 2009-01-07 Advanced Bionutrition Corporation Feed formulations containing docosahexaenoic acid
GB2437909A (en) * 2006-05-12 2007-11-14 Advanced Bionutrition Inc Animal feed comprising docosahexaenois acid from a microbial source
CN105154481A (zh) * 2006-08-01 2015-12-16 帝斯曼营养品股份公司 产油微生物及改良这些微生物的方法
WO2008027991A2 (en) * 2006-08-29 2008-03-06 Martek Biosciences Corporation USE OF DPA(n-6) OILS IN INFANT FORMULA
KR100684642B1 (ko) * 2006-09-14 2007-02-22 주식회사 일신웰스 어유 유래 글리세라이드 유지 조성물 및 이의 제조방법
US20100086979A1 (en) * 2006-10-27 2010-04-08 Thomas Kiy Production of omega-3 fatty acids in microflora of thraustochytriales using modified media
WO2008076975A1 (en) 2006-12-18 2008-06-26 Advanced Bionutrition Corporation A dry food product containing live probiotic
US20080234377A1 (en) * 2007-03-23 2008-09-25 Martek Biosciences Corporation Polyunsaturated fatty acids for treatment of dementia and pre-dementia-related conditions
JP2010532418A (ja) * 2007-06-29 2010-10-07 マーテック バイオサイエンシーズ コーポレーション 多価不飽和脂肪酸のエステルの製造方法および精製方法
EP2071019A1 (en) 2007-12-15 2009-06-17 Lonza AG Method for the cultivation of microoranisms of the order thraustochytriales
EP2105506A1 (de) 2008-03-26 2009-09-30 Lonza Ag Verfahren zur Herstellung PUFAs enthaltender Öle unter Verwendung von Mikroorganismen der Ordnung Labyrinthulomycota
EP2145942A1 (de) * 2008-07-15 2010-01-20 Lonza Ltd. Verfahren zur Isolierung von Ölen aus Zellen und Biomasse
WO2010036334A1 (en) * 2008-09-23 2010-04-01 LiveFuels, Inc. Systems and methods for producing biofuels from algae
ES2602121T3 (es) * 2009-03-19 2017-02-17 Dsm Ip Assets B.V. Composiciones de ácidos grasos de traustoquítridos y métodos de fabricación y usos de las mismas
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
CA2986751A1 (en) 2009-03-27 2010-09-30 Intervet International B.V. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
WO2010121094A1 (en) 2009-04-17 2010-10-21 Livefuels. Inc. Systems and methods for culturing algae with bivalves
KR101799983B1 (ko) 2009-05-26 2017-12-20 어드밴스드 바이오뉴트리션 코프. 생물학적 활성 미생물 및/또는 생활성 물질을 포함하는 안정한 건식분말 조성물 및 제조 방법
US20120137574A1 (en) * 2009-06-16 2012-06-07 LiveFuels, Inc. Systems and methods for harvesting algae
BR122015020119B8 (pt) 2010-01-19 2021-05-04 Dsm Ip Assets Bv óleo microbiano, produtos alimentícios para um animal não humano e biomassa isolada
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
AR080073A1 (es) 2010-01-28 2012-03-14 Advanced Bionutrition Corp Composicion vitrea seca que comprende un material bioactivo
CN103282474A (zh) 2010-04-22 2013-09-04 纳幕尔杜邦公司 从微生物生物质中获得包含多不饱和脂肪酸的组合物的方法
JP5911479B2 (ja) 2010-06-01 2016-04-27 ディーエスエム アイピー アセッツ ビー．ブイ． 細胞からの脂質の抽出およびそれに由来する生産物
CA2805882A1 (en) 2010-08-11 2012-02-16 E. I. Dupont De Nemours And Company Improved aquaculture meat products
US20120204802A1 (en) 2010-08-11 2012-08-16 E. I. Du Pont De Nemours And Company Sustainable aquaculture feeding strategy
US20120040076A1 (en) 2010-08-11 2012-02-16 E. I. Du Pont De Nemours And Company Aquaculture feed compositions
ES2676656T3 (es) 2010-08-13 2018-07-23 Advanced Bionutrition Corp. Composición estabilizante de almacenamiento en seco para materiales biológicos
KR101115357B1 (ko) 2010-09-03 2012-03-06 대상 주식회사 습식 상태의 미세조류로부터 조오일을 추출하는 방법
US8973531B2 (en) * 2010-12-09 2015-03-10 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Automated continuous zooplankton culture system
US9487716B2 (en) 2011-05-06 2016-11-08 LiveFuels, Inc. Sourcing phosphorus and other nutrients from the ocean via ocean thermal energy conversion systems
AU2012285806B2 (en) 2011-07-21 2017-09-14 Dsm Ip Assets B.V. Fatty acid compositions
