RU2226216C2 - Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты, пищевые продукты, содержащие эти кислоты, и штамм ulkenia sp.sam2179 - продуцент этих кислот - Google Patents
Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты, пищевые продукты, содержащие эти кислоты, и штамм ulkenia sp.sam2179 - продуцент этих кислот Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract 19
- 235000021294 Docosapentaenoic acid Nutrition 0.000 title claims abstract 8
- 235000020669 docosahexaenoic acid Nutrition 0.000 title claims abstract 8
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 title claims abstract 7
- 241001491678 Ulkenia Species 0.000 title claims abstract 3
- 239000002253 acid Substances 0.000 title 2
- 150000007513 acids Chemical class 0.000 title 2
- QAPAPLIQQTVEJZ-UHFFFAOYSA-N n-[(3-fluorophenyl)methyl]ethanamine Chemical compound CCNCC1=CC=CC(F)=C1 QAPAPLIQQTVEJZ-UHFFFAOYSA-N 0.000 title 1
- 150000002632 lipids Chemical class 0.000 claims abstract 29
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims abstract 12
- 229940090949 docosahexaenoic acid Drugs 0.000 claims abstract 6
- 244000005700 microbiome Species 0.000 claims abstract 3
- 241001298226 Ulkenia sp. Species 0.000 claims abstract 2
- 238000012258 culturing Methods 0.000 claims abstract 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 7
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 7
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 7
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 7
- 235000013305 food Nutrition 0.000 claims 6
- 235000016709 nutrition Nutrition 0.000 claims 6
- 230000035764 nutrition Effects 0.000 claims 4
- 206010036590 Premature baby Diseases 0.000 claims 2
- 235000008452 baby food Nutrition 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000474 nursing effect Effects 0.000 claims 2
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical group 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 150000004667 medium chain fatty acids Chemical class 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000004071 biological effect Effects 0.000 abstract 1
- YEKFYCQGYMVFKR-UHFFFAOYSA-N docosa-2,4,6,8,10-pentaenoic acid Chemical class CCCCCCCCCCCC=CC=CC=CC=CC=CC(O)=O YEKFYCQGYMVFKR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000035790 physiological processes and functions Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
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- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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Abstract
Изобретение относится к биотехнологии. Способ включает в себя стадии культивирования в среде микроорганизма, который принадлежит к роду Ulkenia, обладающему способностью продуцировать докозагексаеновую (ДГК) и/или докозапентаеновую (ДПА) кислоты, и извлечения липидов из культуры. Способ может дополнительно включать в себя стадию отделения ДГК и/или ДПК из липидов. Штамм Ulkenia sp.SAM2179 обладает способностью продуцировать липиды, содержащие докозагексаеновую кислоту и докозапентаеновую кислоту. Пищевые продукты и корма, содержащие липиды, полученные описанным способом, обладают биологической активностью и регулируют широкий спектр физиологических процессов организма. 12 с. и 10 з.п. ф-лы, 1 ил., 6 табл.
Description
Текст описания в факсимильном виде (см. графическую часть).
Claims (22)
1. Способ получения липидов, содержащих докозагексаеновую кислоту и/или докозапентаеновую кислоту, включающий культивирование в среде микроорганизма, принадлежащего к роду Ulkenia, обладающего способностью продуцировать липиды, содержащие докозагексаеновую кислоту и/или докозапентаеновую кислоту, и извлечение этих липидов из культуры.
2. Способ по п.1, дополнительно включающий выделение докозагексаеновой кислоты из этих липидов.
3. Способ по п.1, дополнительно включающий выделение докозапентаеновой кислоты из этих липидов.
4. Способ по п.1, дополнительно включающий обработку этих липидов грибковой липазой для превращения жирных кислот в положениях 1 и 3 в среднецепочные жирные кислоты с получением структурированных липидов.
5. Штамм Ulkenia sp. SAM2179 (FERM BP-5601), обладающий способностью продуцировать липиды, содержащие докозагексаеновую кислоту и докозапентаеновую кислоту.
6. Пищевой продукт повышенной питательности, содержащий липиды, полученные способом по любому из пп.1-3.
7. Пищевой продукт по п.6, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
8. Пищевой продукт для младенцев, содержащий липиды, полученные способом по любому из пп.1-3.
9. Пищевой продукт для младенцев по п.8, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
10. Пищевой продукт для недоношенных младенцев, содержащий липиды, полученные по способу любого из пп.1-3.
11. Пищевой продукт для недоношенных младенцев по п.10, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
12. Детское питание, содержащее липиды, полученные способом по любому из пп.1-3.
13. Детское питание по п.12, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
14. Питание для пожилых людей, содержащее липиды, полученные способом по любому из пп.1-3.
15. Питание для пожилых людей по п.14, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
16. Парентеральный агент для улучшения питания, содержащий липиды, полученные способом по любому из пп.1-3.
