RU2217429C2 - 1-(3-гетероарилпропил или проп-2-енил)-4-бензилпиперидины, способ их получения и фармацевтическая композиция на их основе - Google Patents
1-(3-гетероарилпропил или проп-2-енил)-4-бензилпиперидины, способ их получения и фармацевтическая композиция на их основе Download PDFInfo
- Publication number
- RU2217429C2 RU2217429C2 RU2000126475/04A RU2000126475A RU2217429C2 RU 2217429 C2 RU2217429 C2 RU 2217429C2 RU 2000126475/04 A RU2000126475/04 A RU 2000126475/04A RU 2000126475 A RU2000126475 A RU 2000126475A RU 2217429 C2 RU2217429 C2 RU 2217429C2
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- compounds
- fluorobenzyl
- piperidin
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- 238000011282 treatment Methods 0.000 claims abstract 4
- 208000018152 Cerebral disease Diseases 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims 7
- 102000015404 Amino Acid Receptors Human genes 0.000 claims 2
- 108010025177 Amino Acid Receptors Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- KSTICMFAFQGYSN-UHFFFAOYSA-N 5-[3-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]prop-1-enyl]-1,3-dihydrobenzimidazol-2-one Chemical compound C1=CC(F)=CC=C1CC1CCN(CC=CC=2C=C3NC(=O)NC3=CC=2)CC1 KSTICMFAFQGYSN-UHFFFAOYSA-N 0.000 claims 1
- DCWVSMOSBUAONF-UHFFFAOYSA-N 5-[3-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]prop-1-enyl]-1,3-dihydroindol-2-one Chemical compound C1=CC(F)=CC=C1CC1CCN(CC=CC=2C=C3CC(=O)NC3=CC=2)CC1 DCWVSMOSBUAONF-UHFFFAOYSA-N 0.000 claims 1
- GRCRMRUZDNKSBD-UHFFFAOYSA-N 6-[3-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]prop-1-enyl]-3h-1,3-benzothiazol-2-one Chemical compound C1=CC(F)=CC=C1CC1CCN(CC=CC=2C=C3SC(=O)NC3=CC=2)CC1 GRCRMRUZDNKSBD-UHFFFAOYSA-N 0.000 claims 1
- CQYRNVNODQPZDL-UHFFFAOYSA-N 6-[3-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]prop-1-enyl]-3h-1,3-benzoxazol-2-one Chemical compound C1=CC(F)=CC=C1CC1CCN(CC=CC=2C=C3OC(=O)NC3=CC=2)CC1 CQYRNVNODQPZDL-UHFFFAOYSA-N 0.000 claims 1
- YNWAFHDAQQTVIT-UHFFFAOYSA-N 6-[3-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]propyl]-3h-1,3-benzoxazol-2-one Chemical compound C1=CC(F)=CC=C1CC1CCN(CCCC=2C=C3OC(=O)NC3=CC=2)CC1 YNWAFHDAQQTVIT-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- -1 prop-2-enyl Chemical group 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- MJYFVDNMTKLGTH-UHFFFAOYSA-N 4-bromo-6-(3,4-dichlorophenyl)sulfanyl-1-[[4-(dimethylcarbamoyl)phenyl]methyl]indole-2-carboxylic acid Chemical compound BrC1=C2C=C(N(C2=CC(=C1)SC1=CC(=C(C=C1)Cl)Cl)CC1=CC=C(C=C1)C(N(C)C)=O)C(=O)O MJYFVDNMTKLGTH-UHFFFAOYSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19812331.0 | 1998-03-20 | ||
| DE19812331A DE19812331A1 (de) | 1998-03-20 | 1998-03-20 | Piperidinderivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000126475A RU2000126475A (ru) | 2003-01-27 |
| RU2217429C2 true RU2217429C2 (ru) | 2003-11-27 |
Family
ID=7861717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000126475/04A RU2217429C2 (ru) | 1998-03-20 | 1999-03-11 | 1-(3-гетероарилпропил или проп-2-енил)-4-бензилпиперидины, способ их получения и фармацевтическая композиция на их основе |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6548516B1 (enExample) |
| EP (1) | EP1068202B1 (enExample) |
| JP (1) | JP4451565B2 (enExample) |
| KR (1) | KR20010042047A (enExample) |