WO2014074772A1 (en) 2012-11-09 2014-05-15 Heliae Development, Llc Mixotrophic, phototrophic, and heterotrophic combination methods and systems
WO2014074770A2 (en) 2012-11-09 2014-05-15 Heliae Development, Llc Balanced mixotrophy methods
WO2014096024A1 (de) * 2012-12-19 2014-06-26 Lonza Ltd Verfahren zur herstellung einer lipid-reichen zusammensetzung aus mikroorganismen
DK2970926T3 (en) 2013-03-13 2018-04-16 Dsm Nutritional Products Ag GENMANIPULATION OF MICROorganisms
FR3005860B1 (fr) * 2013-05-21 2016-01-22 Oreal Compositions comprenant de l'huile d'ulkenia et leurs utilisations pour ameliorer et/ou renforcer la fonction barriere
FR3007652B1 (fr) * 2013-06-28 2015-07-17 Oreal Composition comprenant de l'acide docosahexaenoique et du pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate
EP2826384A1 (de) 2013-07-16 2015-01-21 Evonik Industries AG Verfahren zur Trocknung von Biomasse
ES2953836T3 (es) 2013-12-20 2023-11-16 Dsm Ip Assets Bv Procedimiento para la obtención de aceite microbiano a partir de células microbianas
AU2014369045B2 (en) 2013-12-20 2020-02-27 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
WO2015095690A2 (en) 2013-12-20 2015-06-25 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
US9745538B2 (en) 2013-12-20 2017-08-29 MARA Renewables Corporation Methods of recovering oil from microorganisms
MX370871B (es) 2013-12-20 2020-01-08 Dsm Nutritional Products Ag Métodos para extraer aceite de microorganismos.
AU2014369040B2 (en) 2013-12-20 2019-12-05 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
CZ307271B6 (cs) * 2014-08-26 2018-05-09 Vysoká škola chemicko - technologická v Praze Způsob kultivace mořských protistů, zejména mikroorganismů rodu Thraustochytriales, na médiu obsahujícím odpadní solný roztok z demineralizace sladké mléčné syrovátky
DK180021B1 (en) 2014-10-02 2020-01-22 Evonik Degussa Gmbh Process for producing a PUFA-containing biomass which has high cell stability.
DK179981B1 (en) 2014-10-02 2019-11-29 Evonik Degussa Gmbh Process for producing a PUFA-containing feedstuff by extruding a PUFA-containing biomass
DK179843B1 (en) 2014-10-02 2019-07-31 Evonik Degussa Gmbh Method for raising animals
US11464244B2 (en) 2014-10-02 2022-10-11 Evonik Operations Gmbh Feedstuff of high abrasion resistance and good stability in water, containing PUFAs
AR104042A1 (es) 2015-03-26 2017-06-21 Mara Renewables Corp Producción de alta densidad de biomasa y aceite utilizando glicerol en bruto
KR20180027584A (ko) 2015-07-13 2018-03-14 마라 리뉴어블즈 코퍼레이션 크실로오스의 미세조류 대사를 강화시키는 방법
BR112018001784B1 (pt) 2015-07-29 2022-05-10 Advanced Bionutrition Corp Composições probióticas secas estáveis para usos dietéticos especiais, seu método de preparação e método de preparação de uma fórmula para bebês
WO2017094804A1 (ja) 2015-12-01 2017-06-08 日本水産株式会社 ドコサヘキサエン酸含有油及びその製造方法
US10851395B2 (en) 2016-06-10 2020-12-01 MARA Renewables Corporation Method of making lipids with improved cold flow properties
JP6938163B2 (ja) * 2017-02-06 2021-09-22 長瀬産業株式会社 脂質組成物、その用途及びその製造方法
NL2019436B1 (en) 2017-08-23 2019-03-07 Newtricious Bv Composition comprising a xantophyll and an omega-3 fatty acid and method of use thereof
JP7013416B2 (ja) * 2018-06-21 2022-01-31 マルハニチロ株式会社 腎機能維持及び保護剤、並びに、その効果評価方法
EP3865127A4 (en) * 2018-06-21 2023-01-11 Maruha Nichiro Corporation MEANS OF PRESERVING AND PROTECTING KIDNEY FUNCTION AND METHODS OF EVALUATION OF ITS EFFECTS
FR3085962B1 (fr) 2018-09-14 2021-06-18 Fermentalg Procede d'extracton d'une huile riche en pufa
EP3917329A4 (en) * 2019-02-01 2022-11-30 Mars, Incorporated FOOD COMPOSITION FOR FELINE
WO2023140321A1 (ja) * 2022-01-20 2023-07-27 ホロバイオ株式会社 新規生物育種技術

