RU2126388C1 - 4-аминопиридины и фармацевтическая композиция - Google Patents

4-аминопиридины и фармацевтическая композиция Download PDF

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Publication number
RU2126388C1
RU2126388C1 RU95122612A RU95122612A RU2126388C1 RU 2126388 C1 RU2126388 C1 RU 2126388C1 RU 95122612 A RU95122612 A RU 95122612A RU 95122612 A RU95122612 A RU 95122612A RU 2126388 C1 RU2126388 C1 RU 2126388C1
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RU
Russia
Prior art keywords
group
alkyl
amino
methyl
phenyl
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RU95122612A
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English (en)
Russian (ru)
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RU95122612A (ru
Inventor
Фон Дер Зааль Вольфганг
Хек Райнхард
Лайнерт Херберт
Полл Томас
Штегмайер Карлхайнц
Михель Хельмут
Original Assignee
Берингер Маннхайм ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4306506A external-priority patent/DE4306506A1/de
Priority claimed from DE19934312966 external-priority patent/DE4312966A1/de
Application filed by Берингер Маннхайм ГмбХ filed Critical Берингер Маннхайм ГмбХ
Publication of RU95122612A publication Critical patent/RU95122612A/ru
Application granted granted Critical
Publication of RU2126388C1 publication Critical patent/RU2126388C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU95122612A 1993-03-03 1994-03-02 4-аминопиридины и фармацевтическая композиция RU2126388C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4306506A DE4306506A1 (de) 1993-03-03 1993-03-03 Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DEP4306506.6 1993-03-03
DEP4312966.8 1993-04-21
DE19934312966 DE4312966A1 (de) 1993-04-21 1993-04-21 Neue 4-Aminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
PCT/EP1994/000608 WO1994020467A1 (de) 1993-03-03 1994-03-02 Neue 4-aminopyridine, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
RU95122612A RU95122612A (ru) 1997-09-20
RU2126388C1 true RU2126388C1 (ru) 1999-02-20

Family

ID=25923593

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95122612A RU2126388C1 (ru) 1993-03-03 1994-03-02 4-аминопиридины и фармацевтическая композиция

Country Status (22)

Country Link
EP (1) EP0687253B1 (OSRAM)
JP (1) JPH08507503A (OSRAM)
KR (1) KR100252551B1 (OSRAM)
CN (1) CN1046710C (OSRAM)
AT (1) ATE174590T1 (OSRAM)
AU (1) AU682026B2 (OSRAM)
CA (1) CA2156729A1 (OSRAM)
CZ (1) CZ225495A3 (OSRAM)
DE (1) DE59407494D1 (OSRAM)
DK (1) DK0687253T3 (OSRAM)
ES (1) ES2127919T3 (OSRAM)
FI (1) FI954105A0 (OSRAM)
GR (1) GR3029691T3 (OSRAM)
HU (1) HUT72898A (OSRAM)
IL (1) IL108786A (OSRAM)
NO (1) NO953447D0 (OSRAM)
NZ (1) NZ262725A (OSRAM)
PL (1) PL176455B1 (OSRAM)
RU (1) RU2126388C1 (OSRAM)
SK (1) SK108295A3 (OSRAM)
TW (1) TW257757B (OSRAM)
WO (1) WO1994020467A1 (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2273633C2 (ru) * 2000-10-04 2006-04-10 Киссеи Фармасьютикал Ко., Лтд. Производные 5-амидино-2-гидроксибензолсульфонамида, содержащие их фармацевтические композиции и промежуточные продукты для их получения
RU2353619C2 (ru) * 2007-06-28 2009-04-27 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции
RU2354647C2 (ru) * 2007-06-28 2009-05-10 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе
RU2685261C1 (ru) * 2018-04-05 2019-04-17 Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза

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DE4430755A1 (de) * 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
GB9525620D0 (en) 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
CZ206698A3 (cs) * 1995-12-29 1998-11-11 3- Dimensional Pharmaceuticals, Inc. Amidinové inhibitory proteas
EP0880501A1 (en) 1996-02-02 1998-12-02 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
US6093718A (en) * 1996-08-14 2000-07-25 Zeneca Limited Substituted pyrimidine derivatives and their pharmaceutical use
CA2264037A1 (en) * 1996-09-13 1998-03-19 Merck & Co., Inc. Thrombin inhibitors
GB9821483D0 (en) 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
AU7624298A (en) * 1996-12-03 1998-06-29 Graybill, Todd L. Aminobenzenedicarboxylic acid-based combinatorial libraries
DE69815509T2 (de) 1997-02-13 2004-05-13 Astrazeneca Ab Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren anwendung finden
AU5999698A (en) 1997-02-13 1998-09-08 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
JP4327915B2 (ja) * 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 スルフォンアミド誘導体
AU754253B2 (en) 1998-10-06 2002-11-07 Dainippon Pharmaceutical Co. Ltd. 2,3-disubstituted pyridine derivatives, processes for the preparation thereof, pharmaceutical compositions containing the same and intermediates therefor
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US6635637B2 (en) 2000-08-04 2003-10-21 Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors
US6849635B2 (en) * 2001-05-07 2005-02-01 Smithkline Beecham Corporation Sulfonamides
WO2002089740A2 (en) * 2001-05-07 2002-11-14 Smithkline Beecham Corporation Sulfonamides
ATE402700T1 (de) * 2002-08-27 2008-08-15 Merck Patent Gmbh Glycinamid-derivate als raf-kinase-hemmer
JP2006508061A (ja) 2002-09-20 2006-03-09 ファイザー・プロダクツ・インク エストロゲン受容体に対するアミドおよびスルホンアミドリガンド
WO2005049573A1 (en) 2003-11-05 2005-06-02 F. Hoffmann-La Roche Ag Phenyl derivatives as ppar agonists
CN101622231B (zh) * 2007-02-28 2013-12-04 艾德维纳斯医疗私人有限公司 作为葡糖激酶激活剂的2，2，2-三取代的乙酰胺衍生物、它们的制造方法和药学应用
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) * 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8265575B2 (en) * 2009-06-16 2012-09-11 Mediatek Inc. Methods for handling a transmitting process and communication apparatuses utilizing the same
US8207639B2 (en) 2009-10-23 2012-06-26 Sunonwealth Electric Machine Industry Co., Ltd. Motor and heating dissipating fan including motor having an annular balancing member
CN109172573B (zh) * 2018-09-12 2021-01-26 黑龙江中桂制药有限公司 一种口服抗血栓药物及其用途
CN110669337B (zh) * 2019-07-08 2020-09-25 中国科学院长春应用化学研究所 一种芳香型二胺单体及其制备方法
WO2024243343A2 (en) * 2023-05-23 2024-11-28 John Karanicolas Compounds that re-activate mutant p53