| CN (1) | CN1123571C (enExample) |
| AR (1) | AR014747A1 (enExample) |
| AT (1) | ATE416173T1 (enExample) |
| AU (1) | AU747900B2 (enExample) |
| BR (1) | BR9908902A (enExample) |
| CA (1) | CA2324339C (enExample) |
| DE (2) | DE19812331A1 (enExample) |
| DK (1) | DK1068202T3 (enExample) |
| ES (1) | ES2316184T3 (enExample) |
| HU (1) | HUP0101220A3 (enExample) |
| ID (1) | ID26125A (enExample) |
| NO (1) | NO20004668D0 (enExample) |
| PL (1) | PL342732A1 (enExample) |
| PT (1) | PT1068202E (enExample) |
| RU (1) | RU2217429C2 (enExample) |
| SK (1) | SK13692000A3 (enExample) |
| WO (1) | WO1999048891A1 (enExample) |
| ZA (1) | ZA992191B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ3361A1 (fr) | 2000-05-31 | 2001-12-06 | Warner Lambert Co | Cyclohéxylamines bicycliques et leur utilisation comme antagonistes des récepteurs de nmda |
| DE60112574T2 (de) | 2000-06-06 | 2006-06-08 | Warner-Lambert Co. Llc | Bicyclische cyclohexylamine und ihre verwendung als nmda-rezeptor antagonisten |
| EP1345935A2 (en) | 2000-12-21 | 2003-09-24 | Warner-Lambert Company LLC | Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists |
| MXPA02002749A (es) | 2001-03-27 | 2002-10-28 | Warner Lambert Co | Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato. |
| DE10248067A1 (de) * | 2002-10-07 | 2004-04-15 | Proteosys Ag | Heteroarylpropyl-Piperazine und Heteroarylpropyl-Piperidine |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| KR20120107993A (ko) | 2009-12-15 | 2012-10-04 | 뉴롭, 인코포레이티드 | 신경계 장애의 치료를 위한 화합물 |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| CA2789440C (en) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| CN102133198B (zh) * | 2011-03-09 | 2012-02-08 | 北京四环科宝制药有限公司 | 一种酒石酸艾芬地尔冻干粉针剂及其制备方法 |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| CN103965188A (zh) * | 2013-01-29 | 2014-08-06 | 中山大学 | 含硒多奈哌齐类似物 |
| US10604484B2 (en) * | 2015-04-29 | 2020-03-31 | Janssen Pharmaceutica Nv | Indolone compounds and their use as AMPA receptor modulators |
| ES2865330T3 (es) | 2015-04-29 | 2021-10-15 | Janssen Pharmaceutica Nv | Azabenzimidazoles y su uso como moduladores del receptor AMPA |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1367857A3 (ru) * | 1980-03-06 | 1988-01-15 | Оцука Фармасьютикал Ко,Лтд (Фирма) | Способ получени карбостирильных производных |
| RU2010794C1 (ru) * | 1990-06-15 | 1994-04-15 | Эйсай Ко., ЛТД | Производные циклического амида или их фармакологически приемлемая соль, обладающая антиацетилхолинэстеродной активностью |
| EP0709384A1 (de) * | 1994-10-31 | 1996-05-01 | MERCK PATENT GmbH | Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren |
| WO1997023216A1 (en) * | 1995-12-22 | 1997-07-03 | Warner-Lambert Company | 4-substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW281670B (enExample) | 1993-09-02 | 1996-07-21 | Hoffmann La Roche | |
| FR2717810B1 (fr) * | 1994-03-22 | 1996-04-26 | Adir | Nouvelles aminoalkyl benzoxazolinones et benzothiazolinones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| AU3138595A (en) * | 1994-07-20 | 1996-02-16 | Acea Pharmaceuticals, Inc. | Haloperidol analogs and the use thereof |
| DE19643790A1 (de) | 1996-10-30 | 1998-05-07 | Merck Patent Gmbh | Benzoxazol-Derivat |
-
1998
- 1998-03-20 DE DE19812331A patent/DE19812331A1/de not_active Withdrawn