17. Парентеральный агент по п.16, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
18. Корм для животных, содержащий липиды, полученные способом по любому из пп.1-3.
19. Добавка к корму для животных, содержащая липиды, полученные способом по любому из пп.1-3.
20. Питательный компонент для микроорганизмов, служащих кормом для животных, содержащий липиды, полученные способом по любому из пп.1-3.
21. Питание для беременных женщин или кормящих матерей, содержащее липиды, полученные способом по любому из пп.1-3.
22. Питание для беременных женщин или кормящих матерей по п.21, в котором содержание эйкозапентаеновой кислоты не превышает 1% от общего количества липидов.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19351696 | 1996-07-23 | ||
| JP8/193516 | 1996-07-23 |
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| Publication Number | Publication Date |
|---|---|
| RU99103073A RU99103073A (ru) | 2000-12-27 |
| RU2226216C2 true RU2226216C2 (ru) | 2004-03-27 |
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| RU99103073/13A RU2226216C2 (ru) | 1996-07-23 | 1997-06-06 | Способ получения докозагексаеновой кислоты и докозапентаеновой кислоты, пищевые продукты, содержащие эти кислоты, и штамм ulkenia sp.sam2179 - продуцент этих кислот |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6509178B1 (ru) |
| EP (3) | EP1785492B1 (ru) |
| JP (2) | JP3343358B2 (ru) |
| AT (2) | ATE347607T1 (ru) |
| AU (1) | AU723553C (ru) |
| BR (1) | BR9710394A (ru) |
| CA (1) | CA2261231C (ru) |
| CZ (2) | CZ299658B6 (ru) |
| DE (2) | DE69739894D1 (ru) |
| DK (2) | DK0935667T3 (ru) |
| EE (1) | EE04063B1 (ru) |
| ES (2) | ES2362476T3 (ru) |
| HU (1) | HU229062B1 (ru) |
| ID (1) | ID17466A (ru) |
| IL (2) | IL128166A (ru) |
| LT (1) | LT4550B (ru) |
| LV (1) | LV12329B (ru) |
| NO (2) | NO323173B1 (ru) |
| PL (1) | PL193818B1 (ru) |
| PT (2) | PT1785492E (ru) |
| RU (1) | RU2226216C2 (ru) |
| SI (1) | SI0935667T1 (ru) |
| TR (1) | TR199900130T2 (ru) |
| WO (1) | WO1998003671A1 (ru) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2457836C2 (ru) * | 2006-05-23 | 2012-08-10 | Нестек С.А. | Добавка к материнскому рациону |
| RU2537252C1 (ru) * | 2013-06-29 | 2014-12-27 | Федеральное государственное бюджетное учреждение науки Институт биологии моря им. А.В. Жирмунского Дальневосточного отделения Российской академии наук | Способ получения докозагексаеновой кислоты |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060094089A1 (en) * | 1988-09-07 | 2006-05-04 | Martek Biosciences Corporation | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
| US5340742A (en) * | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| CA2261231C (en) * | 1996-07-23 | 2012-11-27 | Nagase Biochemicals, Ltd. | Process using ulkenia sp. to prepare docosahexaenoic acid and docosapentaenoic acid |
| ATE305048T1 (de) | 1997-08-01 | 2005-10-15 | Martek Biosciences Corp | Dha-enthaltende naehrzusammensetzungen und verfahren zu deren herstellung |
| JP4283351B2 (ja) * | 1998-08-27 | 2009-06-24 | サントリー酒類株式会社 | 新規な油脂組成物の製造方法および用途 |
| WO2000051444A1 (fr) | 1999-03-04 | 2000-09-08 | Suntory Limited | Utilisation d'une matiere contenant de l'acide docosapentaenoique |
| AU2008229885B2 (en) * | 2000-01-19 | 2011-11-17 | Dsm Ip Assets B.V. | Solventless extraction process |
| CZ303446B6 (cs) * | 2000-01-19 | 2012-09-19 | Martek Biosciences Corporation | Zpusob získávání lipidu z mikroorganismu |
| HUP0301794A3 (en) * | 2000-01-28 | 2011-04-28 | Martek Biosciences Corp | Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors |
| EP1276891B1 (en) * | 2000-03-29 | 2005-05-18 | Council of Scientific and Industrial Research | A method for enhancing levels of polyunsaturated fatty acids in thraustochytrids |
| US6410282B1 (en) * | 2000-03-30 | 2002-06-25 | Council Of Scientific And Industrial Research | Method for enhancing levels of polyunsaturated fatty acids in thraustochytrid fungi |
| EP1178118A1 (en) | 2000-08-02 | 2002-02-06 | Dsm N.V. | Isolation of microbial oils |
| DK1911837T3 (da) | 2000-09-28 | 2011-08-29 | Bioriginal Food & Science Corp | FAD5-2 fedtsyredesaturasefamiliemedlem og anvendelser deraf |
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