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SU1097620A1 (ru) * 1983-02-16 1984-06-15 Новокузнецкий научно-исследовательский химико-фармацевтический институт Способ получени диэтил-N-(6-метилпиридил-2)-аминометиленмалоната
SU1318599A1 (ru) * 1985-06-26 1987-06-23 МГУ им.М.В.Ломоносова Способ получени 1-алкил-2-хлор-2-алкоксиэтенилалкил(арил)хлорфосфинов
SU1480766A3 (ru) * 1985-08-17 1989-05-15 Берингер Маннхайм Гмбх (Фирма) Способ получени кристаллического торасемида
EP0359386A2 (en) * 1988-09-12 1990-03-21 General Motors Corporation Method and apparatus for press-forming intricate metallic shapes such as spool valve elements
EP0356176B1 (en) * 1988-08-22 1993-09-22 HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD. Acetamide compounds

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US5539104A (en) * 1991-10-31 1996-07-23 Smithkline Beecham Corp. 1,4 Diazocines as fibrinogen antagonists
AU2915892A (en) * 1991-11-14 1993-06-15 Glaxo Group Limited Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung

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SU1097620A1 (ru) * 1983-02-16 1984-06-15 Новокузнецкий научно-исследовательский химико-фармацевтический институт Способ получени диэтил-N-(6-метилпиридил-2)-аминометиленмалоната
SU1318599A1 (ru) * 1985-06-26 1987-06-23 МГУ им.М.В.Ломоносова Способ получени 1-алкил-2-хлор-2-алкоксиэтенилалкил(арил)хлорфосфинов
SU1480766A3 (ru) * 1985-08-17 1989-05-15 Берингер Маннхайм Гмбх (Фирма) Способ получени кристаллического торасемида
EP0356176B1 (en) * 1988-08-22 1993-09-22 HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD. Acetamide compounds
EP0359386A2 (en) * 1988-09-12 1990-03-21 General Motors Corporation Method and apparatus for press-forming intricate metallic shapes such as spool valve elements

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Кудрин А.Н. Фармакология. - М.: Медицина, 1991, с.19. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2273633C2 (ru) * 2000-10-04 2006-04-10 Киссеи Фармасьютикал Ко., Лтд. Производные 5-амидино-2-гидроксибензолсульфонамида, содержащие их фармацевтические композиции и промежуточные продукты для их получения
RU2273633C9 (ru) * 2000-10-04 2006-10-20 Киссеи Фармасьютикал Ко., Лтд. Производные 5-амидино-2-гидроксибензолсульфонамида, содержащие их фармацевтические композиции и промежуточные продукты для их получения
RU2353619C2 (ru) * 2007-06-28 2009-04-27 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции
RU2354647C2 (ru) * 2007-06-28 2009-05-10 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе
RU2685261C1 (ru) * 2018-04-05 2019-04-17 Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза

Also Published As

Publication number Publication date
CA2156729A1 (en) 1994-09-15
HUT72898A (en) 1996-06-28
CZ225495A3 (en) 1996-01-17
KR100252551B1 (ko) 2000-05-01
HU9502568D0 (en) 1995-11-28
AU6257494A (en) 1994-09-26
EP0687253A1 (de) 1995-12-20
WO1994020467A1 (de) 1994-09-15
IL108786A (en) 1999-04-11
CN1046710C (zh) 1999-11-24
CN1119858A (zh) 1996-04-03
NO953447L (no) 1995-09-01
FI954105A7 (fi) 1995-09-01
IL108786A0 (en) 1994-06-24
DE59407494D1 (de) 1999-01-28
ES2127919T3 (es) 1999-05-01
NO953447D0 (no) 1995-09-01
ATE174590T1 (de) 1999-01-15
GR3029691T3 (en) 1999-06-30
SK108295A3 (en) 1996-06-05
TW257757B (OSRAM) 1995-09-21
PL310520A1 (en) 1995-12-27
FI954105A0 (fi) 1995-09-01
DK0687253T3 (da) 1999-08-23
EP0687253B1 (de) 1998-12-16
JPH08507503A (ja) 1996-08-13
KR960701019A (ko) 1996-02-24
AU682026B2 (en) 1997-09-18
PL176455B1 (pl) 1999-05-31
NZ262725A (en) 1997-05-26

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