-
1999
- 1999-03-11 DE DE59914921T patent/DE59914921D1/de not_active Expired - Lifetime
- 1999-03-11 JP JP2000537874A patent/JP4451565B2/ja not_active Expired - Fee Related
- 1999-03-11 ES ES99915568T patent/ES2316184T3/es not_active Expired - Lifetime
- 1999-03-11 BR BR9908902-5A patent/BR9908902A/pt not_active IP Right Cessation
- 1999-03-11 SK SK1369-2000A patent/SK13692000A3/sk unknown
- 1999-03-11 AT AT99915568T patent/ATE416173T1/de not_active IP Right Cessation
- 1999-03-11 RU RU2000126475/04A patent/RU2217429C2/ru not_active IP Right Cessation
- 1999-03-11 AU AU34105/99A patent/AU747900B2/en not_active Ceased
- 1999-03-11 PL PL99342732A patent/PL342732A1/xx not_active Application Discontinuation
- 1999-03-11 CA CA002324339A patent/CA2324339C/en not_active Expired - Fee Related
- 1999-03-11 ID IDW20002091A patent/ID26125A/id unknown
- 1999-03-11 HU HU0101220A patent/HUP0101220A3/hu unknown
- 1999-03-11 EP EP99915568A patent/EP1068202B1/de not_active Expired - Lifetime
- 1999-03-11 US US09/646,185 patent/US6548516B1/en not_active Expired - Fee Related
- 1999-03-11 DK DK99915568T patent/DK1068202T3/da active
- 1999-03-11 CN CN99804190A patent/CN1123571C/zh not_active Expired - Fee Related
- 1999-03-11 PT PT99915568T patent/PT1068202E/pt unknown
- 1999-03-11 WO PCT/EP1999/001573 patent/WO1999048891A1/de not_active Ceased
- 1999-03-11 KR KR1020007010387A patent/KR20010042047A/ko not_active Withdrawn
- 1999-03-18 ZA ZA9902191A patent/ZA992191B/xx unknown
- 1999-03-19 AR ARP990101208A patent/AR014747A1/es not_active Application Discontinuation
-
2000
- 2000-09-19 NO NO20004668A patent/NO20004668D0/no not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1367857A3 (ru) * | 1980-03-06 | 1988-01-15 | Оцука Фармасьютикал Ко,Лтд (Фирма) | Способ получени карбостирильных производных |
| RU2010794C1 (ru) * | 1990-06-15 | 1994-04-15 | Эйсай Ко., ЛТД | Производные циклического амида или их фармакологически приемлемая соль, обладающая антиацетилхолинэстеродной активностью |
| EP0709384A1 (de) * | 1994-10-31 | 1996-05-01 | MERCK PATENT GmbH | Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren |
| WO1997023216A1 (en) * | 1995-12-22 | 1997-07-03 | Warner-Lambert Company | 4-substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| ID26125A (id) | 2000-11-23 |
| DE59914921D1 (de) | 2009-01-15 |
| BR9908902A (pt) | 2000-11-28 |
| NO20004668L (no) | 2000-09-19 |
| HUP0101220A2 (hu) | 2002-05-29 |
| KR20010042047A (ko) | 2001-05-25 |
| PL342732A1 (en) | 2001-07-02 |
| PT1068202E (pt) | 2009-03-06 |
| AR014747A1 (es) | 2001-03-28 |
| NO20004668D0 (no) | 2000-09-19 |
| DK1068202T3 (da) | 2009-03-16 |
| JP4451565B2 (ja) | 2010-04-14 |
| JP2002507613A (ja) | 2002-03-12 |
| ES2316184T3 (es) | 2009-04-01 |
| WO1999048891A1 (de) | 1999-09-30 |
| CN1123571C (zh) | 2003-10-08 |
| EP1068202A1 (de) | 2001-01-17 |
| HUP0101220A3 (en) | 2003-08-28 |
| ZA992191B (en) | 1999-09-29 |
| CA2324339A1 (en) | 1999-09-30 |
| CN1293673A (zh) | 2001-05-02 |
| AU747900B2 (en) | 2002-05-30 |
| SK13692000A3 (sk) | 2001-02-12 |
| AU3410599A (en) | 1999-10-18 |
| DE19812331A1 (de) | 1999-09-23 |
| EP1068202B1 (de) | 2008-12-03 |
| US6548516B1 (en) | 2003-04-15 |
| ATE416173T1 (de) | 2008-12-15 |
| CA2324339C (en) | 2010-01-12 |
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