RU2134266C1 - Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1) - Google Patents

Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1) Download PDF

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RU2134266C1
RU2134266C1 RU95109927/04A RU95109927A RU2134266C1 RU 2134266 C1 RU2134266 C1 RU 2134266C1 RU 95109927/04 A RU95109927/04 A RU 95109927/04A RU 95109927 A RU95109927 A RU 95109927A RU 2134266 C1 RU2134266 C1 RU 2134266C1
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ylmethyl
indol
benzimidazole
indole
methylpyrrolidin
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RU95109927/04A
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Russian (ru)
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RU95109927A (ru
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Юджин Мейкор Джон (US)
Юджин Мейкор Джон
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Пфайзер Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
RU95109927/04A 1992-11-02 1993-10-19 Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1) RU2134266C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02
US07/970,758 1992-11-02
PCT/US1993/009790 WO1994010171A1 (en) 1992-11-02 1993-10-19 5-arylindole derivatives and their use as serotonin (5-ht1) agonists

Publications (2)

Publication Number Publication Date
RU95109927A RU95109927A (ru) 1997-01-10
RU2134266C1 true RU2134266C1 (ru) 1999-08-10

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US (1) US5886008A (cg-RX-API-DMAC7.html)
EP (2) EP1094064A1 (cg-RX-API-DMAC7.html)
JP (1) JP2788551B2 (cg-RX-API-DMAC7.html)
KR (1) KR0163371B1 (cg-RX-API-DMAC7.html)
CN (1) CN1051313C (cg-RX-API-DMAC7.html)
AT (1) ATE202102T1 (cg-RX-API-DMAC7.html)
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PL (1) PL176091B1 (cg-RX-API-DMAC7.html)
PT (1) PT666858E (cg-RX-API-DMAC7.html)
RU (1) RU2134266C1 (cg-RX-API-DMAC7.html)
TW (1) TW251284B (cg-RX-API-DMAC7.html)
WO (1) WO1994010171A1 (cg-RX-API-DMAC7.html)
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* Cited by examiner, † Cited by third party
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RU2232162C2 (ru) * 1998-09-01 2004-07-10 Верналис Рисерч Лимитед Пирролоиндолы, пиридиноиндолы и азепиноиндолы в качестве агонистов 5-нт2с
RU2434863C2 (ru) * 2006-03-22 2011-11-27 Янссен Фармацевтика Н.В. Производные циклических алкиламинов в качестве ингибиторов взаимодействия между mdm2 и р53

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JPH11513666A (ja) * 1995-10-10 1999-11-24 イーライ・リリー・アンド・カンパニー Ｎ−［２−置換−３−（２−アミノエチル）−１ｈ−インドール−５−イル］−アミド：新規５−ｈｔ▲下１ｆ▼作動剤
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2232162C2 (ru) * 1998-09-01 2004-07-10 Верналис Рисерч Лимитед Пирролоиндолы, пиридиноиндолы и азепиноиндолы в качестве агонистов 5-нт2с
RU2434863C2 (ru) * 2006-03-22 2011-11-27 Янссен Фармацевтика Н.В. Производные циклических алкиламинов в качестве ингибиторов взаимодействия между mdm2 и р53

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BR9307348A (pt) 1999-05-11
JP2788551B2 (ja) 1998-08-20
IL107386A0 (en) 1994-01-25
TW251284B (cg-RX-API-DMAC7.html) 1995-07-11
ZA938137B (en) 1995-05-02
ATE202102T1 (de) 2001-06-15
PL176091B1 (pl) 1999-04-30
GR3036579T3 (en) 2001-12-31
PT666858E (pt) 2001-09-28
IL107386A (en) 1999-03-12
FI111257B (fi) 2003-06-30
NZ257059A (en) 1997-07-27
NO309652B1 (no) 2001-03-05
EP0666858A1 (en) 1995-08-16
FI934825A0 (fi) 1993-11-01
CA2148380A1 (en) 1994-05-11
JPH07508759A (ja) 1995-09-28
KR0163371B1 (ko) 1998-12-01
NO951633D0 (no) 1995-04-28
FI20002505A7 (fi) 2000-11-15
HU222235B1 (hu) 2003-05-28
PL308669A1 (en) 1995-08-21
HUT66011A (en) 1994-08-29
DK0666858T3 (da) 2001-08-27
EP0666858B1 (en) 2001-06-13
ES2157224T3 (es) 2001-08-16
CA2340999C (en) 2005-01-04
FI20002505L (fi) 2000-11-15
EG20396A (en) 1999-02-28
CN1094727A (zh) 1994-11-09
CA2148380C (en) 2001-08-14
WO1994010171A1 (en) 1994-05-11
AU5329494A (en) 1994-05-24
CN1051313C (zh) 2000-04-12
CA2340999A1 (en) 1994-05-11
EP1094064A1 (en) 2001-04-25
CZ283001B6 (cs) 1997-12-17
MY109696A (en) 1997-04-30
DE69330351D1 (de) 2001-07-19
NO951633L (no) 1995-04-28
FI934825L (fi) 1994-05-03
RU95109927A (ru) 1997-01-10
KR950704313A (ko) 1995-11-17
CZ110895A3 (en) 1995-11-15
DE69330351T2 (de) 2001-09-20
US5886008A (en) 1999-03-23
AU685066B2 (en) 1998-01-15

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Effective date: 20031020