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US161864A (en) * 1875-04-13 Improvement in methods of killing vermin
US539759A (en) * 1895-05-21 Laroy s
JPH075484B2 (ja) 1985-03-06 1995-01-25 帝人株式会社 血液脳関門通過性医薬品組成物
KR890701751A (ko) 1987-07-20 1989-12-21 원본 미기재 오메가-3(n-3) 지질의 미생물 생성물
JP2582622B2 (ja) 1987-10-27 1997-02-19 日東化学工業株式会社 糸状菌による高度不飽和脂肪酸の製造法
US5130242A (en) 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5407957A (en) * 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
JPH05308978A (ja) 1992-05-11 1993-11-22 Onoda Cement Co Ltd 藻類によるドコサヘキサエン酸の製造方法
AU5346296A (en) * 1995-04-17 1996-11-07 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fa tty acids by using the microorganisms
JPH0930962A (ja) * 1995-07-21 1997-02-04 Nisshin Oil Mills Ltd:The 医療用油脂含有組成物
DK1785492T3 (da) 1996-07-23 2010-07-26 Nagase Chemtex Corp Fremgangsmåde til fremstilling af docosahexaensyre og docosapentaensyre

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JANE C. PUTNAM, M.S. et all, The effect of variations in dietary fatty acids on the fatty acid composition of erythrocyte phosphatidylcholine and phosphatidylethanolamine in human infants, The American Journal of Clinical Nutrition 36, 1982, July, pp. 106-114. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2457836C2 (ru) * 2006-05-23 2012-08-10 Нестек С.А. Добавка к материнскому рациону
RU2537252C1 (ru) * 2013-06-29 2014-12-27 Федеральное государственное бюджетное учреждение науки Институт биологии моря им. А.В. Жирмунского Дальневосточного отделения Российской академии наук Способ получения докозагексаеновой кислоты

Also Published As

Publication number Publication date
US20030161864A1 (en) 2003-08-28
ES2281913T3 (es) 2007-10-01
NO990270D0 (no) 1999-01-21
AU2979897A (en) 1998-02-10
DE69739894D1 (de) 2010-07-08
SI0935667T1 (sl) 2007-10-31
NO990270L (no) 1999-03-18
PL331326A1 (en) 1999-07-05
IL128166A0 (en) 1999-11-30
HUP9903703A3 (en) 2001-09-28
NO20063977L (no) 1999-03-18
AU723553B2 (en) 2000-08-31
LT99005A (en) 1999-06-25
AU723553C (en) 2005-04-14
CZ19999A3 (cs) 1999-07-14
EP1785492A3 (en) 2007-06-27
EP2213750A1 (en) 2010-08-04
PT935667E (pt) 2007-02-28
DK1785492T3 (da) 2010-07-26
IL187179A0 (en) 2008-02-09
CZ300277B6 (cs) 2009-04-08
DE69737063T2 (de) 2007-07-19
JP2002345452A (ja) 2002-12-03
ID17466A (id) 1998-01-08
HUP9903703A2 (hu) 2000-03-28
JP2000513575A (ja) 2000-10-17
ES2362476T3 (es) 2011-07-06
IL128166A (en) 2011-06-30
HU229062B1 (hu) 2013-07-29
LV12329A (lv) 1999-08-20
JP3538418B2 (ja) 2004-06-14
TR199900130T2 (xx) 1999-04-21
WO1998003671A1 (en) 1998-01-29
CA2261231C (en) 2012-11-27
CA2261231A1 (en) 1998-01-29
DE69737063D1 (de) 2007-01-18
BR9710394A (pt) 2000-01-11
JP3343358B2 (ja) 2002-11-11
NO323173B1 (no) 2007-01-15
EP0935667B1 (en) 2006-12-06
LT4550B (lt) 1999-10-25
US6509178B1 (en) 2003-01-21
EE9900026A (et) 1999-08-16
DK0935667T3 (da) 2007-04-10
PL193818B1 (pl) 2007-03-30
EE04063B1 (et) 2003-06-16
EP1785492A2 (en) 2007-05-16
EP0935667A1 (en) 1999-08-18
CZ299658B6 (cs) 2008-10-08
ATE347607T1 (de) 2006-12-15
PT1785492E (pt) 2010-07-06
EP1785492B1 (en) 2010-05-26
ATE469244T1 (de) 2010-06-15
LV12329B (lv) 2000-02-20
US7514244B2 (en) 2009-04-07
NO326902B1 (no) 2009-03-16

Similar Documents

Publication Publication Date Title
RU2226216C2 (ru) Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты, пищевые продукты, содержащие эти кислоты, и штамм ulkenia sp.sam2179 - продуцент этих кислот
KR100294293B1 (ko) 도코사헥사엔산을 포함하는 식품 및 유아용 조제 분유
RU99103073A (ru) Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты
AU711967B2 (en) Method for production of arachidonic acid
KR101460259B1 (ko) 불비누화 물질 함량을 저감시킨 미생물 유지의 제조 방법 및 그 유지
EP0972844B1 (en) Process for preparing highly unsaturated fatty acid and lipid containing highly unsaturated fatty acid
EP2119791A1 (en) Method for production of polyunsaturated fatty acid and lipid containing the polyunsaturated fatty acid

Legal Events

Date Code Title Description
PC4A Invention patent assignment

Effective date: 20100519

MM4A The patent is invalid due to non-payment of fees

Effective date: 20150607